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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic vesicle endocytosis
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Accession:GO:0048488 term browser browse the term
Definition:A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
Synonyms:related_synonym: synaptic vesicle retrieval
 alt_id: GO:0008099



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synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta involved_in ISO (MGI:6189485|PMID:27840001) SynGO PMID:27840001 MGI:6189485 NCBI chr 6:12,421,006...12,424,449
Ensembl chr 6:12,418,932...12,462,845
JBrowse link
G ACTG1 actin gamma 1 involved_in ISO (MGI:6189485|PMID:27840001) SynGO PMID:27840001 MGI:6189485 NCBI chr 9:635,978...638,328
Ensembl chr 9:635,978...638,328
JBrowse link
G AMPH amphiphysin acts_upstream_of_or_within
involved_in
ISO (MGI:2176305|PMID:11879655) MGI
SynGO
PMID:11879655 MGI:2176305 NCBI chr18:11,132,078...11,261,847
Ensembl chr18:11,143,446...11,260,841
JBrowse link
G AP2B1 adaptor related protein complex 2 subunit beta 1 involved_in ISO (PMID:11102472) SynGO PMID:11102472 NCBI chr 9:37,946,761...38,078,074
Ensembl chr 9:37,946,788...38,078,041
JBrowse link
G AP2M1 adaptor related protein complex 2 subunit mu 1 involved_in ISO PMID:19321783 SynGO PMID:19321783 RGD:12050109 NCBI chr34:17,071,199...17,080,445
Ensembl chr34:17,071,235...17,080,445
JBrowse link
G ARF6 ADP ribosylation factor 6 involved_in ISO PMID:26731518 SynGO PMID:26731518 RGD:11556875 NCBI chr 8:26,445,407...26,449,430
Ensembl chr 8:26,445,647...26,525,530
JBrowse link
G BIN1 bridging integrator 1 involved_in ISO PMID:9348539 SynGO PMID:9348539 RGD:631926 NCBI chr19:23,503,934...23,534,407
Ensembl chr19:23,375,363...23,534,303
JBrowse link
G BTBD8 BTB domain containing 8 involved_in ISO (MGI:6104538|PMID:29262337) SynGO PMID:29262337 MGI:6104538 NCBI chr 6:56,756,682...56,849,849
Ensembl chr 6:56,698,320...56,900,173
JBrowse link
G CANX calnexin involved_in ISS UniProt GO_REF:0000024 NCBI chr11:1,966,612...1,998,620
Ensembl chr11:1,927,888...1,998,604
JBrowse link
G CD24 CD24 molecule acts_upstream_of_or_within ISO (MGI:3625625|PMID:16606832) MGI PMID:16606832 MGI:3625625 NCBI chr12:64,239,957...64,245,114 JBrowse link
G CDK5 cyclin dependent kinase 5 ISO RGD PMID:12855954 RGD:1358501 NCBI chr16:15,105,177...15,113,085
Ensembl chr16:15,101,230...15,109,269
JBrowse link
G CLTC clathrin heavy chain involved_in ISO PMID:16982422 SynGO PMID:16982422 RGD:13702168 NCBI chr 9:34,116,344...34,183,023
Ensembl chr 9:34,116,634...34,182,719
JBrowse link
G DENND1A DENN domain containing 1A acts_upstream_of_or_within ISO (MGI:3694831|PMID:17182770) MGI PMID:17182770 MGI:3694831 NCBI chr 9:58,918,699...59,424,685
Ensembl chr 9:58,919,265...59,424,684
JBrowse link
G DNM1 dynamin 1 involved_in ISO (MGI:3709249|PMID:17463283) SynGO PMID:17463283 MGI:3709249 NCBI chr 9:55,252,802...55,298,244
Ensembl chr 9:55,252,347...55,298,244
JBrowse link
G DNM1L dynamin 1 like involved_in ISO PMID:23792689 SynGO PMID:23792689 RGD:12793033 NCBI chr27:16,161,855...16,211,983
Ensembl chr27:16,163,357...16,211,957
JBrowse link
G DNM2 dynamin 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:50,398,866...50,487,303
Ensembl chr20:50,398,864...50,487,241
JBrowse link
G DNM3 dynamin 3 involved_in ISO (MGI:5285027|PMID:21689597) SynGO PMID:21689597 MGI:5285027 NCBI chr 7:26,569,708...27,024,939
