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ONTOLOGY REPORT - ANNOTATIONS

Term:hydrogen peroxide biosynthetic process
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Accession:GO:0050665 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 biosynthetic process;   hydrogen peroxide anabolism;   hydrogen peroxide biosynthesis;   hydrogen peroxide formation;   hydrogen peroxide generation;   hydrogen peroxide synthesis


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hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:69,890,817...69,928,342
Ensembl chr17:75,445,923...75,479,571 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14980704) Ensembl
MGI		 PMID:14980704 GO_REF:0000107 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14980704) Ensembl
MGI		 PMID:14980704 GO_REF:0000107 NCBI chr15:53,692,877...53,699,279
Ensembl chr15:73,311,720...73,319,447 		JBrowse link
G DUOX1 dual oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:24,077,557...24,113,206
Ensembl chr15:42,431,595...42,467,943 		JBrowse link
G DUOX2 dual oxidase 2 involved_in ISO (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr15:24,040,513...24,061,758
Ensembl chr15:42,395,135...42,414,281 		JBrowse link
G LOC100982531 cytochrome b-245 heavy chain acts_upstream_of_or_within ISO (PMID:15258578) MGI PMID:15258578 NCBI chr  X:30,230,394...30,267,379
Ensembl chr  X:37,939,704...37,973,183 		JBrowse link
G LOC100986914 cytochrome b-245 light chain involved_in ISO PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr16:69,356,396...69,364,225
Ensembl chr16:89,016,349...89,024,719 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (PMID:15258578) MGI PMID:15258578 Ensembl chr 7:81,917,167...81,932,589 JBrowse link
G SOD1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:14679182)
(PMID:15544046)		 RGD
MGI
UniProt		 PMID:10640619 PMID:12514262 PMID:14679182 PMID:15544046 PMID:15880490 RGD:1581090 RGD:1601266 RGD:634854 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:15642720 RGD:2291946 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chr17:3,686,903...3,711,857
Ensembl chr17:3,683,575...3,708,253 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr 6:109,469,750...109,684,086
Ensembl chr 6:113,545,944...113,604,451 		JBrowse link
G LOC100986481 cytochrome c ISO RGD PMID:21410437 RGD:7349317 NCBI chr 7:25,784,900...25,791,598
Ensembl chr 7:25,396,013...25,398,549 		JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOXA1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) UniProt PMID:22814254 NCBI chr15:24,064,967...24,077,641
Ensembl chr15:42,418,234...42,430,749 		JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:24,061,922...24,066,016
Ensembl chr15:42,415,195...42,418,974 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077 		JBrowse link
G NOX4 NADPH oxidase 4 ISO RGD PMID:27279484 RGD:151347625 NCBI chr11:84,330,362...84,496,755 JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:20529999 RGD:27095884 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960 		JBrowse link
G ZNF205 zinc finger protein 205 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:2,054,056...2,061,992
Ensembl chr16:3,233,794...3,241,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16313
    metabolic process 10179
      cellular metabolic process 8945
        cellular biosynthetic process 7125
          hydrogen peroxide biosynthetic process 21
            negative regulation of hydrogen peroxide biosynthetic process 6
            positive regulation of hydrogen peroxide biosynthetic process 6
            regulation of hydrogen peroxide biosynthetic process + 12
Path 2
Term Annotations click to browse term
  biological_process 16313
    metabolic process 10179
      cellular metabolic process 8945
        reactive oxygen species metabolic process 262
          reactive oxygen species biosynthetic process 73
            hydrogen peroxide biosynthetic process 21
              negative regulation of hydrogen peroxide biosynthetic process 6
              positive regulation of hydrogen peroxide biosynthetic process 6
              regulation of hydrogen peroxide biosynthetic process + 12
paths to the root