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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of protein secretion
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Accession:GO:0050709 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
Synonyms:exact_synonym: down regulation of protein secretion;   downregulation of protein secretion
 narrow_synonym: inhibition of protein secretion


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negative regulation of protein secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adtrp androgen-dependent TFPI-regulating protein involved_in ISO
IEA
(PMID:28341552)
GO_REF:0000107
RGD
Ensembl
PMID:28341552 GO_REF:0000107 NCBI chr17:22,930,012...22,993,834 JBrowse link
G Anxa1 annexin A1 IMP RGD PMID:8559285 RGD:2306956 NCBI chr 1:217,861,175...217,877,205 JBrowse link
G Apoe apolipoprotein E involved_in IEA
ISO
GO_REF:0000107
(PMID:27044754)
Ensembl
RGD
PMID:27044754 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852 JBrowse link
G Cyp51 cytochrome P450, family 51 involved_in ISO (MGI:6270905|PMID:20876579) RGD PMID:20876579 MGI:6270905 NCBI chr 4:30,036,956...30,055,410 JBrowse link
G Dph3 diphthamide biosynthesis 3 involved_in ISO (PMID:14980502) RGD PMID:14980502 NCBI chr16:7,288,295...7,293,734 JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO (PMID:16839358) RGD PMID:16839358 NCBI chr 8:49,708,903...49,772,888 JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO (PMID:16839358) RGD PMID:16839358 NCBI chr11:56,879,689...56,931,901 JBrowse link
G Drd4 dopamine receptor D4 involved_in IEA
ISO
GO_REF:0000107
(PMID:16839358)
Ensembl
RGD
PMID:16839358 GO_REF:0000107 NCBI chr 1:196,396,366...196,400,824 JBrowse link
G Erp29 endoplasmic reticulum protein 29 involved_in ISO (PMID:22064321) RGD PMID:22064321 NCBI chr12:35,089,698...35,095,952 JBrowse link
G Frmd4a FERM domain containing 4A involved_in ISO (MGI:5924899|PMID:27044754) RGD PMID:27044754 MGI:5924899 NCBI chr17:73,667,787...74,258,487 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in ISO (MGI:6270905|PMID:20876579) RGD PMID:20876579 MGI:6270905 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Il12a interleukin 12A acts_upstream_of_or_within
involved_in
ISO
IEA
UniProtKB:P29460 (PMID:30106099)
GO_REF:0000107
RGD
Ensembl
PMID:30106099 GO_REF:0000107 NCBI chr 2:152,965,769...152,973,035 JBrowse link
G Il12b interleukin 12B acts_upstream_of_or_within ISO UniProtKB:P29459 (PMID:30106099) RGD PMID:30106099 NCBI chr10:28,888,832...28,903,796 JBrowse link
G Ins2 insulin 2 involved_in ISO (PMID:14739855) RGD PMID:14739855 NCBI chr 1:197,843,277...197,992,522 JBrowse link
G Neo1 neogenin 1 acts_upstream_of_or_within ISO (MGI:4455113|PMID:20065295) RGD PMID:20065295 MGI:4455113 NCBI chr 8:59,273,860...59,426,486 JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:21439629)
UniProt
RGD
PMID:21439629 GO_REF:0000024 NCBI chr10:15,406,832...15,419,765 JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 involved_in ISO (MGI:5009752|PMID:21439629) RGD PMID:21439629 MGI:5009752 NCBI chr10:101,833,157...101,860,283 JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 involved_in ISO
IEA
ISS
(PMID:19074433)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19074433 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:43,046,514...43,059,737 JBrowse link
G Sergef secretion regulating guanine nucleotide exchange factor involved_in ISO (PMID:12459492) RGD PMID:12459492 NCBI chr 1:96,949,660...97,152,529 JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 IMP RGD PMID:10625663 RGD:1299445 NCBI chr10:82,511,101...82,568,706 JBrowse link
G Syt4 synaptotagmin 4 involved_in ISO (MGI:4457852|PMID:19448629) RGD PMID:19448629 MGI:4457852 NCBI chr18:23,036,973...23,046,380 JBrowse link
negative regulation of adiponectin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta involved_in IEA
ISO
GO_REF:0000107
(MGI:3828398|PMID:16865359)
Ensembl
RGD
PMID:16865359 GO_REF:0000107 MGI:3828398 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Rab11fip1 RAB11 family interacting protein 1 involved_in ISO (PMID:24040321) RGD PMID:24040321 NCBI chr16:64,886,902...64,917,491 JBrowse link
