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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of DNA metabolic process
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Accession:GO:0051053 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.
Synonyms:exact_synonym: down regulation of DNA metabolic process;   downregulation of DNA metabolic process;   negative regulation of DNA metabolism
 narrow_synonym: inhibition of DNA metabolic process

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negative regulation of DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sub1 SUB1 regulator of transcription involved_in ISO (PMID:28369605) CACAO PMID:28369605 NCBI chrNW_004955426:18,380,680...18,394,627
Ensembl chrNW_004955426:18,380,117...18,394,627 		JBrowse link
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha acts_upstream_of_or_within
involved_in		 ISO (PMID:15572351)
(PMID:10601318), (PMID:14663139)
(PMID:11371636)		 MGI
ComplexPortal		 PMID:10601318 PMID:11371636 PMID:14663139 PMID:15572351 NCBI chrNW_004955486:3,273,712...3,274,510 JBrowse link
G Dffb DNA fragmentation factor subunit beta involved_in ISO (PMID:11371636) ComplexPortal PMID:11371636 NCBI chrNW_004955486:7,836,013...7,849,875
Ensembl chrNW_004955486:7,838,273...7,850,180 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:27184051 RGD:13781945 NCBI chrNW_004955486:3,637,794...3,655,744
Ensembl chrNW_004955486:3,637,794...3,655,598 		JBrowse link
G Pam16 presequence translocase associated motor 16 ISO RGD PMID:24069394 RGD:13462066 NCBI chrNW_004955442:13,087,082...13,097,048
Ensembl chrNW_004955442:13,087,092...13,097,048 		JBrowse link
negative regulation of DNA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO (PMID:12070119) UniProt PMID:12070119 NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402 		JBrowse link
G Ahr aryl hydrocarbon receptor ISO RGD PMID:12193573 RGD:625678 NCBI chrNW_004955410:20,428,531...20,459,482
Ensembl chrNW_004955410:20,428,546...20,456,836 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 involved_in ISO (PMID:11139470) BHF-UCL PMID:11139470 NCBI chrNW_004955425:2,258,554...2,267,699
Ensembl chrNW_004955425:2,258,392...2,267,878 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A involved_in ISO (PMID:11595739) UniProt PMID:11595739 NCBI chrNW_004955437:6,254,638...6,261,278
Ensembl chrNW_004955437:6,254,309...6,261,479 		JBrowse link
G Chek1 checkpoint kinase 1 ISO RGD PMID:12429946 RGD:2316115 NCBI chrNW_004955412:26,627,606...26,650,554 JBrowse link
G Dach1 dachshund family transcription factor 1 involved_in ISO (PMID:16980615) CACAO PMID:16980615 NCBI chrNW_004955404:34,739,780...35,118,037
Ensembl chrNW_004955404:34,740,026...35,137,490 		JBrowse link
G Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 acts_upstream_of_or_within ISO (PMID:7559602) MGI PMID:7559602 NCBI chrNW_004955410:8,317,640...8,338,407
Ensembl chrNW_004955410:8,317,646...8,338,501 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:10446064 RGD:7771571 NCBI chrNW_004955408:25,481,294...25,484,381
Ensembl chrNW_004955408:25,481,294...25,484,381 		JBrowse link
G Gja1 gap junction protein alpha 1 ISO RGD PMID:14702389 RGD:8662403 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 ISO RGD PMID:23271285 RGD:9831181 NCBI chrNW_004955406:2,793,493...2,975,322
Ensembl chrNW_004955406:2,791,803...2,975,322 		JBrowse link
G Niban2 niban apoptosis regulator 2 involved_in ISO (PMID:14602737), (PMID:17569660), (PMID:20032057) UniProt PMID:14602737 PMID:17569660 PMID:20032057 NCBI chrNW_004955419:1,089,602...1,119,620
Ensembl chrNW_004955419:1,072,243...1,119,620 		JBrowse link
G Nppc natriuretic peptide C ISO RGD PMID:12746286 RGD:1580115 NCBI chrNW_004955453:3,884,580...3,888,494
Ensembl chrNW_004955453:3,884,560...3,888,850 		JBrowse link
G Rgn regucalcin ISO RGD PMID:11500948 RGD:9590199 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910 		JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:11502571 RGD:70312 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
