This term is obsolete.
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Definition:
OBSOLETE. The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Comment:
This term was obsoleted because it represent a specific gene product. Consider annotating to 'regulation of gene expression', 'regulation of transcription' or some signaling term.