G Rab11fip3 RAB11 family interacting protein 3 involved_in ISO (PMID:24040321) RGD PMID:24040321 NCBI chr10:15,002,650...15,086,382 JBrowse link
G Rab11fip5 RAB11 family interacting protein 5 involved_in ISO (PMID:24040321) RGD PMID:24040321 NCBI chr 4:117,871,301...117,908,819 JBrowse link
negative regulation of insulin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 IDA RGD PMID:15163199 RGD:1598646 NCBI chr 1:96,598,663...96,679,495 JBrowse link
G Acvr1c activin A receptor type 1C involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3512292 (MGI:3796011|PMID:18480258)
Ensembl
RGD
PMID:18480258 GO_REF:0000107 MGI:3796011 NCBI chr 3:42,815,490...42,892,423 JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:10952463) RGD PMID:10952463 NCBI chr 1:253,061,480...253,064,280 JBrowse link
G Bmp8a bone morphogenetic protein 8a involved_in ISO (PMID:22579288) RGD PMID:22579288 NCBI chr 5:135,589,839...135,617,785 JBrowse link
G Ccn3 cellular communication network factor 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5517610|PMID:23705021)
UniProt
RGD
PMID:23705021 GO_REF:0000024 MGI:5517610 NCBI chr 7:86,094,000...86,101,022 JBrowse link
G Chga chromogranin A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:121,696,051...121,707,399 JBrowse link
G Drd2 dopamine receptor D2 IMP RGD PMID:18216393 RGD:2311570 NCBI chr 8:49,708,903...49,772,888 JBrowse link
G Fam3d FAM3 metabolism regulating signaling molecule D involved_in ISS
ISO
GO_REF:0000024
(PMID:12160727)
UniProt
RGD
PMID:12160727 GO_REF:0000024 NCBI chr15:16,538,881...16,574,468 JBrowse link
G Ghrl ghrelin and obestatin prepropeptide acts_upstream_of_or_within ISO
IDA
MGI:3709886 (MGI:3709118|PMID:17130496) RGD PMID:17130496, PMID:17130496 MGI:3709118, RGD:8553721 NCBI chr 4:146,865,712...146,869,621 JBrowse link
G Ghsr growth hormone secretagogue receptor acts_upstream_of_or_within IDA PMID:17130496 MGI PMID:17130496 RGD:8553721 NCBI chr 2:110,268,489...110,271,865 JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase IMP RGD PMID:17491019 RGD:2302227 NCBI chr 2:219,787,935...219,830,335 JBrowse link
G Hdac1 histone deacetylase 1 IMP RGD PMID:22772764 RGD:9590127 NCBI chr 5:141,853,992...141,881,057 JBrowse link
G Inhbb inhibin subunit beta B involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
GO_REF:0000107
MGI:1857203 (MGI:3796011|PMID:18480258)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18480258 GO_REF:0000024 GO_REF:0000107 MGI:3796011 NCBI chr13:30,530,860...30,536,566 JBrowse link
G Irs1 insulin receptor substrate 1 involved_in IMP
IEA
ISO
PMID:12435589
GO_REF:0000107
(PMID:15572028)
Ensembl
RGD
PMID:15572028, PMID:12435589 GO_REF:0000107, RGD:729325 NCBI chr 9:83,552,964...83,605,797 JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3770494|PMID:17767909)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17767909 GO_REF:0000024 GO_REF:0000107 MGI:3770494 NCBI chr 3:155,820,255...155,913,383 JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 involved_in ISO (PMID:8923010) RGD PMID:8923010 NCBI chr 1:96,591,048...96,594,574 JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 IDA RGD PMID:16133261 RGD:1581603 NCBI chr 1:198,291,711...198,624,683 JBrowse link
G Midn midnolin acts_upstream_of_or_within IDA PMID:24187134 MGI PMID:24187134 RGD:8655525 NCBI chr 7:9,548,100...9,559,605 JBrowse link
G Mtnr1a melatonin receptor 1A IMP RGD PMID:22288848 RGD:9686057 NCBI chr16:47,144,461...47,163,919 JBrowse link
G Mtnr1b melatonin receptor 1B IMP RGD PMID:18363673 RGD:9588673 NCBI chr 8:12,638,219...12,652,737 JBrowse link
G Nos1 nitric oxide synthase 1 IMP RGD PMID:17130471 RGD:1642149 NCBI chr12:38,615,111...38,795,492 JBrowse link
G Npff neuropeptide FF-amide peptide precursor IDA RGD PMID:1704109 RGD:2316580 NCBI chr 7:133,654,530...133,655,319 JBrowse link
G Pde8b phosphodiesterase 8B IMP RGD PMID:17991719 RGD:2312519 NCBI chr 2:26,275,117...26,479,725 JBrowse link
G Pfkl phosphofructokinase, liver type acts_upstream_of_or_within ISO (MGI:1096000|PMID:9287040) RGD PMID:9287040 MGI:1096000 NCBI chr20:10,664,285...10,686,324 JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in IMP PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 2:225,165,981...225,440,978 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:24187134)