negative regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin ISO RGD PMID:2001740 RGD:9590215 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910 		JBrowse link
negative regulation of DNA demethylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO (PMID:15087456) MGI PMID:15087456 NCBI chrNW_004955421:24,448,446...24,477,885
Ensembl chrNW_004955421:24,457,496...24,478,744 		JBrowse link
G Trim28 tripartite motif containing 28 acts_upstream_of_or_within ISO (PMID:22442485) MGI PMID:22442485 NCBI chrNW_004955584:1,148,903...1,156,001 JBrowse link
negative regulation of DNA endoreduplication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo5 F-box protein 5 involved_in ISO (PMID:17875940) UniProt PMID:17875940 NCBI chrNW_004955439:8,830,658...8,843,653
Ensembl chrNW_004955439:8,830,975...8,843,828 		JBrowse link
negative regulation of DNA recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase involved_in ISO (PMID:9671747) UniProt PMID:9671747 NCBI chrNW_004955416:14,814,753...14,899,865
Ensembl chrNW_004955416:14,842,033...14,899,687 		JBrowse link
G Lig3 DNA ligase 3 acts_upstream_of_or_within ISO (PMID:16648486) MGI PMID:16648486 NCBI chrNW_004955481:9,696,050...9,716,154
Ensembl chrNW_004955481:9,696,054...9,715,637 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:17715146)
(PMID:10545954), (PMID:7628020)		 BHF-UCL
MGI		 PMID:7628020 PMID:10545954 PMID:17715146 NCBI chrNW_004955441:14,188,315...14,247,608
Ensembl chrNW_004955441:14,187,805...14,247,698 		JBrowse link
G Msh3 mutS homolog 3 involved_in ISO (PMID:17715146) BHF-UCL PMID:17715146 NCBI chrNW_004955418:29,149,595...29,274,067
Ensembl chrNW_004955418:29,150,085...29,274,437 		JBrowse link
G Msh6 mutS homolog 6 involved_in
acts_upstream_of_or_within		 ISO (PMID:17715146)
(PMID:10545954)		 BHF-UCL
MGI		 PMID:10545954 PMID:17715146 NCBI chrNW_004955441:14,451,207...14,471,316
Ensembl chrNW_004955441:14,451,307...14,471,227 		JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase acts_upstream_of_or_within ISO (PMID:12509447) MGI PMID:12509447 NCBI chrNW_004955561:463,586...602,354
Ensembl chrNW_004955561:464,343...599,789 		JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chrNW_004955528:531,680...578,003
Ensembl chrNW_004955528:532,385...572,398 		JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 involved_in ISO (PMID:22704558) UniProt PMID:22704558 NCBI chrNW_004955440:2,683,041...2,907,859
Ensembl chrNW_004955440:2,680,787...2,888,345 		JBrowse link
negative regulation of DNA recombination at telomere term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf2ip TERF2 interacting protein involved_in ISO (MGI:4440768|PMID:20339076), (MGI:4839412|PMID:20622869) UniProt PMID:20339076 PMID:20622869 MGI:4440768 MGI:4839412 NCBI chrNW_004955484:1,917,902...1,924,482
Ensembl chrNW_004955484:1,917,767...1,925,044 		JBrowse link
negative regulation of DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase involved_in ISO (PMID:35210392) UniProt PMID:35210392 NCBI chrNW_004955493:8,593,104...8,607,297 JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:17049931) UniProt PMID:17049931 NCBI chrNW_004955414:16,436,899...16,442,325
Ensembl chrNW_004955414:16,436,899...16,443,073 		JBrowse link
negative regulation of DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atr ATR serine/threonine kinase involved_in ISO (PMID:14657349) UniProt PMID:14657349 NCBI chrNW_004955508:3,337,036...3,440,313
Ensembl chrNW_004955508:3,337,432...3,440,257 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISO (PMID:12671034) UniProt PMID:12671034 NCBI chrNW_004955506:3,151,133...3,154,613
Ensembl chrNW_004955506:3,151,133...3,154,613 		JBrowse link
G Gmnn geminin DNA replication inhibitor involved_in ISO (PMID:9635433)
(MGI:2388867|PMID:12192004)		 UniProt PMID:9635433 PMID:12192004 MGI:2388867 NCBI chrNW_004955483:2,283,518...2,344,982
