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ONTOLOGY REPORT - ANNOTATIONS

Term:leukocyte tethering or rolling
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Accession:GO:0050901 term browser browse the term
Definition:Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).


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leukocyte tethering or rolling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADD2 adducin 2 involved_in IMP (PMID:25425738) CAFA PMID:25425738 NCBI chr 2:70,656,784...70,768,200
Ensembl chr 2:70,607,618...70,768,225 		JBrowse link
G CHST4 carbohydrate sulfotransferase 4 acts_upstream_of_or_within ISO (PMID:14597732) MGI PMID:14597732 NCBI chr16:71,526,120...71,538,748
Ensembl chr16:71,525,233...71,538,748 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735 		JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21093315) Ensembl
MGI		 PMID:21093315 GO_REF:0000107 NCBI chr 8:117,794,490...118,111,826
Ensembl chr 8:117,794,490...118,111,826 		JBrowse link
G GCNT1 glucosaminyl (N-acetyl) transferase 1 involved_in IMP (PMID:23027862) UniProt PMID:23027862 NCBI chr 9:76,393,869...76,507,416
Ensembl chr 9:76,419,850...76,651,203 		JBrowse link
G GOLPH3 golgi phosphoprotein 3 involved_in IMP (PMID:23027862) UniProt PMID:23027862 NCBI chr 5:32,124,716...32,174,319
Ensembl chr 5:32,124,716...32,174,319 		JBrowse link
G ITGA4 integrin subunit alpha 4 involved_in IMP (PMID:18308860) UniProt PMID:18308860 NCBI chr 2:181,457,205...181,538,940
Ensembl chr 2:181,457,202...181,538,940 		JBrowse link
G ITGB1 integrin subunit beta 1 involved_in IMP (PMID:18308860) UniProt PMID:18308860 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792 		JBrowse link
G ITGB7 integrin subunit beta 7 involved_in IMP (PMID:18308860) UniProt PMID:18308860 NCBI chr12:53,191,323...53,207,251
Ensembl chr12:53,191,323...53,207,282 		JBrowse link
G JAM2 junctional adhesion molecule 2 involved_in IDA (PMID:19740376) ARUK-UCL PMID:19740376 NCBI chr21:25,639,258...25,717,562
Ensembl chr21:25,639,258...25,717,562 		JBrowse link
G LEP leptin involved_in ISO
IEA		 RGD
Ensembl		 PMID:20150963 GO_REF:0000107 RGD:5128596 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G MADCAM1 mucosal vascular addressin cell adhesion molecule 1 involved_in IDA
IBA
IEA		 (PMID:18308860) UniProt
GO_Central
TreeGrafter		 PMID:18308860 GO_REF:0000033 GO_REF:0000118 NCBI chr19:496,486...505,343
Ensembl chr19:489,176...505,343 		JBrowse link
G PODXL2 podocalyxin like 2 involved_in IDA
IBA
IEA		 (PMID:18606703) UniProt
GO_Central
TreeGrafter		 PMID:18606703 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:127,629,185...127,672,802
Ensembl chr 3:127,629,185...127,672,802 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IDA (PMID:12082081) BHF-UCL PMID:12082081 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813 		JBrowse link
G SELE selectin E involved_in IMP
IBA		 (PMID:18029551) BHF-UCL
GO_Central		 PMID:18029551 GO_REF:0000033 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SELL selectin L involved_in IMP
IBA		 (PMID:28011641) UniProt
GO_Central		 PMID:28011641 GO_REF:0000033 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702 		JBrowse link
G SELP selectin P involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IMP		 (PMID:15956287)
(PMID:28011641)		 Ensembl
MGI
GO_Central
UniProt		 PMID:15956287 PMID:28011641 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193 		JBrowse link
G SELPLG selectin P ligand involved_in
acts_upstream_of_or_within		 IDA
ISO
IEA
IBA		 (PMID:25425738)
(PMID:15956287)		 CAFA
MGI
TreeGrafter
GO_Central		 PMID:15956287 PMID:25425738 GO_REF:0000033 GO_REF:0000118 NCBI chr12:108,621,895...108,633,894
Ensembl chr12:108,621,895...108,633,894 		JBrowse link
G SPN sialophorin involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876 		JBrowse link
G TNF tumor necrosis factor involved_in IDA (PMID:10820279) BHF-UCL PMID:10820279 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 involved_in IDA
IEP		 (PMID:18308860)
(PMID:2688898)		 UniProt
BHF-UCL		 PMID:2688898 PMID:18308860 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
negative regulation of leukocyte tethering or rolling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL21 C-C motif chemokine ligand 21 involved_in IDA (PMID:18308860) UniProt PMID:18308860 NCBI chr 9:34,709,005...34,710,136
