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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell receptor signaling pathway
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Accession:GO:0050853 term browser browse the term
Definition:The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
Synonyms:exact_synonym: B cell receptor signalling pathway;   B lymphocyte receptor signaling pathway;   B lymphocyte receptor signalling pathway


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B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1927957|PMID:11120811), (MGI:3839222|PMID:19228876) Ensembl
Ensembl
MGI		 PMID:11120811 PMID:19228876 GO_REF:0000107 MGI:1927957 MGI:3839222 NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,711 		JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:12,369,332...12,404,822
Ensembl chr 6:12,367,758...12,404,822 		JBrowse link
G BLK BLK proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:14,688,489...14,745,946
Ensembl chr14:14,688,123...14,746,414 		JBrowse link
G BLNK B cell linker involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:107,630,477...107,715,421
Ensembl chr14:107,625,803...107,715,368 		JBrowse link
G BMX BMX non-receptor tyrosine kinase involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr  X:12,044,110...12,096,042
Ensembl chr  X:12,044,349...12,096,638 		JBrowse link
G BTK Bruton tyrosine kinase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr  X:82,981,512...83,014,475
Ensembl chr  X:82,981,515...83,014,573 		JBrowse link
G CD19 CD19 molecule involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:1095647|PMID:9254656)		 GO_Central
Ensembl
GO_Central
MGI		 PMID:9254656 PMID:21873635 GO_REF:0000107 MGI:1095647 NCBI chr 3:18,592,785...18,601,273
Ensembl chr 3:18,592,879...18,603,595 		JBrowse link
G CD38 CD38 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:11,083,682...11,130,783
Ensembl chr 8:11,083,682...11,130,785 		JBrowse link
G CD79A CD79a molecule involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:21873635)
(MGI:3521842|PMID:1373499), (MGI:79455|PMID:8626447)		 InterPro
Ensembl
InterPro
GO_Central
MGI
GO_Central
Ensembl		 PMID:1373499 PMID:8626447 PMID:21873635 GO_REF:0000002 GO_REF:0000107 MGI:3521842 MGI:79455 NCBI chr 6:49,996,116...49,999,294
Ensembl chr 6:49,975,957...50,010,059 		JBrowse link
G CD79B CD79b molecule involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:3521842|PMID:1373499), (MGI:79455|PMID:8626447)		 GO_Central
InterPro
GO_Central
MGI
InterPro		 PMID:1373499 PMID:8626447 PMID:21873635 GO_REF:0000002 MGI:3521842 MGI:79455 NCBI chr12:15,052,966...15,056,441
Ensembl chr12:15,053,007...15,056,441 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,926...107,289,103 		JBrowse link
G FCRL5 Fc receptor like 5 acts_upstream_of ISO (MGI:5471851|PMID:23509253) MGI PMID:23509253 MGI:5471851 NCBI chr 4:92,578,672...92,631,713 JBrowse link
G ITK IL2 inducible T cell kinase involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr16:66,010,766...66,082,263
Ensembl chr16:66,010,768...66,082,185 		JBrowse link
G KDSR 3-ketodihydrosphingosine reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G KDSR 3-ketodihydrosphingosine reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:158,288,544...158,329,898
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G KLHL6 kelch like family member 6 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr13:121,426,618...121,487,260 JBrowse link
G LAT2 linker for activation of T cells family member 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:11,353,213...11,372,100
Ensembl chr 3:11,352,579...11,372,096 		JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:77358|PMID:7499277)		 GO_Central
GO_Central
MGI		 PMID:7499277 PMID:21873635 MGI:77358 NCBI chr 6:88,719,886...88,745,922
Ensembl chr 6:88,720,176...88,745,917 		JBrowse link
G LIME1 Lck interacting transmembrane adaptor 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3769059|PMID:16249387) MGI
Ensembl
InterPro		 PMID:16249387 GO_REF:0000002 GO_REF:0000107 MGI:3769059 NCBI chr17:62,652,618...62,655,342 JBrowse link
G LOC100523213 immunoglobulin lambda-like polypeptide 5 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr14:49,951,542...49,960,517 JBrowse link
G LOC102160313 T-cell receptor delta chain C region involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 7:76,554,354...76,565,679
Ensembl chr 7:76,469,954...76,673,728 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5471851|PMID:23509253)
(MGI:77358|PMID:7499277)		 Ensembl
Ensembl