Ensembl chrNW_004955483:2,282,485...2,293,924 		JBrowse link
G Gtpbp4 GTP binding protein 4 involved_in ISO (PMID:17210637) HGNC-UCL PMID:17210637 NCBI chrNW_004955492:5,594...33,558
Ensembl chrNW_004955492:5,594...34,111 		JBrowse link
G Hcrt hypocretin neuropeptide precursor ISO in seminiferous tubules at epithelial cycle stage V RGD PMID:16141395 RGD:1600965 NCBI chrNW_004955451:16,235,819...16,237,457
Ensembl chrNW_004955451:16,235,819...16,237,457 		JBrowse link
G Hmgb1 high mobility group box 1 ISO RGD PMID:18191612 RGD:2316772 NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chrNW_004955414:19,146,304...19,163,923
Ensembl chrNW_004955414:19,145,432...19,163,923 		JBrowse link
G Mapk15 mitogen-activated protein kinase 15 ISO RGD PMID:9891064 RGD:632686 NCBI chrNW_004955454:2,413,393...2,420,703
Ensembl chrNW_004955454:2,413,822...2,419,276 		JBrowse link
G Pds5a PDS5 cohesin associated factor A involved_in ISO (PMID:19907496) UniProt PMID:19907496 NCBI chrNW_004955443:7,475,434...7,603,548
Ensembl chrNW_004955443:7,475,385...7,604,714 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in ISO (PMID:14657349) UniProt PMID:14657349 NCBI chrNW_004955575:78,686...115,072
Ensembl chrNW_004955575:78,335...115,129 		JBrowse link
G Slfn11 schlafen family member 11 involved_in ISO (PMID:29395061) UniProt PMID:29395061 NCBI chrNW_004955481:9,885,798...9,900,330 JBrowse link
G Terf1 telomeric repeat binding factor 1 involved_in ISO (PMID:11327863) BHF-UCL PMID:11327863 NCBI chrNW_004955444:7,103,282...7,149,450
Ensembl chrNW_004955444:7,103,552...7,150,323 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:11884608) MGI PMID:11884608 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
G Tspyl2 TSPY like 2 involved_in ISO (PMID:11395479) UniProt PMID:11395479 NCBI chrNW_004955475:160,768...167,359
Ensembl chrNW_004955475:160,964...167,440 		JBrowse link
G Wapl WAPL cohesin release factor involved_in ISO (PMID:19907496) UniProt PMID:19907496 NCBI chrNW_004955510:5,596,622...5,674,221
Ensembl chrNW_004955510:5,593,335...5,674,221 		JBrowse link
negative regulation of DNA strand resection involved in replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dynll1 dynein light chain LC8-type 1 involved_in ISO (PMID:30464262), (PMID:37696958) UniProt PMID:30464262 PMID:37696958 NCBI chrNW_004955455:11,148,041...11,150,860
Ensembl chrNW_004955455:11,148,047...11,150,859 		JBrowse link
negative regulation of DNA-templated DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:19906994) ComplexPortal PMID:19906994 NCBI chrNW_004955541:2,683,030...2,687,883
Ensembl chrNW_004955541:2,683,408...2,687,102 		JBrowse link
G Gmnn geminin DNA replication inhibitor involved_in ISO (PMID:11125146), (PMID:19906994) CAFA PMID:11125146 PMID:19906994 NCBI chrNW_004955483:2,283,518...2,344,982
Ensembl chrNW_004955483:2,282,485...2,293,924 		JBrowse link
negative regulation of double-strand break repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 involved_in ISO (PMID:20725033) UniProt PMID:20725033 NCBI chrNW_004955422:21,047,184...21,055,596
Ensembl chrNW_004955422:21,047,184...21,055,616 		JBrowse link
G Rnf169 ring finger protein 169 involved_in ISO (PMID:22492721), (PMID:22733822)
(PMID:22742833)		 UniProt PMID:22492721 PMID:22733822 PMID:22742833 NCBI chrNW_004955414:16,899,101...16,962,690
Ensembl chrNW_004955414:16,899,155...16,962,381 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) BHF-UCL PMID:17690110 NCBI chrNW_004955410:22,003,981...22,005,483 JBrowse link
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in ISO (PMID:9461559) UniProt PMID:9461559 NCBI chrNW_004955513:652,048...799,182
Ensembl chrNW_004955513:653,252...799,239 		JBrowse link
G C1qbp complement C1q binding protein involved_in ISO (PMID:31353207) UniProt PMID:31353207 NCBI chrNW_004955467:10,788,142...10,792,272
Ensembl chrNW_004955467:10,788,277...10,792,449 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO (MGI:6241455|PMID:30356214)
