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ONTOLOGY REPORT - ANNOTATIONS


Term:lung alveolus development
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Accession:GO:0048286 term browser browse the term
Definition:The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
Synonyms:exact_synonym: alveolarization;   alveologenesis


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lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca12 ATP binding cassette subfamily A member 12 NOT|acts_upstream_of_or_within ISO (MGI:3829841|PMID:18957418)
(MGI:3807143|PMID:18632686)
MGI PMID:18632686 PMID:18957418 MGI:3807143 MGI:3829841 NCBI chrNW_004936586:1,938,617...2,094,231 JBrowse link
G Ada adenosine deaminase acts_upstream_of_or_within ISO (MGI:1861066|PMID:10899903) MGI PMID:10899903 MGI:1861066 NCBI chrNW_004936530:2,217,713...2,224,070 JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO (MGI:54141|PMID:937819) MGI PMID:937819 MGI:54141 NCBI chrNW_004936683:2,874,022...2,936,214 JBrowse link
G Atxn1 ataxin 1 acts_upstream_of_or_within ISO (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chrNW_004936552:2,498,711...2,521,225 JBrowse link
G Atxn1l ataxin 1 like acts_upstream_of_or_within ISO (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chrNW_004936475:21,941,682...21,953,071 JBrowse link
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (PMID:8674409) MGI PMID:8674409 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (MGI:3799581|PMID:18552156) BHF-UCL PMID:18552156 MGI:3799581 NCBI chrNW_004936726:1,543,263...1,711,422 JBrowse link
G Cic capicua transcriptional repressor acts_upstream_of_or_within ISO (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chrNW_004936706:216,394...243,361 JBrowse link
G Dbn1 drebrin 1 ISO RGD PMID:15928322 RGD:10398812 NCBI chrNW_004936597:1,735,589...1,751,628 JBrowse link
G Edn2 endothelin 2 acts_upstream_of_or_within ISO (MGI:5514104|PMID:23676500) MGI PMID:23676500 MGI:5514104 NCBI chrNW_004936474:23,061,219...23,064,525 JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISO (MGI:4366137|PMID:19710174) UniProt PMID:19710174 MGI:4366137 NCBI chrNW_004936623:2,457,709...2,462,956 JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO (MGI:3688953|PMID:16989802)
(MGI:3716020|PMID:17560563)
MGI PMID:16989802 PMID:17560563 MGI:3688953 MGI:3716020 NCBI chrNW_004936480:18,114,231...18,195,884 JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO (MGI:3688953|PMID:16989802) MGI PMID:16989802 MGI:3688953 NCBI chrNW_004936486:10,506,680...10,606,272 JBrowse link
G Flt4 fms related receptor tyrosine kinase 4 acts_upstream_of_or_within ISO (MGI:5582954|PMID:24733830) MGI PMID:24733830 MGI:5582954 NCBI chrNW_004936739:240,572...281,925 JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO (MGI:2135612|PMID:11493558) MGI PMID:11493558 MGI:2135612 NCBI chrNW_004943883:4...1,756 JBrowse link
G Foxp2 forkhead box P2 acts_upstream_of_or_within ISO (MGI:3710027|PMID:17428829) MGI PMID:17428829 MGI:3710027 NCBI chrNW_004936589:4,120,162...4,661,258 JBrowse link
G Fzd1 frizzled class receptor 1 ISO RGD PMID:17911382 RGD:2304247 NCBI chrNW_004936621:2,899,183...2,903,427 JBrowse link
G Hopx HOP homeobox acts_upstream_of_or_within ISO (MGI:3709528|PMID:16510470) MGI PMID:16510470 MGI:3709528 NCBI chrNW_004936482:18,841,220...18,872,136 JBrowse link
G Hoxa5 homeobox A5 acts_upstream_of_or_within ISO (MGI:3606710|PMID:15295088), (MGI:3665532|PMID:17003488) MGI PMID:15295088 PMID:17003488 MGI:3606710 MGI:3665532 NCBI chrNW_004936478:3,768,757...3,771,850 JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chrNW_004936469:43,039,494...43,086,041 JBrowse link
G Igf1 insulin like growth factor 1 acts_upstream_of_or_within ISO (MGI:3640953|PMID:16691571) MGI PMID:16691571 MGI:3640953 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Igfbp5 insulin like growth factor binding protein 5 involved_in ISO (MGI:3039207|PMID:15010534) BHF-UCL PMID:15010534 MGI:3039207 NCBI chrNW_004936586:647,553...666,595 JBrowse link
G Itgb6 integrin subunit beta 6 acts_upstream_of_or_within ISO (MGI:3040752|PMID:12634787) MGI PMID:12634787 MGI:3040752 NCBI chrNW_004936469:18,581,855...18,650,109 JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within ISO (MGI:2181852|PMID:12053176) MGI PMID:12053176 MGI:2181852 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Lif LIF interleukin 6 family cytokine acts_upstream_of_or_within ISO (MGI:3640953|PMID:16691571) MGI PMID:16691571 MGI:3640953 NCBI chrNW_004936904:410,043...413,256 JBrowse link
