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ONTOLOGY REPORT - ANNOTATIONS


Term:neuron fate specification
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Accession:GO:0048665 term browser browse the term
Definition:The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.



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neuron fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:1857470 (MGI:3639051|PMID:16469766)
(MGI:5897542|PMID:24243019)
UniProt
RGD
PMID:16469766 PMID:24243019 GO_REF:0000024 MGI:3639051 MGI:5897542 NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993
JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3823133|PMID:18997111)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:18997111 GO_REF:0000024 GO_REF:0000107 MGI:3823133 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
G Dmrta2 DMRT-like family A2 acts_upstream_of_or_within ISO (MGI:5013657|PMID:21576465) RGD PMID:21576465 MGI:5013657 NCBI chr 5:124,805,883...124,811,694
Ensembl chr 5:124,805,883...124,811,630
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 acts_upstream_of_or_within ISO MGI:4418499 (MGI:5577209|PMID:24584053) RGD PMID:24584053 MGI:5577209 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 acts_upstream_of_or_within ISO MGI:102780 (MGI:5319720|PMID:22513373) RGD PMID:22513373 MGI:5319720 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
JBrowse link
G Fev FEV transcription factor, ETS family member acts_upstream_of_or_within ISO MGI:2449922 (MGI:4836772|PMID:20818386) RGD PMID:20818386 MGI:4836772 NCBI chr 9:76,439,164...76,443,603
Ensembl chr 9:76,439,172...76,443,065
JBrowse link
G Foxa1 forkhead box A1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1347476 (MGI:3720545|PMID:17596284)
Ensembl
RGD
PMID:17596284 GO_REF:0000107 MGI:3720545 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Foxa2 forkhead box A2 acts_upstream_of_or_within ISO MGI:1347472|MGI:2176222|MGI:2177337 (MGI:3720545|PMID:17596284), (MGI:3767119|PMID:17922007) RGD PMID:17596284 PMID:17922007 MGI:3720545 MGI:3767119 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Gsx2 GS homeobox 2 acts_upstream_of_or_within ISO MGI:2150162 (MGI:3579956|PMID:15930101) RGD PMID:15930101 MGI:3579956 NCBI chr14:33,123,799...33,126,151
Ensembl chr14:33,124,381...33,126,105
JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in IBA
ISO
PMID:21873635
(MGI:3815381|PMID:18849985)
RGD PMID:18849985 PMID:21873635 MGI:3815381, RGD:13792537 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584
JBrowse link
G Isl2 ISL LIM homeobox 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:55,923,805...55,928,790
Ensembl chr 8:55,923,805...55,928,790
JBrowse link
G Myt1l myelin transcription factor 1-like involved_in ISS
ISO
GO_REF:0000024
(MGI:5897487|PMID:28379941), (MGI:5897542|PMID:24243019)
UniProt
RGD
PMID:24243019 PMID:28379941 GO_REF:0000024 MGI:5897487 MGI:5897542 NCBI chr 6:46,164,742...46,564,234
Ensembl chr 6:46,428,150...46,561,671
JBrowse link
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1932100|MGI:97451 (MGI:3611719|PMID:16339193), (MGI:4360136|PMID:19592574) RGD PMID:16339193 PMID:19592574 MGI:3611719 MGI:4360136 NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 IMP RGD PMID:15247919 RGD:2325628 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
JBrowse link
G Pou3f2 POU class 3 homeobox 2 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5897542|PMID:24243019)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:24243019 GO_REF:0000024 GO_REF:0000107 MGI:5897542 NCBI chr 5:36,077,930...36,083,838
Ensembl chr 5:36,077,930...36,083,838
JBrowse link
G Pou4f1 POU class 4 homeobox 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:4367920|PMID:19877281), (MGI:4454975|PMID:20096094)
Ensembl
RGD
PMID:19877281 PMID:20096094 GO_REF:0000107 MGI:4367920 MGI:4454975 NCBI chr15:81,255,566...81,260,057
Ensembl chr15:81,257,781...81,259,728
JBrowse link
G Six1 SIX homeobox 1 acts_upstream_of_or_within ISO MGI:109344 (MGI:5319720|PMID:22513373) RGD PMID:22513373 MGI:5319720 NCBI chr 6:91,746,739...91,751,975
Ensembl chr 6:91,746,739...91,751,975
JBrowse link
G Tlx3 T-cell leukemia, homeobox 3 acts_upstream_of_or_within ISO MGI:104867 (MGI:3607682|PMID:16234809) RGD PMID:16234809 MGI:3607682 NCBI chr10:17,789,706...17,792,207
Ensembl chr10:17,790,053...17,792,207
JBrowse link
auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh1 atonal bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:2155983 (MGI:1339217|PMID:10364557) RGD PMID:10364557 MGI:1339217 NCBI chr 4:93,912,068...93,914,163
Ensembl chr 4:93,912,068...93,914,154
JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esrp1 epithelial splicing regulatory protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5915403|PMID:29107558)
UniProt
RGD
