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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell receptor signaling pathway
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Accession:GO:0050853 term browser browse the term
Definition:The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
Synonyms:exact_synonym: B cell receptor signalling pathway;   B lymphocyte receptor signaling pathway;   B lymphocyte receptor signalling pathway


show annotations for term's descendants           Sort by:
B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:2153718 (PMID:11120811), (PMID:19228876) RGD PMID:11120811 PMID:19228876 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO
IEA
ISS		 (PMID:9020138)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:9020138 GO_REF:0000024 GO_REF:0000107 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in ISO
IEA		 (PMID:17875758)
GO_REF:0000107		 RGD
Ensembl		 PMID:17875758 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase involved_in ISO UniProtKB:Q8NDB2 (PMID:23555801), (PMID:876631) RGD PMID:876631 PMID:23555801 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031 		JBrowse link
G Blnk B-cell linker involved_in ISO (PMID:11606584), (PMID:9697839) RGD PMID:9697839 PMID:11606584 NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113 		JBrowse link
G Bmx BMX non-receptor tyrosine kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:30,227,251...30,290,015
Ensembl chr  X:30,227,251...30,289,993 		JBrowse link
G Btk Bruton tyrosine kinase involved_in ISO
IBA		 (PMID:15509800)
GO_REF:0000033		 RGD
GO_Central		 PMID:15509800 GO_REF:0000033 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Cd19 CD19 molecule involved_in
acts_upstream_of_or_within		 ISO
IBA		 (MGI:5476553|PMID:23499492)
(PMID:9254656)
GO_REF:0000033		 RGD
GO_Central		 PMID:9254656 PMID:23499492 GO_REF:0000033 MGI:5476553 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975 		JBrowse link
G Cd38 CD38 molecule involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd79a CD79a molecule involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:8626447)
(PMID:1373499), (PMID:8626447)		 GO_Central
RGD		 PMID:1373499 PMID:8626447 GO_REF:0000033 NCBI chr 1:80,493,581...80,497,936
Ensembl chr 1:80,493,581...80,497,935 		JBrowse link
G Cd79b CD79b molecule involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:8626447)
(PMID:1373499), (PMID:8626447)		 GO_Central
RGD		 PMID:1373499 PMID:8626447 GO_REF:0000033 NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in ISO
IBA		 (PMID:17875758)
GO_REF:0000033		 RGD
GO_Central		 PMID:17875758 GO_REF:0000033 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Fcrl5 Fc receptor-like 5 acts_upstream_of ISO MGI:96055|MGI:96892 (PMID:23509253) RGD PMID:23509253 NCBI chr 2:172,881,763...172,912,912
Ensembl chr 2:172,881,448...172,913,148 		JBrowse link
G Grb2 growth factor receptor bound protein 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:9199344)		 Ensembl
RGD		 PMID:9199344 GO_REF:0000107 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Ighe immunoglobulin heavy constant epsilon involved_in ISO (PMID:8976175) RGD PMID:8976175
G Itk IL2-inducible T-cell kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:30,753,344...30,814,685
Ensembl chr10:30,753,344...30,814,685 		JBrowse link
G Klhl6 kelch-like family member 6 involved_in ISO (MGI:3603885|PMID:16166635) RGD PMID:16166635 MGI:3603885 NCBI chr11:80,970,917...81,010,593
Ensembl chr11:80,970,917...81,009,677 		JBrowse link
G Lat2 linker for activation of T cells family, member 2 involved_in ISO
IBA
IEA		 (PMID:12514734)
GO_REF:0000033
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:12514734 GO_REF:0000033 GO_REF:0000118 NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000118
(PMID:7499277)
GO_REF:0000033		 TreeGrafter
RGD
GO_Central		 PMID:7499277 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Lime1 Lck interacting transmembrane adaptor 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:16249387)		 GO_Central
RGD		 PMID:16249387 GO_REF:0000033 NCBI chr 3:168,490,535...168,496,627
Ensembl chr 3:168,490,074...168,493,127 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO MGI:3053558 (PMID:23509253), (PMID:7499277) RGD PMID:7499277 PMID:23509253 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:9254656)		 Ensembl
RGD		 PMID:9254656 GO_REF:0000107 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(MGI:3829850|PMID:18955699)		 UniProt
RGD		 PMID:18955699 GO_REF:0000024 MGI:3829850 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mnda myeloid cell nuclear differentiation antigen involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201 		JBrowse link