Ensembl chr 7:26,574,453...27,024,759
JBrowse link
G FCHO2 FCH and mu domain containing endocytic adaptor 2 involved_in ISO PMID:20448150
(MGI:5320276|PMID:20448150)
SynGO
ParkinsonsUK-UCL
PMID:20448150 MGI:5320276 RGD:12050101 NCBI chr 2:55,905,497...56,011,395
Ensembl chr 2:55,905,520...56,009,131
JBrowse link
G GRN granulin precursor ISO RGD PMID:21813674 RGD:5509044 NCBI chr 9:19,077,430...19,085,443
Ensembl chr 9:19,077,427...19,082,268
JBrowse link
G ITSN1 intersectin 1 involved_in ISO (MGI:3811659|PMID:18676989) SynGO PMID:18676989 MGI:3811659 NCBI chr31:29,144,754...29,360,134 JBrowse link
G KIAA1109 KIAA1109 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:17,841,450...18,047,002
Ensembl chr19:17,841,967...18,044,276
JBrowse link
G NLGN4X neuroligin 4 X-linked involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:3,409,529...3,708,234 JBrowse link
G OPHN1 oligophrenin 1 acts_upstream_of_or_within ISO (MGI:4359148|PMID:19481455) MGI PMID:19481455 MGI:4359148 NCBI chr  X:52,418,390...52,983,155
Ensembl chr  X:52,455,373...52,982,244
JBrowse link
G PACSIN1 protein kinase C and casein kinase substrate in neurons 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:3,754,075...3,811,717
Ensembl chr12:3,753,717...3,809,986
JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in ISO PMID:21808019 SynGO PMID:21808019 RGD:13506237 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616
JBrowse link
G RAB27B RAB27B, member RAS oncogene family involved_in ISO PMID:20926670 SynGO PMID:20926670 RGD:13432355 NCBI chr 1:20,695,100...20,832,745
Ensembl chr 1:20,700,514...20,832,975
JBrowse link
G SCRIB scribble planar cell polarity protein involved_in ISO (MGI:4365512|PMID:19458197) SynGO PMID:19458197 MGI:4365512 NCBI chr13:37,356,405...37,374,765
Ensembl chr13:37,356,405...37,374,681
JBrowse link
G SH3GL2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in
acts_upstream_of_or_within
ISO PMID:22099461
(MGI:4359148|PMID:19481455)
SynGO
MGI
PMID:19481455 PMID:22099461 MGI:4359148 RGD:13702445 NCBI chr11:37,720,793...37,769,027
Ensembl chr11:37,577,053...37,767,572
JBrowse link
G SNAP91 synaptosome associated protein 91 involved_in ISO PMID:21808019 SynGO PMID:21808019 RGD:13506237 NCBI chr12:43,919,925...44,058,315
Ensembl chr12:43,919,925...44,058,616
JBrowse link
G SNCA synuclein alpha involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr32:12,915,871...13,079,338
Ensembl chr32:12,916,215...13,060,383
JBrowse link
G SNCB synuclein beta involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:36,710,236...36,719,455
Ensembl chr 4:36,616,039...36,764,501
JBrowse link
G STON2 stonin 2 involved_in ISO PMID:22727701
(PMID:21102408)
SynGO
UniProt
PMID:21102408 PMID:22727701 RGD:12050122 NCBI chr 8:53,591,194...53,725,710
Ensembl chr 8:53,597,780...53,725,688
JBrowse link
G STX1A syntaxin 1A involved_in ISO (PMID:26635000) UniProt PMID:26635000 NCBI chr 6:6,574,616...6,583,002
Ensembl chr 6:6,574,631...6,581,833
JBrowse link
G SYNJ1 synaptojanin 1 acts_upstream_of_or_within
involved_in
ISO (MGI:3797309|PMID:18093523)
(PMID:18093523)
MGI
ParkinsonsUK-UCL
PMID:18093523 MGI:3797309 NCBI chr31:27,308,169...27,399,226
Ensembl chr31:27,308,169...27,399,197
JBrowse link
G SYP synaptophysin involved_in ISO (MGI:5141572|PMID:21658579) SynGO PMID:21658579 MGI:5141572 NCBI chr  X:42,288,071...42,301,802
Ensembl chr  X:42,288,148...42,299,487
JBrowse link
