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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of B cell activation
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Accession:GO:0050869 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.
Synonyms:exact_synonym: down regulation of B cell activation;   downregulation of B cell activation;   negative regulation of B lymphocyte activation
 narrow_synonym: inhibition of B cell activation


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negative regulation of B cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BANK1 B cell scaffold protein with ankyrin repeats 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16546095) Ensembl
MGI
TreeGrafter		 PMID:16546095 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:94,216,751...94,507,965
Ensembl chr 4:104,813,791...105,171,527 		JBrowse link
G BTK Bruton tyrosine kinase ISO RGD PMID:25545336 RGD:151665128 NCBI chr  X:90,551,874...90,588,786
Ensembl chr  X:100,684,017...100,725,187 		JBrowse link
G FAS Fas cell surface death receptor acts_upstream_of_or_within ISO (PMID:6610701) MGI PMID:6610701 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FOXJ1 forkhead box J1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:70,084,920...70,089,865
Ensembl chr17:75,638,634...75,641,666 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10704460) Ensembl
MGI		 PMID:10704460 GO_REF:0000107 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190 		JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (MGI:4460047|PMID:20519653) ARUK-UCL PMID:20519653 MGI:4460047 NCBI chr 1:30,005,941...30,031,366
Ensembl chr 1:31,032,963...31,058,385 		JBrowse link
G SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr21:1,228,632...1,399,331
Ensembl chr21:14,595,688...14,711,613 		JBrowse link
G TBC1D10C TBC1 domain family member 10C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23109291) Ensembl
MGI		 PMID:23109291 GO_REF:0000107 NCBI chr11:62,762,075...62,768,569
Ensembl chr11:66,073,830...66,080,019 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:135,617,465...135,634,085
Ensembl chr 6:139,705,255...139,720,819 		JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT3 fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (PMID:16618805) MGI PMID:16618805 NCBI chr13:9,283,747...9,381,553
Ensembl chr13:27,627,178...27,723,940 		JBrowse link
G HMGB3 high mobility group box 3 acts_upstream_of_or_within ISO (PMID:12714519) MGI PMID:12714519 NCBI chr  X:140,632,163...140,639,774 JBrowse link
G ID2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (PMID:18523151) MGI PMID:18523151 NCBI chr2A:8,681,592...8,684,014
Ensembl chr2A:8,847,776...8,850,720 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in ISO (PMID:18941195)
(MGI:3814493|PMID:18941195)		 UniProt PMID:18941195 MGI:3814493 NCBI chr 8:40,507,027...40,555,053 JBrowse link
negative regulation of B cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041 		JBrowse link
G BTK Bruton tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7680896) Ensembl
MGI		 PMID:7680896 GO_REF:0000107 NCBI chr  X:90,551,874...90,588,786
Ensembl chr  X:100,684,017...100,725,187 		JBrowse link
G BTLA B and T lymphocyte associated acts_upstream_of_or_within ISO (PMID:12796776) MGI PMID:12796776 NCBI chr 3:109,613,554...109,649,305
Ensembl chr 3:116,538,273...116,573,575 		JBrowse link
G CASP3 caspase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12970760) Ensembl
MGI		 PMID:12970760 GO_REF:0000107 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CD300A CD300a molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:68,403,647...68,426,285
Ensembl chr17:73,965,008...73,983,928 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (MGI:3615850|PMID:15964995) HGNC-UCL PMID:15964995 MGI:3615850 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498 		JBrowse link
G FCGR2B Fc gamma receptor IIb acts_upstream_of_or_within ISO (PMID:12385742), (PMID:8552190) MGI PMID:8552190 PMID:12385742 NCBI chr 1:137,074,342...137,090,962
Ensembl chr 1:140,882,043...140,890,637 		JBrowse link
G IL10 interleukin 10 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9184696) MGI
Ensembl		 PMID:9184696 GO_REF:0000107 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10704460) Ensembl
MGI		 PMID:10704460 GO_REF:0000107 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190 		JBrowse link
G LOC100982539 signal transducer CD24 acts_upstream_of_or_within ISO (PMID:8920854) MGI PMID:8920854 NCBI chr 6:104,783,720...104,789,509
Ensembl chr 6:108,655,624...108,657,847 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:52,318,497...52,455,741
Ensembl chr 8:49,755,708...49,825,287 		JBrowse link
G MNDA myeloid cell nuclear differentiation antigen involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:134,190,768...134,208,723
Ensembl chr 1:137,992,523...137,999,587 		JBrowse link
G PAWR pro-apoptotic WT1 regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12970181) Ensembl
MGI		 PMID:12970181 GO_REF:0000107 NCBI chr12:77,114,282...77,224,116
Ensembl chr12:79,969,517...80,070,796 		JBrowse link
G PKN1 protein kinase N1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23223530) Ensembl
MGI		 PMID:23223530 GO_REF:0000107 NCBI chr19:13,996,454...14,035,272
Ensembl chr19:14,846,463...14,879,205 		JBrowse link
G PTEN phosphatase and tensin homolog acts_upstream_of_or_within ISO (PMID:16027169) MGI PMID:16027169 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:149,454,748...149,539,566
Ensembl chr 1:153,160,661...153,213,402 		JBrowse link
G TNFRSF13B TNF receptor superfamily member 13B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15240667) TreeGrafter
MGI		 PMID:15240667 GO_REF:0000118 NCBI chr17:34,321,121...34,355,020
Ensembl chr17:39,252,858...39,292,053 		JBrowse link
G TNFRSF21 TNF receptor superfamily member 21 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:46,815,762...46,894,286
Ensembl chr 6:48,079,749...48,158,356 		JBrowse link
G TSC2 TSC complex subunit 2 acts_upstream_of_or_within ISO (PMID:16027169) MGI PMID:16027169 NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:32,821,279...32,825,488
Ensembl chr19:41,570,683...41,575,226 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:51,883,695...51,890,266
Ensembl chr 3:53,112,494...53,119,053 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17137798) Ensembl
MGI		 PMID:17137798 GO_REF:0000107 NCBI chr 5:137,467,161...137,511,569
Ensembl chr 5:143,600,789...143,622,913 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15240705) Ensembl
MGI		 PMID:15240705 GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 1:183,094,601...183,246,957 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16313
    immune system process 2386
      leukocyte activation 974
        lymphocyte activation 790
          B cell activation 275
            negative regulation of B cell activation 37
              negative regulation of B cell differentiation + 6
              negative regulation of B cell proliferation 21
              negative regulation of isotype switching + 4
Path 2
Term Annotations click to browse term
  biological_process 16313
    biological regulation 11327
      regulation of biological process 10982
        regulation of multicellular organismal process 3123
          negative regulation of multicellular organismal process 1227
            negative regulation of cell activation 222
              negative regulation of leukocyte activation 203
                negative regulation of lymphocyte activation 177
                  negative regulation of B cell activation 37
                    negative regulation of B cell differentiation + 6
                    negative regulation of B cell proliferation 21
                    negative regulation of isotype switching + 4
paths to the root