G Ms4a1 membrane spanning 4-domains A1 involved_in ISO (PMID:18474602) RGD PMID:18474602 NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO		 GO_REF:0000024
(PMID:17875758)		 UniProt
RGD		 PMID:17875758 GO_REF:0000024 NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934 		JBrowse link
G Nfam1 NFAT activating protein with ITAM motif 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:15143214)		 GO_Central
RGD		 PMID:15143214 GO_REF:0000033 NCBI chr 7:114,139,318...114,175,395
Ensembl chr 7:114,139,345...114,175,442 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17367755)		 Ensembl
RGD		 PMID:17367755 GO_REF:0000107 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in ISO (PMID:17367755) RGD PMID:17367755 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:17367755) RGD PMID:17367755 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:11606584), (PMID:15509800)
(MGI:1861532|PMID:10925250)		 Ensembl
RGD		 PMID:10925250 PMID:11606584 PMID:15509800 GO_REF:0000107 MGI:1861532 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Plekha1 pleckstrin homology domain containing A1 involved_in ISO (PMID:12101241) RGD PMID:12101241 NCBI chr 1:185,427,982...185,479,157
Ensembl chr 1:185,428,048...185,479,156 		JBrowse link
G Prkcb protein kinase C, beta involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3626015|PMID:12118249)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:12118249 GO_REF:0000024 GO_REF:0000107 MGI:3626015 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1856074|MGI:3053558 (PMID:23509253), (PMID:9254656)		 Ensembl
RGD		 PMID:9254656 PMID:23509253 GO_REF:0000107 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2181288 (PMID:7499277), (PMID:9254656)
(MGI:3687418|PMID:8692271)		 UniProt
RGD		 PMID:7499277 PMID:8692271 PMID:9254656 GO_REF:0000024 MGI:3687418 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Rftn1 raftlin lipid raft linker 1 involved_in ISO (PMID:12805216) RGD PMID:12805216 NCBI chr 9:10,804,611...11,002,084
Ensembl chr 9:10,804,611...11,002,084 		JBrowse link
G Sh2b2 SH2B adaptor protein 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:9233773)
(PMID:10872802)		 RGD PMID:9233773 PMID:10872802 NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 involved_in ISO MGI:98355 (PMID:24043312) RGD PMID:24043312 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
ISS		 GO_REF:0000107
(PMID:9199344)
(PMID:7499277), (PMID:8626447)
GO_REF:0000118
GO_REF:0000033
(PMID:15509800)
GO_REF:0000024		 Ensembl
RGD
TreeGrafter
GO_Central
UniProt		 PMID:7499277 PMID:8626447 PMID:9199344 PMID:15509800 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tec tec protein tyrosine kinase involved_in ISO
IBA		 (PMID:10518561)
GO_REF:0000033		 RGD
GO_Central		 PMID:10518561 GO_REF:0000033 NCBI chr14:35,352,551...35,461,585
Ensembl chr14:35,352,829...35,461,557 		JBrowse link
G Txk TXK tyrosine kinase involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr14:35,463,369...35,519,448
Ensembl chr14:35,463,944...35,519,448 		JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 2:197,011,901...197,354,321
Ensembl chr 2:197,011,831...197,354,321 		JBrowse link
B cell receptor apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:15214043) RGD PMID:15214043 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:23728777) RGD PMID:23728777 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
negative regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd22 CD22 molecule involved_in ISO
IBA		 (PMID:24169826), (PMID:26017478)
GO_REF:0000033		 RGD
GO_Central		 PMID:24169826 PMID:26017478 GO_REF:0000033 NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322 		JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:21482706) RGD PMID:21482706 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Fcgr2b Fc gamma receptor 2B involved_in ISO (PMID:24169826) RGD PMID:24169826 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fcrl5 Fc receptor-like 5 acts_upstream_of_or_within ISO MGI:96055|MGI:96892 (PMID:23509253) RGD PMID:23509253 NCBI chr 2:172,881,763...172,912,912
Ensembl chr 2:172,881,448...172,913,148 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:5896692|PMID:28039360) RGD PMID:28039360 MGI:5896692 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650 		JBrowse link
G Lpxn leupaxin involved_in ISO
IBA		 (PMID:17640867)
GO_REF:0000033
(MGI:3722965|PMID:17640867)		 RGD
GO_Central		 PMID:17640867 GO_REF:0000033 MGI:3722965 NCBI chr 1:209,928,297...209,963,085