G SYT5 synaptotagmin 5 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:102,456,767...102,463,750
Ensembl chr 1:102,456,782...102,463,749
JBrowse link
G TBC1D24 TBC1 domain family member 24 acts_upstream_of_or_within ISO (MGI:6279048|PMID:30335140) MGI PMID:30335140 MGI:6279048 NCBI chr 6:38,531,547...38,557,472 JBrowse link
G VAMP2 vesicle associated membrane protein 2 involved_in ISO (MGI:3573806|PMID:15475946) UniProt PMID:15475946 MGI:3573806 NCBI chr 5:32,975,372...32,977,967 JBrowse link
clathrin-dependent synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTBD8 BTB domain containing 8 involved_in IEA InterPro GO_REF:0000002 NCBI chr 6:56,756,682...56,849,849
Ensembl chr 6:56,698,320...56,900,173
JBrowse link
G ITSN1 intersectin 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr31:29,144,754...29,360,134 JBrowse link
negative regulation of synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT11 synaptotagmin 11 involved_in ISO PMID:26589353 ParkinsonsUK-UCL PMID:26589353 RGD:11079192 NCBI chr 7:41,910,102...41,929,020
Ensembl chr 7:41,912,920...41,929,617
JBrowse link
positive regulation of synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA13 ATP binding cassette subfamily A member 13 involved_in ISO (MGI:6694370|PMID:33478937) UniProt PMID:33478937 MGI:6694370 NCBI chr18:136,338...353,974
Ensembl chr18:135,690...352,871
JBrowse link
G AP2M1 adaptor related protein complex 2 subunit mu 1 ISO RGD PMID:19762466 RGD:13461856 NCBI chr34:17,071,199...17,080,445
Ensembl chr34:17,071,235...17,080,445
JBrowse link
G BCL2L1 BCL2 like 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355
JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:17437541 RGD:8554440 NCBI chr 9:55,252,802...55,298,244
Ensembl chr 9:55,252,347...55,298,244
JBrowse link
G DNM1L dynamin 1 like involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr27:16,161,855...16,211,983
Ensembl chr27:16,163,357...16,211,957
JBrowse link
G LRRK2 leucine rich repeat kinase 2 ISO RGD PMID:18445495 RGD:13462049 NCBI chr27:13,282,824...13,420,917
Ensembl chr27:13,283,756...13,420,870
JBrowse link
G MFF mitochondrial fission factor involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr25:40,111,860...40,142,246
Ensembl chr25:40,111,894...40,141,776
JBrowse link
G NLGN1 neuroligin 1 involved_in ISO (MGI:4355770|PMID:19628693) BHF-UCL PMID:19628693 MGI:4355770 RGD:8554760 NCBI chr34:37,397,772...38,203,634
Ensembl chr34:37,572,629...38,203,177
JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein ISO RGD PMID:21808019 RGD:13506237 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616
JBrowse link
G PPP3CC protein phosphatase 3 catalytic subunit gamma ISO RGD PMID:26627835 RGD:11532172 NCBI chr25:34,732,268...34,839,743
Ensembl chr25:34,725,226...34,838,994
JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 ISO RGD PMID:14532001 RGD:13464359 NCBI chr20:55,279,622...55,311,579
Ensembl chr20:55,279,621...55,311,536
JBrowse link
G SNAP91 synaptosome associated protein 91 ISO RGD PMID:21808019 RGD:13506237 NCBI chr12:43,919,925...44,058,315
Ensembl chr12:43,919,925...44,058,616
JBrowse link
G TOR1A torsin family 1 member A involved_in ISO (PMID:21102408) UniProt PMID:21102408 NCBI chr 9:54,017,895...54,027,049
Ensembl chr 9:54,017,952...54,026,680
JBrowse link
regulation of synaptic vesicle budding from presynaptic endocytic zone membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC2A4 solute carrier family 2 member 4 involved_in ISO PMID:28111082 SynGO PMID:28111082 RGD:13702195 NCBI chr 5:32,238,095...32,244,022
