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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of lipid biosynthetic process
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Accession:GO:0051055 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
Synonyms:exact_synonym: down regulation of lipid biosynthetic process;   downregulation of lipid biosynthetic process;   negative regulation of lipid anabolism;   negative regulation of lipid biosynthesis;   negative regulation of lipid formation;   negative regulation of lipid synthesis;   negative regulation of lipogenesis
 narrow_synonym: inhibition of lipid biosynthetic process



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negative regulation of lipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO (PMID:12042316) Alzheimers_University_of_Toronto PMID:12042316 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,259...51,377,794
JBrowse link
G ASXL3 ASXL transcriptional regulator 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:117,334,177...117,518,589
Ensembl chr 6:117,334,200...117,518,026
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (MGI:3819735|PMID:18544705) UniProt PMID:18544705 MGI:3819735 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,982
JBrowse link
G LOC100510975 coiled-coil domain-containing protein 3 acts_upstream_of_or_within ISO (MGI:6108413|PMID:28827783) MGI PMID:28827783 MGI:6108413 NCBI chr10:59,052,979...59,144,791
Ensembl chr10:59,052,910...59,144,797
JBrowse link
G LOC106504546 serpin A12 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5563627|PMID:22837305) Ensembl
MGI
PMID:22837305 GO_REF:0000107 MGI:5563627 NCBI chr 7:115,720,892...115,734,810
Ensembl chr 7:115,720,677...115,734,816
JBrowse link
G STK11 serine/threonine kinase 11 acts_upstream_of_or_within ISO (MGI:5562992|PMID:24295069) MGI PMID:24295069 MGI:5562992 NCBI chr 2:77,229,888...77,249,322
Ensembl chr 2:77,230,372...77,249,327
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,215
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr 2:47,385,244...47,444,664
Ensembl chr 2:47,385,191...47,446,538
JBrowse link
G LOC100621006 RE1-silencing transcription factor-like involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 8:56,048,280...56,215,011
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
G REST RE1 silencing transcription factor involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 8:56,035,182...56,061,140
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in ISO (PMID:16959810) UniProt PMID:16959810 NCBI chr 6:80,110,238...80,138,165 JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5501367|PMID:23747249) Ensembl
MGI
PMID:23747249 GO_REF:0000107 MGI:5501367 NCBI chr 2:3,583,027...3,586,985
Ensembl chr 2:3,583,027...3,587,825
JBrowse link
G MALRD1 MAM and LDL receptor class A domain containing 1 acts_upstream_of_or_within ISO (MGI:5501367|PMID:23747249) MGI PMID:23747249 MGI:5501367 NCBI chr10:54,782,806...55,381,043 JBrowse link
G PROX1 prospero homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:129,527,704...129,583,693
Ensembl chr 9:129,532,164...129,580,979
JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:23,053,129...23,058,865
Ensembl chr 5:23,050,114...23,058,470
JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:124,619,887...124,629,638
Ensembl chr 4:124,621,258...124,629,639
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,637...118,506,691
JBrowse link
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(PMID:25691431)
GO_Central
MGI
PMID:21873635 PMID:25691431 NCBI chr15:94,359,784...94,377,331
Ensembl chr15:94,359,333...94,377,303
JBrowse link
G ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(PMID:25691431)
GO_Central
MGI
PMID:21873635 PMID:25691431 NCBI chr 5:21,262,134...21,264,689
Ensembl chr 5:21,262,193...21,264,687
JBrowse link
G ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:25691431)
(MGI:5638294|PMID:25691431)
(PMID:21873635)
Ensembl
MGI
GO_Central
PMID:21873635 PMID:25691431 GO_REF:0000107 MGI:5638294 NCBI chr12:22,411,130...22,417,744
Ensembl chr12:22,411,259...22,429,621
JBrowse link
G SPHK1 sphingosine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:5,114,946...5,122,580
Ensembl chr12:5,114,948...5,120,119
JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IEA
ISO
Ensembl
RGD
PMID:9225228 GO_REF:0000107 RGD:10059686 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,259...51,377,794
JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:48,643,722...48,662,648
Ensembl chr15:48,643,724...48,662,536
JBrowse link
G LOC110258909 isopentenyl-diphosphate Delta-isomerase 1-like acts_upstream_of_or_within ISO (MGI:5490819|PMID:17202134) MGI PMID:17202134 MGI:5490819
G SOD1 superoxide dismutase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,215
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr 2:47,385,244...47,444,664
Ensembl chr 2:47,385,191...47,446,538
JBrowse link
G LOC100621006 RE1-silencing transcription factor-like involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 8:56,048,280...56,215,011
