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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic vesicle endocytosis
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Accession:GO:0048488 term browser browse the term
Definition:A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
Synonyms:related_synonym: synaptic vesicle retrieval
 alt_id: GO:0008099


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synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin beta involved_in ISO (MGI:6189485|PMID:27840001) SynGO PMID:27840001 MGI:6189485 NCBI chrNW_004936765:667,107...670,627 JBrowse link
G Actg1 actin gamma 1 involved_in ISO (MGI:6189485|PMID:27840001) SynGO PMID:27840001 MGI:6189485 NCBI chrNW_004936594:5,170,711...5,173,251 JBrowse link
G Amph amphiphysin involved_in
acts_upstream_of_or_within
ISO (MGI:2176305|PMID:11879655) SynGO
MGI
PMID:11879655 MGI:2176305 NCBI chrNW_004936478:13,959,669...14,183,835 JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 involved_in ISO (PMID:11102472) SynGO PMID:11102472 NCBI chrNW_004936490:5,156...127,666 JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 involved_in ISO PMID:19321783 SynGO PMID:19321783 RGD:12050109 NCBI chrNW_004936578:5,680,748...5,691,666 JBrowse link
G Arf6 ADP ribosylation factor 6 involved_in ISO PMID:26731518 SynGO PMID:26731518 RGD:11556875 NCBI chrNW_004936583:181,490...185,466 JBrowse link
G Bin1 bridging integrator 1 involved_in ISO PMID:9348539 SynGO PMID:9348539 RGD:631926 NCBI chrNW_004936469:44,128,308...44,185,739 JBrowse link
G Btbd8 BTB domain containing 8 involved_in ISO (MGI:6104538|PMID:29262337) SynGO PMID:29262337 MGI:6104538 NCBI chrNW_004936537:6,899,271...6,977,420 JBrowse link
G Canx calnexin involved_in ISO (MGI:5288282|PMID:21747946) SynGO PMID:21747946 MGI:5288282 NCBI chrNW_004936739:1,051,853...1,085,658 JBrowse link
G Cdk5 cyclin dependent kinase 5 ISO RGD PMID:12855954 RGD:1358501 NCBI chrNW_004936527:6,478,934...6,483,848 JBrowse link
G Cltc clathrin heavy chain involved_in ISO PMID:16982422 SynGO PMID:16982422 RGD:13702168 NCBI chrNW_004936490:3,659,682...3,726,222 JBrowse link
G Dennd1a DENN domain containing 1A acts_upstream_of_or_within ISO (MGI:3694831|PMID:17182770) MGI PMID:17182770 MGI:3694831 NCBI chrNW_004936487:11,815,040...12,332,603 JBrowse link
G Dnm1 dynamin 1 involved_in ISO (MGI:3709249|PMID:17463283) SynGO PMID:17463283 MGI:3709249 NCBI chrNW_004936487:15,767,897...15,797,722 JBrowse link
G Dnm1l dynamin 1 like involved_in ISO PMID:23792689 SynGO PMID:23792689 RGD:12793033 NCBI chrNW_004936607:3,576,357...3,632,423 JBrowse link
G Dnm2 dynamin 2 involved_in ISO (MGI:5285027|PMID:21689597) SynGO PMID:21689597 MGI:5285027 NCBI chrNW_004936659:957,408...1,046,393 JBrowse link
G Dnm3 dynamin 3 involved_in ISO (MGI:5285027|PMID:21689597) SynGO PMID:21689597 MGI:5285027 NCBI chrNW_004936481:14,971,977...15,411,253 JBrowse link
G Fcho2 FCH and mu domain containing endocytic adaptor 2 involved_in ISO PMID:20448150
(MGI:5320276|PMID:20448150)
SynGO
ParkinsonsUK-UCL
PMID:20448150 MGI:5320276 RGD:12050101 NCBI chrNW_004936549:3,455,172...3,565,507 JBrowse link
G Grn granulin precursor ISO RGD PMID:21813674 RGD:5509044 NCBI chrNW_004936541:793,548...800,271 JBrowse link
G Itsn1 intersectin 1 involved_in ISO (MGI:3811659|PMID:18676989) SynGO PMID:18676989 MGI:3811659 NCBI chrNW_004936500:8,490,514...8,678,127 JBrowse link
G LOC101968601 signal transducer CD24 acts_upstream_of_or_within ISO (MGI:3625625|PMID:16606832) MGI PMID:16606832 MGI:3625625 NCBI chrNW_004936491:16,706,745...16,707,010 JBrowse link
