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ONTOLOGY REPORT - ANNOTATIONS

Term:isotype switching to IgG isotypes
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Accession:GO:0048291 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:exact_synonym: class switching to IgG isotypes;   isotype switch recombination to IgG isotypes


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isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959 		JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25404367) Ensembl
MGI		 PMID:25404367 GO_REF:0000107 NCBI chr17:25,944,259...26,009,317
Ensembl chr17:25,436,195...25,496,242 		JBrowse link
G CD28 CD28 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7688139) Ensembl
MGI		 PMID:7688139 GO_REF:0000107 NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213 		JBrowse link
G CD40 CD40 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12882831) Ensembl
MGI
TreeGrafter		 PMID:12882831 GO_REF:0000107 GO_REF:0000118 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL2 interleukin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1830926) Ensembl
MGI		 PMID:1830926 GO_REF:0000107 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12882831), (PMID:14988498) TreeGrafter
MGI		 PMID:12882831 PMID:14988498 GO_REF:0000118 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:36,899,828...36,957,076
Ensembl chr 3:37,189,439...37,245,801 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461 		JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 Ensembl chr16:30,186,326...30,190,654 JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:146,546,658...146,605,912
Ensembl chr 7:158,276,798...158,330,911 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:7,433,031...7,459,560
Ensembl chr 7:6,167,403...6,202,984 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9015183) Ensembl
MGI		 PMID:9015183 GO_REF:0000107 NCBI chr 1:174,246,389...174,364,893
Ensembl chr 1:178,556,104...178,672,994 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12882831) Ensembl
MGI		 PMID:12882831 GO_REF:0000107 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G IL27RA interleukin 27 receptor subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11057672) Ensembl
MGI		 PMID:11057672 GO_REF:0000107 Ensembl chr19:14,323,618...14,343,627 JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17137798) Ensembl
MGI		 PMID:17137798 GO_REF:0000107 NCBI chr 5:137,467,161...137,511,569
Ensembl chr 5:143,600,789...143,622,913 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:126,418,071...126,448,917 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16313
    immune system process 2386
      somatic diversification of immune receptors 84
        somatic diversification of immunoglobulins 71
          somatic recombination of immunoglobulin gene segments 65
            somatic recombination of immunoglobulin genes involved in immune response 57
              isotype switching 57
                isotype switching to IgG isotypes 18
                  negative regulation of isotype switching to IgG isotypes 0
                  positive regulation of isotype switching to IgG isotypes 13
                  regulation of isotype switching to IgG isotypes + 17
Path 2
Term Annotations click to browse term
  biological_process 16313
    metabolic process 10179
      cellular metabolic process 8945
        cellular aromatic compound metabolic process 5217
          nucleobase-containing compound metabolic process 4994
            nucleic acid metabolic process 4498
              DNA metabolic process 917
                DNA recombination 323
                  somatic cell DNA recombination 77
                    somatic diversification of immune receptors via germline recombination within a single locus 77
                      somatic recombination of immunoglobulin gene segments 65
                        somatic recombination of immunoglobulin genes involved in immune response 57
                          isotype switching 57
                            isotype switching to IgG isotypes 18
                              negative regulation of isotype switching to IgG isotypes 0
                              positive regulation of isotype switching to IgG isotypes 13
                              regulation of isotype switching to IgG isotypes + 17
paths to the root