Ensembl chr 1:209,929,202...209,963,084 		JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:30111844) RGD PMID:30111844 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Plcl2 phospholipase C-like 2 acts_upstream_of_or_within ISO MGI:2679632 (PMID:14517301) RGD PMID:14517301 NCBI chr 9:3,292,564...3,477,009
Ensembl chr 9:3,292,695...3,477,009 		JBrowse link
positive regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5476553|PMID:23499492)
(PMID:20237408)		 UniProt
Ensembl
RGD		 PMID:20237408 PMID:23499492 GO_REF:0000024 GO_REF:0000107 MGI:5476553 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660 		JBrowse link
G Cmtm3 CKLF-like MARVEL transmembrane domain containing 3 acts_upstream_of_or_within ISO (PMID:15196959) RGD PMID:15196959 NCBI chr19:622,563...630,721
Ensembl chr19:604,458...629,790 		JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:30111844) RGD PMID:30111844 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Mir18a microRNA 18a involved_in ISO (PMID:24169826) RGD PMID:24169826 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir19a microRNA 19a involved_in ISO (PMID:24169826), (PMID:26017478) RGD PMID:24169826 PMID:26017478 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Nfam1 NFAT activating protein with ITAM motif 1 involved_in ISO (MGI:3044463|PMID:15143214) RGD PMID:15143214 MGI:3044463 NCBI chr 7:114,139,318...114,175,395
Ensembl chr 7:114,139,345...114,175,442 		JBrowse link
G Prkcb protein kinase C, beta involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3700457|PMID:16301747)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16301747 GO_REF:0000024 GO_REF:0000107 MGI:3700457 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkch protein kinase C, eta involved_in ISO
ISS		 (PMID:18780722)
GO_REF:0000024		 RGD
UniProt		 PMID:18780722 GO_REF:0000024 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654 		JBrowse link
G Slc39a10 solute carrier family 39 member 10 acts_upstream_of_or_within ISO MGI:5642299 (PMID:25074919) RGD PMID:25074919 NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325 		JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO
IBA		 (PMID:10518561)
GO_REF:0000033		 RGD
GO_Central		 PMID:10518561 GO_REF:0000033 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245 		JBrowse link
regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd19 CD19 molecule involved_in ISO (PMID:9382888)
(MGI:1100180|PMID:9382888)		 RGD PMID:9382888 MGI:1100180 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975 		JBrowse link
G Fcmr Fc mu receptor involved_in ISS
ISO		 GO_REF:0000024
(MGI:5888941|PMID:28135254)		 UniProt
RGD		 PMID:28135254 GO_REF:0000024 MGI:5888941 NCBI chr13:42,337,363...42,351,706
Ensembl chr13:42,337,414...42,351,653 		JBrowse link
G Gcsam germinal center-associated, signaling and motility involved_in ISO
IBA		 (PMID:23299888)
GO_REF:0000033		 RGD
GO_Central		 PMID:23299888 GO_REF:0000033 NCBI chr11:55,195,757...55,207,011
Ensembl chr11:55,196,712...55,206,992 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:2152233|PMID:11672542)		 UniProt
GO_Central
RGD		 PMID:11672542 GO_REF:0000024 GO_REF:0000033 MGI:2152233 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    immune system process 3017
      activation of immune response 572
        immune response-activating signaling pathway 485
          immune response-activating cell surface receptor signaling pathway 304
            antigen receptor-mediated signaling pathway 193
              B cell receptor signaling pathway 61
                B cell receptor apoptotic signaling pathway 2
                negative regulation of B cell receptor signaling pathway 8
                positive regulation of B cell receptor signaling pathway 10
                regulation of B cell receptor signaling pathway + 22
Path 2
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of biological process 13322
        regulation of immune system process 1705
          positive regulation of immune system process 1186
            positive regulation of immune response 804
              activation of immune response 572
                immune response-activating signaling pathway 485
                  immune response-activating cell surface receptor signaling pathway 304
                    antigen receptor-mediated signaling pathway 193
                      B cell receptor signaling pathway 61
                        B cell receptor apoptotic signaling pathway 2
                        negative regulation of B cell receptor signaling pathway 8
                        positive regulation of B cell receptor signaling pathway 10
                        regulation of B cell receptor signaling pathway + 22
paths to the root