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ONTOLOGY REPORT - ANNOTATIONS


Term:lung alveolus development
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Accession:GO:0048286 term browser browse the term
Definition:The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
Synonyms:exact_synonym: alveolarization;   alveologenesis


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lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca12 ATP-binding cassette, sub-family A (ABC1), member 12 acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
IMP (MGI:3807143|PMID:18632686)
(MGI:3829841|PMID:18957418)
MGI PMID:18632686 PMID:18957418 MGI:3807143 MGI:3829841 NCBI chr 1:71,243,090...71,414,910
Ensembl chr 1:71,242,276...71,414,910
JBrowse link
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 acts_upstream_of_or_within ISO MGI
RGD
PMID:22587910 GO_REF:0000096 MGI:4417868 RGD:6893470 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ada adenosine deaminase acts_upstream_of_or_within IMP (MGI:1861066|PMID:10899903) MGI PMID:10899903 MGI:1861066 NCBI chr 2:163,726,571...163,750,239
Ensembl chr 2:163,726,584...163,750,239
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide acts_upstream_of_or_within IMP (MGI:54141|PMID:937819) MGI PMID:937819 MGI:54141 NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926
JBrowse link
G Atxn1 ataxin 1 acts_upstream_of_or_within IGI (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chr13:45,549,755...45,964,991
Ensembl chr13:45,549,755...45,965,008
JBrowse link
G Atxn1l ataxin 1-like acts_upstream_of_or_within IMP
IGI
(MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chr 8:109,726,451...109,737,794
Ensembl chr 8:109,726,451...109,737,739
JBrowse link
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (MGI:81070|PMID:8674409) MGI PMID:8674409 MGI:81070 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) involved_in IMP (MGI:3799581|PMID:18552156) BHF-UCL PMID:18552156 MGI:3799581 NCBI chr 1:59,764,279...59,878,081
Ensembl chr 1:59,763,400...59,879,014
JBrowse link
G Cic capicua transcriptional repressor acts_upstream_of_or_within IGI
IMP
(MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chr 7:25,267,658...25,294,159
Ensembl chr 7:25,267,704...25,294,159
JBrowse link
G Dbn1 drebrin 1 ISO RGD PMID:15928322 RGD:10398812 NCBI chr13:55,473,428...55,488,126
Ensembl chr13:55,473,429...55,488,111
JBrowse link
G Edn2 endothelin 2 acts_upstream_of_or_within IMP (MGI:5514104|PMID:23676500) MGI PMID:23676500 MGI:5514104 NCBI chr 4:120,161,206...120,167,360
Ensembl chr 4:120,161,206...120,167,360
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in IMP (MGI:4366137|PMID:19710174) UniProt PMID:19710174 MGI:4366137 NCBI chr 4:150,853,796...150,868,889
Ensembl chr 4:150,853,919...150,868,892
JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within IMP
IGI
(MGI:3716020|PMID:17560563)
(MGI:3688953|PMID:16989802)
MGI PMID:16989802 PMID:17560563 MGI:3688953 MGI:3716020 NCBI chr13:118,714,699...118,792,573
Ensembl chr13:118,669,791...118,792,115
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within IMP
IGI
(MGI:3688953|PMID:16989802) MGI PMID:16989802 MGI:3688953 NCBI chr 7:130,162,451...130,266,808
Ensembl chr 7:130,162,451...133,123,350
JBrowse link
G Flt4 FMS-like tyrosine kinase 4 acts_upstream_of_or_within IMP (MGI:5582954|PMID:24733830) MGI PMID:24733830 MGI:5582954 NCBI chr11:49,609,679...49,652,739
Ensembl chr11:49,609,263...49,652,739
JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within IMP (MGI:2135612|PMID:11493558) MGI PMID:11493558 MGI:2135612 NCBI chr 8:121,084,386...121,088,154
Ensembl chr 8:121,084,386...121,088,144
JBrowse link
G Foxp2 forkhead box P2 acts_upstream_of_or_within IMP (MGI:3710027|PMID:17428829) MGI PMID:17428829 MGI:3710027 NCBI chr 6:14,901,349...15,441,977
Ensembl chr 6:14,901,349...15,441,977
JBrowse link
G Fzd1 frizzled class receptor 1 ISO RGD PMID:17911382 RGD:2304247 NCBI chr 5:4,753,839...4,758,216