Ensembl chr 5:32,238,095...32,244,021
JBrowse link
regulation of synaptic vesicle endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTBD9 BTB domain containing 9 acts_upstream_of_or_within ISO (MGI:5438074|PMID:22536397) MGI PMID:22536397 MGI:5438074 NCBI chr12:7,154,805...7,564,050
Ensembl chr12:7,154,925...7,564,017
JBrowse link
G CALM1 calmodulin 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr 8:61,398,231...61,408,874
Ensembl chr 8:61,398,244...61,406,195
JBrowse link
G CALM2 calmodulin 2 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr10:49,299,698...49,314,533
Ensembl chr10:49,299,897...49,314,457
JBrowse link
G CALM3 calmodulin 3 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr 1:109,284,729...109,294,491
Ensembl chr 1:109,286,155...109,294,391
JBrowse link
G DGKQ diacylglycerol kinase theta involved_in ISO (MGI:5807028|PMID:26748701) SynGO PMID:26748701 MGI:5807028 NCBI chr 3:91,544,350...91,554,494
Ensembl chr 3:91,544,219...91,554,565
JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:16648848 RGD:13504740 NCBI chr 9:55,252,802...55,298,244
Ensembl chr 9:55,252,347...55,298,244
JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:13,282,824...13,420,917
Ensembl chr27:13,283,756...13,420,870
JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein ISO RGD PMID:18842885 RGD:8554167 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616
JBrowse link
G PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma involved_in ISO (MGI:3054280|PMID:15386003) SynGO PMID:15386003 MGI:3054280 NCBI chr20:55,751,055...55,801,740
Ensembl chr20:55,751,158...55,799,160
JBrowse link
G PPP3CB protein phosphatase 3 catalytic subunit beta involved_in ISO (MGI:4830393|PMID:20810903) SynGO PMID:20810903 MGI:4830393 NCBI chr 4:23,976,023...24,028,139
Ensembl chr 4:23,977,317...24,028,153
JBrowse link
G PPP3CC protein phosphatase 3 catalytic subunit gamma involved_in ISO PMID:26627835 SynGO PMID:26627835 RGD:11532172 NCBI chr25:34,732,268...34,839,743
Ensembl chr25:34,725,226...34,838,994
JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:27160703) ARUK-UCL PMID:27160703 NCBI chr 7:66,862,614...67,001,538
Ensembl chr 7:66,862,608...67,142,853
JBrowse link
G SCAMP5 secretory carrier membrane protein 5 involved_in ISO PMID:25057210 SynGO PMID:25057210 RGD:13702419 NCBI chr30:38,007,967...38,029,541
Ensembl chr30:38,008,035...38,030,881
JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 ISO RGD PMID:22750032 RGD:13463484 NCBI chr20:55,279,622...55,311,579
Ensembl chr20:55,279,621...55,311,536
JBrowse link
G SLC17A7 solute carrier family 17 member 7 ISO RGD PMID:16815333 RGD:13504741 NCBI chr 1:107,054,242...107,064,444
Ensembl chr 1:107,054,410...107,063,550
JBrowse link
G SNAP91 synaptosome associated protein 91 ISO RGD PMID:18842885 RGD:8554167 NCBI chr12:43,919,925...44,058,315
Ensembl chr12:43,919,925...44,058,616
JBrowse link
G SYT7 synaptotagmin 7 involved_in ISO (MGI:6189675|PMID:14532108) SynGO PMID:14532108 MGI:6189675 NCBI chr18:54,863,072...54,926,121
Ensembl chr18:54,861,754...54,921,367
JBrowse link
G VAMP4 vesicle associated membrane protein 4 involved_in ISO PMID:26607000 SynGO PMID:26607000 RGD:11058152 NCBI chr 7:27,278,200...27,303,499
Ensembl chr 7:27,278,231...27,302,225
JBrowse link