(MGI:6370284|PMID:31544964)
(PMID:30356214), (PMID:31544964)		 UniProt PMID:30356214 PMID:31544964 MGI:6241455 MGI:6370284 NCBI chrNW_004955493:8,593,104...8,607,297 JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 involved_in ISO (PMID:28512243) UniProt PMID:28512243 NCBI chrNW_004955597:326,601...397,112 JBrowse link
G Fancb FA complementation group B acts_upstream_of_or_within ISO (PMID:25520194) MGI PMID:25520194 NCBI chrNW_004955519:3,337,138...3,364,963
Ensembl chrNW_004955519:3,343,446...3,363,814 		JBrowse link
G Fbh1 F-box DNA helicase 1 involved_in ISO (PMID:19736316)
(MGI:5566975|PMID:24108124)		 UniProt PMID:19736316 PMID:24108124 MGI:5566975 NCBI chrNW_004955421:22,535,777...22,579,965
Ensembl chrNW_004955421:22,535,777...22,579,965 		JBrowse link
G Helb DNA helicase B involved_in ISO (PMID:26774285)
(MGI:5766842|PMID:26774285)		 UniProt PMID:26774285 MGI:5766842 NCBI chrNW_004955458:12,929,345...12,971,059
Ensembl chrNW_004955458:12,929,447...12,974,154 		JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISO (PMID:32832608) UniProt PMID:32832608 NCBI chrNW_004955422:19,557,498...19,565,044
Ensembl chrNW_004955422:19,557,498...19,565,036 		JBrowse link
G Klhl15 kelch like family member 15 involved_in ISO (PMID:27561354), (PMID:35219381) UniProt PMID:27561354 PMID:35219381 NCBI chrNW_004955509:4,377,975...4,439,287
Ensembl chrNW_004955509:4,375,240...4,439,287 		JBrowse link
G Kmt5a lysine methyltransferase 5A involved_in ISO (PMID:27338793) UniProt PMID:27338793 NCBI chrNW_004955482:5,488,151...5,500,764
Ensembl chrNW_004955482:5,485,649...5,501,636 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chrNW_004955486:2,191,903...2,197,193
Ensembl chrNW_004955486:2,191,903...2,198,538 		JBrowse link
G Magef1 MAGE family member F1 involved_in ISO (PMID:29225034) UniProt PMID:29225034 NCBI chrNW_004955420:22,797,581...22,799,301 JBrowse link
G Parpbp PARP1 binding protein involved_in ISO (PMID:22153967) UniProt PMID:22153967 NCBI chrNW_004955405:37,297,816...37,357,191
Ensembl chrNW_004955405:37,297,329...37,361,803 		JBrowse link
G Plk1 polo like kinase 1 involved_in ISO (PMID:28512243) UniProt PMID:28512243 NCBI chrNW_004955493:2,206,353...2,217,231
Ensembl chrNW_004955493:2,206,353...2,217,231 		JBrowse link
G Polq DNA polymerase theta involved_in ISO (MGI:5920742|PMID:28687761)
(MGI:5621198|PMID:25642960), (MGI:6869820|PMID:29058711)
(PMID:28695890)
(PMID:25642963), (PMID:36455556)		 UniProt PMID:25642960 PMID:25642963 PMID:28687761 PMID:28695890 PMID:29058711 More... MGI:5621198 MGI:5920742 MGI:6869820 NCBI chrNW_004955427:20,779,332...20,895,094
Ensembl chrNW_004955427:20,778,952...20,894,989 		JBrowse link
G Recql5 RecQ like helicase 5 acts_upstream_of_or_within ISO (PMID:25520194) MGI PMID:25520194 NCBI chrNW_004955506:6,574,802...6,612,763
Ensembl chrNW_004955506:6,575,408...6,612,186 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (PMID:23333306)
(MGI:5468037|PMID:23306437), (MGI:5476381|PMID:23333305)		 UniProt PMID:23306437 PMID:23333305 PMID:23333306 MGI:5468037 MGI:5476381 NCBI chrNW_004955440:16,977,710...17,047,809
Ensembl chrNW_004955440:16,979,042...17,041,748 		JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chrNW_004955415:16,180,074...16,282,937
Ensembl chrNW_004955415:16,180,051...16,280,864 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chrNW_004955510:6,021,477...6,114,745
Ensembl chrNW_004955510:6,075,510...6,114,898 		JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in ISO (PMID:25294876) UniProt PMID:25294876 NCBI chrNW_004955402:7,544,265...7,661,191
Ensembl chrNW_004955402:7,544,265...7,649,067 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23333306), (PMID:23345425)
(MGI:5887194|PMID:20362325)
(MGI:5476381|PMID:23333305)		 UniProt PMID:20362325 PMID:23333305 PMID:23333306 PMID:23345425 MGI:5476381 MGI:5887194 NCBI chrNW_004955416:9,962,736...10,035,433