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
G REST RE1 silencing transcription factor involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 8:56,035,182...56,061,140
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
negative regulation of fatty acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADL acyl-CoA dehydrogenase long chain involved_in ISO (MGI:3526480|PMID:15639194) BHF-UCL PMID:15639194 MGI:3526480 NCBI chr15:112,935,631...112,969,381
Ensembl chr15:112,933,498...112,969,578
JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,573,521...52,581,755
Ensembl chr12:52,576,401...52,581,755
JBrowse link
G APOC3 apolipoprotein C3 involved_in ISO (PMID:11060345), (PMID:18635818) BHF-UCL PMID:11060345 PMID:18635818 NCBI chr 9:44,211,171...44,213,538 JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,855,570
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO PMID:16054098 UniProt PMID:16054098 RGD:11059593 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,342,856...74,372,638
JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:48,643,722...48,662,648
Ensembl chr15:48,643,724...48,662,536
JBrowse link
G INSIG1 insulin induced gene 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3603108|PMID:16100574) Ensembl
MGI
PMID:16100574 GO_REF:0000107 MGI:3603108 NCBI chr18:2,885,494...2,898,758
Ensembl chr18:2,885,611...2,898,767
JBrowse link
G INSIG2 insulin induced gene 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3603108|PMID:16100574) Ensembl
MGI
PMID:16100574 GO_REF:0000107 MGI:3603108 NCBI chr15:23,676,684...23,699,591
Ensembl chr15:23,676,683...23,699,585
JBrowse link
G TRIB3 tribbles pseudokinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:34,808,273...34,819,592
Ensembl chr17:34,807,534...34,816,451
JBrowse link
G WDTC1 WD and tetratricopeptide repeats 1 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
(PMID:21873635)
(MGI:3770497|PMID:17767906)
GO_Central
MGI
Ensembl
PMID:17767906 PMID:21873635 GO_REF:0000107 MGI:3770497 NCBI chr 6:84,467,532...84,537,069
Ensembl chr 6:84,467,734...84,536,585
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696486|PMID:17234593) Ensembl
MGI
PMID:17234593 GO_REF:0000107 MGI:3696486 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,606
JBrowse link
negative regulation of phosphatidate phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LPIN1 lipin 1 ISO RGD PMID:21715287 RGD:38599010 NCBI chr 3:124,940,557...125,074,137
Ensembl chr 3:124,940,548...125,074,123
JBrowse link
negative regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LPCAT1 lysophosphatidylcholine acyltransferase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4460850|PMID:20018880) Ensembl
MGI
PMID:20018880 GO_REF:0000107 MGI:4460850 NCBI chr16:79,134,396...79,173,775
Ensembl chr16:79,134,465...79,173,775
JBrowse link
negative regulation of phosphatidylinositol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFA platelet derived growth factor subunit A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:296,399...322,967
Ensembl chr 3:303,311...323,036
JBrowse link
G PDGFB platelet derived growth factor subunit B involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:8,986,461...9,007,446 JBrowse link
negative regulation of phospholipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 involved_in ISO (PMID:24201375) ARUK-UCL PMID:24201375 RGD:14697729
G SLC27A1 solute carrier family 27 member 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:60,203,374...60,235,689
Ensembl chr 2:60,203,374...60,235,652
JBrowse link
negative regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIBF1 progesterone immunomodulatory binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:45,076,046...45,362,708
Ensembl chr11:45,076,061...45,362,891
JBrowse link
G SIRT1 sirtuin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,157...71,123,299
JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1 member C3 involved_in ISO (PMID:21851338) UniProt PMID:21851338 NCBI chr10:65,650,223...65,679,878
Ensembl chr10:65,576,464...65,678,248
JBrowse link
G PRMT3 protein arginine methyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:38,884,311...39,032,944
Ensembl chr 2:38,884,361...39,032,916
JBrowse link
negative regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 involved_in ISO (PMID:24201375) ARUK-UCL PMID:24201375 RGD:14697729
G ATG7 autophagy related 7 acts_upstream_of_or_within ISO (MGI:5613260|PMID:25332431) MGI PMID:25332431 MGI:5613260 NCBI chr13:67,301,756...67,699,141
Ensembl chr13:67,417,938...67,707,660
JBrowse link
negative regulation of steroid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,215
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G HRH1 histamine receptor H1 ISO RGD PMID:15917347 RGD:2316921 NCBI chr13:67,209,261...67,411,174
Ensembl chr13:67,209,127...67,411,171
JBrowse link
G INSIG1 insulin induced gene 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3603108|PMID:16100574) Ensembl
MGI
PMID:16100574 GO_REF:0000107 MGI:3603108 NCBI chr18:2,885,494...2,898,758
Ensembl chr18:2,885,611...2,898,767
JBrowse link
