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ONTOLOGY REPORT - ANNOTATIONS


Term:thymus development
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Accession:GO:0048538 term browser browse the term
Definition:The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
Comment:Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere.



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thymus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:2153718 (MGI:2153797|PMID:2065352) RGD PMID:2065352 MGI:2153797 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor involved_in ISO (MGI:4849324|PMID:21048919) RGD PMID:21048919 MGI:4849324 NCBI chr 3:167,265,435...167,270,197
Ensembl chr 3:167,265,296...167,270,195
JBrowse link
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO MGI:3589207|MGI:3688435 (MGI:3588595|PMID:16025118), (MGI:3688426|PMID:17002498) RGD PMID:16025118 PMID:17002498 MGI:3588595 MGI:3688426 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Asxl1 ASXL transcriptional regulator 1 acts_upstream_of_or_within ISO MGI:4418244 (MGI:4418016|PMID:19861679) RGD PMID:19861679 MGI:4418016 NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538
JBrowse link
G Atm ATM serine/threonine kinase acts_upstream_of_or_within ISO MGI:1926343 (MGI:83357|PMID:8843194) RGD PMID:8843194 MGI:83357 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bcl11b BAF chromatin remodeling complex subunit BCL11B acts_upstream_of_or_within ISO MGI:2663971 (MGI:2662810|PMID:12717433) RGD PMID:12717433 MGI:2662810 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224
JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:1197519|MGI:1857134|MGI:2156165 (MGI:3767491|PMID:15818405), (MGI:894988|PMID:9241272) RGD PMID:9241272 PMID:15818405 MGI:3767491 MGI:894988 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:88138 (MGI:3767491|PMID:15818405) RGD PMID:15818405 MGI:3767491 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO MGI:97847 (MGI:3832113|PMID:18952847) RGD PMID:18952847 MGI:3832113 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 acts_upstream_of_or_within ISO MGI:1856936 (MGI:53759|PMID:5037658) RGD PMID:5037658 MGI:53759 NCBI chr 3:36,906,771...37,169,191
Ensembl chr 3:36,910,427...37,168,944
JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO MGI:5547539 (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965
JBrowse link
G Ccnb2 cyclin B2 acts_upstream_of_or_within ISO MGI:2429974 (MGI:1203433|PMID:9539739) RGD PMID:9539739 MGI:1203433 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 acts_upstream_of_or_within ISO MGI:109360|MGI:2179740 (MGI:4457799|PMID:20549734) RGD PMID:20549734 MGI:4457799 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein acts_upstream_of_or_within ISO MGI:98493 (MGI:3614586|PMID:16399080) RGD PMID:16399080 MGI:3614586 NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238
JBrowse link
G Ctc1 CST telomere replication complex component 1 acts_upstream_of_or_within ISO MGI:5427642 (MGI:5426340|PMID:22531781) RGD PMID:22531781 MGI:5426340 NCBI chr10:53,714,614...53,735,298
Ensembl chr10:53,714,644...53,735,298
JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO MGI:1858008 (MGI:3588595|PMID:16025118) RGD PMID:16025118 MGI:3588595 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ephb3 Eph receptor B3 involved_in ISO (MGI:4366231|PMID:19598115) RGD PMID:19598115 MGI:4366231 NCBI chr11:79,840,668...79,859,467
Ensembl chr11:79,840,668...79,859,370
JBrowse link
G Fadd Fas associated via death domain involved_in ISS
ISO
GO_REF:0000024
UniProtKB:Q9QZL0 (MGI:5291865|PMID:21876153)
UniProt
RGD
PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fgf10 fibroblast growth factor 10 involved_in ISO (PMID:17969154) RGD PMID:17969154 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgf3 fibroblast growth factor 3 acts_upstream_of_or_within ISO MGI:3027990 (MGI:3690261|PMID:17000704) RGD PMID:17000704 MGI:3690261 NCBI chr 1:200,001,261...200,005,187