Ensembl chrNW_004955416:9,962,897...10,035,278 		JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO (PMID:30612738) UniProt PMID:30612738 NCBI chrNW_004955545:2,218,794...2,236,665
Ensembl chrNW_004955545:2,220,548...2,236,646 		JBrowse link
negative regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aunip aurora kinase A and ninein interacting protein involved_in ISO (PMID:29042561) UniProt PMID:29042561 NCBI chrNW_004955452:5,323,345...5,336,589
Ensembl chrNW_004955452:5,325,426...5,336,833 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor involved_in ISO (PMID:25820262) UniProt PMID:25820262 NCBI chrNW_004955556:745,175...812,215
Ensembl chrNW_004955556:748,231...813,133 		JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO (PMID:19549901) UniProt PMID:19549901 NCBI chrNW_004955458:12,493,790...12,624,805 JBrowse link
G Hsf1 heat shock transcription factor 1 involved_in ISO (PMID:26359349) UniProt PMID:26359349 NCBI chrNW_004955454:2,907,265...2,932,352
Ensembl chrNW_004955454:2,907,265...2,932,351 		JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 involved_in ISO (PMID:28241136) UniProt PMID:28241136 NCBI chrNW_004955442:12,761,962...12,777,549
Ensembl chrNW_004955442:12,775,630...12,777,549 		JBrowse link
negative regulation of double-strand break repair via single-strand annealing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogg1 8-oxoguanine DNA glycosylase acts_upstream_of_or_within ISO (PMID:19506022) MGI PMID:19506022 NCBI chrNW_004955561:1,277,362...1,282,949
Ensembl chrNW_004955561:1,277,365...1,282,793 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly(ADP-ribose) polymerase family member 3 involved_in ISO (MGI:6214451|PMID:26000965) UniProt PMID:26000965 MGI:6214451 NCBI chrNW_004955532:3,591,484...3,597,549
Ensembl chrNW_004955532:3,591,499...3,597,549 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:10490661) MGI PMID:10490661 NCBI chrNW_004955420:19,998,960...20,021,200
Ensembl chrNW_004955420:19,998,742...20,022,259 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO (PMID:17137798) MGI PMID:17137798 NCBI chrNW_004955415:11,643,846...11,666,131
Ensembl chrNW_004955415:11,643,846...11,666,131 		JBrowse link
negative regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 ISO RGD PMID:23800874 RGD:11557986 NCBI chrNW_004955429:14,076,976...14,301,034
Ensembl chrNW_004955429:14,076,960...14,304,236 		JBrowse link
G Lig3 DNA ligase 3 involved_in ISO (PMID:21878356) CACAO PMID:21878356 NCBI chrNW_004955481:9,696,050...9,716,154
Ensembl chrNW_004955481:9,696,054...9,715,637 		JBrowse link
negative regulation of mitotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankle1 ankyrin repeat and LEM domain containing 1 involved_in ISO (MGI:5800654|PMID:27010503) UniProt PMID:27010503 MGI:5800654 NCBI chrNW_004955524:933,200...936,933 JBrowse link
G Blm BLM RecQ like helicase involved_in
acts_upstream_of_or_within		 ISO (MGI:5800654|PMID:27010503)
(PMID:11101838)
(PMID:17210642)
(PMID:16914751), (PMID:9808625)		 UniProt
MGI		 PMID:9808625 PMID:11101838 PMID:16914751 PMID:17210642 PMID:27010503 MGI:5800654 NCBI chrNW_004955416:14,814,753...14,899,865
Ensembl chrNW_004955416:14,842,033...14,899,687 		JBrowse link
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:15480418) MGI PMID:15480418 NCBI chrNW_004955421:3,890,291...3,936,892
Ensembl chrNW_004955421:3,890,306...3,936,526 		JBrowse link
negative regulation of protection from non-homologous end joining at telomere term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (PMID:14690602) BHF-UCL PMID:14690602 NCBI chrNW_004955555:2,393,510...2,430,180
Ensembl chrNW_004955555:2,393,278...2,406,582 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:14690602) BHF-UCL PMID:14690602 NCBI chrNW_004955442:4,833,453...4,861,201
Ensembl chrNW_004955442:4,831,721...4,861,122 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 involved_in ISO (MGI:3758502|PMID:14690602) BHF-UCL PMID:14690602 MGI:3758502 NCBI chrNW_004955555:1,293,416...1,315,839