G INSIG2 insulin induced gene 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3603108|PMID:16100574) Ensembl
MGI
PMID:16100574 GO_REF:0000107 MGI:3603108 NCBI chr15:23,676,684...23,699,591
Ensembl chr15:23,676,683...23,699,585
JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 involved_in
acts_upstream_of
IEA
ISS
Ensembl
HGNC-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr  X:26,117,874...26,122,951
Ensembl chr  X:26,117,868...26,122,995
JBrowse link
G WNT4 Wnt family member 4 involved_in ISO (PMID:15317892), (PMID:18182450) UniProt PMID:15317892 PMID:18182450 NCBI chr 6:80,110,238...80,138,165 JBrowse link
negative regulation of steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE8B phosphodiesterase 8B involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5526088|PMID:21187369) Ensembl
MGI
PMID:21187369 GO_REF:0000107 MGI:5526088 NCBI chr 2:86,007,190...86,323,796 JBrowse link
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKKL1 dickkopf like acrosomal protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,462,367...54,468,363
Ensembl chr 6:54,463,759...54,468,361
JBrowse link
G WNT4 Wnt family member 4 involved_in ISO (PMID:12949260)
(MGI:2675528|PMID:12949260)
UniProt PMID:12949260 MGI:2675528 NCBI chr 6:80,110,238...80,138,165 JBrowse link
negative regulation of triglyceride biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1H4 nuclear receptor subfamily 1 group H member 4 ISO RGD PMID:29148806 RGD:15042869 NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,288...83,684,604
JBrowse link
G SIK1 salt inducible kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:206,454,695...206,465,802 JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAI1 snail family transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:51,546,446...51,552,498
Ensembl chr17:51,546,393...51,552,504
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:79,264,880...79,268,475
Ensembl chr 4:79,264,878...79,268,475
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16581
    negative regulation of biological process 5312
      negative regulation of metabolic process 2995
        negative regulation of biosynthetic process 1574
          negative regulation of lipid biosynthetic process 55
            negative regulation of abscisic acid biosynthetic process 0
            negative regulation of butyryl-CoA catabolic process to butanol 0
            negative regulation of carotenoid biosynthetic process 0
            negative regulation of diacylglycerol biosynthetic process 0
            negative regulation of emericellamide biosynthetic process + 0
            negative regulation of ent-pimara-8(14),15-diene biosynthetic process 0
            negative regulation of fatty acid biosynthetic process + 13
            negative regulation of gibberellin biosynthetic process 0
            negative regulation of isoprene biosynthetic process 0
            negative regulation of juvenile hormone biosynthetic process 0
            negative regulation of methyl-branched fatty acid biosynthetic process 0
            negative regulation of phospholipid biosynthetic process + 6
            negative regulation of retinoic acid biosynthetic process 2
            negative regulation of sphingolipid biosynthetic process + 6
            negative regulation of steroid biosynthetic process + 25
            negative regulation of triglyceride biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 16581
    biological regulation 12071
      regulation of biological process 11445
        regulation of metabolic process 6298
          regulation of primary metabolic process 5350
            regulation of lipid metabolic process 360
              negative regulation of lipid metabolic process 105
                negative regulation of lipid biosynthetic process 55
                  negative regulation of abscisic acid biosynthetic process 0
                  negative regulation of butyryl-CoA catabolic process to butanol 0
                  negative regulation of carotenoid biosynthetic process 0
                  negative regulation of diacylglycerol biosynthetic process 0
                  negative regulation of emericellamide biosynthetic process + 0
                  negative regulation of ent-pimara-8(14),15-diene biosynthetic process 0
                  negative regulation of fatty acid biosynthetic process + 13
                  negative regulation of gibberellin biosynthetic process 0
                  negative regulation of isoprene biosynthetic process 0
                  negative regulation of juvenile hormone biosynthetic process 0
                  negative regulation of methyl-branched fatty acid biosynthetic process 0
                  negative regulation of phospholipid biosynthetic process + 6
                  negative regulation of retinoic acid biosynthetic process 2
                  negative regulation of sphingolipid biosynthetic process + 6
                  negative regulation of steroid biosynthetic process + 25
                  negative regulation of triglyceride biosynthetic process + 3
paths to the root