synaptic vesicle budding from presynaptic endocytic zone membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNM1 dynamin 1 involved_in ISO (MGI:5285027|PMID:21689597) SynGO PMID:21689597 MGI:5285027 NCBI chr 9:55,252,802...55,298,244
Ensembl chr 9:55,252,347...55,298,244
JBrowse link
G DNM3 dynamin 3 involved_in ISO (MGI:5285027|PMID:21689597) SynGO PMID:21689597 MGI:5285027 NCBI chr 7:26,569,708...27,024,939
Ensembl chr 7:26,574,453...27,024,759
JBrowse link
G SNAP91 synaptosome associated protein 91 involved_in ISO (MGI:5707086|PMID:26412491) SynGO PMID:26412491 MGI:5707086 NCBI chr12:43,919,925...44,058,315
Ensembl chr12:43,919,925...44,058,616
JBrowse link
synaptic vesicle uncoating term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNAJC6 DnaJ heat shock protein family (Hsp40) member C6 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:44,882,111...45,021,152
Ensembl chr 5:44,884,283...45,120,203
JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 involved_in ISO (MGI:5300660|PMID:22099461) SynGO PMID:22099461 MGI:5300660 NCBI chr20:55,279,622...55,311,579
Ensembl chr20:55,279,621...55,311,536
JBrowse link
G SH3GL2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in ISO (MGI:5300660|PMID:22099461) SynGO PMID:22099461 MGI:5300660 NCBI chr11:37,720,793...37,769,027
Ensembl chr11:37,577,053...37,767,572
JBrowse link
G SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3 involved_in ISO (MGI:5300660|PMID:22099461) SynGO PMID:22099461 MGI:5300660 NCBI chr 3:55,287,460...55,340,736
Ensembl chr 3:55,287,460...55,340,571
JBrowse link
G SYNJ1 synaptojanin 1 involved_in
acts_upstream_of_or_within
ISO (MGI:1346710|PMID:10535736)
(MGI:1346710|PMID:10535736), (MGI:5300660|PMID:22099461)
(MGI:2447947|PMID:12481038)
SynGO
MGI
PMID:10535736 PMID:12481038 PMID:22099461 MGI:1346710 MGI:2447947 MGI:5300660 NCBI chr31:27,308,169...27,399,226
Ensembl chr31:27,308,169...27,399,197
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13875
    localization 5411
      establishment of localization 3938
        establishment of localization in cell 1877
          presynaptic endocytosis 62
            synaptic vesicle endocytosis 62
              bulk synaptic vesicle endocytosis 0
              clathrin-dependent synaptic vesicle endocytosis 2
              negative regulation of synaptic vesicle endocytosis + 1
              positive regulation of synaptic vesicle endocytosis 13
              regulation of synaptic vesicle endocytosis + 26
              synaptic vesicle budding from presynaptic endocytic zone membrane + 4
              synaptic vesicle uncoating + 5
Path 2
Term Annotations click to browse term
  biological_process 13875
    localization 5411
      establishment of localization 3938
        transport 3775
          vesicle-mediated transport 1291
            vesicle-mediated transport in synapse 256
              synaptic vesicle cycle 225
                synaptic vesicle recycling 73
                  synaptic vesicle endocytosis 62
                    bulk synaptic vesicle endocytosis 0
                    clathrin-dependent synaptic vesicle endocytosis 2
                    negative regulation of synaptic vesicle endocytosis + 1
                    positive regulation of synaptic vesicle endocytosis 13
                    regulation of synaptic vesicle endocytosis + 26
                    synaptic vesicle budding from presynaptic endocytic zone membrane + 4
                    synaptic vesicle uncoating + 5
paths to the root