ParkinsonsUK-UCL
RGD
PMID:24187134 GO_REF:0000024 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Psmd9 proteasome 26S subunit, non-ATPase 9 involved_in IMP PMID:16099819 BHF-UCL PMID:16099819 RGD:8554418 NCBI chr12:33,337,182...33,357,468 JBrowse link
G Ptger3 prostaglandin E receptor 3 IDA RGD PMID:10531320 RGD:10043332 NCBI chr 2:246,606,131...246,750,970 JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within ISO MGI:3522021 (MGI:3513751|PMID:15520383) RGD PMID:15520383 MGI:3513751 NCBI chr12:35,365,436...35,424,925 JBrowse link
G Rest RE1-silencing transcription factor involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:20942606)
UniProt
Ensembl
RGD
PMID:20942606 GO_REF:0000024 GO_REF:0000107 NCBI chr14:30,859,109...30,879,828 JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 involved_in ISO (MGI:5619445|PMID:23092880) RGD PMID:23092880 MGI:5619445 NCBI chr10:104,878,487...105,176,986 JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:17994217)
Ensembl
RGD
PMID:17994217 GO_REF:0000107 NCBI chr16:68,575,763...68,613,905 JBrowse link
G Sirt4 sirtuin 4 involved_in
acts_upstream_of_or_within
ISO (PMID:17715127)
MGI:3769237|MGI:95753 (MGI:3769241|PMID:16959573)
RGD PMID:16959573 PMID:17715127 MGI:3769241 NCBI chr12:41,125,533...41,139,440 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within ISO MGI:2177773 (MGI:3770077|PMID:16890542) RGD PMID:16890542 MGI:3770077 NCBI chr10:45,007,637...45,029,650 JBrowse link
G Stxbp5l syntaxin binding protein 5L acts_upstream_of_or_within ISO (MGI:5296997|PMID:21998599) RGD PMID:21998599 MGI:5296997 NCBI chr11:63,334,667...63,654,270 JBrowse link
G Sytl4 synaptotagmin-like 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3770077|PMID:16890542)
Ensembl
RGD
PMID:16890542 GO_REF:0000107 MGI:3770077 NCBI chr  X:97,135,500...97,185,867 JBrowse link
G Uts2 urotensin 2 IMP RGD PMID:17931748 RGD:2306798 NCBI chr 5:161,450,846...161,456,235 JBrowse link
G Vsnl1 visinin-like 1 acts_upstream_of_or_within ISO (MGI:3694336|PMID:16731532) RGD PMID:16731532 MGI:3694336 NCBI chr 6:34,038,641...34,159,479 JBrowse link
negative regulation of insulin secretion involved in cellular response to glucose stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07067882.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Adra2a adrenoceptor alpha 2A involved_in ISO
IMP
(PMID:19965390) RGD PMID:19965390, PMID:19965390 RGD:2316628 NCBI chr 1:253,061,480...253,064,280 JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:17360501 RGD:2306172 NCBI chr 4:84,222,897...84,265,924 JBrowse link
G Eny2 ENY2, transcription and export complex 2 subunit IMP RGD PMID:22649445 RGD:9590329 NCBI chr 7:75,581,215...75,605,903 JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B acts_upstream_of_or_within ISO MGI:2182644 (MGI:4421103|PMID:19805579) RGD PMID:19805579 MGI:4421103 NCBI chr 6:27,832,128...27,850,600 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase IMP RGD PMID:20610886 RGD:5508687 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Jagn1 jagunal homolog 1 IMP RGD PMID:26882284 RGD:11520872 NCBI chr 4:146,591,577...146,596,287 JBrowse link
G Klf7 Kruppel like factor 7 involved_in ISO (PMID:16339272) RGD PMID:16339272 NCBI chr 9:65,437,535...65,484,720 JBrowse link
G LOC259246 alpha-2u globulin PGCL1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 IMP RGD PMID:19690174 RGD:7495848 NCBI chr 9:42,200,708...42,326,708 JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 acts_upstream_of_or_within ISO (MGI:5467193|PMID:22587331) RGD PMID:22587331 MGI:5467193 NCBI chr 2:39,535,680...39,647,378 JBrowse link
G Pde1c phosphodiesterase 1C IMP RGD PMID:18706893 RGD:2302857 NCBI chr 4:85,300,858...85,777,948 JBrowse link
G Pde3b phosphodiesterase 3B IMP RGD PMID:18706893 RGD:2302857 NCBI chr 1:168,606,762...168,770,078 JBrowse link
G Pde4c phosphodiesterase 4C IMP RGD PMID:18706893 RGD:2302857 NCBI chr16:18,690,727...18,711,555 JBrowse link
G Pde8b phosphodiesterase 8B IMP RGD PMID:18706893 RGD:2302857 NCBI chr 2:26,275,117...26,479,725 JBrowse link
G Pim3 Pim-3 proto-oncogene, serine/threonine kinase involved_in ISS
ISO
