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ONTOLOGY REPORT - ANNOTATIONS

Term:isotype switching to IgE isotypes
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Accession:GO:0048289 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:exact_synonym: class switch recombination to IgE isotypes;   class switching to IgE isotypes;   isotype switch recombination to IgE isotypes

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isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chrNW_004936578:2,371,976...2,395,034
Ensembl chrNW_004936578:2,371,945...2,395,071 		JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chrNW_004936721:1,118,376...1,125,282
Ensembl chrNW_004936721:1,118,782...1,132,308 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chrNW_004936646:1,297,530...1,312,508
Ensembl chrNW_004936646:1,296,290...1,312,157 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chrNW_004936578:2,371,976...2,395,034
Ensembl chrNW_004936578:2,371,945...2,395,071 		JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chrNW_004936721:1,118,376...1,125,282
Ensembl chrNW_004936721:1,118,782...1,132,308 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO (PMID:17137798) MGI PMID:17137798 NCBI chrNW_004936504:12,053,470...12,103,346 JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) BHF-UCL PMID:12496423 MGI:3763508 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin like cytokine factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:2,372,889...2,376,316
Ensembl chrNW_004936599:2,372,031...2,376,939 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chrNW_004936646:1,297,530...1,312,508
Ensembl chrNW_004936646:1,296,290...1,312,157 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    immune system process 2209
      leukocyte activation 921
        lymphocyte activation 751
          lymphocyte activation involved in immune response 195
            B cell activation involved in immune response 92
              isotype switching 56
                isotype switching to IgE isotypes 6
                  interleukin-4-dependent isotype switching to IgE isotypes + 1
                  negative regulation of isotype switching to IgE isotypes 3
                  positive regulation of isotype switching to IgE isotypes + 3
                  regulation of isotype switching to IgE isotypes + 6
Path 2
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      organic substance metabolic process 9204
        organic cyclic compound metabolic process 5206
          nucleobase-containing compound metabolic process 4756
            nucleic acid metabolic process 4277
              DNA metabolic process 875
                DNA recombination 311
                  somatic cell DNA recombination 76
                    somatic diversification of immune receptors via germline recombination within a single locus 76
                      somatic recombination of immunoglobulin gene segments 64
                        somatic recombination of immunoglobulin genes involved in immune response 56
                          isotype switching 56
                            isotype switching to IgE isotypes 6
                              interleukin-4-dependent isotype switching to IgE isotypes + 1
                              negative regulation of isotype switching to IgE isotypes 3
                              positive regulation of isotype switching to IgE isotypes + 3
                              regulation of isotype switching to IgE isotypes + 6
paths to the root