Ensembl chrNW_004955555:1,293,416...1,315,839 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in ISO (MGI:3758502|PMID:14690602) BHF-UCL PMID:14690602 MGI:3758502 NCBI chrNW_004955418:27,174,510...27,426,245
Ensembl chrNW_004955418:27,173,659...27,426,264 		JBrowse link
negative regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (PMID:25620558)
(MGI:5522574|PMID:24115439), (MGI:5645200|PMID:22579284)		 BHF-UCL PMID:22579284 PMID:24115439 PMID:25620558 MGI:5522574 MGI:5645200 NCBI chrNW_004955528:531,680...578,003
Ensembl chrNW_004955528:532,385...572,398 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:15507207) BHF-UCL PMID:15507207 NCBI chrNW_004955484:7,318,813...7,344,221
Ensembl chrNW_004955484:7,318,860...7,347,430 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 involved_in ISO (PMID:19581589) BHF-UCL PMID:19581589 NCBI chrNW_004955453:16,967,453...17,054,634
Ensembl chrNW_004955453:16,967,453...17,054,634 		JBrowse link
negative regulation of telomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator activated receptor gamma ISO RGD PMID:16556873 RGD:1580657 NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387 		JBrowse link
negative regulation of telomere capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:17694070) BHF-UCL PMID:17694070 NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545 		JBrowse link
G Nbn nibrin involved_in ISO (PMID:17694070) BHF-UCL PMID:17694070 NCBI chrNW_004955417:6,840,916...6,880,479
Ensembl chrNW_004955417:6,839,312...6,880,133 		JBrowse link
G Rad50 RAD50 double strand break repair protein involved_in ISO (PMID:17694070) BHF-UCL PMID:17694070 NCBI chrNW_004955408:3,953,801...4,035,494
Ensembl chrNW_004955408:3,953,800...4,035,494 		JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor involved_in ISO (PMID:12676087) BHF-UCL PMID:12676087 NCBI chrNW_004955481:940,041...1,177,998
Ensembl chrNW_004955481:940,041...1,177,998 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:24270157) BHF-UCL PMID:24270157 NCBI chrNW_004955484:7,318,813...7,344,221
Ensembl chrNW_004955484:7,318,860...7,347,430 		JBrowse link
negative regulation of telomere maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (PMID:17055345) UniProt PMID:17055345 NCBI chrNW_004955555:2,393,510...2,430,180
Ensembl chrNW_004955555:2,393,278...2,406,582 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:17055345) UniProt PMID:17055345 NCBI chrNW_004955442:4,833,453...4,861,201
Ensembl chrNW_004955442:4,831,721...4,861,122 		JBrowse link
negative regulation of telomere maintenance in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (MGI:5645200|PMID:22579284) BHF-UCL PMID:22579284 MGI:5645200 NCBI chrNW_004955528:531,680...578,003
Ensembl chrNW_004955528:532,385...572,398 		JBrowse link
negative regulation of telomere maintenance via recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:15507207)
(MGI:5883205|PMID:24120135)		 BHF-UCL PMID:15507207 PMID:24120135 MGI:5883205 NCBI chrNW_004955484:7,318,813...7,344,221
Ensembl chrNW_004955484:7,318,860...7,347,430 		JBrowse link
negative regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD shelterin complex subunit and telomerase recruitment factor involved_in ISO (PMID:15380063)
(PMID:15181449)		 BHF-UCL PMID:15181449 PMID:15380063 NCBI chrNW_004955484:9,022,520...9,025,446
Ensembl chrNW_004955484:9,022,520...9,025,446 		JBrowse link
G Ctc1 CST telomere replication complex component 1 involved_in ISO (PMID:22763445) BHF-UCL PMID:22763445 NCBI chrNW_004955467:8,673,069...8,700,730
Ensembl chrNW_004955467:8,673,128...8,702,165 		JBrowse link
G Dcp2 decapping mRNA 2 involved_in ISO (PMID:26950371) BHF-UCL PMID:26950371 NCBI chrNW_004955408:32,868,184...32,923,788
Ensembl chrNW_004955408:32,868,184...32,916,807 		JBrowse link
G Exosc10 exosome component 10 involved_in ISO (PMID:26950371) BHF-UCL PMID:26950371 NCBI chrNW_004955486:2,601,362...2,626,451
