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ONTOLOGY REPORT - ANNOTATIONS


Term:trimethyllysine dioxygenase activity
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Accession:GO:0050353 term browser browse the term
Definition:Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate.
Synonyms:related_synonym: 6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating);   N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating);   TML dioxygenase activity;   TML hydroxylase activity;   TML-alpha-ketoglutarate dioxygenase activity;   TMLD activity;   epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity;   trimethyllysine alpha-ketoglutarate dioxygenase activity;   trimethyllysine,2-oxoglutarate dioxygenase activity
 xref: EC:1.14.11.8;   KEGG_REACTION:R03451;   MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN;   RHEA:14181;   reactome:R-HSA-71241 "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA"



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trimethyllysine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tmlhe trimethyllysine hydroxylase, epsilon NOT|enables IDA
ISO
IEA
(PMID:15754339)
GO_REF:0000002
(PMID:37553674)
(PMID:11431483), (PMID:23092983)
RGD
InterPro
PMID:11431483 PMID:15754339 PMID:23092983 PMID:37553674 PMID:11431483 GO_REF:0000002, RGD:70558 NCBI chr20:91,234...138,942
Ensembl chr20:91,272...140,386
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  molecular_function 21088
    catalytic activity 6122
      oxidoreductase activity 868
        dioxygenase activity 100
          2-oxoglutarate-dependent dioxygenase activity 64
            trimethyllysine dioxygenase activity 1
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