PMID:29107558 GO_REF:0000024 MGI:5915403 NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062
JBrowse link
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 acts_upstream_of_or_within ISO MGI:95729 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Gli3 GLI family zinc finger 3 acts_upstream_of_or_within ISO MGI:95728 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within ISO MGI:4840420 (MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:4355593 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577
JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 acts_upstream_of_or_within ISO MGI:95729 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Gli3 GLI family zinc finger 3 acts_upstream_of_or_within ISO MGI:95728 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within ISO MGI:4840420 (MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:4355593 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577
JBrowse link
spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxc10 homeo box C10 acts_upstream_of_or_within ISO MGI:96202 (MGI:3771768|PMID:18065432) RGD PMID:18065432 MGI:3771768 NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966
JBrowse link
G Hoxd10 homeo box D10 acts_upstream_of_or_within ISO MGI:96192 (MGI:3771768|PMID:18065432) RGD PMID:18065432 MGI:3771768 NCBI chr 3:59,594,516...59,597,725
Ensembl chr 3:59,594,516...59,597,725
JBrowse link
G Isl1 ISL LIM homeobox 1 acts_upstream_of_or_within ISO MGI:102673 (MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:4356383 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584
JBrowse link
G Isl2 ISL LIM homeobox 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:102673 (MGI:4356383|PMID:19666821)
Ensembl
RGD
PMID:19666821 GO_REF:0000107 MGI:4356383 NCBI chr 8:55,923,805...55,928,790
Ensembl chr 8:55,923,805...55,928,790
JBrowse link
G Lhx3 LIM homeobox 3 acts_upstream_of_or_within ISO MGI:101791|MGI:109156 (MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:4356383 NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480
JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2182358|MGI:2182361|MGI:2182363 (MGI:1344237|PMID:10482234)
RGD PMID:10482234 PMID:21873635 MGI:1344237, RGD:13792537 NCBI chr 4:5,866,506...5,871,465
Ensembl chr 4:5,866,506...5,871,465
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 acts_upstream_of_or_within ISO MGI:3573868 (MGI:3531376|PMID:15769945) RGD PMID:15769945 MGI:3531376 NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149
JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbx1 developing brain homeobox 1 acts_upstream_of_or_within ISO MGI:2182329 (MGI:2136554|PMID:11239429) RGD PMID:11239429 MGI:2136554 NCBI chr 1:99,349,608...99,354,038
Ensembl chr 1:99,349,608...99,354,038
JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 acts_upstream_of_or_within ISO MGI:4420993 (MGI:5435948|PMID:22932389) RGD PMID:22932389 MGI:5435948 NCBI chr 1:223,244,340...223,264,254
Ensembl chr 1:223,248,747...223,262,530
JBrowse link
G Lhx3 LIM homeobox 3 acts_upstream_of_or_within ISO (MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:4356383 NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480
JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within IDA PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Sox1 SRY-box transcription factor 1 acts_upstream_of_or_within ISO MGI:3653406 (MGI:4834949|PMID:20844123) RGD PMID:20844123 MGI:4834949 NCBI chr16:77,134,795...77,139,628 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cellular developmental process 4543
        cell fate specification 100
          neuron fate specification 32
            auditory receptor cell fate specification + 2
            photoreceptor cell fate specification + 0
            spinal cord association neuron specification 0
            spinal cord commissural neuron specification 0
            spinal cord motor neuron cell fate specification + 10
            ventral spinal cord interneuron specification + 8
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure development 6306
        multicellular organism development 5727
          system development 5373
            nervous system development 2743
              neurogenesis 1965
                generation of neurons 1805
                  neuron differentiation 1631
                    neuron fate commitment 75
                      neuron fate specification 32
                        auditory receptor cell fate specification + 2
                        photoreceptor cell fate specification + 0
                        spinal cord association neuron specification 0
                        spinal cord commissural neuron specification 0
                        spinal cord motor neuron cell fate specification + 10
                        ventral spinal cord interneuron specification + 8
paths to the root