GO_REF:0000024
(MGI:5294526|PMID:21099329)
UniProt
RGD
PMID:21099329 GO_REF:0000024 MGI:5294526 NCBI chr 7:119,953,377...119,956,587 JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 IMP RGD PMID:20167843 RGD:12904047 NCBI chr 3:76,889,922...76,899,427 JBrowse link
G Ucp2 uncoupling protein 2 IMP RGD PMID:21172424 RGD:7204422 NCBI chr 1:154,839,242...154,845,612 JBrowse link
negative regulation of matrix metallopeptidase secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd200 Cd200 molecule involved_in ISO
IEA
(PMID:29101312)
GO_REF:0000107
RGD
Ensembl
PMID:29101312 GO_REF:0000107 NCBI chr11:55,410,166...55,437,527 JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 IMP RGD PMID:22105553 RGD:11522738 NCBI chr 1:134,038,644...134,057,969 JBrowse link
negative regulation of pancreatic amylase secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Madd MAP-kinase activating death domain IMP RGD PMID:23702376 RGD:9588639 NCBI chr 3:77,114,330...77,157,865 JBrowse link
negative regulation of prolactin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa5 annexin A5 IMP RGD PMID:15256781 RGD:10053690 NCBI chr 2:119,314,007...119,344,703 JBrowse link
negative regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2r coagulation factor II (thrombin) receptor involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5315674|PMID:21859963)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:21859963 GO_REF:0000024 GO_REF:0000107 MGI:5315674 NCBI chr 2:26,869,343...26,885,856 JBrowse link
negative regulation of secretion of lysosomal enzymes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2651471 (MGI:3697540|PMID:16979922) RGD PMID:16979922 MGI:3697540 NCBI chr14:1,031,588...1,059,494 JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 involved_in IEA
ISO
GO_REF:0000107
(MGI:3822255|PMID:18806227)
Ensembl
RGD
PMID:18806227 GO_REF:0000107 MGI:3822255 NCBI chr 3:77,158,808...77,168,907 JBrowse link
negative regulation of Wnt protein secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprm1 opioid receptor, mu 1 involved_in ISO
ISS
(PMID:20214800)
GO_REF:0000024
RGD
UniProt
PMID:20214800 GO_REF:0000024 NCBI chr 1:43,160,057...43,413,409 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    negative regulation of biological process 5618
      negative regulation of cellular process 5114
        negative regulation of secretion by cell 188
          negative regulation of protein secretion 85
            negative regulation of BMP secretion + 0
            negative regulation of Wnt protein secretion 1
            negative regulation of adiponectin secretion 4
            negative regulation of insulin secretion + 54
            negative regulation of matrix metallopeptidase secretion 2
            negative regulation of pancreatic amylase secretion 1
            negative regulation of pancreatic trypsinogen secretion 0
            negative regulation of prolactin secretion 1
            negative regulation of renin secretion into blood stream 1
            negative regulation of secretion of lysosomal enzymes 2
Path 2
Term Annotations click to browse term
  biological_process 19492
    localization 6444
      macromolecule localization 3015
        protein localization 2573
          establishment of protein localization 1696
            protein transport 1571
              protein secretion 413
                regulation of protein secretion 318
                  negative regulation of protein secretion 85
                    negative regulation of BMP secretion + 0
                    negative regulation of Wnt protein secretion 1
                    negative regulation of adiponectin secretion 4
                    negative regulation of insulin secretion + 54
                    negative regulation of matrix metallopeptidase secretion 2
                    negative regulation of pancreatic amylase secretion 1
                    negative regulation of pancreatic trypsinogen secretion 0
                    negative regulation of prolactin secretion 1
                    negative regulation of renin secretion into blood stream 1
                    negative regulation of secretion of lysosomal enzymes 2
paths to the root