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ONTOLOGY REPORT - ANNOTATIONS

Term:homocysteine metabolic process
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Accession:GO:0050667 term browser browse the term
Definition:The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
Synonyms:exact_synonym: Hcy metabolic process;   Hcy metabolism;   homocysteine metabolism


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homocysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase acts_upstream_of_or_within
involved_in		 TAS
IDA
ISO		 MGI:1857139 (MGI:1888627|PMID:10953023), (MGI:1890086|PMID:10993757), (MGI:3039983|PMID:15131763), (MGI:3510570|PMID:15555590), (MGI:3611588|PMID:15916860), (MGI:3656462|PMID:15622513), (MGI:3663564|PMID:16226235), (MGI:3798351|PMID:18541157), (MGI:71081|PMID:7878023)
(PMID:19010420), (PMID:20031578), (PMID:23981774)		 RGD PMID:7878023 PMID:10953023 PMID:10993757 PMID:15131763 PMID:15555590 More... MGI:1888627 MGI:1890086 MGI:3039983 MGI:3510570 MGI:3611588 MGI:3656462 MGI:3663564 MGI:3798351 MGI:71081, RGD:634704, RGD:1359024 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033 		JBrowse link
G Cth cystathionine gamma-lyase IDA RGD PMID:9359866 RGD:1359024 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Dpep1 dipeptidase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20031578)		 UniProt
RGD		 PMID:20031578 GO_REF:0000024 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257 		JBrowse link
G Mmut methylmalonyl-CoA mutase involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in IEP
ISO		 (PMID:20031578) RGD PMID:20031578 PMID:18726220 RGD:2317121 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IDA
IBA
IMP		 PMID:21873635 RGD
GO_Central		 PMID:11730351 PMID:21873635 PMID:21121936 RGD:1601423, RGD:13792537, RGD:7207080 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IBA
ISO		 PMID:21873635
(MGI:3710265|PMID:17369066)		 RGD PMID:17369066 PMID:21873635 MGI:3710265, RGD:13792537 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Nox4 NADPH oxidase 4 involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
homocysteine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blmh bleomycin hydrolase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212 		JBrowse link
G Cbs cystathionine beta synthase involved_in ISS
ISO		 GO_REF:0000024
(PMID:18776696), (PMID:24416422)		 UniProt
RGD		 PMID:18776696 PMID:24416422 GO_REF:0000024 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (PMID:11466310) RGD PMID:11466310 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
positive regulation of homocysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase IMP RGD PMID:15779086 RGD:2289784 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
transsulfuration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase IDA RGD PMID:16636197 RGD:1600624 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Cth cystathionine gamma-lyase involved_in TAS
IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
GO_REF:0000002
(PMID:19428278)		 Ensembl
InterPro
RGD		 PMID:19428278 PMID:15347670 PMID:21873635 GO_REF:0000002 GO_REF:0000107, RGD:1600762, RGD:13792537 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Mpst mercaptopyruvate sulfurtransferase IDA RGD PMID:17130129 RGD:9685559 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (MGI:5621260|PMID:23190757) RGD PMID:23190757 MGI:5621260 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      cellular metabolic process 9531
        sulfur compound metabolic process 303
          sulfur amino acid metabolic process 31
            homocysteine metabolic process 13
              homocysteine biosynthetic process + 0
              homocysteine catabolic process 3
              negative regulation of homocysteine metabolic process 0
              positive regulation of homocysteine metabolic process 1
              regulation of homocysteine metabolic process + 1
              transsulfuration 4
Path 2
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      cellular metabolic process 9531
        organic acid metabolic process 1055
          oxoacid metabolic process 1044
            carboxylic acid metabolic process 1029
              amino acid metabolic process 290
                alpha-amino acid metabolic process 210
                  homocysteine metabolic process 13
                    homocysteine biosynthetic process + 0
                    homocysteine catabolic process 3
                    negative regulation of homocysteine metabolic process 0
                    positive regulation of homocysteine metabolic process 1
                    regulation of homocysteine metabolic process + 1
                    transsulfuration 4
paths to the root