Ensembl chr 5:4,753,839...4,758,035
JBrowse link
G Gh growth hormone acts_upstream_of_or_within ISO MGI
RGD
PMID:18985281 GO_REF:0000096 MGI:4417868 RGD:2315627 NCBI chr11:106,300,261...106,303,703
Ensembl chr11:106,300,271...106,301,865
JBrowse link
G Hopx HOP homeobox acts_upstream_of_or_within IMP (MGI:3709528|PMID:16510470) MGI PMID:16510470 MGI:3709528 NCBI chr 5:77,086,986...77,115,123
Ensembl chr 5:77,086,988...77,115,121
JBrowse link
G Hoxa5 homeobox A5 acts_upstream_of_or_within IMP (MGI:3606710|PMID:15295088), (MGI:3665532|PMID:17003488) MGI PMID:15295088 PMID:17003488 MGI:3606710 MGI:3665532 NCBI chr 6:52,201,754...52,204,587
Ensembl chr 6:52,201,754...52,204,587
JBrowse link
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within IMP (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chr 1:36,068,400...36,106,446
Ensembl chr 1:36,068,400...36,106,446
JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within IMP
IGI
(MGI:3640953|PMID:16691571) MGI PMID:16691571 MGI:3640953 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 involved_in IMP (MGI:3039207|PMID:15010534) BHF-UCL PMID:15010534 MGI:3039207 NCBI chr 1:72,858,065...72,874,865
Ensembl chr 1:72,857,932...72,874,884
JBrowse link
G Itgb6 integrin beta 6 acts_upstream_of_or_within IMP
IDA
(MGI:3040752|PMID:12634787) MGI PMID:12634787 MGI:3040752 NCBI chr 2:60,598,292...60,722,603
Ensembl chr 2:60,598,292...60,722,643
JBrowse link
G Kdr kinase insert domain protein receptor acts_upstream_of_or_within IMP (MGI:2181852|PMID:12053176) MGI PMID:12053176 MGI:2181852 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Lif leukemia inhibitory factor acts_upstream_of_or_within IGI (MGI:3640953|PMID:16691571) MGI PMID:16691571 MGI:3640953 NCBI chr11:4,257,568...4,272,514
Ensembl chr11:4,257,557...4,272,514
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 acts_upstream_of_or_within IMP (MGI:3703634|PMID:17121831) MGI PMID:17121831 MGI:3703634 NCBI chr 3:100,562,203...100,685,473
Ensembl chr 3:100,562,208...100,685,503
JBrowse link
G Man2a1 mannosidase 2, alpha 1 acts_upstream_of_or_within IGI (MGI:3652665|PMID:16754854) MGI PMID:16754854 MGI:3652665 NCBI chr17:64,600,688...64,755,110
Ensembl chr17:64,600,736...64,755,110
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 acts_upstream_of_or_within IMP (MGI:3796918|PMID:18324732) MGI PMID:18324732 MGI:3796918 NCBI chr17:24,897,506...24,936,977
Ensembl chr17:24,892,153...24,936,977
JBrowse link
G Mecp2 methyl CpG binding protein 2 ISO RGD PMID:21425435 RGD:8552971 NCBI chr  X:74,026,592...74,085,690
Ensembl chr  X:74,026,592...74,135,363
JBrowse link
G Meg3 maternally expressed 3 acts_upstream_of_or_within IMP (MGI:3841506|PMID:19264764) MGI PMID:19264764 MGI:3841506 NCBI chr12:109,540,996...109,571,729
Ensembl chr12:109,541,001...109,571,726
JBrowse link
G Mmp12 matrix metallopeptidase 12 acts_upstream_of_or_within IMP (MGI:3040752|PMID:12634787) MGI PMID:12634787 MGI:3040752 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Myocd myocardin acts_upstream_of_or_within IMP (MGI:4941650|PMID:21357509) MGI PMID:21357509 MGI:4941650 NCBI chr11:65,173,608...65,269,989
Ensembl chr11:65,176,561...65,269,989
JBrowse link
G Pdgfa platelet derived growth factor, alpha involved_in
acts_upstream_of_or_within
IMP (MGI:1098909|PMID:9374392)
(MGI:5543868|PMID:23938297)
(MGI:3622881|PMID:11803579)
UniProt
MGI
PMID:9374392 PMID:11803579 PMID:23938297 MGI:1098909 MGI:3622881 MGI:5543868 NCBI chr 5:138,976,014...139,000,792
Ensembl chr 5:138,976,014...138,997,370
JBrowse link
G Pdpn podoplanin acts_upstream_of_or_within IMP (MGI:3703126|PMID:16869965) MGI PMID:16869965 MGI:3703126 NCBI chr 4:143,267,409...143,299,564
Ensembl chr 4:143,267,431...143,299,564
JBrowse link
G Pgr progesterone receptor acts_upstream_of_or_within IMP (MGI:5576858|PMID:24190884) MGI PMID:24190884 MGI:5576858 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within IMP (MGI:5426441|PMID:22730381) MGI PMID:22730381 MGI:5426441 NCBI chr 6:11,907,725...12,100,156
