ONTOLOGY REPORT - ANNOTATIONS
Term: enteric nervous system development
Accession: GO:0048484
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Definition: The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation.
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Ednra
endothelin receptor type A
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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Ednrb
endothelin receptor type B
involved_in
ISO
(MGI:1330409|PMID:10021336)
RGD
PMID:10021336
MGI:1330409
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Gdnf
glial cell derived neurotrophic factor
involved_in
IEA ISS ISO
GO_REF:0000107 GO_REF:0000024 (MGI:81285|PMID:8657308), (MGI:81286|PMID:8657306)
Ensembl UniProt RGD
PMID:8657306 PMID:8657308
GO_REF:0000024 GO_REF:0000107 MGI:81285 MGI:81286
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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Hlx
H2.0-like homeobox
acts_upstream_of_or_within
ISO
MGI:2182089 (MGI:3703127|PMID:16854219)
RGD
PMID:16854219
MGI:3703127
NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
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Kif26a
kinesin family member 26A
involved_in
ISO
(MGI:4410392|PMID:19914172)
RGD
PMID:19914172
MGI:4410392
NCBI chr 6:131,214,839...131,250,874
Ensembl chr 6:131,214,861...131,250,320
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Ntf3
neurotrophin 3
acts_upstream_of_or_within
ISO
MGI:1933844 (MGI:3505802|PMID:15497153)
RGD
PMID:15497153
MGI:3505802
NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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Phactr4
phosphatase and actin regulator 4
involved_in
ISO
(MGI:5302129|PMID:22215812)
RGD
PMID:22215812
MGI:5302129
NCBI chr 5:144,549,350...144,621,259
Ensembl chr 5:144,549,363...144,620,865
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Phox2b
paired-like homeobox 2b
involved_in
ISO IBA
(PMID:12640453) (MGI:1337891|PMID:10360575) PMID:21873635
RGD
PMID:10360575 PMID:12640453 PMID:21873635
MGI:1337891 , RGD:13792537
NCBI chr14:41,066,012...41,069,202
Ensembl chr14:41,066,264...41,068,978
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Ret
ret proto-oncogene
acts_upstream_of_or_within
ISO
MGI:2136894 (MGI:1313212|PMID:9834195)
RGD
PMID:9834195
MGI:1313212
NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
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Slc6a4
solute carrier family 6 member 4
involved_in
ISO
(MGI:5810846|PMID:27111230)
RGD
PMID:27111230
MGI:5810846
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Sox10
SRY-box transcription factor 10
involved_in acts_upstream_of_or_within
IBA ISO
PMID:21873635 MGI:1857401|MGI:3701358 (MGI:3701016|PMID:16790476), (MGI:56157|PMID:6512238) (MGI:3527299|PMID:15572147)
RGD
PMID:6512238 PMID:15572147 PMID:16790476 PMID:21873635
MGI:3527299 MGI:3701016 MGI:56157 , RGD:13792537
NCBI chr 7:110,725,274...110,734,651
Ensembl chr 7:110,725,274...110,735,544
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Sox8
SRY-box transcription factor 8
involved_in
IBA ISS ISO
PMID:21873635 GO_REF:0000024 (MGI:3527299|PMID:15572147)
UniProt RGD
PMID:15572147 PMID:21873635
GO_REF:0000024 MGI:3527299 , RGD:13792537
NCBI chr10:14,584,829...14,589,818
Ensembl chr10:14,584,829...14,589,818
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Tlx2
T-cell leukemia homeobox 2
acts_upstream_of_or_within
ISO
MGI:2448951 (MGI:1095635|PMID:9259577)
RGD
PMID:9259577
MGI:1095635
NCBI chr 4:115,573,736...115,576,097
Ensembl chr 4:115,573,799...115,575,642
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