G LOC101968921 angiotensin-converting enzyme ISO RGD PMID:22587910 RGD:6893470 NCBI chrNW_004936541:4,157,847...4,178,156 JBrowse link
G LOC101969021 somatotropin ISO RGD PMID:18985281 RGD:2315627 NCBI chrNW_004936541:4,524,397...4,528,234 JBrowse link
G Man1a2 mannosidase alpha class 1A member 2 acts_upstream_of_or_within ISO (MGI:3703634|PMID:17121831) MGI PMID:17121831 MGI:3703634 NCBI chrNW_004936627:2,499,666...2,640,195 JBrowse link
G Man2a1 mannosidase alpha class 2A member 1 acts_upstream_of_or_within ISO (MGI:3652665|PMID:16754854) MGI PMID:16754854 MGI:3652665 NCBI chrNW_004936531:4,331,354...4,494,110 JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 acts_upstream_of_or_within ISO (MGI:3796918|PMID:18324732) MGI PMID:18324732 MGI:3796918 NCBI chrNW_004936694:2,223,020...2,263,388 JBrowse link
G Mecp2 methyl-CpG binding protein 2 ISO RGD PMID:21425435 RGD:8552971 NCBI chrNW_004936809:902,938...967,771 JBrowse link
G Mmp12 matrix metallopeptidase 12 acts_upstream_of_or_within ISO (MGI:3040752|PMID:12634787) MGI PMID:12634787 MGI:3040752 NCBI chrNW_004936551:5,107,567...5,117,843 JBrowse link
G Myocd myocardin acts_upstream_of_or_within ISO (MGI:4941650|PMID:21357509) MGI PMID:21357509 MGI:4941650 NCBI chrNW_004936595:5,256,615...5,356,563 JBrowse link
G Pdgfa platelet derived growth factor subunit A involved_in
acts_upstream_of_or_within
ISO (MGI:1098909|PMID:9374392)
(MGI:5543868|PMID:23938297)
(MGI:3622881|PMID:11803579)
UniProt
MGI
PMID:9374392 PMID:11803579 PMID:23938297 MGI:1098909 MGI:3622881 MGI:5543868 NCBI chrNW_004936754:808,894...828,554 JBrowse link
G Pdpn podoplanin acts_upstream_of_or_within ISO (MGI:3703126|PMID:16869965) MGI PMID:16869965 MGI:3703126 NCBI chrNW_004936474:1,751,159...1,779,011 JBrowse link
G Pgr progesterone receptor acts_upstream_of_or_within ISO (MGI:5576858|PMID:24190884) MGI PMID:24190884 MGI:5576858 NCBI chrNW_004936551:6,498,553...6,573,212 JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within ISO (MGI:5426441|PMID:22730381) MGI PMID:22730381 MGI:5426441 NCBI chrNW_004936761:585,261...768,794 JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic involved_in ISO (MGI:4438146|PMID:19465597) UniProt PMID:19465597 MGI:4438146 NCBI chrNW_004936508:9,550,201...9,559,493 JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO (MGI:1346745|PMID:10518543) MGI PMID:10518543 MGI:1346745 NCBI chrNW_004936526:3,584,194...3,611,719 JBrowse link
G Pthlh parathyroid hormone like hormone acts_upstream_of_or_within ISO (MGI:3042805|PMID:15162506) MGI PMID:15162506 MGI:3042805 NCBI chrNW_004936760:197,525...209,212 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO (MGI:5486592|PMID:23583643) MGI PMID:23583643 MGI:5486592 NCBI chrNW_004936487:11,341,663...11,393,275 JBrowse link
G Selenon selenoprotein N acts_upstream_of_or_within ISO (MGI:5494499|PMID:23325319) MGI PMID:23325319 MGI:5494499 NCBI chrNW_004936474:10,381,646...10,396,638 JBrowse link
G Sftpd surfactant protein D involved_in ISO (PMID:9751757) UniProt PMID:9751757 NCBI chrNW_004936716:60,754...73,010 JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO (MGI:5469541|PMID:23085521) MGI PMID:23085521 MGI:5469541 NCBI chrNW_004936535:9,177,305...9,242,743 JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO (MGI:5469952|PMID:22945695) MGI PMID:22945695 MGI:5469952 NCBI chrNW_004936475:18,667,563...18,755,132 JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (MGI:3795352|PMID:18374910) MGI PMID:18374910 MGI:3795352 NCBI chrNW_004936566:1,630,698...1,632,607 JBrowse link
G Stk40 serine/threonine kinase 40 acts_upstream_of_or_within ISO (MGI:5486391|PMID:23293024) MGI PMID:23293024 MGI:5486391 NCBI chrNW_004936474:18,771,434...18,816,086 JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in ISO (PMID:17273977) DFLAT PMID:17273977 NCBI chrNW_004936471:33,224,174...33,245,076 JBrowse link
G Tcf21 transcription factor 21 acts_upstream_of_or_within ISO (MGI:1347485|PMID:10572052) MGI PMID:10572052 MGI:1347485 NCBI chrNW_004936560:1,733,903...1,736,895 JBrowse link
