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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta metabolic process
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Accession:GO:0050435 term browser browse the term
Definition:The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).
Synonyms:exact_synonym: beta-amyloid metabolism


show annotations for term's descendants           Sort by:
amyloid-beta metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G APEH acylaminoacyl-peptide hydrolase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:49,606,294...49,615,896
Ensembl chr 3:50,843,220...50,853,516 		JBrowse link
G BACE1 beta-secretase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25592972) RGD
MGI
TreeGrafter
Ensembl		 PMID:10531052 PMID:25592972 GO_REF:0000107 GO_REF:0000118 RGD:69771 NCBI chr11:112,120,950...112,151,505
Ensembl chr11:116,054,303...116,084,812 		JBrowse link
G BACE2 beta-secretase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:27,500,453...27,612,795
Ensembl chr21:40,831,203...40,938,280 		JBrowse link
G BECN1 beclin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18497889) Ensembl
MGI		 PMID:18497889 GO_REF:0000107 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G IDE insulin degrading enzyme involved_in ISO
IEA		 catabolism RGD
TreeGrafter
Ensembl		 PMID:15749695 PMID:18411275 GO_REF:0000107 GO_REF:0000118 RGD:1626704 RGD:2325981 NCBI chr10:89,196,295...89,320,223
Ensembl chr10:92,716,540...92,833,353 		JBrowse link
G LOC100971190 putative N-acetyltransferase 8B involved_in ISO (PMID:19011241) UniProt PMID:19011241 NCBI chr2A:73,761,907...73,763,964
Ensembl chr2A:75,297,531...75,298,213 		JBrowse link
G MGAT3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase acts_upstream_of_or_within ISO (PMID:25592972) MGI PMID:25592972 NCBI chr22:20,363,244...20,398,471
Ensembl chr22:38,214,029...38,215,630 		JBrowse link
G MME membrane metalloendopeptidase acts_upstream_of_or_within ISO (PMID:12074840) MGI PMID:12074840 NCBI chr 3:152,085,694...152,240,148
Ensembl chr 3:160,197,566...160,292,119 		JBrowse link
G NCSTN nicastrin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17913918) Ensembl
MGI		 PMID:17913918 GO_REF:0000107 NCBI chr 1:135,697,592...135,713,293
Ensembl chr 1:139,618,229...139,633,911 		JBrowse link
G NRDC nardilysin convertase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:51,038,711...51,130,404
Ensembl chr 1:52,535,603...52,625,998 		JBrowse link
G PSEN1 presenilin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12684521) Ensembl
MGI		 PMID:12684521 GO_REF:0000107 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876 		JBrowse link
G PSEN2 presenilin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10846187)
(PMID:12684521)		 TreeGrafter
MGI		 PMID:10846187 PMID:12684521 GO_REF:0000118 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295 		JBrowse link
G REN renin ISO RGD PMID:22609375 RGD:6892653 NCBI chr 1:179,757,653...179,769,530
Ensembl chr 1:184,046,117...184,057,393 		JBrowse link
G UNC13A unc-13 homolog A acts_upstream_of_or_within ISO (PMID:15123597) MGI PMID:15123597 NCBI chr19:17,088,654...17,175,559
Ensembl chr19:18,068,006...18,150,642 		JBrowse link
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:62,811...77,897
Ensembl chr19:1,018,095...1,042,104 		JBrowse link
G ADAM10 ADAM metallopeptidase domain 10 involved_in ISO PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chr15:37,562,930...37,717,175
Ensembl chr15:55,873,606...56,027,188 		JBrowse link
G APH1A aph-1 homolog A, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:125,610,649...125,614,261
Ensembl chr 1:129,262,002...129,265,810 		JBrowse link
G APH1B aph-1 homolog B, gamma-secretase subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16371134) Ensembl
MGI		 PMID:16371134 GO_REF:0000107 NCBI chr15:42,224,593...42,256,202
Ensembl chr15:60,520,031...60,551,599 		JBrowse link
G BACE1 beta-secretase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:112,120,950...112,151,505
Ensembl chr11:116,054,303...116,084,812 		JBrowse link
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:23,729,204...23,878,820
Ensembl chr21:37,137,253...37,231,987 		JBrowse link
G NCSTN nicastrin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16371134) Ensembl
MGI		 PMID:16371134 GO_REF:0000107 NCBI chr 1:135,697,592...135,713,293
Ensembl chr 1:139,618,229...139,633,911 		JBrowse link
G PSEN1 presenilin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20130175)
(PMID:16371134)		 Ensembl
MGI		 PMID:16371134 PMID:20130175 GO_REF:0000107 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876 		JBrowse link
G PSEN2 presenilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295 		JBrowse link
G PSENEN presenilin enhancer, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:32,675,331...32,677,285
Ensembl chr19:41,409,662...41,411,089 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5553242|PMID:18429932)
(MGI:5487687|PMID:23467355), (MGI:5774886|PMID:27030769)		 Alzheimers_University_of_Toronto