MGI		 PMID:7499277 PMID:23509253 GO_REF:0000107 MGI:5471851 MGI:77358 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,786,099...75,868,591 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 acts_upstream_of_or_within ISO (MGI:1095647|PMID:9254656) MGI PMID:9254656 MGI:1095647 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523 		JBrowse link
G MEF2C myocyte enhancer factor 2C involved_in ISS UniProt
UniProt		 GO_REF:0000024 NCBI chr 2:96,122,407...96,296,927
Ensembl chr 2:96,122,407...96,296,842 		JBrowse link
G MNDA myeloid cell nuclear differentiation antigen involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 Ensembl chr 4:91,416,410...91,433,243 JBrowse link
G MS4A1 membrane spanning 4-domains A1 involved_in ISO (PMID:18474602) UniProt PMID:18474602 NCBI chr 2:11,216,238...11,229,060 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 5:19,677,613...19,720,550
Ensembl chr 5:19,677,875...19,723,132 		JBrowse link
G NFAM1 NFAT activating protein with ITAM motif 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:3044463|PMID:15143214)		 GO_Central
GO_Central
MGI		 PMID:15143214 PMID:21873635 MGI:3044463 NCBI chr 5:6,296,921...6,333,371
Ensembl chr 5:6,298,573...6,336,731 		JBrowse link
G NFATC2 nuclear factor of activated T cells 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr17:52,743,570...52,907,373
Ensembl chr17:52,743,570...52,906,821 		JBrowse link
G PLCG2 phospholipase C gamma 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:6,433,146...6,603,092
Ensembl chr 6:6,433,153...6,603,060 		JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:131,960,932...132,016,664
Ensembl chr14:131,946,792...132,016,660 		JBrowse link
G PRKCB protein kinase C beta involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:21,995,227...22,383,628
Ensembl chr 3:21,995,231...22,383,264 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5471851|PMID:23509253)
(MGI:1095647|PMID:9254656)		 Ensembl
Ensembl
MGI		 PMID:9254656 PMID:23509253 GO_REF:0000107 MGI:1095647 MGI:5471851 NCBI chr 5:63,762,109...63,779,086
Ensembl chr 5:63,762,112...63,808,350 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:77358|PMID:7499277)
(MGI:1095647|PMID:9254656)		 Ensembl
Ensembl
MGI		 PMID:7499277 PMID:9254656 GO_REF:0000107 MGI:1095647 MGI:77358 NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,466,373...21,764,560 		JBrowse link
G RFTN1 raftlin, lipid raft linker 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr13:3,454,448...3,675,072
Ensembl chr13:3,454,448...3,675,021 		JBrowse link
G SH2B2 SH2B adaptor protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1859033|PMID:10872802) MGI
Ensembl		 PMID:10872802 GO_REF:0000107 MGI:1859033 NCBI chr 3:9,670,838...9,695,325
Ensembl chr 3:9,668,818...9,695,174 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
IBA
ISS
ISO		 (PMID:21873635)
(MGI:77358|PMID:7499277), (MGI:79455|PMID:8626447)		 Ensembl
Ensembl
GO_Central
UniProt
GO_Central
MGI
UniProt		 PMID:7499277 PMID:8626447 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:77358 MGI:79455 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,712...2,161,172 		JBrowse link
G TEC tec protein tyrosine kinase involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 8:38,051,053...38,182,259
Ensembl chr 8:38,051,056...38,182,182 		JBrowse link
G VAV3 vav guanine nucleotide exchange factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:111,825,071...112,202,833
Ensembl chr 4:111,824,896...112,202,825 		JBrowse link
B cell receptor apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144 		JBrowse link
negative regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD22 CD22 molecule involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:44,820,593...44,834,392
Ensembl chr 6:44,820,683...44,835,956 		JBrowse link
G CD300A CD300a molecule involved_in ISO (PMID:21482706) UniProt PMID:21482706 NCBI chr12:6,665,578...6,681,329 JBrowse link
G FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) involved_in ISO (PMID:24169826) ARUK-UCL PMID:24169826 NCBI chr 4:88,873,762...88,892,964 JBrowse link
G FCRL5 Fc receptor like 5 acts_upstream_of_or_within ISO (MGI:5471851|PMID:23509253) MGI PMID:23509253 MGI:5471851 NCBI chr 4:92,578,672...92,631,713 JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:52,664,869...52,667,643
Ensembl chr12:52,664,873...52,667,610 		JBrowse link
G LOC100158069 Fc receptor-like protein 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:92,460,744...92,506,002
Ensembl chr 4:92,460,859...92,504,038 		JBrowse link
G LPXN leupaxin involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 2:12,534,780...12,582,756
Ensembl chr 2:12,534,840...12,582,745 		JBrowse link
G PLCL2 phospholipase C like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2677607|PMID:14517301) Ensembl