Ensembl chr 1:200,001,261...200,005,187
JBrowse link
G Foxe1 forkhead box E1 involved_in ISO (PMID:15494458) RGD PMID:15494458 NCBI chr 5:60,630,027...60,632,835
Ensembl chr 5:60,630,027...60,632,835
JBrowse link
G Foxn1 forkhead box N1 acts_upstream_of_or_within IMP
ISO
MGI:5297717 (MGI:5296987|PMID:22072979) RGD PMID:22072979 PMID:8790387 MGI:5296987, RGD:1300512 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710
JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO MGI:2683927 (MGI:2682543|PMID:14670303), (MGI:3813999|PMID:17082577)
MGI:2683927 (MGI:3813999|PMID:17082577)
RGD PMID:14670303 PMID:17082577 MGI:2682543 MGI:3813999 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:4413411|PMID:19008477)
Ensembl
RGD
PMID:19008477 GO_REF:0000107 MGI:4413411 NCBI chr16:32,917,826...32,919,880
Ensembl chr16:32,917,823...32,919,891
JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:4453944|PMID:20122914)
Ensembl
RGD
PMID:20122914 GO_REF:0000107 MGI:4453944 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K IEP RGD PMID:16488668 RGD:10002779 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Hoxa3 homeobox A3 acts_upstream_of_or_within ISO MGI:1857992|MGI:96184|MGI:96207|MGI:97485 (MGI:1201272|PMID:9520319), (MGI:2149273|PMID:11476574), (MGI:74186|PMID:7635047) RGD PMID:7635047 PMID:9520319 PMID:11476574 MGI:1201272 MGI:2149273 MGI:74186 NCBI chr 4:81,269,243...81,313,218
Ensembl chr 4:81,269,243...81,313,218
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO MGI:2158738 (MGI:68746|PMID:7923373) RGD PMID:7923373 MGI:68746 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 acts_upstream_of_or_within ISO MGI:1856923 (MGI:1096257|PMID:9376320) RGD PMID:9376320 MGI:1096257 NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690
JBrowse link
G Lmo4 LIM domain only 4 acts_upstream_of_or_within ISO MGI:1306784 (MGI:4457799|PMID:20549734) RGD PMID:20549734 MGI:4457799 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 acts_upstream_of_or_within ISO (MGI:1932181|PMID:11313860) RGD PMID:11313860 MGI:1932181 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mafb MAF bZIP transcription factor B acts_upstream_of_or_within ISO MGI:3663168 (MGI:3839521|PMID:19164599) RGD PMID:19164599 MGI:3839521 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1346867 (MGI:3832113|PMID:18952847)
Ensembl
RGD
PMID:18952847 GO_REF:0000107 MGI:3832113 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 acts_upstream_of_or_within ISO MGI:1346866 (MGI:3832113|PMID:18952847) RGD PMID:18952847 MGI:3832113 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 acts_upstream_of_or_within ISO MGI:1346859 (MGI:3832113|PMID:18952847) RGD PMID:18952847 MGI:3832113 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 acts_upstream_of_or_within ISO MGI:1346858 (MGI:3832113|PMID:18952847) RGD PMID:18952847 MGI:3832113 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myb MYB proto-oncogene, transcription factor acts_upstream_of_or_within ISO MGI:3047076 (MGI:3763573|PMID:17927961) RGD PMID:17927961 MGI:3763573 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within ISO MGI:2182778 (MGI:1289938|PMID:9768749) RGD PMID:9768749 MGI:1289938 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
JBrowse link
G Pax1 paired box 1 acts_upstream_of_or_within ISO MGI:96175 (MGI:2149273|PMID:11476574) RGD PMID:11476574 MGI:2149273 NCBI chr 3:134,789,291...134,801,636
Ensembl chr 3:134,789,182...134,801,636
JBrowse link
G Pbx1 PBX homeobox 1 acts_upstream_of_or_within ISO MGI:2155612 (MGI:3522524|PMID:15581866) RGD PMID:15581866 MGI:3522524 NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594
JBrowse link
G Prdx2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2668456 (MGI:3050700|PMID:15259009)
Ensembl
RGD
