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ONTOLOGY REPORT - ANNOTATIONS


Term:lung alveolus development
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Accession:GO:0048286 term browser browse the term
Definition:The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
Synonyms:exact_synonym: alveolarization;   alveologenesis


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lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA12 ATP binding cassette subfamily A member 12 involved_in
acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
IEA
ISO
(MGI:3807143|PMID:18632686)
(MGI:3829841|PMID:18957418)
Ensembl
MGI
PMID:18632686 PMID:18957418 GO_REF:0000107 MGI:3807143 MGI:3829841 NCBI chr 2:214,931,542...215,138,626
Ensembl chr 2:214,931,542...215,138,626
JBrowse link
G ACE angiotensin I converting enzyme ISO RGD PMID:22587910 RGD:6893470 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ADA adenosine deaminase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1861066|PMID:10899903) Ensembl
MGI
PMID:10899903 GO_REF:0000107 MGI:1861066 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
G ATP7A ATPase copper transporting alpha involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:54141|PMID:937819) UniProt
MGI
PMID:937819 GO_REF:0000024 MGI:54141 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G ATXN1 ataxin 1 acts_upstream_of_or_within ISO (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chr 6:16,299,112...16,761,490
Ensembl chr 6:16,299,112...16,761,491
JBrowse link
G ATXN1L ataxin 1 like involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5298126|PMID:22014525) Ensembl
MGI
PMID:22014525 GO_REF:0000107 MGI:5298126 NCBI chr16:71,845,976...71,857,328
Ensembl chr16:71,845,976...71,885,268
JBrowse link
G BMP4 bone morphogenetic protein 4 acts_upstream_of_or_within IDA (PMID:8674409) MGI PMID:8674409 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 2:202,376,310...202,567,751
Ensembl chr 2:202,376,327...202,567,751
JBrowse link
G CIC capicua transcriptional repressor acts_upstream_of_or_within ISO (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chr19:42,268,530...42,295,796
Ensembl chr19:42,268,537...42,295,797
JBrowse link
G DBN1 drebrin 1 ISO RGD PMID:15928322 RGD:10398812 NCBI chr 5:177,456,610...177,480,368
Ensembl chr 5:177,456,608...177,474,401
JBrowse link
G EDN2 endothelin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5514104|PMID:23676500) Ensembl
MGI
PMID:23676500 GO_REF:0000107 MGI:5514104 NCBI chr 1:41,478,775...41,484,699
Ensembl chr 1:41,478,775...41,484,683
JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:8,011,725...8,026,309
Ensembl chr 1:8,004,404...8,026,309
JBrowse link
G FGF10 fibroblast growth factor 10 acts_upstream_of_or_within ISO (MGI:3716020|PMID:17560563)
(MGI:3688953|PMID:16989802)
MGI PMID:16989802 PMID:17560563 MGI:3688953 MGI:3716020 NCBI chr 5:44,300,247...44,389,706
Ensembl chr 5:44,300,247...44,389,706
Ensembl chr 5:44,300,247...44,389,706
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:3688953|PMID:16989802) UniProt
MGI
PMID:16989802 GO_REF:0000024 MGI:3688953 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,334...121,598,458
Ensembl chr10:121,478,334...121,598,458
JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5582954|PMID:24733830) Ensembl
MGI
PMID:24733830 GO_REF:0000107 MGI:5582954 NCBI chr 5:180,601,506...180,650,298
Ensembl chr 5:180,601,506...180,649,624
JBrowse link
G FOXF1 forkhead box F1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2135612|PMID:11493558) Ensembl
MGI
PMID:11493558 GO_REF:0000107 MGI:2135612 NCBI chr16:86,510,527...86,515,422
Ensembl chr16:86,510,527...86,515,422
JBrowse link
G FOXP2 forkhead box P2 acts_upstream_of_or_within ISO (MGI:3710027|PMID:17428829) MGI PMID:17428829 MGI:3710027 NCBI chr 7:114,086,327...114,693,765
Ensembl chr 7:114,086,327...114,693,772
JBrowse link
G FZD1 frizzled class receptor 1 ISO RGD PMID:17911382 RGD:2304247 NCBI chr 7:91,264,433...91,271,326
Ensembl chr 7:91,264,433...91,271,326
JBrowse link