Ensembl chr 6:11,907,809...12,081,205
JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic involved_in IMP (MGI:4438146|PMID:19465597) UniProt PMID:19465597 MGI:4438146 NCBI chr17:83,215,283...83,225,069
Ensembl chr17:83,215,292...83,225,070
JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within IMP (MGI:1346745|PMID:10518543) MGI PMID:10518543 MGI:1346745 NCBI chr 1:180,227,004...180,263,467
Ensembl chr 1:180,227,004...180,263,438
JBrowse link
G Pthlh parathyroid hormone-like peptide acts_upstream_of_or_within IMP (MGI:3042805|PMID:15162506) MGI PMID:15162506 MGI:3042805 NCBI chr 6:147,252,109...147,264,013
Ensembl chr 6:147,252,101...147,264,183
JBrowse link
G Rc3h2 ring finger and CCCH-type zinc finger domains 2 acts_upstream_of_or_within IMP (MGI:5486592|PMID:23583643) MGI PMID:23583643 MGI:5486592 NCBI chr 2:37,368,861...37,424,370
Ensembl chr 2:37,370,069...37,422,903
JBrowse link
G Selenon selenoprotein N acts_upstream_of_or_within IMP (MGI:5494499|PMID:23325319) MGI PMID:23325319 MGI:5494499 NCBI chr 4:134,537,892...134,552,166
Ensembl chr 4:134,537,892...134,552,166
JBrowse link
G Sftpd surfactant associated protein D involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr14:41,172,212...41,185,198
Ensembl chr14:41,172,214...41,185,149
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 acts_upstream_of_or_within IMP (MGI:5469541|PMID:23085521) MGI PMID:23085521 MGI:5469541 NCBI chr 3:50,364,936...50,499,087
Ensembl chr 3:49,892,526...50,443,614
JBrowse link
G Slfn4 schlafen 4 ISO RGD PMID:17911382 RGD:2304247 NCBI chr11:83,175,172...83,190,216
Ensembl chr11:83,175,186...83,190,216
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3, neutral acts_upstream_of_or_within IMP (MGI:5469952|PMID:22945695) MGI PMID:22945695 MGI:5469952 NCBI chr 8:106,252,548...106,337,965
Ensembl chr 8:106,252,548...106,337,988
JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 acts_upstream_of_or_within IDA (MGI:3795352|PMID:18374910) MGI PMID:18374910 MGI:3795352 NCBI chr 3:34,649,995...34,652,461
Ensembl chr 3:34,650,405...34,652,461
JBrowse link
G Stk40 serine/threonine kinase 40 acts_upstream_of_or_within IMP (MGI:5486391|PMID:23293024) MGI PMID:23293024 MGI:5486391 NCBI chr 4:126,103,942...126,141,029
Ensembl chr 4:126,103,957...126,141,029
JBrowse link
G Stra6 stimulated by retinoic acid gene 6 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:58,063,793...58,154,004
Ensembl chr 9:58,063,788...58,153,996
JBrowse link
G Tcf21 transcription factor 21 acts_upstream_of_or_within IMP (MGI:1347485|PMID:10572052) MGI PMID:10572052 MGI:1347485 NCBI chr10:22,817,263...22,820,143
Ensembl chr10:22,817,281...22,820,174
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within IDA (MGI:3040752|PMID:12634787) MGI PMID:12634787 MGI:3040752 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in IMP (MGI:77427|PMID:7493022) BHF-UCL PMID:7493022 MGI:77427 NCBI chr12:86,056,743...86,079,041
Ensembl chr12:86,056,745...86,079,041
JBrowse link
G Tmem38b transmembrane protein 38B acts_upstream_of_or_within IMP (MGI:3850579|PMID:19515693) MGI PMID:19515693 MGI:3850579 NCBI chr 4:53,825,988...53,862,019
Ensembl chr 4:53,826,045...53,862,019
JBrowse link
G Tmtc3 transmembrane and tetratricopeptide repeat containing 3 acts_upstream_of_or_within IMP (MGI:5300435|PMID:21956870) MGI PMID:21956870 MGI:5300435 NCBI chr10:100,443,902...100,487,365
Ensembl chr10:100,443,902...100,487,350
JBrowse link
G Tns3 tensin 3 acts_upstream_of_or_within IMP (MGI:3531231|PMID:15733665) MGI PMID:15733665 MGI:3531231 NCBI chr11:8,431,652...8,664,758
Ensembl chr11:8,431,652...8,664,681
JBrowse link
G Vegfa vascular endothelial growth factor A acts_upstream_of_or_within ISO MGI
RGD
PMID:16230500 GO_REF:0000096 MGI:4417868 RGD:1580552 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Wnt5a wingless-type MMTV integration site family, member 5A ISO RGD PMID:17911382 RGD:2304247 NCBI chr14:28,504,543...28,527,448