G Tgfb1 transforming growth factor beta 1 acts_upstream_of_or_within ISO (MGI:3040752|PMID:12634787) MGI PMID:12634787 MGI:3040752 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Tgfb3 transforming growth factor beta 3 involved_in ISO (MGI:77427|PMID:7493022) BHF-UCL PMID:7493022 MGI:77427 NCBI chrNW_004936488:4,986,712...5,008,728 JBrowse link
G Tmem38b transmembrane protein 38B acts_upstream_of_or_within ISO (MGI:3850579|PMID:19515693) MGI PMID:19515693 MGI:3850579 NCBI chrNW_004936559:6,501,890...6,553,446 JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 acts_upstream_of_or_within ISO (MGI:5300435|PMID:21956870) MGI PMID:21956870 MGI:5300435 NCBI chrNW_004936507:5,305,489...5,349,828 JBrowse link
G Tns3 tensin 3 acts_upstream_of_or_within ISO (MGI:3531231|PMID:15733665) MGI PMID:15733665 MGI:3531231 NCBI chrNW_004936478:21,784,486...21,924,240 JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:16230500 RGD:1580552 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
G Wnt5a Wnt family member 5A ISO RGD PMID:17911382 RGD:2304247 NCBI chrNW_004936473:6,031,627...6,052,211 JBrowse link
G Znf157 zinc finger protein 157 acts_upstream_of_or_within ISO (MGI:5424261|PMID:22588720) MGI PMID:22588720 MGI:5424261 NCBI chrNW_004936502:13,127,503...13,158,443 JBrowse link
alveolar primary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in ISO (PMID:17273977) DFLAT PMID:17273977 NCBI chrNW_004936471:33,224,174...33,245,076 JBrowse link
alveolar secondary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chrNW_004936477:21,591,772...21,606,289 JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chrNW_004936597:1,388,394...1,397,731 JBrowse link
G Foxa1 forkhead box A1 acts_upstream_of_or_within ISO (MGI:3613241|PMID:16214823) MGI PMID:16214823 MGI:3613241 NCBI chrNW_004936494:11,529,546...11,535,224 JBrowse link
lung saccule development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl1 ASXL transcriptional regulator 1 acts_upstream_of_or_within ISO (MGI:5585348|PMID:24860998) MGI PMID:24860998 MGI:5585348 NCBI chrNW_004936485:19,218,494...19,297,188 JBrowse link
G Creb1 cAMP responsive element binding protein 1 acts_upstream_of_or_within ISO (MGI:4950818|PMID:21408140) MGI PMID:21408140 MGI:4950818 NCBI chrNW_004936631:3,721,307...3,785,346 JBrowse link
G Fgf10 fibroblast growth factor 10 involved_in ISO (PMID:17071719) UniProt PMID:17071719 NCBI chrNW_004936480:18,114,231...18,195,884 JBrowse link
G Gata6 GATA binding protein 6 acts_upstream_of_or_within ISO (MGI:3695537|PMID:17164424) MGI PMID:17164424 MGI:3695537 NCBI chrNW_004936550:1,814,336...1,844,399 JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO (MGI:3584290|PMID:16049328) MGI PMID:16049328 MGI:3584290 NCBI chrNW_004936599:3,902,903...3,918,471 JBrowse link
G Nkx2-1 NK2 homeobox 1 acts_upstream_of_or_within ISO (MGI:3695537|PMID:17164424) MGI PMID:17164424 MGI:3695537 NCBI chrNW_004936494:10,517,488...10,520,567 JBrowse link
G Ptges3 prostaglandin E synthase 3 acts_upstream_of_or_within ISO (MGI:3714109|PMID:17438133) MGI PMID:17438133 MGI:3714109 NCBI chrNW_004936646:969,674...990,532 JBrowse link
positive regulation of lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:23962064 RGD:10395379 NCBI chrNW_004936508:5,855,748...5,938,879 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12130
    developmental process 5716
      anatomical structure development 5344
        lung alveolus development 67
          lung saccule development + 11
          negative regulation of lung alveolus development 0
          positive regulation of lung alveolus development 1
          regulation of lung alveolus development + 1
Path 2
Term Annotations click to browse term
  biological_process 12130
    developmental process 5716
      anatomical structure development 5344
        multicellular organism development 4894
          system development 4605
            animal organ development 3548
              respiratory tube development 248
                lung development 245
                  lung alveolus development 67
                    lung saccule development + 11
                    negative regulation of lung alveolus development 0
                    positive regulation of lung alveolus development 1
                    regulation of lung alveolus development + 1
paths to the root