PMID:15259009 GO_REF:0000107 MGI:3050700 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO MGI:109284|MGI:1930934 (MGI:3760494|PMID:17698590) RGD PMID:17698590 MGI:3760494 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO MGI:1202717 (MGI:3760494|PMID:17698590) RGD PMID:17698590 MGI:3760494 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 IEP RGD PMID:18457575 RGD:9850287 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO MGI:88190 (MGI:3832113|PMID:18952847) RGD PMID:18952847 MGI:3832113 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rag1 recombination activating 1 acts_upstream_of_or_within ISO MGI:1353616 (MGI:3811961|PMID:18684012) RGD PMID:18684012 MGI:3811961 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO
GO_REF:0000024
UniProtKB:Q61160 (MGI:5291865|PMID:21876153)
UniProt
RGD
PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3836494|PMID:19109233)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19109233 GO_REF:0000024 GO_REF:0000107 MGI:3836494 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Six1 SIX homeobox 1 acts_upstream_of_or_within ISO MGI:106034|MGI:2655195 (MGI:3624596|PMID:16530750) RGD PMID:16530750 MGI:3624596 NCBI chr 6:91,746,739...91,751,975
Ensembl chr 6:91,746,739...91,751,975
JBrowse link
G Six4 SIX homeobox 4 acts_upstream_of_or_within ISO MGI:102780 (MGI:3624596|PMID:16530750) RGD PMID:16530750 MGI:3624596 NCBI chr 6:91,802,328...91,816,062
Ensembl chr 6:91,802,329...91,815,992
JBrowse link
G Slc46a2 solute carrier family 46, member 2 acts_upstream_of_or_within ISO MGI:97848 (MGI:3811961|PMID:18684012) RGD PMID:18684012 MGI:3811961 NCBI chr 5:74,800,226...74,808,128
Ensembl chr 5:74,800,226...74,808,128
JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO MGI:3522206 (MGI:3832113|PMID:18952847) RGD PMID:18952847 MGI:3832113 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Tbx1 T-box transcription factor 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:14585638)
MGI:3664784 (MGI:3770747|PMID:17916582)
UniProt
RGD
PMID:14585638 PMID:17916582 GO_REF:0000024 MGI:3770747 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 acts_upstream_of_or_within ISO MGI:2386570|MGI:2388050 (MGI:3703113|PMID:17078885) RGD PMID:17078885 MGI:3703113 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tyr tyrosinase acts_upstream_of_or_within ISO MGI:1856308 (MGI:1861540|PMID:10890980) RGD PMID:10890980 MGI:1861540 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (MGI:5300225|PMID:22201126) RGD PMID:22201126 MGI:5300225 NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO MGI:2180033 (MGI:2178865|PMID:11923874) RGD PMID:11923874 MGI:2178865 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110
JBrowse link
thymus epithelium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator involved_in IBA
ISO
PMID:21873635
(MGI:3818193|PMID:19015306)
RGD PMID:19015306 PMID:21873635 MGI:3818193, RGD:13792537 NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060
JBrowse link
G Foxn1 forkhead box N1 involved_in ISO (MGI:5437206|PMID:21109991) RGD PMID:21109991 MGI:5437206 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    immune system process 2730
      immune system development 1129
        hematopoietic or lymphoid organ development 1061
          thymus development 59
            neural crest cell differentiation involved in thymus development 0
            thymus epithelium morphogenesis + 2
Path 2
Term Annotations click to browse term
  biological_process 18734
    developmental process 6893
      anatomical structure development 6368
        multicellular organism development 5437
          system development 4939
            immune system development 1129
              hematopoietic or lymphoid organ development 1061
                thymus development 59
                  neural crest cell differentiation involved in thymus development 0
                  thymus epithelium morphogenesis + 2
paths to the root