Ensembl chr 9:34,709,005...34,710,136 		JBrowse link
G CCL25 C-C motif chemokine ligand 25 involved_in IDA (PMID:18308860) UniProt PMID:18308860 NCBI chr19:8,052,341...8,062,650
Ensembl chr19:8,052,318...8,062,660 		JBrowse link
G CCL28 C-C motif chemokine ligand 28 involved_in IDA (PMID:18308860) UniProt PMID:18308860 NCBI chr 5:43,356,975...43,412,391
Ensembl chr 5:43,376,645...43,412,391 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 involved_in IDA (PMID:18308860) UniProt PMID:18308860 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493 		JBrowse link
positive regulation of leukocyte tethering or rolling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 ISO RGD PMID:21415394 RGD:13792556 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9342361) Ensembl
MGI		 PMID:9342361 GO_REF:0000107 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CHST2 carbohydrate sulfotransferase 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:143,119,771...143,124,014
Ensembl chr 3:143,119,771...143,124,014 		JBrowse link
G CHST4 carbohydrate sulfotransferase 4 involved_in ISS UniProt GO_REF:0000024 NCBI chr16:71,526,120...71,538,748
Ensembl chr16:71,525,233...71,538,748 		JBrowse link
G ELANE elastase, neutrophil expressed involved_in ISO
IEA		 RGD
Ensembl		 PMID:20860667 GO_REF:0000107 RGD:10450565 NCBI chr19:852,303...856,243
Ensembl chr19:851,014...856,247 		JBrowse link
G FUT4 fucosyltransferase 4 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:94,543,921...94,549,895
Ensembl chr11:94,543,921...94,549,895 		JBrowse link
G FUT7 fucosyltransferase 7 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:137,030,174...137,032,088
Ensembl chr 9:137,030,174...137,032,088 		JBrowse link
G GCNT1 glucosaminyl (N-acetyl) transferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:76,393,869...76,507,416
Ensembl chr 9:76,419,850...76,651,203 		JBrowse link
G GP1BA glycoprotein Ib platelet subunit alpha involved_in ISO
IEA		 RGD
Ensembl		 PMID:12218538 GO_REF:0000107 RGD:150527852 NCBI chr17:4,932,277...4,935,023
Ensembl chr17:4,932,277...4,935,023 		JBrowse link
G ITGA4 integrin subunit alpha 4 involved_in ISO
IEA		 RGD
Ensembl		 PMID:9394821 GO_REF:0000107 RGD:9698423 NCBI chr 2:181,457,205...181,538,940
Ensembl chr 2:181,457,202...181,538,940 		JBrowse link
G PAWR pro-apoptotic WT1 regulator ISO RGD PMID:12133973 RGD:9835372 NCBI chr12:79,584,879...79,690,964
Ensembl chr12:79,574,979...79,690,964 		JBrowse link
G PTAFR platelet activating factor receptor involved_in ISO
IEA		 RGD
Ensembl		 PMID:10528212 GO_REF:0000107 RGD:10041051 NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936 		JBrowse link
G SELE selectin E involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SELP selectin P involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193 		JBrowse link
G ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 involved_in IMP
IEA		 (PMID:25498912) UniProt
Ensembl		 PMID:25498912 GO_REF:0000107 NCBI chr11:126,355,686...126,414,638
Ensembl chr11:126,355,640...126,440,344 		JBrowse link
regulation of leukocyte tethering or rolling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FUT7 fucosyltransferase 7 involved_in IMP (PMID:23192350) UniProt PMID:23192350 NCBI chr 9:137,030,174...137,032,088
Ensembl chr 9:137,030,174...137,032,088 		JBrowse link
G FUT9 fucosyltransferase 9 involved_in IMP (PMID:23192350) UniProt PMID:23192350 NCBI chr 6:96,015,974...96,215,612
Ensembl chr 6:96,015,974...96,215,612 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    immune system process 3213
      leukocyte migration 446
        cellular extravasation 83
          leukocyte tethering or rolling 36
            negative regulation of leukocyte tethering or rolling 4
            positive regulation of leukocyte tethering or rolling 15
            regulation of leukocyte tethering or rolling + 20
Path 2
Term Annotations click to browse term
  biological_process 19770
    cellular process 18460
      cell motility 2109
        cell migration 1853
          leukocyte migration 446
            cellular extravasation 83
              leukocyte tethering or rolling 36
                negative regulation of leukocyte tethering or rolling 4
                positive regulation of leukocyte tethering or rolling 15
                regulation of leukocyte tethering or rolling + 20
paths to the root