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ONTOLOGY REPORT - ANNOTATIONS


Term:lung alveolus development
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Accession:GO:0048286 term browser browse the term
Definition:The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
Synonyms:exact_synonym: alveolarization;   alveologenesis


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lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA12 ATP binding cassette subfamily A member 12 involved_in
NOT|acts_upstream_of_or_within
IEA
ISO
(MGI:3829841|PMID:18957418)
(MGI:3807143|PMID:18632686)
Ensembl
MGI
PMID:18632686 PMID:18957418 GO_REF:0000107 MGI:3807143 MGI:3829841 NCBI chr15:117,244,704...117,451,009
Ensembl chr15:117,244,763...117,451,261
JBrowse link
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO RGD PMID:22587910 RGD:6893470 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,639
JBrowse link
G ADA adenosine deaminase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1861066|PMID:10899903) Ensembl
MGI
PMID:10899903 GO_REF:0000107 MGI:1861066 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,495...47,072,245
JBrowse link
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (MGI:54141|PMID:937819) MGI PMID:937819 MGI:54141 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,874...62,110,058
JBrowse link
G ATXN1 ataxin 1 acts_upstream_of_or_within ISO (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chr 7:12,299,938...12,730,850
Ensembl chr 7:12,300,999...12,720,718
JBrowse link
G ATXN1L ataxin 1 like involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5298126|PMID:22014525) Ensembl
MGI
PMID:22014525 GO_REF:0000107 MGI:5298126 NCBI chr 6:14,836,732...14,848,474
Ensembl chr 6:14,836,749...14,848,423
JBrowse link
G BMP4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (PMID:8674409) MGI PMID:8674409 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,134...183,792,417
JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:105,971,577...106,132,496
Ensembl chr15:105,970,427...106,135,730
JBrowse link
G CIC capicua transcriptional repressor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5298126|PMID:22014525) Ensembl
MGI
PMID:22014525 GO_REF:0000107 MGI:5298126 NCBI chr 6:49,638,986...49,664,146
Ensembl chr 6:49,638,988...49,662,947
JBrowse link
G DBN1 drebrin 1 ISO RGD PMID:15928322 RGD:10398812 NCBI chr 2:80,480,603...80,495,797
Ensembl chr 2:80,479,460...80,496,873
JBrowse link
G EDN2 endothelin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5514104|PMID:23676500) Ensembl
MGI
PMID:23676500 GO_REF:0000107 MGI:5514104 NCBI chr 6:169,751,956...169,758,011
Ensembl chr 6:169,752,026...169,758,583
JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:68,667,651...68,682,629
Ensembl chr 6:68,669,153...68,682,624
JBrowse link
G FGF10 fibroblast growth factor 10 acts_upstream_of_or_within ISO (MGI:3716020|PMID:17560563)
(MGI:3688953|PMID:16989802)
MGI PMID:16989802 PMID:17560563 MGI:3688953 MGI:3716020 NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,469...28,777,541
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO (MGI:3688953|PMID:16989802) MGI PMID:16989802 MGI:3688953 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,710...131,579,703
JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 acts_upstream_of_or_within ISO (MGI:5582954|PMID:24733830) MGI PMID:24733830 MGI:5582954 NCBI chr 2:78,076,008...78,115,137
Ensembl chr 2:78,076,080...78,115,137
JBrowse link
G FOXF1 forkhead box F1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2135612|PMID:11493558) Ensembl
MGI
PMID:11493558 GO_REF:0000107 MGI:2135612 NCBI chr 6:2,579,348...2,598,122
Ensembl chr 6:2,592,993...2,597,659
JBrowse link
G FOXP2 forkhead box P2 acts_upstream_of_or_within ISO (MGI:3710027|PMID:17428829) MGI PMID:17428829 MGI:3710027 NCBI chr18:31,335,102...31,890,523
Ensembl chr18:31,336,931...31,888,899
JBrowse link
G FZD1 frizzled class receptor 1 ISO RGD PMID:17911382 RGD:2304247 NCBI chr 9:71,346,994...71,356,488
