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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of membrane protein ectodomain proteolysis
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Accession:GO:0051043 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


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negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1624291
RGD:1600115
G Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 JBrowse link 2 206,928,708 206,997,915 RGD:1624291
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 JBrowse link 5 74,248,996 74,368,167 RGD:1624291
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:1624291
RGD:13792537
G Timp2 TIMP metallopeptidase inhibitor 2 JBrowse link 10 107,338,465 107,386,072 RGD:13792537
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:1624291
RGD:13792537
RGD:1600115
G Timp4 TIMP metallopeptidase inhibitor 4 JBrowse link 4 147,156,948 147,163,467 RGD:13792537
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam8 ADAM metallopeptidase domain 8 JBrowse link 1 212,317,510 212,332,895 RGD:1624291
G Adam9 ADAM metallopeptidase domain 9 JBrowse link 16 71,810,377 71,887,926 RGD:1624291
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:1624291
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1600115
RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 JBrowse link 17 42,085,027 42,131,344 RGD:1600115
RGD:1624291
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Nrdc nardilysin convertase JBrowse link 5 128,629,949 128,694,209 RGD:1624291
RGD:1600115
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 JBrowse link 3 80,072,425 80,081,058 RGD:1624291
G Rgma repulsive guidance molecule BMP co-receptor a JBrowse link 1 134,699,053 134,742,512 RGD:1624291
G Sh3d19 SH3 domain containing 19 JBrowse link 2 185,268,028 185,431,834 RGD:1624291
G Snx33 sorting nexin 33 JBrowse link 8 61,584,656 61,596,055 RGD:1624291
G Snx9 sorting nexin 9 JBrowse link 1 46,780,142 46,826,250 RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19676
    cellular process 18449
      cellular metabolic process 10780
        regulation of cellular metabolic process 6113
          regulation of cellular catabolic process 769
            regulation of membrane protein ectodomain proteolysis 23
              negative regulation of membrane protein ectodomain proteolysis 7
              positive regulation of membrane protein ectodomain proteolysis 16
Path 2
Term Annotations click to browse term
  biological_process 19676
    metabolic process 11952
      organic substance metabolic process 11358
        macromolecule metabolic process 9814
          protein metabolic process 6075
            proteolysis 1872
              membrane protein proteolysis 57
                membrane protein ectodomain proteolysis 47
                  regulation of membrane protein ectodomain proteolysis 23
                    negative regulation of membrane protein ectodomain proteolysis 7
                    positive regulation of membrane protein ectodomain proteolysis 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.