Ensembl
MGI		 PMID:14517301 GO_REF:0000107 MGI:2677607 NCBI chr13:3,992,230...4,201,574
Ensembl chr13:3,992,835...4,201,569 		JBrowse link
positive regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD81 CD81 molecule involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 2:1,625,728...1,641,662
Ensembl chr 2:1,506,652...1,641,667 		JBrowse link
G CMTM3 CKLF like MARVEL transmembrane domain containing 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3047050|PMID:15196959) Ensembl
MGI		 PMID:15196959 GO_REF:0000107 MGI:3047050 NCBI chr 6:27,308,146...27,320,449
Ensembl chr 6:27,308,141...27,317,308 		JBrowse link
G FOXP1 forkhead box P1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:52,346,844...52,974,358
Ensembl chr13:52,347,849...52,974,261 		JBrowse link
G MIR18A microRNA mir-18a involved_in ISO (PMID:24169826) ARUK-UCL PMID:24169826 NCBI chr11:60,734,791...60,734,882
Ensembl chr11:60,734,791...60,734,882 		JBrowse link
G MIR19A microRNA mir-19a involved_in ISO (PMID:24169826), (PMID:26017478) ARUK-UCL PMID:24169826 PMID:26017478 NCBI chr11:60,734,939...60,735,020
Ensembl chr11:60,734,939...60,735,020 		JBrowse link
G NFAM1 NFAT activating protein with ITAM motif 1 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 5:6,296,921...6,333,371
Ensembl chr 5:6,298,573...6,336,731 		JBrowse link
G PRKCB protein kinase C beta involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:21,995,227...22,383,628
Ensembl chr 3:21,995,231...22,383,264 		JBrowse link
G PRKCH protein kinase C eta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:190,205,041...190,439,433
Ensembl chr 1:190,205,678...190,439,433 		JBrowse link
G SLC39A10 solute carrier family 39 member 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5586914|PMID:25074919) Ensembl
Ensembl
MGI		 PMID:25074919 GO_REF:0000107 MGI:5586914 NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,839...99,726,404 		JBrowse link
G STAP1 signal transducing adaptor family member 1 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 8:65,318,861...65,372,838
Ensembl chr 8:65,332,522...65,392,965 		JBrowse link
regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLK BLK proto-oncogene, Src family tyrosine kinase involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr14:14,688,489...14,745,946
Ensembl chr14:14,688,123...14,746,414 		JBrowse link
G CD19 CD19 molecule involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:18,592,785...18,601,273
Ensembl chr 3:18,592,879...18,603,595 		JBrowse link
G GCSAM germinal center associated signaling and motility involved_in IBA
IEA		 (PMID:21873635) GO_Central
InterPro
Ensembl
GO_Central
InterPro		 PMID:21873635 GO_REF:0000002 GO_REF:0000107 NCBI chr13:147,623,212...147,643,942
Ensembl chr13:147,623,212...147,643,942 		JBrowse link
G GCSAML germinal center associated signaling and motility like involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 2:56,690,853...56,744,757
Ensembl chr 2:56,687,496...56,744,620 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,786,099...75,868,591 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17268
    immune system process 2488
      activation of immune response 282
        immune response-activating signal transduction 205
          immune response-activating cell surface receptor signaling pathway 204
            antigen receptor-mediated signaling pathway 169
              B cell receptor signaling pathway 57
                B cell receptor apoptotic signaling pathway 1
                negative regulation of B cell receptor signaling pathway 8
                positive regulation of B cell receptor signaling pathway 10
                regulation of B cell receptor signaling pathway + 23
Path 2
Term Annotations click to browse term
  biological_process 17268
    biological regulation 12761
      regulation of biological process 12126
        positive regulation of biological process 6483
          positive regulation of immune system process 881
            positive regulation of immune response 500
              activation of immune response 282
                immune response-activating signal transduction 205
                  immune response-activating cell surface receptor signaling pathway 204
                    antigen receptor-mediated signaling pathway 169
                      B cell receptor signaling pathway 57
                        B cell receptor apoptotic signaling pathway 1
                        negative regulation of B cell receptor signaling pathway 8
                        positive regulation of B cell receptor signaling pathway 10
                        regulation of B cell receptor signaling pathway + 23
paths to the root