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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of membrane protein ectodomain proteolysis
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Accession:GO:0051043 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


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negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 involved_in ISO
ISS
(PMID:18383040)
GO_REF:0000024
RGD
UniProt
PMID:18383040 GO_REF:0000024 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 acts_upstream_of_or_within ISO (MGI:5702499|PMID:26651291) RGD PMID:26651291 MGI:5702499 NCBI chr 2:191,947,322...192,012,996 JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 involved_in ISO (PMID:12207026) RGD PMID:12207026 NCBI chr 5:71,908,520...72,027,323 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 involved_in IBA
ISO
PMID:21873635
(PMID:12714508)
RGD PMID:12714508, PMID:21873635 RGD:13792537 NCBI chr  X:1,212,969...1,217,714 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:18383040)
Ensembl
RGD
PMID:18383040, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 7:17,520,827...17,571,871 JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:148,306,021...148,312,558 JBrowse link
positive regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 involved_in IBA
ISO
PMID:21873635
(MGI:3040545|PMID:14761956)
(PMID:15220135), (PMID:17548643)
RGD PMID:14761956 PMID:15220135 PMID:17548643, PMID:21873635 MGI:3040545, RGD:13792537 NCBI chr 1:194,776,559...194,789,330 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 involved_in ISO (MGI:1326990|PMID:9857183) RGD PMID:9857183 MGI:1326990 NCBI chr16:67,022,538...67,101,647 JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:17655843) RGD PMID:17655843 NCBI chr 1:253,061,480...253,064,280 JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA
UniProtKB:P05067:PRO_0000000092 (PMID:15950758), (PMID:25015123)
GO_REF:0000107
RGD
Ensembl
PMID:15950758 PMID:25015123 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852 JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:P02649 (PMID:25015123) RGD PMID:25015123 NCBI chr11:24,019,774...24,236,584 JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5447609|PMID:17720976)
(PMID:17720976)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17720976 GO_REF:0000024 GO_REF:0000107 MGI:5447609 NCBI chr17:40,084,427...40,132,035 JBrowse link
G Ifng interferon gamma involved_in ISO (PMID:18373975) RGD PMID:18373975 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Il1b interleukin 1 beta involved_in ISO
IEA
(PMID:18373975)
GO_REF:0000107
RGD
Ensembl
PMID:18373975 GO_REF:0000107 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Nrdc nardilysin convertase involved_in ISO
IEA
(PMID:18355445)
GO_REF:0000107
RGD
Ensembl
PMID:18355445 GO_REF:0000107 NCBI chr 5:123,755,807...123,818,910 JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 involved_in ISO (PMID:15280379) RGD PMID:15280379 NCBI chr 3:77,227,187...77,235,820 JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a acts_upstream_of_or_within ISO (MGI:5702499|PMID:26651291) RGD PMID:26651291 MGI:5702499 NCBI chr 1:127,128,934...127,172,918 JBrowse link
G Sh3d19 SH3 domain containing 19 involved_in ISO (PMID:15280379) RGD PMID:15280379 NCBI chr 2:171,356,244...171,516,042 JBrowse link
G Snx33 sorting nexin 33 involved_in ISO (PMID:18353773), (PMID:18419754) RGD PMID:18353773 PMID:18419754 NCBI chr 8:57,315,861...57,328,522 JBrowse link
G Snx9 sorting nexin 9 involved_in ISO (PMID:18353773) RGD PMID:18353773 NCBI chr 1:46,424,897...46,510,096 JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:18373975) RGD PMID:18373975 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in ISO
IBA
(PMID:22480688)
PMID:21873635
RGD PMID:22480688, PMID:21873635 RGD:13792537 NCBI chr 5:157,070,642...157,104,216 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18342
      cellular metabolic process 10753
        regulation of cellular metabolic process 5945
          regulation of cellular catabolic process 770
            regulation of membrane protein ectodomain proteolysis 23
              negative regulation of membrane protein ectodomain proteolysis 7
              positive regulation of membrane protein ectodomain proteolysis 16
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      organic substance metabolic process 11334
        macromolecule metabolic process 9790
          protein metabolic process 5890
            proteolysis 1876
              membrane protein proteolysis 58
                membrane protein ectodomain proteolysis 48
                  regulation of membrane protein ectodomain proteolysis 23
                    negative regulation of membrane protein ectodomain proteolysis 7
                    positive regulation of membrane protein ectodomain proteolysis 16
paths to the root