Ensembl chr14:28,504,750...28,527,448
JBrowse link
G Zfp157 zinc finger protein 157 acts_upstream_of_or_within IMP (MGI:5424261|PMID:22588720) MGI PMID:22588720 MGI:5424261 NCBI chr 5:138,441,458...138,460,900
Ensembl chr 5:138,441,468...138,460,694
JBrowse link
alveolar primary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stra6 stimulated by retinoic acid gene 6 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:58,063,793...58,154,004
Ensembl chr 9:58,063,788...58,153,996
JBrowse link
alveolar secondary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within IGI (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chr 5:33,721,724...33,737,068
Ensembl chr 5:33,721,674...33,737,068
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 acts_upstream_of_or_within IGI (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chr13:55,152,818...55,168,759
Ensembl chr13:55,152,640...55,168,759
JBrowse link
G Foxa1 forkhead box A1 acts_upstream_of_or_within IMP (MGI:3613241|PMID:16214823) MGI PMID:16214823 MGI:3613241 NCBI chr12:57,540,628...57,548,029
Ensembl chr12:57,540,628...57,546,916
JBrowse link
lung saccule development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl1 ASXL transcriptional regulator 1 acts_upstream_of_or_within IMP (MGI:5585348|PMID:24860998) MGI PMID:24860998 MGI:5585348 NCBI chr 2:153,345,830...153,404,007
Ensembl chr 2:153,345,829...153,404,007
JBrowse link
G Creb1 cAMP responsive element binding protein 1 acts_upstream_of_or_within IMP (MGI:4950818|PMID:21408140) MGI PMID:21408140 MGI:4950818 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Fgf10 fibroblast growth factor 10 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr13:118,714,699...118,792,573
Ensembl chr13:118,669,791...118,792,115
JBrowse link
G Gata6 GATA binding protein 6 acts_upstream_of_or_within IGI (MGI:3695537|PMID:17164424) MGI PMID:17164424 MGI:3695537 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within IMP (MGI:3584290|PMID:16049328) MGI PMID:16049328 MGI:3584290 NCBI chr19:5,740,900...5,758,536
Ensembl chr19:5,740,904...5,758,532
JBrowse link
G Nkx2-1 NK2 homeobox 1 acts_upstream_of_or_within IGI (MGI:3695537|PMID:17164424) MGI PMID:17164424 MGI:3695537 NCBI chr12:56,531,935...56,536,908
Ensembl chr12:56,531,958...56,536,908
JBrowse link
G Ptges3 prostaglandin E synthase 3 acts_upstream_of_or_within IMP (MGI:3714109|PMID:17438133) MGI PMID:17438133 MGI:3714109 NCBI chr10:128,058,982...128,077,254
Ensembl chr10:128,058,954...128,077,272
JBrowse link
G Sfta3-ps surfactant associated 3, pseudogene acts_upstream_of_or_within IMP (MGI:5578059|PMID:24939938) MGI PMID:24939938 MGI:5578059 NCBI chr12:56,490,428...56,529,420
Ensembl chr12:56,488,321...56,529,427
JBrowse link
positive regulation of lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:23962064 RGD:10395379 NCBI chr17:86,753,864...86,833,410
Ensembl chr17:86,753,700...86,833,410
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28596
    developmental process 7074
      anatomical structure development 6543
        lung alveolus development 70
          lung saccule development + 12
          negative regulation of lung alveolus development 0
          positive regulation of lung alveolus development 1
          regulation of lung alveolus development + 1
Path 2
Term Annotations click to browse term
  biological_process 28596
    developmental process 7074
      anatomical structure development 6543
        multicellular organism development 6004
          system development 5415
            animal organ development 4164
              respiratory tube development 271
                lung development 268
                  lung alveolus development 70
                    lung saccule development + 12
                    negative regulation of lung alveolus development 0
                    positive regulation of lung alveolus development 1
                    regulation of lung alveolus development + 1
paths to the root