G LOC101975550 synaptophysin involved_in ISO (MGI:5141572|PMID:21658579) SynGO PMID:21658579 MGI:5141572 NCBI chrNW_004936721:1,062,206...1,075,935 JBrowse link
G Ophn1 oligophrenin 1 acts_upstream_of_or_within ISO (MGI:4359148|PMID:19481455) MGI PMID:19481455 MGI:4359148 NCBI chrNW_004936635:6,966...243,209 JBrowse link
G Pacsin1 protein kinase C and casein kinase substrate in neurons 1 involved_in ISO (MGI:5304995|PMID:21926968) SynGO PMID:21926968 MGI:5304995 NCBI chrNW_004936476:24,574,106...24,622,494 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO PMID:21808019 SynGO PMID:21808019 RGD:13506237 NCBI chrNW_004936498:13,785,638...13,885,931 JBrowse link
G Rab27b RAB27B, member RAS oncogene family involved_in ISO PMID:20926670 SynGO PMID:20926670 RGD:13432355 NCBI chrNW_004936497:9,039,552...9,176,182 JBrowse link
G Scrib scribble planar cell polarity protein involved_in ISO (MGI:4365512|PMID:19458197) SynGO PMID:19458197 MGI:4365512 NCBI chrNW_004936470:8,349,175...8,370,099 JBrowse link
G Snap91 synaptosome associated protein 91 involved_in ISO PMID:21808019 SynGO PMID:21808019 RGD:13506237 NCBI chrNW_004936510:7,222,200...7,345,138 JBrowse link
G Snca synuclein alpha involved_in ISO (MGI:3850310|PMID:18980610), (MGI:5605098|PMID:25009269)
(MGI:5605098|PMID:25009269)
UniProt
SynGO
PMID:18980610 PMID:25009269 MGI:3850310 MGI:5605098 NCBI chrNW_004936685:2,077,017...2,175,298 JBrowse link
G Sncb synuclein beta involved_in ISO (MGI:5605098|PMID:25009269) SynGO PMID:25009269 MGI:5605098 NCBI chrNW_004936597:878,270...888,346 JBrowse link
G Ston2 stonin 2 involved_in ISO (PMID:21102408)
PMID:22727701
UniProt
SynGO
PMID:21102408 PMID:22727701 RGD:12050122 NCBI chrNW_004936488:9,689,595...9,816,672 JBrowse link
G Stx1a syntaxin 1A involved_in ISO (PMID:26635000) UniProt PMID:26635000 NCBI chrNW_004936543:2,909,560...2,918,175 JBrowse link
G Synj1 synaptojanin 1 involved_in
acts_upstream_of_or_within
ISO (PMID:18093523)
(MGI:3797309|PMID:18093523)
ParkinsonsUK-UCL
MGI
PMID:18093523 MGI:3797309 NCBI chrNW_004936500:9,484,571...9,565,980 JBrowse link
G Tbc1d24 TBC1 domain family member 24 acts_upstream_of_or_within ISO (MGI:6279048|PMID:30335140) MGI PMID:30335140 MGI:6279048 NCBI chrNW_004936694:1,556,717...1,582,019 JBrowse link
G Vamp2 vesicle associated membrane protein 2 involved_in ISO (MGI:3573806|PMID:15475946) UniProt PMID:15475946 MGI:3573806 NCBI chrNW_004936595:1,385,692...1,389,484 JBrowse link
clathrin-dependent synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btbd8 BTB domain containing 8 involved_in ISO (MGI:6104538|PMID:29262337) UniProt PMID:29262337 MGI:6104538 NCBI chrNW_004936537:6,899,271...6,977,420 JBrowse link
negative regulation of synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt11 synaptotagmin 11 involved_in ISO PMID:26589353 ParkinsonsUK-UCL PMID:26589353 RGD:11079192 NCBI chrNW_004936580:5,123,196...5,142,976 JBrowse link
positive regulation of synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2m1 adaptor related protein complex 2 subunit mu 1 ISO RGD PMID:19762466 RGD:13461856 NCBI chrNW_004936578:5,680,748...5,691,666 JBrowse link
G Bcl2l1 BCL2 like 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:17437541 RGD:8554440 NCBI chrNW_004936487:15,767,897...15,797,722 JBrowse link
G Dnm1l dynamin 1 like involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004936607:3,576,357...3,632,423 JBrowse link