G GH1 growth hormone 1 ISO RGD PMID:18985281 RGD:2315627 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G HOPX HOP homeobox acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3709528|PMID:16510470) MGI
Ensembl
PMID:16510470 GO_REF:0000107 MGI:3709528 NCBI chr 4:56,647,992...56,681,866
Ensembl chr 4:56,647,988...56,681,899
JBrowse link
G HOXA5 homeobox A5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3606710|PMID:15295088), (MGI:3665532|PMID:17003488) Ensembl
MGI
PMID:15295088 PMID:17003488 GO_REF:0000107 MGI:3606710 MGI:3665532 NCBI chr 7:27,141,052...27,143,681
Ensembl chr 7:27,141,052...27,143,681
JBrowse link
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chr 2:128,265,480...128,318,868
Ensembl chr 2:128,236,716...128,318,868
JBrowse link
G IGF1 insulin like growth factor 1 acts_upstream_of_or_within ISO (MGI:3640953|PMID:16691571) MGI PMID:16691571 MGI:3640953 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:216,672,105...216,695,549
Ensembl chr 2:216,672,105...216,695,549
JBrowse link
G ITGB6 integrin subunit beta 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3040752|PMID:12634787) Ensembl
MGI
PMID:12634787 GO_REF:0000107 MGI:3040752 NCBI chr 2:160,099,671...160,200,272
Ensembl chr 2:160,099,667...160,200,313
JBrowse link
G KDR kinase insert domain receptor acts_upstream_of_or_within ISO (MGI:2181852|PMID:12053176) MGI PMID:12053176 MGI:2181852 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G LIF LIF interleukin 6 family cytokine involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3640953|PMID:16691571) Ensembl
MGI
PMID:16691571 GO_REF:0000107 MGI:3640953 NCBI chr22:30,240,453...30,257,487
Ensembl chr22:30,240,453...30,246,759
JBrowse link
G MAN1A2 mannosidase alpha class 1A member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3703634|PMID:17121831) Ensembl
MGI
PMID:17121831 GO_REF:0000107 MGI:3703634 NCBI chr 1:117,367,393...117,528,872
Ensembl chr 1:117,367,449...117,528,872
JBrowse link
G MAN2A1 mannosidase alpha class 2A member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3652665|PMID:16754854) Ensembl
MGI
PMID:16754854 GO_REF:0000107 MGI:3652665 NCBI chr 5:109,689,417...109,869,625
Ensembl chr 5:109,689,366...109,869,625
Ensembl chr 5:109,689,366...109,869,625
JBrowse link
G MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 acts_upstream_of_or_within ISO (MGI:3796918|PMID:18324732) MGI PMID:18324732 MGI:3796918 NCBI chr16:1,706,183...1,770,351
Ensembl chr16:1,706,183...1,770,351
Ensembl chr16:1,706,183...1,770,351
JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO RGD PMID:21425435 RGD:8552971 NCBI chr  X:154,021,573...154,097,717
Ensembl chr  X:154,021,573...154,137,103
JBrowse link
G MEG3 maternally expressed 3 acts_upstream_of_or_within ISO (MGI:3841506|PMID:19264764) MGI PMID:19264764 MGI:3841506 NCBI chr14:100,826,108...100,861,026
Ensembl chr14:100,779,410...100,861,031
JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3040752|PMID:12634787) Ensembl
MGI
PMID:12634787 GO_REF:0000107 MGI:3040752 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
JBrowse link
G MYOCD myocardin involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4941650|PMID:21357509) Ensembl
MGI
PMID:21357509 GO_REF:0000107 MGI:4941650 NCBI chr17:12,665,890...12,768,949
Ensembl chr17:12,665,890...12,768,949
JBrowse link
G PDGFA platelet derived growth factor subunit A involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:5543868|PMID:23938297)
(MGI:3622881|PMID:11803579)
UniProt
MGI
PMID:11803579 PMID:23938297 GO_REF:0000024 MGI:3622881 MGI:5543868 NCBI chr 7:497,245...520,668
Ensembl chr 7:497,258...520,296
JBrowse link
G PDPN podoplanin acts_upstream_of_or_within ISO (MGI:3703126|PMID:16869965) MGI PMID:16869965 MGI:3703126 NCBI chr 1:13,583,757...13,617,957
Ensembl chr 1:13,583,465...13,617,957
JBrowse link
G PGR progesterone receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5576858|PMID:24190884) Ensembl
MGI
PMID:24190884 GO_REF:0000107 MGI:5576858 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PHF14 PHD finger protein 14 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5426441|PMID:22730381) Ensembl
MGI
