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ONTOLOGY REPORT - ANNOTATIONS


Term:calcium ion-regulated exocytosis of neurotransmitter
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Accession:GO:0048791 term browser browse the term
Definition:The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels.



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calcium ion-regulated exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (MGI:1353373|PMID:10670432) MGI PMID:10670432 MGI:1353373 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729
JBrowse link
G DOC2B double C2 domain beta involved_in ISO PMID:20150444
(MGI:4439222|PMID:20150444)
UniProt PMID:20150444 MGI:4439222 RGD:8554647 NCBI chr17:19,854...58,336 JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 acts_upstream_of_or_within ISO (MGI:3703478|PMID:17124501) MGI PMID:17124501 MGI:3703478 NCBI chr 6:69,714,807...70,231,260
Ensembl chr 6:73,008,176...73,523,422
JBrowse link
G RIMS2 regulating synaptic membrane exocytosis 2 acts_upstream_of_or_within ISO (MGI:3703478|PMID:17124501) MGI PMID:17124501 MGI:3703478 NCBI chr 8:100,156,403...100,894,128 JBrowse link
G SNAP25 synaptosome associated protein 25 ISO RGD PMID:14980208 RGD:1581082 NCBI chr20:10,164,236...10,252,856
Ensembl chr20:10,218,358...10,252,841
JBrowse link
G STX1B syntaxin 1B involved_in ISO (MGI:3803800|PMID:18703708) ParkinsonsUK-UCL PMID:18703708 MGI:3803800 NCBI chr16:23,956,426...23,979,646
Ensembl chr16:31,356,907...31,378,870
JBrowse link
G SYT1 synaptotagmin 1 acts_upstream_of_or_within ISO (MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:5141208 NCBI chr12:76,392,955...76,981,800
Ensembl chr12:79,595,704...79,829,923
JBrowse link
G SYT7 synaptotagmin 7 involved_in ISO (MGI:5707519|PMID:26738595) UniProt PMID:26738595 MGI:5707519 NCBI chr11:56,814,694...56,880,439
Ensembl chr11:60,175,403...60,242,375
JBrowse link
fast, calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT1 synaptotagmin 1 involved_in ISO (MGI:3653150|PMID:9194562), (MGI:69538|PMID:7954835)
(MGI:3040539|PMID:12526776)
ParkinsonsUK-UCL PMID:7954835 PMID:9194562 PMID:12526776 MGI:3040539 MGI:3653150 MGI:69538 NCBI chr12:76,392,955...76,981,800
Ensembl chr12:79,595,704...79,829,923
JBrowse link
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT1 synaptotagmin 1 involved_in ISO (MGI:2179533|PMID:11242035) UniProt PMID:11242035 MGI:2179533 NCBI chr12:76,392,955...76,981,800
Ensembl chr12:79,595,704...79,829,923
JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in ISO (MGI:5634021|PMID:25719439) SynGO PMID:25719439 MGI:5634021 NCBI chr 3:62,321,496...62,797,298 JBrowse link
G STXBP1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chr 9:98,731,527...98,811,608
Ensembl chr 9:127,434,080...127,486,152
JBrowse link
G SYT6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chr 1:88,397,809...88,467,493
Ensembl chr 1:123,452,889...123,514,795
JBrowse link
G UNC13A unc-13 homolog A involved_in ISO (MGI:5819330|PMID:26575293) SynGO PMID:26575293 MGI:5819330 NCBI chr19:17,088,654...17,175,559
Ensembl chr19:18,068,006...18,150,642
JBrowse link
G UNC13B unc-13 homolog B involved_in ISO (MGI:5819330|PMID:26575293) SynGO PMID:26575293 MGI:5819330 NCBI chr 9:35,011,350...35,255,148
Ensembl chr 9:35,817,353...36,059,894
JBrowse link
regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO (MGI:4866942|PMID:21106823) MGI PMID:21106823 MGI:4866942 NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923
JBrowse link
G RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 involved_in ISO (MGI:3652690|PMID:16782817) ParkinsonsUK-UCL PMID:16782817 MGI:3652690 NCBI chr2B:24,692,363...24,810,685
Ensembl chr2B:139,125,375...139,242,721
JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RX7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068
JBrowse link
G SYT4 synaptotagmin 4 involved_in ISO (MGI:4457852|PMID:19448629) SynGO PMID:19448629 MGI:4457852 NCBI chr18:36,540,756...36,550,439
Ensembl chr18:40,089,938...40,099,721
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12786
    cellular process 11938
      vesicle-mediated transport 1181
        vesicle-mediated transport in synapse 245
          synaptic vesicle exocytosis 130
            calcium ion-regulated exocytosis of neurotransmitter 17
              fast, calcium ion-dependent exocytosis of neurotransmitter 1
              negative regulation of calcium ion-dependent exocytosis of neurotransmitter 0
              positive regulation of calcium ion-dependent exocytosis of neurotransmitter 1
              presynaptic dense core vesicle exocytosis + 7
              regulation of calcium ion-dependent exocytosis of neurotransmitter + 5
              slow, calcium ion-dependent exocytosis of neurotransmitter 0
Path 2
Term Annotations click to browse term
  biological_process 12786
    localization 5077
      establishment of localization 3615
        transport 3454
          export from cell 885
            secretion by cell 840
              signal release 568
                signal release from synapse 171
                  neurotransmitter secretion 171
                    synaptic vesicle exocytosis 130
                      calcium ion-regulated exocytosis of neurotransmitter 17
                        fast, calcium ion-dependent exocytosis of neurotransmitter 1
                        negative regulation of calcium ion-dependent exocytosis of neurotransmitter 0
                        positive regulation of calcium ion-dependent exocytosis of neurotransmitter 1
                        presynaptic dense core vesicle exocytosis + 7
                        regulation of calcium ion-dependent exocytosis of neurotransmitter + 5
                        slow, calcium ion-dependent exocytosis of neurotransmitter 0
paths to the root