Ensembl chr 9:71,349,988...71,352,104
JBrowse link
G HOPX HOP homeobox acts_upstream_of_or_within ISO (MGI:3709528|PMID:16510470) MGI PMID:16510470 MGI:3709528 NCBI chr 8:55,862,191...55,901,628 JBrowse link
G HOXA5 homeobox A5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3606710|PMID:15295088), (MGI:3665532|PMID:17003488) Ensembl
MGI
PMID:15295088 PMID:17003488 GO_REF:0000107 MGI:3606710 MGI:3665532 NCBI chr18:45,429,691...45,432,723
Ensembl chr18:45,421,663...45,432,885
JBrowse link
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3715036|PMID:17405882) Ensembl
MGI
PMID:17405882 GO_REF:0000107 MGI:3715036 NCBI chr15:59,066,448...59,108,780
Ensembl chr15:59,066,603...59,108,777
JBrowse link
G IGF1 insulin like growth factor 1 acts_upstream_of_or_within ISO (MGI:3640953|PMID:16691571) MGI PMID:16691571 MGI:3640953 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 involved_in ISO (MGI:3039207|PMID:15010534) BHF-UCL PMID:15010534 MGI:3039207 NCBI chr15:118,861,816...118,877,787
Ensembl chr15:118,857,479...118,878,522
JBrowse link
G ITGB6 integrin subunit beta 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3040752|PMID:12634787) Ensembl
MGI
PMID:12634787 GO_REF:0000107 MGI:3040752 NCBI chr15:67,041,516...67,175,409
Ensembl chr15:67,041,519...67,175,234
JBrowse link
G KDR kinase insert domain receptor acts_upstream_of_or_within ISO (MGI:2181852|PMID:12053176) MGI PMID:12053176 MGI:2181852 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,116...41,856,339
JBrowse link
G LIF LIF interleukin 6 family cytokine involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3640953|PMID:16691571) Ensembl
MGI
PMID:16691571 GO_REF:0000107 MGI:3640953 NCBI chr14:47,221,540...47,239,513
Ensembl chr14:47,221,560...47,238,749
JBrowse link
G LOC100738836 insulin-like growth factor-binding protein 5 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr15:118,857,479...118,878,522 JBrowse link
G MAN1A2 mannosidase alpha class 1A member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3703634|PMID:17121831) Ensembl
MGI
PMID:17121831 GO_REF:0000107 MGI:3703634 NCBI chr 4:103,214,929...103,377,132
Ensembl chr 4:103,214,934...103,376,507
JBrowse link
G MAN2A1 mannosidase alpha class 2A member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3652665|PMID:16754854) Ensembl
MGI
PMID:16754854 GO_REF:0000107 MGI:3652665 NCBI chr 2:114,675,786...114,853,133
Ensembl chr 2:114,675,916...114,856,055
JBrowse link
G MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 acts_upstream_of_or_within ISO (MGI:3796918|PMID:18324732) MGI PMID:18324732 MGI:3796918 NCBI chr 3:40,196,873...40,241,453
Ensembl chr 3:40,195,649...40,241,283
JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO RGD PMID:21425435 RGD:8552971 NCBI chr  X:124,735,523...124,789,063
Ensembl chr  X:124,735,656...124,789,110
JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3040752|PMID:12634787) Ensembl
MGI
PMID:12634787 GO_REF:0000107 MGI:3040752 NCBI chr 9:33,473,625...33,483,630
Ensembl chr 9:33,473,085...33,483,679
JBrowse link
G MYOCD myocardin involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4941650|PMID:21357509) Ensembl
MGI
PMID:21357509 GO_REF:0000107 MGI:4941650 NCBI chr12:56,931,628...57,029,258
Ensembl chr12:56,931,317...57,029,538
JBrowse link
G PDGFA platelet derived growth factor subunit A acts_upstream_of_or_within
involved_in
ISO (MGI:5543868|PMID:23938297)
(MGI:1098909|PMID:9374392)
(MGI:3622881|PMID:11803579)
MGI
UniProt
PMID:9374392 PMID:11803579 PMID:23938297 MGI:1098909 MGI:3622881 MGI:5543868 NCBI chr 3:296,399...322,967
Ensembl chr 3:303,311...323,036
JBrowse link
G PDPN podoplanin acts_upstream_of_or_within ISO (MGI:3703126|PMID:16869965) MGI PMID:16869965 MGI:3703126 NCBI chr 6:73,019,063...73,050,000
Ensembl chr 6:73,019,057...73,049,998
JBrowse link
G PGR progesterone receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5576858|PMID:24190884) Ensembl
MGI
PMID:24190884 GO_REF:0000107 MGI:5576858 NCBI chr 9:32,035,684...32,129,776
