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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of T cell receptor signaling pathway
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Accession:GO:0050860 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
Synonyms:exact_synonym: down regulation of T cell receptor signaling pathway;   downregulation of T cell receptor signaling pathway;   negative regulation of T cell receptor signalling pathway;   negative regulation of T lymphocyte receptor signaling pathway;   negative regulation of T lymphocyte receptor signalling pathway;   negative regulation of TCR signaling pathway
 narrow_synonym: inhibition of T cell receptor signaling pathway


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negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTN2A2 butyrophilin subfamily 2 member A2 acts_upstream_of_or_within ISO (PMID:23589618) MGI PMID:23589618 NCBI chr 7:20,954,229...20,968,390
Ensembl chr 7:20,954,173...20,967,794 		JBrowse link
G BTNL2 butyrophilin like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16751379) Ensembl
MGI		 PMID:16751379 GO_REF:0000107 NCBI chr 7:24,789,988...24,809,920
Ensembl chr 7:24,790,614...24,807,432 		JBrowse link
G CBLB Cbl proto-oncogene B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14738763) Ensembl
MGI		 PMID:14738763 GO_REF:0000107 NCBI chr13:153,480,525...153,700,115
Ensembl chr13:153,395,978...153,700,056 		JBrowse link
G CD160 CD160 molecule involved_in ISO (PMID:18193050) UniProt PMID:18193050 NCBI chr 4:99,579,891...99,585,808 JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (PMID:18424730) UniProt PMID:18424730 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G DGKZ diacylglycerol kinase zeta involved_in ISO (MGI:2672999|PMID:12883552) UniProt PMID:12883552 MGI:2672999 NCBI chr 2:16,134,046...16,176,043
Ensembl chr 2:16,134,048...16,176,238 		JBrowse link
G DUSP22 dual specificity phosphatase 22 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24714587) Ensembl
MGI		 PMID:24714587 GO_REF:0000107 NCBI chr 7:43,437...96,270
Ensembl chr 7:43,487...96,267 		JBrowse link
G DUSP3 dual specificity phosphatase 3 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr12:19,336,308...19,349,739
Ensembl chr12:19,336,354...19,349,734 		JBrowse link
G ELF1 E74 like ETS transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14738763) Ensembl
MGI		 PMID:14738763 GO_REF:0000107 NCBI chr11:25,772,090...25,896,613
Ensembl chr11:25,772,316...25,900,802 		JBrowse link
G EZR ezrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,403,362...8,452,750
Ensembl chr 1:8,403,453...8,452,742 		JBrowse link
G GBP1 guanylate binding protein 1, interferon-inducible involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:127,425,699...127,442,132
Ensembl chr 4:127,425,200...127,442,127 		JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870) ARUK-UCL PMID:18619870 MGI:3803048 NCBI chr 6:87,363,911...87,390,371
Ensembl chr 6:87,363,912...87,390,288 		JBrowse link
G LGALS3 galectin 3 involved_in ISO (MGI:4355752|PMID:19706535) BHF-UCL PMID:19706535 MGI:4355752 NCBI chr 1:184,478,639...184,496,155
Ensembl chr 1:184,478,710...184,497,951 		JBrowse link
G LOC100517285 leukocyte immunoglobulin-like receptor subfamily A member 6 involved_in ISO (PMID:22387553)
(PMID:16493035)		 BHF-UCL
ARUK-UCL		 PMID:16493035 PMID:22387553 NCBI chr 6:58,996,449...59,001,088 JBrowse link
G NDRG3 NDRG family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,905,957...39,987,754
Ensembl chr17:39,905,958...39,969,659 		JBrowse link
G PAWR pro-apoptotic WT1 regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12970181) Ensembl
MGI		 PMID:12970181 GO_REF:0000107 NCBI chr 5:101,693,145...101,797,842
Ensembl chr 5:101,693,246...101,797,838 		JBrowse link
G PHPT1 phosphohistidine phosphatase 1 involved_in ISO (PMID:18796614) BHF-UCL PMID:18796614
G PRNP prion protein involved_in ISO (MGI:4943618|PMID:20145049) BHF-UCL PMID:20145049 MGI:4943618 NCBI chr17:13,694,195...13,705,126
Ensembl chr17:13,694,190...13,705,124 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in ISO (PMID:18056643) UniProt PMID:18056643 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9064344) Ensembl
MGI		 PMID:9064344 GO_REF:0000107 NCBI chr 5:63,762,109...63,779,086
Ensembl chr 5:63,762,112...63,808,350 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:14,548,489...14,724,823
Ensembl chr 2:14,548,428...14,724,474 		JBrowse link
G PVRIG PVR related immunoglobulin domain containing involved_in IEA
IBA		 InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:8,230,311...8,232,840
Ensembl chr 3:8,230,328...8,232,836 		JBrowse link
G SH2D1A SH2 domain containing 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:101,824,602...101,847,265
Ensembl chr  X:101,824,367...101,849,671 		JBrowse link
G SLA2 Src like adaptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,875,625...39,904,838
Ensembl chr17:39,875,628...39,902,940 		JBrowse link
G THY1 Thy-1 cell surface antigen involved_in ISO (MGI:1096761|PMID:9285719) UniProt PMID:9285719 MGI:1096761 NCBI chr 9:46,607,022...46,612,691
Ensembl chr 9:46,607,494...46,612,269 		JBrowse link
G UBASH3A ubiquitin associated and SH3 domain containing A involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:14738763) Ensembl
MGI
GO_Central
TreeGrafter		 PMID:14738763 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:205,744,395...205,786,484
Ensembl chr13:205,744,393...205,787,056 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17813
    immune system process 2474
      negative regulation of immune system process 542
        negative regulation of antigen receptor-mediated signaling pathway 35
          negative regulation of T cell receptor signaling pathway 27
            termination of T cell signal transduction 0
Path 2
Term Annotations click to browse term
  biological_process 17813
    biological regulation 12832
      regulation of biological process 12482
        regulation of immune system process 1544
          positive regulation of immune system process 1073
            positive regulation of immune response 708
              activation of immune response 513
                immune response-activating signaling pathway 448
                  immune response-activating cell surface receptor signaling pathway 278
                    antigen receptor-mediated signaling pathway 179
                      T cell receptor signaling pathway 132
                        regulation of T cell receptor signaling pathway 49
                          negative regulation of T cell receptor signaling pathway 27
                            termination of T cell signal transduction 0
paths to the root