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ONTOLOGY REPORT - ANNOTATIONS

Term:isotype switching to IgA isotypes
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Accession:GO:0048290 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:exact_synonym: class switching to IgA isotypes;   isotype switch recombination to IgA isotypes


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isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in ISO (MGI:5787846|PMID:27174992) UniProt PMID:27174992 MGI:5787846 NCBI chr 6:165,094,563...165,109,774
Ensembl chr 6:170,069,689...170,084,779 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:36,899,828...36,957,076
Ensembl chr 3:37,189,439...37,245,801 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461 		JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23241889) Ensembl
MGI		 PMID:23241889 GO_REF:0000107 NCBI chr 4:2,009,276...2,119,182
Ensembl chr 4:1,945,307...2,027,425 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:7,433,031...7,459,560
Ensembl chr 7:6,167,403...6,202,984 		JBrowse link
G TGFB1 transforming growth factor beta 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14988498) MGI
Ensembl		 PMID:14988498 GO_REF:0000107 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TNFSF12 TNF superfamily member 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:7,581,163...7,589,809
Ensembl chr17:7,567,766...7,575,575 		JBrowse link
G TNFSF13 TNF superfamily member 13 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14988498) MGI
TreeGrafter
Ensembl		 PMID:14988498 GO_REF:0000107 GO_REF:0000118 NCBI chr17:7,589,931...7,593,527
Ensembl chr17:7,576,465...7,579,834 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    immune system process 2406
      leukocyte activation 979
        lymphocyte activation 795
          lymphocyte activation involved in immune response 203
            B cell activation involved in immune response 94
              isotype switching 57
                isotype switching to IgA isotypes 8
                  negative regulation of isotype switching to IgA isotypes 0
                  positive regulation of isotype switching to IgA isotypes 7
                  regulation of isotype switching to IgA isotypes + 7
Path 2
Term Annotations click to browse term
  biological_process 16440
    metabolic process 10303
      organic substance metabolic process 9869
        organic cyclic compound metabolic process 5562
          nucleobase-containing compound metabolic process 5109
            nucleic acid metabolic process 4613
              DNA metabolic process 917
                DNA recombination 322
                  somatic cell DNA recombination 77
                    somatic diversification of immune receptors via germline recombination within a single locus 77
                      somatic recombination of immunoglobulin gene segments 65
                        somatic recombination of immunoglobulin genes involved in immune response 57
                          isotype switching 57
                            isotype switching to IgA isotypes 8
                              negative regulation of isotype switching to IgA isotypes 0
                              positive regulation of isotype switching to IgA isotypes 7
                              regulation of isotype switching to IgA isotypes + 7
paths to the root