Ensembl chr 9:32,035,684...32,129,221
JBrowse link
G PHF14 PHD finger protein 14 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5426441|PMID:22730381) Ensembl
MGI
PMID:22730381 GO_REF:0000107 MGI:5426441 NCBI chr 9:80,677,185...80,866,160
Ensembl chr 9:80,677,967...80,866,146
JBrowse link
G PKDCC protein kinase domain containing, cytoplasmic involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,258,456...98,268,539
Ensembl chr 3:98,258,460...98,268,557
JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (MGI:1346745|PMID:10518543) MGI PMID:10518543 MGI:1346745 NCBI chr10:14,532,556...14,561,862
Ensembl chr10:14,532,550...14,561,858
JBrowse link
G PTHLH parathyroid hormone like hormone acts_upstream_of_or_within ISO (MGI:3042805|PMID:15162506) MGI PMID:15162506 MGI:3042805 NCBI chr 5:45,750,968...45,763,421
Ensembl chr 5:45,751,292...45,763,415
JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5486592|PMID:23583643) Ensembl
MGI
PMID:23583643 GO_REF:0000107 MGI:5486592 NCBI chr 1:263,769,403...263,822,101
Ensembl chr 1:263,772,168...263,822,104
JBrowse link
G SELENON selenoprotein N involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5494499|PMID:23325319) Ensembl
MGI
PMID:23325319 GO_REF:0000107 MGI:5494499 NCBI chr 6:83,246,934...83,262,748
Ensembl chr 6:83,246,934...83,262,746
JBrowse link
G SFTPD surfactant protein D involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:82,051,400...82,069,258
Ensembl chr14:82,051,451...82,067,976
JBrowse link
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5469541|PMID:23085521) Ensembl
MGI
PMID:23085521 GO_REF:0000107 MGI:5469541 NCBI chr 8:88,608,083...88,690,589
Ensembl chr 8:88,607,884...88,940,100
JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO (MGI:5469952|PMID:22945695) MGI PMID:22945695 MGI:5469952 NCBI chr 6:28,938,287...29,025,397
Ensembl chr 6:28,938,290...29,025,357
JBrowse link
G SOX2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (MGI:3795352|PMID:18374910) MGI PMID:18374910 MGI:3795352 NCBI chr13:119,668,476...119,669,435 JBrowse link
G STK40 serine/threonine kinase 40 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5486391|PMID:23293024) Ensembl
MGI
PMID:23293024 GO_REF:0000107 MGI:5486391 NCBI chr 6:92,441,231...92,484,363
Ensembl chr 6:92,424,984...92,483,709
JBrowse link
G STRA6 signaling receptor and transporter of retinol STRA6 involved_in ISO (PMID:17273977) DFLAT PMID:17273977 NCBI chr 7:59,317,930...59,347,274
Ensembl chr 7:59,318,010...59,347,267
JBrowse link
G TCF21 transcription factor 21 involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:1347485|PMID:10572052) UniProt
MGI
PMID:10572052 GO_REF:0000024 MGI:1347485 NCBI chr 1:29,975,280...29,978,273
Ensembl chr 1:29,973,380...29,978,255
JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3040752|PMID:12634787) Ensembl
MGI
PMID:12634787 GO_REF:0000107 MGI:3040752 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TGFB3 transforming growth factor beta 3 involved_in ISO (MGI:77427|PMID:7493022) BHF-UCL PMID:7493022 MGI:77427 NCBI chr 7:99,133,873...99,162,239
Ensembl chr 7:99,133,511...99,162,232
JBrowse link
G TMEM38B transmembrane protein 38B involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3850579|PMID:19515693) Ensembl
MGI
PMID:19515693 GO_REF:0000107 MGI:3850579 NCBI chr 1:246,973,447...247,024,019
Ensembl chr 1:246,973,436...247,027,527
JBrowse link
G TMTC3 transmembrane O-mannosyltransferase targeting cadherins 3 acts_upstream_of_or_within ISO (MGI:5300435|PMID:21956870) MGI PMID:21956870 MGI:5300435 NCBI chr 5:94,328,452...94,384,266
Ensembl chr 5:94,276,769...94,384,142
JBrowse link
G TNS3 tensin 3 acts_upstream_of_or_within ISO (MGI:3531231|PMID:15733665) MGI PMID:15733665 MGI:3531231 NCBI chr18:48,960,938...49,192,434
Ensembl chr18:48,961,023...49,192,433
JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:16230500 RGD:1580552 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
G WNT5A Wnt family member 5A ISO RGD PMID:17911382 RGD:2304247 NCBI chr13:37,344,684...37,367,215
