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ONTOLOGY REPORT - ANNOTATIONS

Term:calcium ion-regulated exocytosis of neurotransmitter
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Accession:GO:0048791 term browser browse the term
Definition:The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels.

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calcium ion-regulated exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209 (MGI:1353373|PMID:10670432) RGD PMID:10670432 MGI:1353373 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550 		JBrowse link
G Doc2b double C2 domain beta involved_in IDA
ISO
IEA		 PMID:20150444
(MGI:4439222|PMID:20150444)
GO_REF:0000107		 RGD
Ensembl		 PMID:20150444, PMID:20150444, PMID:20150444 GO_REF:0000107 MGI:4439222, RGD:8554647, RGD:8554647 NCBI chr10:63,921,255...63,952,944
Ensembl chr10:63,928,064...63,952,726 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:2152972 (MGI:3703478|PMID:17124501)
PMID:21873635		 RGD PMID:17124501, PMID:21873635, PMID:21873635 MGI:3703478, RGD:13792537, RGD:13792537 NCBI chr 9:28,440,408...28,973,246
Ensembl chr 9:28,442,229...28,973,246 		JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 acts_upstream_of_or_within
involved_in		 ISS
ISO
IBA		 GO_REF:0000024
MGI:2152971 (MGI:3703478|PMID:17124501)
PMID:21873635		 ParkinsonsUK-UCL
RGD		 PMID:17124501, PMID:21873635, PMID:21873635 GO_REF:0000024 MGI:3703478, RGD:13792537, RGD:13792537 NCBI chr 7:78,091,998...78,594,164
Ensembl chr 7:78,092,037...78,594,138 		JBrowse link
G Rims3 regulating synaptic membrane exocytosis 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 5:139,790,395...139,819,014
Ensembl chr 5:139,783,951...139,819,016 		JBrowse link
G Snap25 synaptosome associated protein 25 IDA RGD PMID:14980208 RGD:1581082 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400 		JBrowse link
G Stx1b syntaxin 1B involved_in ISO (MGI:3803800|PMID:18703708) RGD PMID:18703708 MGI:3803800 NCBI chr 1:199,251,842...199,270,465
Ensembl chr 1:199,251,844...199,270,627 		JBrowse link
G Syt1 synaptotagmin 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:1857252 (MGI:5141208|PMID:21521611)
PMID:21873635		 RGD PMID:21521611, PMID:21873635, PMID:21873635 MGI:5141208, RGD:13792537, RGD:13792537 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798 		JBrowse link
G Syt2 synaptotagmin 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr13:51,569,248...51,577,824
Ensembl chr13:51,534,025...51,578,052 		JBrowse link
G Syt5 synaptotagmin 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 1:72,859,806...72,867,934
Ensembl chr 1:72,860,218...72,867,930 		JBrowse link
G Syt7 synaptotagmin 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5707519|PMID:26738595)		 UniProt
RGD		 PMID:26738595 GO_REF:0000024 MGI:5707519 NCBI chr 1:226,435,816...226,498,008
Ensembl chr 1:226,435,979...226,493,377 		JBrowse link
G Syt8 synaptotagmin 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 1:215,605,408...215,607,602
Ensembl chr 1:215,605,404...215,607,696 		JBrowse link
fast, calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt1 synaptotagmin 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3040539|PMID:12526776), (MGI:3653150|PMID:9194562), (MGI:69538|PMID:7954835)		 ParkinsonsUK-UCL
RGD		 PMID:7954835 PMID:9194562 PMID:12526776 GO_REF:0000024 MGI:3040539 MGI:3653150 MGI:69538 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798 		JBrowse link
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt1 synaptotagmin 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:2179533|PMID:11242035)		 UniProt
RGD		 PMID:11242035 GO_REF:0000024 MGI:2179533 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q8BYR5 (MGI:5634021|PMID:25719439)		 Ensembl
RGD		 PMID:25719439 GO_REF:0000107 MGI:5634021 NCBI chr15:15,275,489...15,690,575
Ensembl chr15:15,275,541...15,667,778 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) RGD PMID:11545717 MGI:3621672 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417 		JBrowse link
G Syt6 synaptotagmin 6 involved_in IDA
IMP		 PMID:26216953 SynGO PMID:26216953, PMID:26216953, PMID:26216953, PMID:26216953 RGD:13702162, RGD:13702162, RGD:13702162, RGD:13702162 NCBI chr 2:206,064,181...206,119,034
Ensembl chr 2:206,064,179...206,127,907 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO
IBA		 UniProtKB:Q9Z1N9 (MGI:5819330|PMID:26575293)
PMID:21873635		 RGD PMID:26575293, PMID:21873635, PMID:21873635 MGI:5819330, RGD:13792537, RGD:13792537 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO
IBA		 (MGI:5819330|PMID:26575293)
PMID:21873635		 RGD PMID:26575293, PMID:21873635, PMID:21873635 MGI:5819330, RGD:13792537, RGD:13792537 NCBI chr 5:58,505,449...58,714,396
Ensembl chr 5:58,505,500...58,715,576 		JBrowse link
G Unc13c unc-13 homolog C involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 8:80,202,736...80,656,363
Ensembl chr 8:80,203,609...80,631,926 		JBrowse link
regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO (MGI:4866942|PMID:21106823) RGD PMID:21106823 MGI:4866942 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326 		JBrowse link
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3652690|PMID:16782817)		 ParkinsonsUK-UCL
RGD		 PMID:16782817 GO_REF:0000024 MGI:3652690 NCBI chr13:44,578,208...44,649,876
Ensembl chr13:44,615,553...44,648,620 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X 7 involved_in EXP
IDA		 PMID:24037803 SynGO PMID:24037803, PMID:24037803, PMID:24037803, PMID:24037803 RGD:13702177, RGD:13702177, RGD:13702177, RGD:13702177 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042 		JBrowse link
G Syt4 synaptotagmin 4 involved_in ISO (MGI:4457852|PMID:19448629) RGD PMID:19448629 MGI:4457852 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20082
    cellular process 18900
      vesicle-mediated transport 1686
        vesicle-mediated transport in synapse 279
          synaptic vesicle exocytosis 155
            calcium ion-regulated exocytosis of neurotransmitter 22
              fast, calcium ion-dependent exocytosis of neurotransmitter 1
              negative regulation of calcium ion-dependent exocytosis of neurotransmitter 0
              positive regulation of calcium ion-dependent exocytosis of neurotransmitter 1
              presynaptic dense core vesicle exocytosis + 8
              regulation of calcium ion-dependent exocytosis of neurotransmitter + 5
              slow, calcium ion-dependent exocytosis of neurotransmitter 0
Path 2
Term Annotations click to browse term
  biological_process 20082
    localization 6506
      establishment of localization 4918
        transport 4755
          export from cell 1018
            secretion by cell 967
              signal release 621
                signal release from synapse 208
                  neurotransmitter secretion 208
                    synaptic vesicle exocytosis 155
                      calcium ion-regulated exocytosis of neurotransmitter 22
                        fast, calcium ion-dependent exocytosis of neurotransmitter 1
                        negative regulation of calcium ion-dependent exocytosis of neurotransmitter 0
                        positive regulation of calcium ion-dependent exocytosis of neurotransmitter 1
                        presynaptic dense core vesicle exocytosis + 8
                        regulation of calcium ion-dependent exocytosis of neurotransmitter + 5
                        slow, calcium ion-dependent exocytosis of neurotransmitter 0
paths to the root