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ONTOLOGY REPORT - ANNOTATIONS


Term:homocysteine metabolic process
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Accession:GO:0050667 term browser browse the term
Definition:The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
Synonyms:exact_synonym: Hcy metabolic process;   Hcy metabolism;   homocysteine metabolism



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homocysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase acts_upstream_of_or_within
involved_in
TAS
ISO
IDA
MGI:1857139 (MGI:1888627|PMID:10953023), (MGI:1890086|PMID:10993757), (MGI:3039983|PMID:15131763), (MGI:3510570|PMID:15555590), (MGI:3611588|PMID:15916860), (MGI:3656462|PMID:15622513), (MGI:3663564|PMID:16226235), (MGI:3798351|PMID:18541157), (MGI:71081|PMID:7878023)
(PMID:19010420), (PMID:20031578), (PMID:23981774)
RGD PMID:7878023 PMID:10953023 PMID:10993757 PMID:15131763 PMID:15555590 More... MGI:1888627 MGI:1890086 MGI:3039983 MGI:3510570 MGI:3611588 MGI:3656462 MGI:3663564 MGI:3798351 MGI:71081, RGD:634704, RGD:1359024 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Cth cystathionine gamma-lyase IDA RGD PMID:9359866 RGD:1359024 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Dpep1 dipeptidase 1 involved_in ISO
ISS
(PMID:20031578)
GO_REF:0000024
RGD
UniProt
PMID:20031578 GO_REF:0000024 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
JBrowse link
G Mmut methylmalonyl-CoA mutase involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in IEP
ISO
(PMID:20031578) RGD PMID:20031578 PMID:18726220 RGD:2317121 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
IMP
RGD PMID:11730351 PMID:21121936 RGD:1601423, RGD:7207080 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IBA
ISO
PMID:21873635
(MGI:3710265|PMID:17369066)
RGD PMID:17369066 PMID:21873635 MGI:3710265, RGD:13792537 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425
JBrowse link
G Nox4 NADPH oxidase 4 involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
homocysteine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blmh bleomycin hydrolase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212
JBrowse link
G Cbs cystathionine beta synthase involved_in ISO
ISS
(PMID:18776696), (PMID:24416422)
GO_REF:0000024
RGD
UniProt
PMID:18776696 PMID:24416422 GO_REF:0000024 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (PMID:11466310) RGD PMID:11466310 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425
JBrowse link
positive regulation of homocysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase IMP RGD PMID:15779086 RGD:2289784 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
transsulfuration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase IDA RGD PMID:16636197 RGD:1600624 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Cth cystathionine gamma-lyase involved_in TAS
IEA
IBA
ISO
GO_REF:0000002
PMID:21873635
(PMID:19428278)
InterPro
RGD
PMID:19428278 PMID:15347670 PMID:21873635 GO_REF:0000002, RGD:1600762, RGD:13792537 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:17130129 PMID:21873635 RGD:9685559, RGD:13792537 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (MGI:5621260|PMID:23190757) RGD PMID:23190757 MGI:5621260 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
JBrowse link
G Tst thiosulfate sulfurtransferase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19391
    metabolic process 11735
      cellular metabolic process 10655
        organic acid metabolic process 1008
          sulfur amino acid metabolic process 32
            homocysteine metabolic process 14
              homocysteine biosynthetic process + 0
              homocysteine catabolic process 3
              negative regulation of homocysteine metabolic process 0
              positive regulation of homocysteine metabolic process 1
              regulation of homocysteine metabolic process + 1
              transsulfuration 5
Path 2
Term Annotations click to browse term
  biological_process 19391
    metabolic process 11735
      organic substance metabolic process 11277
        organic acid metabolic process 1008
          oxoacid metabolic process 976
            carboxylic acid metabolic process 957
              cellular amino acid metabolic process 272
                alpha-amino acid metabolic process 200
                  homocysteine metabolic process 14
                    homocysteine biosynthetic process + 0
                    homocysteine catabolic process 3
                    negative regulation of homocysteine metabolic process 0
                    positive regulation of homocysteine metabolic process 1
                    regulation of homocysteine metabolic process + 1
                    transsulfuration 5
paths to the root