ARUK-UCL		 PMID:18429932 PMID:23467355 PMID:27030769 MGI:5487687 MGI:5553242 MGI:5774886 NCBI chr19:62,811...77,897
Ensembl chr19:1,018,095...1,042,104 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G BIN1 bridging integrator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:33,168,767...33,228,075
Ensembl chr2B:127,716,550...127,775,378 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:69,185,045...69,208,766
Ensembl chr17:74,737,164...74,762,039 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr17:15,578,658...15,596,313
Ensembl chr17:15,797,949...15,810,299 		JBrowse link
G IGF1 insulin like growth factor 1 involved_in ISO (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:26094765) ARUK-UCL
Ensembl		 PMID:26094765 GO_REF:0000107 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:9,389,829...9,404,099
Ensembl chr19:10,053,254...10,066,853 		JBrowse link
G PRNP prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:4,713,616...4,728,847
Ensembl chr20:4,523,155...4,523,916 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:14,192,293...14,352,357
Ensembl chr18:17,833,047...17,990,086 		JBrowse link
G RTN1 reticulon 1 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chr14:40,198,279...40,472,255 JBrowse link
G RTN2 reticulon 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:42,434,085...42,446,862
Ensembl chr19:51,030,708...51,043,404 		JBrowse link
G RTN3 reticulon 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:59,039,313...59,117,572
Ensembl chr11:62,391,284...62,468,595 		JBrowse link
G RTN4 reticulon 4 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chr2A:55,129,272...55,207,031 JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:116,297,014...116,477,399
Ensembl chr11:120,222,491...120,402,432 		JBrowse link
G SPON1 spondin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16227578) Ensembl
MGI		 PMID:16227578 GO_REF:0000107 NCBI chr11:14,063,166...14,368,180
Ensembl chr11:13,776,671...14,057,741 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:22086926) ARUK-UCL
Ensembl		 PMID:22086926 GO_REF:0000107 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) ARUK-UCL PMID:17293612 NCBI chr21:28,534,697...28,619,590
Ensembl chr21:41,839,115...41,933,050 		JBrowse link
G APOE apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G CASP3 caspase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G CSNK1E casein kinase 1 epsilon ISO RGD PMID:17360493 RGD:10395238 NCBI chr22:19,202,599...19,229,344
Ensembl chr22:37,027,094...37,072,942 		JBrowse link
G EFNA1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,475,128...130,482,531
Ensembl chr 1:134,083,855...134,091,228 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:108,664,475...108,818,802
Ensembl chr2B:227,248,958...227,402,790 		JBrowse link
G GSAP gamma-secretase activating protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:69,231,374...69,340,215
Ensembl chr 7:83,043,730...83,146,026 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:39,118,330...39,130,768
Ensembl chr19:47,710,197...47,726,948 		JBrowse link
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IFNGR1 interferon gamma receptor 1 involved_in ISO (MGI:3697769|PMID:17255335) ARUK-UCL PMID:17255335 MGI:3697769 NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 involved_in ISO (MGI:4437154|PMID:20164328) ARUK-UCL PMID:20164328 MGI:4437154 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G LRRTM3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17098871) MGI
Ensembl		 PMID:17098871 GO_REF:0000107 NCBI chr10:63,407,003...63,594,210
Ensembl chr10:65,722,425...65,893,608 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit acts_upstream_of
involved_in		 ISO
IEA		 (MGI:6414694|PMID:21329555) ARUK-UCL
Ensembl		 PMID:21329555 GO_REF:0000107 MGI:6414694 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:11,167,353...11,331,339
Ensembl chr2A:11,318,370...11,478,986 		JBrowse link
G SLC2A13 solute carrier family 2 member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:48,609,170...48,948,828
Ensembl chr12:49,469,306...49,803,110 		JBrowse link
G SP1 Sp1 transcription factor acts_upstream_of
involved_in		 ISO
IEA		 (PMID:14701757) ARUK-UCL
Ensembl		 PMID:14701757 GO_REF:0000107 NCBI chr12:35,338,492...35,374,462
Ensembl chr12:36,127,681...36,158,356 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PICALM phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO (MGI:5637941|PMID:26005850) ARUK-UCL PMID:26005850 MGI:5637941 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684 		JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:55,683,121...55,728,365
Ensembl chr14:74,526,733...74,572,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    metabolic process 10303
      amide metabolic process 413
        amyloid-beta metabolic process 56
          amyloid-beta formation + 45
Path 2
Term Annotations click to browse term
  biological_process 16440
    metabolic process 10303
      organic substance metabolic process 9869
        organonitrogen compound metabolic process 4927
          amyloid-beta metabolic process 56
            amyloid-beta formation + 45
paths to the root