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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of B cell activation
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Accession:GO:0050869 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.
Synonyms:exact_synonym: down regulation of B cell activation;   downregulation of B cell activation;   negative regulation of B lymphocyte activation
 narrow_synonym: inhibition of B cell activation



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negative regulation of B cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bank1 B-cell scaffold protein with ankyrin repeats 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:88336 (MGI:3665389|PMID:16546095)
RGD PMID:16546095 PMID:21873635 MGI:3665389, RGD:13792537 NCBI chr 2:224,530,475...224,800,420
Ensembl chr 2:224,530,475...224,800,405
JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO MGI:1856334 (MGI:55958|PMID:6610701) RGD PMID:6610701 MGI:55958 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Foxj1 forkhead box J1 involved_in ISO (MGI:3589323|PMID:16002694) RGD PMID:16002694 MGI:3589323 NCBI chr10:101,566,299...101,570,249
Ensembl chr10:101,566,304...101,570,237
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO MGI:2386884 (MGI:1354084|PMID:10704460) RGD PMID:10704460 MGI:1354084 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:4460047|PMID:20519653) RGD PMID:20519653 MGI:4460047 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
JBrowse link
G Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 involved_in IBA
ISO
PMID:21873635
(MGI:4437539|PMID:19923443)
RGD PMID:19923443 PMID:21873635 MGI:4437539, RGD:13792537 NCBI chr11:14,484,523...14,534,900
Ensembl chr11:14,483,893...14,534,900
JBrowse link
G Tbc1d10c TBC1 domain family, member 10C acts_upstream_of_or_within ISO MGI:1932389|MGI:5578034 (MGI:5576870|PMID:23109291) RGD PMID:23109291 MGI:5576870 NCBI chr 1:201,476,258...201,484,876
Ensembl chr 1:201,477,157...201,564,920
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (MGI:4946158|PMID:21088135) RGD PMID:21088135 MGI:4946158 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt3 Fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (MGI:3623701|PMID:16618805) RGD PMID:16618805 MGI:3623701 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Hmgb3 high mobility group box 3 acts_upstream_of_or_within ISO (MGI:2670545|PMID:12714519) RGD PMID:12714519 MGI:2670545 NCBI chr  X:149,296,309...149,301,294
Ensembl chr  X:149,296,375...149,301,292
JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO MGI:2384134 (MGI:3805135|PMID:18523151) RGD PMID:18523151 MGI:3805135 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO
IEA
(PMID:18941195)
(MGI:3814493|PMID:18941195)
GO_REF:0000107
RGD
Ensembl
PMID:18941195 GO_REF:0000107 MGI:3814493 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
negative regulation of B cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
JBrowse link
G Btk Bruton tyrosine kinase acts_upstream_of_or_within ISO MGI:1856317 (MGI:65977|PMID:7680896) RGD PMID:7680896 MGI:65977 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G Btla B and T lymphocyte associated acts_upstream_of_or_within ISO MGI:3027713 (MGI:2665193|PMID:12796776) RGD PMID:12796776 MGI:2665193 NCBI chr11:55,563,683...55,588,187
Ensembl chr11:55,564,899...55,587,181
JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO MGI:2178778 (MGI:2677082|PMID:12970760) RGD PMID:12970760 MGI:2677082 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO (MGI:3757615|PMID:8920854) RGD PMID:8920854 MGI:3757615 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:21482706) RGD PMID:21482706 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (MGI:3615850|PMID:15964995) RGD PMID:15964995 MGI:3615850 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Fcgr2b Fc gamma receptor IIb acts_upstream_of_or_within ISO MGI:1857166 (MGI:3608295|PMID:12385742), (MGI:78617|PMID:8552190) RGD PMID:8552190 PMID:12385742 MGI:3608295 MGI:78617 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Il10 interleukin 10 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:9184696)
UniProt
RGD
PMID:9184696 GO_REF:0000024 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386884 (MGI:1354084|PMID:10704460)
Ensembl
RGD
PMID:10704460 GO_REF:0000107 MGI:1354084 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IBA
ISO
PMID:21873635
(MGI:894972|PMID:9252121)
RGD PMID:9252121 PMID:21873635 MGI:894972, RGD:13792537 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Mnda myeloid cell nuclear differentiation antigen involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201
JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2678021 (MGI:2675524|PMID:12970181)
Ensembl
RGD
PMID:12970181 GO_REF:0000107 MGI:2675524 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pkn1 protein kinase N1 acts_upstream_of_or_within ISO MGI:5475202 (MGI:5467878|PMID:23223530) RGD PMID:23223530 MGI:5467878 NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107
JBrowse link
G Prdm1 PR/SET domain 1 acts_upstream_of_or_within ISO (MGI:3826899|PMID:18845144) RGD PMID:18845144 MGI:3826899 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:5284769|PMID:18172933) RGD PMID:18172933 MGI:5284769 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
JBrowse link
G Tnfrsf13b TNF receptor superfamily member 13B involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3052983 (MGI:3051152|PMID:15240667)
RGD PMID:15240667 PMID:21873635 MGI:3051152, RGD:13792537 NCBI chr10:45,801,860...45,824,932
Ensembl chr10:45,801,860...45,822,987
JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:3628730|PMID:12515813)
GO_REF:0000024
RGD
UniProt
PMID:12515813 PMID:21873635 GO_REF:0000024 MGI:3628730, RGD:13792537 NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO
IBA
(PMID:21727189)
(MGI:5295549|PMID:21727189)
PMID:21873635
RGD PMID:21727189 PMID:21873635 MGI:5295549, RGD:13792537 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (MGI:6214451|PMID:26000965) RGD PMID:26000965 MGI:6214451 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782
JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:44,820,693...44,837,935
Ensembl chr  X:44,820,820...44,837,934
JBrowse link
G Thoc1 THO complex 1 involved_in ISO
IEA
(MGI:5520039|PMID:22144908)
GO_REF:0000107
RGD
Ensembl
PMID:22144908 GO_REF:0000107 MGI:5520039 NCBI chr18:983,606...1,020,379
Ensembl chr18:983,824...1,019,114
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (MGI:3695768|PMID:16275384) RGD PMID:16275384 MGI:3695768 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO MGI:3695433 (MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:3694584 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19834
    negative regulation of biological process 5740
      negative regulation of immune system process 443
        negative regulation of leukocyte activation 208
          negative regulation of lymphocyte activation 176
            negative regulation of B cell activation 38
              negative regulation of B cell differentiation + 4
              negative regulation of B cell proliferation 21
              negative regulation of isotype switching + 6
Path 2
Term Annotations click to browse term
  biological_process 19834
    biological regulation 13775
      regulation of biological process 13033
        regulation of cellular process 12501
          regulation of cell activation 771
            regulation of leukocyte activation 717
              negative regulation of leukocyte activation 208
                negative regulation of lymphocyte activation 176
                  negative regulation of B cell activation 38
                    negative regulation of B cell differentiation + 4
                    negative regulation of B cell proliferation 21
                    negative regulation of isotype switching + 6
paths to the root