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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of membrane protein ectodomain proteolysis
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Accession:GO:0051043 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


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regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TSPAN15 tetraspanin 15 involved_in IDA (PMID:31792032), (PMID:34739841) UniProt PMID:31792032 PMID:34739841 NCBI chr10:69,451,465...69,549,508
Ensembl chr10:69,451,465...69,507,666 		JBrowse link
G TSPAN17 tetraspanin 17 involved_in IDA (PMID:28600292) UniProt PMID:28600292 NCBI chr 5:176,647,484...176,659,051
Ensembl chr 5:176,647,387...176,659,054 		JBrowse link
G TSPAN5 tetraspanin 5 involved_in IDA (PMID:28600292), (PMID:31792032) UniProt PMID:28600292 PMID:31792032 NCBI chr 4:98,470,367...98,658,611
Ensembl chr 4:98,470,367...98,658,611 		JBrowse link
negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 involved_in IDA (PMID:18383040) BHF-UCL PMID:18383040 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G LRIG2 leucine rich repeats and immunoglobulin like domains 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26651291) Ensembl
MGI		 PMID:26651291 GO_REF:0000107 NCBI chr 1:113,073,198...113,132,260
Ensembl chr 1:113,073,198...113,132,260 		JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 involved_in IMP (PMID:12207026) BHF-UCL PMID:12207026 NCBI chr 9:109,375,694...109,538,420
Ensembl chr 9:109,375,466...109,498,313 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in TAS (PMID:27853422) ARUK-UCL PMID:27853422 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 involved_in IDA
IBA
IEA		 (PMID:12714508) UniProt
GO_Central
TreeGrafter		 PMID:12714508 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 involved_in IMP
IBA		 (PMID:18383040) BHF-UCL
GO_Central		 PMID:18383040 GO_REF:0000033 NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041 		JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:12,153,068...12,158,912
Ensembl chr 3:12,153,068...12,158,912 		JBrowse link
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM8 ADAM metallopeptidase domain 8 involved_in IDA
IBA
IEA		 (PMID:15220135), (PMID:17548643) BHF-UCL
GO_Central
TreeGrafter
Ensembl		 PMID:15220135 PMID:17548643 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr10:133,262,423...133,276,868
Ensembl chr10:133,262,420...133,276,868 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 involved_in ISS (PMID:8647900) BHF-UCL PMID:8647900 NCBI chr 8:38,996,973...39,105,261
Ensembl chr 8:38,996,754...39,105,445 		JBrowse link
G ADRA2A adrenoceptor alpha 2A involved_in IDA (PMID:17655843) BHF-UCL PMID:17655843 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907 		JBrowse link
G APOE apolipoprotein E involved_in IDA
IGI		 (PMID:15950758)
(PMID:25015123)		 BHF-UCL
ARUK-UCL		 PMID:15950758 PMID:25015123 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G APP amyloid beta precursor protein involved_in IGI
IDA		 (PMID:25015123) ARUK-UCL PMID:25015123 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme involved_in IC (PMID:17010968) BHF-UCL PMID:17010968 NCBI chr15:90,868,588...90,883,457
Ensembl chr15:90,868,588...90,883,564 		JBrowse link
G GPLD1 glycosylphosphatidylinositol specific phospholipase D1 involved_in IDA (PMID:17720976) UniProt PMID:17720976 NCBI chr 6:24,423,969...24,495,287
Ensembl chr 6:24,424,565...24,495,205 		JBrowse link
G IFNG interferon gamma involved_in IDA (PMID:18373975) BHF-UCL PMID:18373975 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1B interleukin 1 beta involved_in IDA (PMID:18373975) BHF-UCL PMID:18373975 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G NRDC nardilysin convertase involved_in IDA (PMID:18355445) BHF-UCL PMID:18355445 NCBI chr 1:51,789,210...51,878,727
Ensembl chr 1:51,789,191...51,878,805 		JBrowse link
G PACSIN3 protein kinase C and casein kinase substrate in neurons 3 involved_in IMP (PMID:15280379) BHF-UCL PMID:15280379 NCBI chr11:47,177,522...47,186,434
Ensembl chr11:47,177,522...47,186,443 		JBrowse link
G RGMA repulsive guidance molecule BMP co-receptor a involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26651291) Ensembl
MGI		 PMID:26651291 GO_REF:0000107 NCBI chr15:93,035,271...93,089,211
Ensembl chr15:93,035,271...93,089,211 		JBrowse link
G SH3D19 SH3 domain containing 19 involved_in IMP (PMID:15280379) BHF-UCL PMID:15280379 NCBI chr 4:151,120,281...151,325,605
Ensembl chr 4:151,102,751...151,325,605 		JBrowse link
G SNX33 sorting nexin 33 involved_in IDA (PMID:18353773), (PMID:18419754) UniProt PMID:18353773 PMID:18419754 NCBI chr15:75,647,912...75,662,301
Ensembl chr15:75,647,912...75,662,301 		JBrowse link
G SNX9 sorting nexin 9 involved_in IDA (PMID:18353773) UniProt PMID:18353773 NCBI chr 6:157,823,246...157,945,077
Ensembl chr 6:157,700,387...157,945,077 		JBrowse link
G TNF tumor necrosis factor involved_in IDA (PMID:18373975) BHF-UCL PMID:18373975 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B involved_in IMP
IEA
IBA		 (PMID:22480688) BHF-UCL
TreeGrafter
GO_Central		 PMID:22480688 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      regulation of metabolic process 7352
        regulation of catabolic process 1249
          regulation of cellular catabolic process 497
            regulation of membrane protein ectodomain proteolysis 28
              negative regulation of membrane protein ectodomain proteolysis 8
              positive regulation of membrane protein ectodomain proteolysis 17
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      organic substance metabolic process 11967
        macromolecule metabolic process 10246
          protein metabolic process 4391
            proteolysis 1544
              membrane protein proteolysis 64
                membrane protein ectodomain proteolysis 53
                  regulation of membrane protein ectodomain proteolysis 28
                    negative regulation of membrane protein ectodomain proteolysis 8
                    positive regulation of membrane protein ectodomain proteolysis 17
paths to the root