Ensembl chr13:37,344,699...37,367,207
JBrowse link
G ZNF157 zinc finger protein 157 acts_upstream_of_or_within ISO (MGI:5424261|PMID:22588720) MGI PMID:22588720 MGI:5424261 NCBI chr  X:41,905,319...41,921,484
Ensembl chr  X:41,905,226...41,920,880
JBrowse link
alveolar primary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STRA6 signaling receptor and transporter of retinol STRA6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:59,317,930...59,347,274
Ensembl chr 7:59,318,010...59,347,267
JBrowse link
alveolar secondary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGFR3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chr 8:879,151...894,968
Ensembl chr 8:879,151...895,912
JBrowse link
G FGFR4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chr 2:80,841,536...80,853,791
Ensembl chr 2:80,841,536...80,853,796
JBrowse link
G FOXA1 forkhead box A1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3613241|PMID:16214823) Ensembl
MGI
PMID:16214823 GO_REF:0000107 MGI:3613241 NCBI chr 7:62,471,233...62,479,638
Ensembl chr 7:62,471,228...62,479,223
JBrowse link
lung saccule development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASXL1 ASXL transcriptional regulator 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5585348|PMID:24860998) Ensembl
MGI
PMID:24860998 GO_REF:0000107 MGI:5585348 NCBI chr17:35,985,978...36,067,122
Ensembl chr17:35,985,535...36,067,122
JBrowse link
G CREB1 cAMP responsive element binding protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4950818|PMID:21408140) Ensembl
MGI
PMID:21408140 GO_REF:0000107 MGI:4950818 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,697,408...110,771,755
JBrowse link
G FGF10 fibroblast growth factor 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,469...28,777,541
JBrowse link
G GATA6 GATA binding protein 6 acts_upstream_of_or_within ISO (MGI:3695537|PMID:17164424) MGI PMID:17164424 MGI:3695537 NCBI chr 6:107,282,709...107,314,725
Ensembl chr 6:107,282,847...107,314,634
JBrowse link
G LTBP3 latent transforming growth factor beta binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3584290|PMID:16049328) Ensembl
MGI
PMID:16049328 GO_REF:0000107 MGI:3584290 NCBI chr 2:6,701,455...6,720,191
Ensembl chr 2:6,701,340...6,720,172
JBrowse link
G NKX2-1 NK2 homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3695537|PMID:17164424) Ensembl
MGI
PMID:17164424 GO_REF:0000107 MGI:3695537 NCBI chr 7:63,487,200...63,491,580
Ensembl chr 7:63,487,807...63,491,575
JBrowse link
G PTGES3 prostaglandin E synthase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3714109|PMID:17438133) Ensembl
MGI
PMID:17438133 GO_REF:0000107 MGI:3714109 NCBI chr 5:22,000,335...22,022,830
Ensembl chr 5:22,000,339...22,021,663
JBrowse link
positive regulation of lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:23962064 RGD:10395379 NCBI chr 3:94,167,759...94,253,662
Ensembl chr 3:94,165,815...94,254,079
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16534
    developmental process 6336
      anatomical structure development 5874
        lung alveolus development 67
          lung saccule development + 11
          negative regulation of lung alveolus development 0
          positive regulation of lung alveolus development 1
          regulation of lung alveolus development + 1
Path 2
Term Annotations click to browse term
  biological_process 16534
    developmental process 6336
      anatomical structure development 5874
        multicellular organism development 5373
          system development 4991
            animal organ development 3832
              respiratory tube development 262
                lung development 259
                  lung alveolus development 67
                    lung saccule development + 11
                    negative regulation of lung alveolus development 0
                    positive regulation of lung alveolus development 1
                    regulation of lung alveolus development + 1
paths to the root