Ensembl chrNW_004955486:2,601,322...2,626,876 		JBrowse link
G Gnl3l G protein nucleolar 3 like involved_in ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chrNW_004955475:1,792,268...1,849,601
Ensembl chrNW_004955475:1,792,268...1,854,288 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 involved_in ISO (PMID:23935072) BHF-UCL PMID:23935072 NCBI chrNW_004955458:1,530,163...1,536,874 JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C involved_in ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chrNW_004955550:1,949,975...2,002,297
Ensembl chrNW_004955550:1,949,975...2,002,297 		JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chrNW_004955406:8,000,269...8,021,554
Ensembl chrNW_004955406:8,000,269...8,021,554 		JBrowse link
G Nat10 N-acetyltransferase 10 involved_in ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chrNW_004955422:12,085,970...12,122,644
Ensembl chrNW_004955422:12,085,970...12,122,425 		JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase involved_in ISO (PMID:23657261) BHF-UCL PMID:23657261 NCBI chrNW_004955450:10,722,570...10,729,852
Ensembl chrNW_004955450:10,722,016...10,727,565 		JBrowse link
G Pinx1 PIN2 (TERF1) interacting telomerase inhibitor 1 involved_in ISO (PMID:11701125)
(PMID:21119197)		 BHF-UCL PMID:11701125 PMID:21119197 NCBI chrNW_004955403:52,284,378...52,361,924
Ensembl chrNW_004955403:52,284,166...52,362,206 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:19567472) UniProt PMID:19567472 NCBI chrNW_004955450:3,654,854...3,692,057
Ensembl chrNW_004955450:3,656,498...3,692,406 		JBrowse link
G Pot1 protection of telomeres 1 involved_in ISO (PMID:15181449) BHF-UCL PMID:15181449 NCBI chrNW_004955479:6,140,599...6,230,512
Ensembl chrNW_004955479:6,140,501...6,209,031 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chrNW_004955445:19,213,210...19,227,670
Ensembl chrNW_004955445:19,215,161...19,228,695 		JBrowse link
G Stn1 STN1 subunit of CST complex involved_in ISO (PMID:22763445) BHF-UCL PMID:22763445 NCBI chrNW_004955485:6,748,682...6,784,119
Ensembl chrNW_004955485:6,748,234...6,784,762 		JBrowse link
G Ten1 TEN1 subunit of CST complex involved_in ISO (PMID:22763445) BHF-UCL PMID:22763445 NCBI chrNW_004955506:6,252,146...6,286,675
Ensembl chrNW_004955506:6,250,726...6,287,093 		JBrowse link
G Tent4b terminal nucleotidyltransferase 4B involved_in ISO (PMID:26950371) BHF-UCL PMID:26950371 NCBI chrNW_004955433:8,288,432...8,347,347
Ensembl chrNW_004955433:8,288,432...8,347,347 		JBrowse link
G Terf1 telomeric repeat binding factor 1 involved_in ISO (PMID:11971978) BHF-UCL PMID:11971978 NCBI chrNW_004955444:7,103,282...7,149,450
Ensembl chrNW_004955444:7,103,552...7,150,323 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:17055345)
(PMID:11971978)		 BHF-UCL PMID:11971978 PMID:17055345 NCBI chrNW_004955484:7,318,813...7,344,221
Ensembl chrNW_004955484:7,318,860...7,347,430 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO (PMID:10597287) BHF-UCL PMID:10597287 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
negative regulation of telomere maintenance via telomere lengthening term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:18812185) BHF-UCL PMID:18812185 NCBI chrNW_004955442:4,833,453...4,861,201
Ensembl chrNW_004955442:4,831,721...4,861,122 		JBrowse link
G Mcrs1 microspherule protein 1 involved_in ISO (PMID:15044100) BHF-UCL PMID:15044100 NCBI chrNW_004955547:180,783...189,980
Ensembl chrNW_004955547:178,301...189,980 		JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 involved_in ISO (MGI:5705431|PMID:26586427) BHF-UCL PMID:26586427 MGI:5705431 NCBI chrNW_004955489:520,875...557,609
Ensembl chrNW_004955489:520,875...557,615 		JBrowse link
G Slx1a SLX1 homolog A, structure-specific endonuclease subunit involved_in ISO (PMID:24012755) BHF-UCL PMID:24012755 NCBI chrNW_004955493:6,797,913...6,800,555 JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit involved_in ISO (PMID:24012755) BHF-UCL PMID:24012755 NCBI chrNW_004955442:13,765,660...13,792,106