G Lrrk2 leucine rich repeat kinase 2 ISO RGD PMID:18445495 RGD:13462049 NCBI chrNW_004936607:628,469...761,117 JBrowse link
G Mff mitochondrial fission factor involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004936525:8,604,478...8,636,352 JBrowse link
G Nlgn1 neuroligin 1 involved_in ISO PMID:19628693
(MGI:4355770|PMID:19628693)
BHF-UCL PMID:19628693 MGI:4355770 RGD:8554760 NCBI chrNW_004936703:951,935...1,415,991 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO RGD PMID:21808019 RGD:13506237 NCBI chrNW_004936498:13,785,638...13,885,931 JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma ISO RGD PMID:26627835 RGD:11532172 NCBI chrNW_004936555:6,216,202...6,283,012 JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 ISO RGD PMID:14532001 RGD:13464359 NCBI chrNW_004936588:2,504,372...2,535,993 JBrowse link
G Snap91 synaptosome associated protein 91 ISO RGD PMID:21808019 RGD:13506237 NCBI chrNW_004936510:7,222,200...7,345,138 JBrowse link
G Tor1a torsin family 1 member A involved_in ISO (PMID:21102408) UniProt PMID:21102408 NCBI chrNW_004936487:17,012,661...17,020,657 JBrowse link
regulation of synaptic vesicle budding from presynaptic endocytic zone membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 involved_in ISO PMID:28111082 SynGO PMID:28111082 RGD:13702195 NCBI chrNW_004936595:567,267...574,051 JBrowse link
regulation of synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btbd9 BTB domain containing 9 acts_upstream_of_or_within ISO (MGI:5438074|PMID:22536397) MGI PMID:22536397 MGI:5438074 NCBI chrNW_004936476:20,953,377...21,351,925 JBrowse link
G Calm1 calmodulin 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004936488:17,580,425...17,588,480 JBrowse link
G Calm2 calmodulin 2 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004936508:5,207,909...5,223,780 JBrowse link
G Calm3 calmodulin 3 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004936664:471,446...480,858 JBrowse link
G Dgkq diacylglycerol kinase theta involved_in ISO (MGI:5807028|PMID:26748701) SynGO PMID:26748701 MGI:5807028 NCBI chrNW_004936477:22,225,624...22,238,825 JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:16648848 RGD:13504740 NCBI chrNW_004936487:15,767,897...15,797,722 JBrowse link
G Lrrk2 leucine rich repeat kinase 2 involved_in ISO (MGI:6189511|PMID:25501810) SynGO PMID:25501810 MGI:6189511 NCBI chrNW_004936607:628,469...761,117 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO RGD PMID:18842885 RGD:8554167 NCBI chrNW_004936498:13,785,638...13,885,931 JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma involved_in ISO (MGI:3054280|PMID:15386003) SynGO PMID:15386003 MGI:3054280 NCBI chrNW_004936588:2,070,873...2,088,144 JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta involved_in ISO (MGI:4830393|PMID:20810903) SynGO PMID:20810903 MGI:4830393 NCBI chrNW_004936521:5,576,705...5,614,738 JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma involved_in ISO PMID:26627835 SynGO PMID:26627835 RGD:11532172 NCBI chrNW_004936555:6,216,202...6,283,012 JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:27160703) ARUK-UCL PMID:27160703 NCBI chrNW_004936550:730,462...874,601 JBrowse link
G Scamp5 secretory carrier membrane protein 5 involved_in ISO PMID:25057210 SynGO PMID:25057210 RGD:13702419 NCBI chrNW_004936471:33,936,721...33,958,439 JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 ISO RGD PMID:22750032 RGD:13463484 NCBI chrNW_004936588:2,504,372...2,535,993 JBrowse link
G Slc17a7 solute carrier family 17 member 7 ISO RGD PMID:16815333 RGD:13504741 NCBI chrNW_004936664:3,307,562...3,318,184 JBrowse link