PMID:22730381 GO_REF:0000107 MGI:5426441 NCBI chr 7:10,973,872...11,169,618
Ensembl chr 7:10,973,336...11,169,623
Ensembl chr 7:10,973,336...11,169,623
JBrowse link
G PKDCC protein kinase domain containing, cytoplasmic involved_in ISS UniProt GO_REF:0000024 NCBI chr 2:42,048,021...42,058,517
Ensembl chr 2:42,048,021...42,058,517
JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (MGI:1346745|PMID:10518543) MGI PMID:10518543 MGI:1346745 NCBI chr 1:226,870,594...226,903,829
Ensembl chr 1:226,870,184...226,896,105
Ensembl chr 1:226,870,184...226,896,105
JBrowse link
G PTHLH parathyroid hormone like hormone acts_upstream_of_or_within ISO (MGI:3042805|PMID:15162506) MGI PMID:15162506 MGI:3042805 NCBI chr12:27,958,084...27,972,864
Ensembl chr12:27,958,084...27,972,733
JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5486592|PMID:23583643) Ensembl
MGI
PMID:23583643 GO_REF:0000107 MGI:5486592 NCBI chr 9:122,844,556...122,905,359
Ensembl chr 9:122,844,556...122,905,359
JBrowse link
G SELENON selenoprotein N acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5494499|PMID:23325319) MGI
Ensembl
PMID:23325319 GO_REF:0000107 MGI:5494499 NCBI chr 1:25,800,193...25,818,221
Ensembl chr 1:25,800,176...25,818,221
JBrowse link
G SFTPD surfactant protein D involved_in IMP (PMID:9751757) UniProt PMID:9751757 NCBI chr10:79,937,740...79,982,236
Ensembl chr10:79,937,740...79,982,614
Ensembl chr10:79,937,740...79,982,614
JBrowse link
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5469541|PMID:23085521) Ensembl
MGI
PMID:23085521 GO_REF:0000107 MGI:5469541 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SLFN12 schlafen family member 12 ISO RGD PMID:17911382 RGD:2304247 NCBI chr17:35,407,171...35,433,310
Ensembl chr17:35,411,060...35,433,283
Ensembl chr17:35,411,060...35,433,283
JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5469952|PMID:22945695) Ensembl
MGI
PMID:22945695 GO_REF:0000107 MGI:5469952 NCBI chr16:68,358,327...68,448,703
Ensembl chr16:68,358,327...68,448,508
JBrowse link
G SOX2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (MGI:3795352|PMID:18374910) MGI PMID:18374910 MGI:3795352 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
JBrowse link
G STK40 serine/threonine kinase 40 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5486391|PMID:23293024) Ensembl
MGI
PMID:23293024 GO_REF:0000107 MGI:5486391 NCBI chr 1:36,339,628...36,385,924
Ensembl chr 1:36,339,624...36,385,896
Ensembl chr 1:36,339,624...36,385,896
JBrowse link
G STRA6 signaling receptor and transporter of retinol STRA6 involved_in IMP (PMID:17273977) DFLAT PMID:17273977 NCBI chr15:74,179,466...74,212,267
Ensembl chr15:74,179,466...74,212,267
JBrowse link
G TCF21 transcription factor 21 involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:1347485|PMID:10572052) UniProt
MGI
PMID:10572052 GO_REF:0000024 MGI:1347485 NCBI chr 6:133,889,113...133,895,537
Ensembl chr 6:133,889,138...133,895,553
Ensembl chr 6:133,889,138...133,895,553
JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3040752|PMID:12634787) Ensembl
MGI
PMID:12634787 GO_REF:0000107 MGI:3040752 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB3 transforming growth factor beta 3 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
JBrowse link
G TMEM38B transmembrane protein 38B involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3850579|PMID:19515693) Ensembl
MGI
PMID:19515693 GO_REF:0000107 MGI:3850579 NCBI chr 9:105,694,541...105,776,629
Ensembl chr 9:105,694,541...105,776,629
JBrowse link
G TMTC3 transmembrane O-mannosyltransferase targeting cadherins 3 acts_upstream_of_or_within ISO (MGI:5300435|PMID:21956870) MGI PMID:21956870 MGI:5300435 NCBI chr12:88,142,307...88,199,887
Ensembl chr12:88,142,296...88,199,887
JBrowse link
G TNS3 tensin 3 acts_upstream_of_or_within ISO (MGI:3531231|PMID:15733665) MGI PMID:15733665 MGI:3531231 NCBI chr 7:47,275,154...47,582,553
Ensembl chr 7:47,275,154...47,582,558
JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:16230500 RGD:1580552 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G WNT5A Wnt family member 5A ISO RGD PMID:17911382 RGD:2304247 NCBI chr 3:55,465,715...55,505,261