Ensembl chrNW_004955442:13,770,340...13,791,314 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:24012755) BHF-UCL PMID:24012755 NCBI chrNW_004955484:7,318,813...7,344,221
Ensembl chrNW_004955484:7,318,860...7,347,430 		JBrowse link
G Tnks tankyrase involved_in ISO (PMID:25939383) BHF-UCL PMID:25939383 NCBI chrNW_004955463:5,589,194...5,770,141
Ensembl chrNW_004955463:5,588,423...5,764,581 		JBrowse link
G Tnks2 tankyrase 2 involved_in ISO (PMID:25939383) BHF-UCL PMID:25939383 NCBI chrNW_004955425:1,419,013...1,492,267
Ensembl chrNW_004955425:1,417,679...1,492,267 		JBrowse link
negative regulation of telomeric D-loop disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf1 telomeric repeat binding factor 1 involved_in ISO (PMID:15200954) BHF-UCL PMID:15200954 NCBI chrNW_004955444:7,103,282...7,149,450
Ensembl chrNW_004955444:7,103,552...7,150,323 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:15200954) BHF-UCL PMID:15200954 NCBI chrNW_004955484:7,318,813...7,344,221
Ensembl chrNW_004955484:7,318,860...7,347,430 		JBrowse link
replication fork arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slfn11 schlafen family member 11 involved_in ISO (PMID:29395061) UniProt PMID:29395061 NCBI chrNW_004955481:9,885,798...9,900,330 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    metabolic process 7467
      negative regulation of metabolic process 2396
        negative regulation of nucleobase-containing compound metabolic process 1283
          negative regulation of DNA metabolic process 120
            negative regulation of DNA biosynthetic process + 34
            negative regulation of DNA catabolic process + 5
            negative regulation of DNA demethylation 2
            negative regulation of DNA ligation + 0
            negative regulation of DNA primase activity 0
            negative regulation of DNA recombination + 38
            negative regulation of DNA repair + 32
            negative regulation of DNA replication + 20
            negative regulation of deoxyribonuclease activity + 0
            negative regulation of meiotic DNA double-strand break formation + 0
            negative regulation of mitochondrial DNA metabolic process + 2
            negative regulation of mitotic recombination-dependent replication fork processing 0
            negative regulation of t-circle formation 3
            negative regulation of telomere maintenance + 35
Path 2
Term Annotations click to browse term
  biological_process 12346
    metabolic process 7467
      organic substance metabolic process 7146
        organic cyclic compound metabolic process 4092
          nucleobase-containing compound metabolic process 3735
            nucleic acid metabolic process 3369
              DNA metabolic process 760
                regulation of DNA metabolic process 408
                  negative regulation of DNA metabolic process 120
                    negative regulation of DNA biosynthetic process + 34
                    negative regulation of DNA catabolic process + 5
                    negative regulation of DNA demethylation 2
                    negative regulation of DNA ligation + 0
                    negative regulation of DNA primase activity 0
                    negative regulation of DNA recombination + 38
                    negative regulation of DNA repair + 32
                    negative regulation of DNA replication + 20
                    negative regulation of deoxyribonuclease activity + 0
                    negative regulation of meiotic DNA double-strand break formation + 0
                    negative regulation of mitochondrial DNA metabolic process + 2
                    negative regulation of mitotic recombination-dependent replication fork processing 0
                    negative regulation of t-circle formation 3
                    negative regulation of telomere maintenance + 35
paths to the root