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ONTOLOGY REPORT - ANNOTATIONS


Term:homocysteine metabolic process
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Accession:GO:0050667 term browser browse the term
Definition:The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
Synonyms:exact_synonym: Hcy metabolic process;   Hcy metabolism;   homocysteine metabolism



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homocysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase involved_in
acts_upstream_of_or_within
TAS
IDA
ISO
(PMID:19010420), (PMID:20031578), (PMID:23981774)
MGI:1857139 (MGI:1888627|PMID:10953023), (MGI:1890086|PMID:10993757), (MGI:3039983|PMID:15131763), (MGI:3510570|PMID:15555590), (MGI:3611588|PMID:15916860), (MGI:3656462|PMID:15622513), (MGI:3663564|PMID:16226235), (MGI:3798351|PMID:18541157), (MGI:71081|PMID:7878023)
RGD PMID:7878023 PMID:10953023 PMID:10993757 PMID:15131763 PMID:15555590 More... MGI:1888627 MGI:1890086 MGI:3039983 MGI:3510570 MGI:3611588 MGI:3656462 MGI:3663564 MGI:3798351 MGI:71081, RGD:634704, RGD:1359024 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Cth cystathionine gamma-lyase IDA RGD PMID:9359866 RGD:1359024 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Dpep1 dipeptidase 1 involved_in ISO
ISS
(PMID:20031578)
GO_REF:0000024
RGD
UniProt
PMID:20031578 GO_REF:0000024 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
JBrowse link
G Mmut methylmalonyl-CoA mutase involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in IEP
ISO
(PMID:20031578) RGD PMID:20031578 PMID:18726220 RGD:2317121 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IDA
IBA
IEA
IMP
GO_REF:0000033
GO_REF:0000118
GO_Central
TreeGrafter
RGD
PMID:11730351 PMID:21121936 GO_REF:0000033 GO_REF:0000118, RGD:1601423, RGD:7207080 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO
IBA
IEA
(MGI:3710265|PMID:17369066)
GO_REF:0000033
GO_REF:0000118
RGD
GO_Central
TreeGrafter
PMID:17369066 GO_REF:0000033 GO_REF:0000118 MGI:3710265 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425
JBrowse link
G Nox4 NADPH oxidase 4 involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
homocysteine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blmh bleomycin hydrolase involved_in IEA
IBA
GO_REF:0000118
GO_REF:0000033
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212
JBrowse link
G Cbs cystathionine beta synthase involved_in ISO
ISS
(PMID:18776696), (PMID:24416422)
GO_REF:0000024
RGD
UniProt
PMID:18776696 PMID:24416422 GO_REF:0000024 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (PMID:11466310) RGD PMID:11466310 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425
JBrowse link
positive regulation of homocysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase IMP RGD PMID:15779086 RGD:2289784 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
transsulfuration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase IDA RGD PMID:16636197 RGD:1600624 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Cth cystathionine gamma-lyase involved_in TAS
IBA
IEA
ISO
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
GO_REF:0000002
(PMID:19428278)
GO_Central
TreeGrafter
Ensembl
InterPro
RGD
PMID:19428278 PMID:15347670 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:1600762 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase IDA RGD PMID:17130129 RGD:9685559 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO
IEA
(MGI:5621260|PMID:23190757)
GO_REF:0000107
RGD
Ensembl
PMID:23190757 GO_REF:0000107 MGI:5621260 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20350
    metabolic process 11904
      cellular metabolic process 10470
        sulfur compound metabolic process 341
          sulfur amino acid metabolic process 31
            homocysteine metabolic process 13
              homocysteine biosynthetic process + 0
              homocysteine catabolic process 3
              negative regulation of homocysteine metabolic process 0
              positive regulation of homocysteine metabolic process 1
              regulation of homocysteine metabolic process + 1
              transsulfuration 4
Path 2
Term Annotations click to browse term
  biological_process 20350
    metabolic process 11904
      cellular metabolic process 10470
        organic acid metabolic process 1075
          oxoacid metabolic process 1057
            carboxylic acid metabolic process 1038
              non-proteinogenic amino acid metabolic process 72
                homocysteine metabolic process 13
                  homocysteine biosynthetic process + 0
                  homocysteine catabolic process 3
                  negative regulation of homocysteine metabolic process 0
                  positive regulation of homocysteine metabolic process 1
                  regulation of homocysteine metabolic process + 1
                  transsulfuration 4
paths to the root