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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of membrane protein ectodomain proteolysis
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Accession:GO:0051043 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


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regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tspan15 tetraspanin 15 involved_in ISO (PMID:31792032), (PMID:34739841) RGD PMID:31792032 PMID:34739841 NCBI chr20:30,130,528...30,174,912
Ensembl chr20:30,130,530...30,174,930 		JBrowse link
G Tspan17 tetraspanin 17 involved_in IEA
ISO		 GO_REF:0000107
(PMID:28600292)		 Ensembl
RGD		 PMID:28600292 GO_REF:0000107 NCBI chr17:9,819,212...9,826,851
Ensembl chr17:9,819,202...9,826,834 		JBrowse link
G Tspan5 tetraspanin 5 involved_in ISS
ISO		 GO_REF:0000024
(PMID:28600292), (PMID:31792032)		 UniProt
RGD		 PMID:28600292 PMID:31792032 GO_REF:0000024 NCBI chr 2:227,294,180...227,469,361
Ensembl chr 2:227,294,217...227,465,664 		JBrowse link
negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 involved_in ISO
ISS		 (PMID:18383040)
GO_REF:0000024		 RGD
UniProt		 PMID:18383040 GO_REF:0000024 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 acts_upstream_of_or_within ISO (PMID:26651291) RGD PMID:26651291 NCBI chr 2:191,947,322...192,012,996
Ensembl chr 2:191,949,819...192,012,579 		JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 involved_in ISO (PMID:12207026) RGD PMID:12207026 NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 involved_in ISO
IBA		 (PMID:12714508)
GO_REF:0000033		 RGD
GO_Central		 PMID:12714508 GO_REF:0000033 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 involved_in ISO
IEA
IBA		 (PMID:18383040)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:18383040 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558 		JBrowse link
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 involved_in ISO
IBA		 (PMID:15220135), (PMID:17548643)
GO_REF:0000033
(MGI:3040545|PMID:14761956)		 RGD
GO_Central		 PMID:14761956 PMID:15220135 PMID:17548643 GO_REF:0000033 MGI:3040545 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 involved_in ISO (MGI:1326990|PMID:9857183) RGD PMID:9857183 MGI:1326990 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:17655843) RGD PMID:17655843 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA		 UniProtKB:P05067-PRO_0000000092 (PMID:15950758), (PMID:25015123)
GO_REF:0000107		 RGD
Ensembl		 PMID:15950758 PMID:25015123 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:P02649 (PMID:25015123) RGD PMID:25015123 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5447609|PMID:17720976)
(PMID:17720976)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17720976 GO_REF:0000024 GO_REF:0000107 MGI:5447609 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939 		JBrowse link
G Ifng interferon gamma involved_in ISO (PMID:18373975) RGD PMID:18373975 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:18373975) RGD PMID:18373975 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Nrdc nardilysin convertase involved_in ISO
ISS
IEA		 (PMID:18355445)
(MGI:4414693|PMID:19935654)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:18355445 PMID:19935654 GO_REF:0000024 GO_REF:0000107 MGI:4414693 NCBI chr 5:123,755,807...123,818,910
Ensembl chr 5:123,755,806...123,818,595 		JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 involved_in ISO (PMID:15280379) RGD PMID:15280379 NCBI chr 3:77,227,187...77,235,820
Ensembl chr 3:77,222,710...77,235,811 		JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a acts_upstream_of_or_within ISO (PMID:26651291) RGD PMID:26651291 NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918 		JBrowse link
G Sh3d19 SH3 domain containing 19 involved_in ISO (PMID:15280379) RGD PMID:15280379 NCBI chr 2:171,356,244...171,516,042
Ensembl chr 2:171,356,251...171,515,561 		JBrowse link
G Snx33 sorting nexin 33 involved_in ISO (PMID:18353773), (PMID:18419754) RGD PMID:18353773 PMID:18419754 NCBI chr 8:57,315,861...57,328,522
Ensembl chr 8:57,317,161...57,327,538 		JBrowse link
G Snx9 sorting nexin 9 involved_in ISO (PMID:18353773) RGD PMID:18353773 NCBI chr 1:46,424,897...46,510,096
Ensembl chr 1:46,423,553...46,509,036 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:18373975) RGD PMID:18373975 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in ISO
IBA		 (PMID:22480688)
GO_REF:0000033		 RGD
GO_Central		 PMID:22480688 GO_REF:0000033 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    regulation of biological process 13128
      regulation of cellular process 12525
        regulation of cellular metabolic process 6096
          regulation of cellular catabolic process 419
            regulation of membrane protein ectodomain proteolysis 26
              negative regulation of membrane protein ectodomain proteolysis 7
              positive regulation of membrane protein ectodomain proteolysis 16
Path 2
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      macromolecule metabolic process 10147
        protein metabolic process 5694
          proteolysis 1815
            membrane protein proteolysis 65
              membrane protein ectodomain proteolysis 52
                regulation of membrane protein ectodomain proteolysis 26
                  negative regulation of membrane protein ectodomain proteolysis 7
                  positive regulation of membrane protein ectodomain proteolysis 16
paths to the root