G Snap91 synaptosome associated protein 91 ISO RGD PMID:18842885 RGD:8554167 NCBI chrNW_004936510:7,222,200...7,345,138 JBrowse link
G Syt7 synaptotagmin 7 involved_in ISO (MGI:6189675|PMID:14532108) SynGO PMID:14532108 MGI:6189675 NCBI chrNW_004936581:1,516,199...1,557,992 JBrowse link
G Vamp4 vesicle associated membrane protein 4 involved_in ISO PMID:26607000 SynGO PMID:26607000 RGD:11058152 NCBI chrNW_004936481:15,480,865...15,515,851 JBrowse link
synaptic vesicle budding from presynaptic endocytic zone membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnm1 dynamin 1 involved_in ISO (MGI:5285027|PMID:21689597) SynGO PMID:21689597 MGI:5285027 NCBI chrNW_004936487:15,767,897...15,797,722 JBrowse link
G Dnm3 dynamin 3 involved_in ISO (MGI:5285027|PMID:21689597) SynGO PMID:21689597 MGI:5285027 NCBI chrNW_004936481:14,971,977...15,411,253 JBrowse link
G Snap91 synaptosome associated protein 91 involved_in ISO (MGI:5707086|PMID:26412491) SynGO PMID:26412491 MGI:5707086 NCBI chrNW_004936510:7,222,200...7,345,138 JBrowse link
synaptic vesicle uncoating term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 involved_in ISO (MGI:4439191|PMID:20160091) SynGO PMID:20160091 MGI:4439191 NCBI chrNW_004936692:2,788,477...2,836,094 JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 involved_in ISO (MGI:5300660|PMID:22099461) SynGO PMID:22099461 MGI:5300660 NCBI chrNW_004936588:2,504,372...2,535,993 JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 involved_in ISO (MGI:5300660|PMID:22099461) SynGO PMID:22099461 MGI:5300660 NCBI chrNW_004936483:18,051,023...18,176,514 JBrowse link
G Synj1 synaptojanin 1 acts_upstream_of_or_within
involved_in
ISO (MGI:2447947|PMID:12481038)
(MGI:1346710|PMID:10535736), (MGI:5300660|PMID:22099461)
MGI
SynGO
PMID:10535736 PMID:12481038 PMID:22099461 MGI:1346710 MGI:2447947 MGI:5300660 NCBI chrNW_004936500:9,484,571...9,565,980 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12173
    localization 4895
      establishment of localization 3491
        establishment of localization in cell 1691
          presynaptic endocytosis 57
            synaptic vesicle endocytosis 57
              bulk synaptic vesicle endocytosis 0
              clathrin-dependent synaptic vesicle endocytosis 1
              negative regulation of synaptic vesicle endocytosis + 1
              positive regulation of synaptic vesicle endocytosis 12
              regulation of synaptic vesicle endocytosis + 25
              synaptic vesicle budding from presynaptic endocytic zone membrane + 4
              synaptic vesicle uncoating + 4
Path 2
Term Annotations click to browse term
  biological_process 12173
    localization 4895
      establishment of localization 3491
        transport 3325
          vesicle-mediated transport 1144
            vesicle-mediated transport in synapse 245
              synaptic vesicle cycle 213
                synaptic vesicle recycling 68
                  synaptic vesicle endocytosis 57
                    bulk synaptic vesicle endocytosis 0
                    clathrin-dependent synaptic vesicle endocytosis 1
                    negative regulation of synaptic vesicle endocytosis + 1
                    positive regulation of synaptic vesicle endocytosis 12
                    regulation of synaptic vesicle endocytosis + 25
                    synaptic vesicle budding from presynaptic endocytic zone membrane + 4
                    synaptic vesicle uncoating + 4
paths to the root