Ensembl chr 3:55,465,715...55,490,539
JBrowse link
G ZNF157 zinc finger protein 157 acts_upstream_of_or_within ISO (MGI:5424261|PMID:22588720) MGI PMID:22588720 MGI:5424261 NCBI chr  X:47,370,578...47,414,498
Ensembl chr  X:47,370,583...47,414,305
Ensembl chr  X:47,370,583...47,414,305
JBrowse link
alveolar primary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STRA6 signaling receptor and transporter of retinol STRA6 involved_in IMP (PMID:17273977) DFLAT PMID:17273977 NCBI chr15:74,179,466...74,212,267
Ensembl chr15:74,179,466...74,212,267
JBrowse link
alveolar secondary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGFR3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chr 4:1,793,293...1,808,872
Ensembl chr 4:1,793,293...1,808,872
JBrowse link
G FGFR4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chr 5:177,086,915...177,098,144
Ensembl chr 5:177,086,905...177,098,144
JBrowse link
G FOXA1 forkhead box A1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3613241|PMID:16214823) Ensembl
MGI
PMID:16214823 GO_REF:0000107 MGI:3613241 NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059
JBrowse link
lung saccule development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASXL1 ASXL transcriptional regulator 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5585348|PMID:24860998) Ensembl
MGI
PMID:24860998 GO_REF:0000107 MGI:5585348 NCBI chr20:32,358,062...32,439,319
Ensembl chr20:32,358,330...32,439,319
JBrowse link
G CREB1 cAMP responsive element binding protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4950818|PMID:21408140) Ensembl
MGI
PMID:21408140 GO_REF:0000107 MGI:4950818 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G FGF10 fibroblast growth factor 10 involved_in IMP (PMID:17071719) UniProt PMID:17071719 NCBI chr 5:44,300,247...44,389,706
Ensembl chr 5:44,300,247...44,389,706
Ensembl chr 5:44,300,247...44,389,706
JBrowse link
G GATA6 GATA binding protein 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3695537|PMID:17164424) Ensembl
MGI
PMID:17164424 GO_REF:0000107 MGI:3695537 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
G LTBP3 latent transforming growth factor beta binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3584290|PMID:16049328) Ensembl
MGI
PMID:16049328 GO_REF:0000107 MGI:3584290 NCBI chr11:65,538,559...65,558,389
Ensembl chr11:65,538,805...65,558,930
Ensembl chr11:65,538,805...65,558,930
JBrowse link
G NKX2-1 NK2 homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3695537|PMID:17164424) Ensembl
MGI
PMID:17164424 GO_REF:0000107 MGI:3695537 NCBI chr14:36,516,397...36,520,232
Ensembl chr14:36,516,392...36,521,149
JBrowse link
G PTGES3 prostaglandin E synthase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3714109|PMID:17438133) Ensembl
MGI
PMID:17438133 GO_REF:0000107 MGI:3714109 NCBI chr12:56,663,349...56,689,575
Ensembl chr12:56,663,341...56,688,408
JBrowse link
positive regulation of lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:23962064 RGD:10395379 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18673
    developmental process 7498
      anatomical structure development 6921
        lung alveolus development 69
          lung saccule development + 11
          negative regulation of lung alveolus development 0
          positive regulation of lung alveolus development 1
          regulation of lung alveolus development + 1
Path 2
Term Annotations click to browse term
  biological_process 18673
    developmental process 7498
      anatomical structure development 6921
        multicellular organism development 6398
          system development 5803
            animal organ development 4450
              respiratory tube development 271
                lung development 267
                  lung alveolus development 69
                    lung saccule development + 11
                    negative regulation of lung alveolus development 0
                    positive regulation of lung alveolus development 1
                    regulation of lung alveolus development + 1
paths to the root