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ONTOLOGY REPORT - ANNOTATIONS


Term:lung alveolus development
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Accession:GO:0048286 term browser browse the term
Definition:The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
Synonyms:exact_synonym: alveolarization;   alveologenesis


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lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA12 ATP binding cassette subfamily A member 12 acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
ISO (MGI:3807143|PMID:18632686)
(MGI:3829841|PMID:18957418)
MGI PMID:18632686 PMID:18957418 MGI:3807143 MGI:3829841 NCBI chr2B:102,194,286...102,401,175
Ensembl chr2B:220,668,957...220,873,566
JBrowse link
G ACE angiotensin I converting enzyme ISO RGD PMID:22587910 RGD:6893470 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
JBrowse link
G ADA adenosine deaminase acts_upstream_of_or_within ISO (MGI:1861066|PMID:10899903) MGI PMID:10899903 MGI:1861066 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
JBrowse link
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (MGI:54141|PMID:937819) MGI PMID:937819 MGI:54141 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756
JBrowse link
G ATXN1 ataxin 1 acts_upstream_of_or_within ISO (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chr 6:16,155,049...16,952,827
Ensembl chr 6:16,526,563...16,548,566
JBrowse link
G ATXN1L ataxin 1 like acts_upstream_of_or_within ISO (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chr16:53,153,416...53,165,311 JBrowse link
G BMP4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (PMID:8674409) MGI PMID:8674409 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752
JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 involved_in ISO (MGI:3799581|PMID:18552156) BHF-UCL PMID:18552156 MGI:3799581 NCBI chr2B:89,631,622...89,823,438
Ensembl chr2B:207,780,741...207,961,072
JBrowse link
G CIC capicua transcriptional repressor acts_upstream_of_or_within ISO (MGI:5298126|PMID:22014525) MGI PMID:22014525 MGI:5298126 NCBI chr19:39,156,204...39,183,498
Ensembl chr19:47,751,520...47,774,699
JBrowse link
G DBN1 drebrin 1 ISO RGD PMID:15928322 RGD:10398812 NCBI chr 5:172,758,316...172,774,974
Ensembl chr 5:179,820,791...179,836,872
JBrowse link
G EDN2 endothelin 2 acts_upstream_of_or_within ISO (MGI:5514104|PMID:23676500) MGI PMID:23676500 MGI:5514104 NCBI chr 1:40,777,582...40,783,410
Ensembl chr 1:42,092,811...42,098,721
JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in ISO (MGI:4366137|PMID:19710174) UniProt PMID:19710174 MGI:4366137 NCBI chr 1:6,771,619...6,786,217
Ensembl chr 1:8,011,848...8,033,674
JBrowse link
G FGF10 fibroblast growth factor 10 acts_upstream_of_or_within ISO (MGI:3716020|PMID:17560563)
(MGI:3688953|PMID:16989802)
MGI PMID:16989802 PMID:17560563 MGI:3688953 MGI:3716020 NCBI chr 5:65,979,443...66,069,314
Ensembl chr 5:71,028,187...71,111,706
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO (MGI:3688953|PMID:16989802) MGI PMID:16989802 MGI:3688953 NCBI chr10:118,055,854...118,175,440
Ensembl chr10:121,469,735...121,588,815
JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 acts_upstream_of_or_within ISO (MGI:5582954|PMID:24733830) MGI PMID:24733830 MGI:5582954 NCBI chr 5:175,804,728...175,852,703
Ensembl chr 5:183,115,856...183,149,006
JBrowse link
G FOXF1 forkhead box F1 acts_upstream_of_or_within ISO (MGI:2135612|PMID:11493558) MGI PMID:11493558 MGI:2135612 NCBI chr16:67,183,416...67,188,211
Ensembl chr16:86,516,119...86,519,949
JBrowse link
G FOXP2 forkhead box P2 acts_upstream_of_or_within ISO (MGI:3710027|PMID:17428829) MGI PMID:17428829 MGI:3710027 NCBI chr 7:106,040,118...106,648,741
Ensembl chr 7:119,077,332...119,343,893
JBrowse link
G FZD1 frizzled class receptor 1 ISO RGD PMID:17911382 RGD:2304247 NCBI chr 7:83,269,906...83,277,608 JBrowse link
G HOPX HOP homeobox acts_upstream_of_or_within ISO (MGI:3709528|PMID:16510470) MGI PMID:16510470 MGI:3709528 NCBI chr 4:67,240,801...67,274,419
Ensembl chr 4:73,833,886...73,843,060
JBrowse link
G HOXA5 homeobox A5 acts_upstream_of_or_within ISO (MGI:3606710|PMID:15295088), (MGI:3665532|PMID:17003488) MGI PMID:15295088 PMID:17003488 MGI:3606710 MGI:3665532 NCBI chr 7:27,786,040...27,789,339
Ensembl chr 7:27,385,175...27,388,990
JBrowse link
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 acts_upstream_of_or_within ISO (MGI:3715036|PMID:17405882) MGI PMID:17405882 MGI:3715036 NCBI chr2B:31,949,260...32,002,848 JBrowse link
G IGF1 insulin like growth factor 1 acts_upstream_of_or_within ISO (MGI:3640953|PMID:16691571) MGI PMID:16691571 MGI:3640953 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177
JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 involved_in ISO (MGI:3039207|PMID:15010534) BHF-UCL PMID:15010534 MGI:3039207 NCBI chr2B:103,932,983...103,956,475
Ensembl chr2B:222,534,967...222,558,432
JBrowse link
G ITGB6 integrin subunit beta 6 acts_upstream_of_or_within ISO (MGI:3040752|PMID:12634787) MGI PMID:12634787 MGI:3040752 NCBI chr2B:47,386,913...47,496,491
Ensembl chr2B:164,764,251...164,867,426
JBrowse link
G KDR kinase insert domain receptor acts_upstream_of_or_within ISO (MGI:2181852|PMID:12053176) MGI PMID:12053176 MGI:2181852 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
JBrowse link
G LIF LIF interleukin 6 family cytokine acts_upstream_of_or_within ISO (MGI:3640953|PMID:16691571) MGI PMID:16691571 MGI:3640953 NCBI chr22:11,276,576...11,282,972
Ensembl chr22:29,078,862...29,095,608
JBrowse link
G LOC100971425 somatotropin ISO RGD PMID:18985281 RGD:2315627 NCBI chr17:58,010,848...58,013,421 JBrowse link
G MAN1A2 mannosidase alpha class 1A member 2 acts_upstream_of_or_within ISO (MGI:3703634|PMID:17121831) MGI PMID:17121831 MGI:3703634 NCBI chr 1:84,993,586...85,153,199
Ensembl chr 1:119,994,812...120,148,623
JBrowse link
G MAN2A1 mannosidase alpha class 2A member 1 acts_upstream_of_or_within ISO (MGI:3652665|PMID:16754854) MGI PMID:16754854 MGI:3652665 NCBI chr 5:105,034,104...105,219,011
Ensembl chr 5:110,841,349...111,025,187
JBrowse link
G MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 acts_upstream_of_or_within ISO (MGI:3796918|PMID:18324732) MGI PMID:18324732 MGI:3796918 NCBI chr16:327,995...392,691
Ensembl chr16:1,759,171...1,821,246
JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO RGD PMID:21425435 RGD:8552971 NCBI chr  X:143,571,864...143,647,192
Ensembl chr  X:153,465,204...153,527,854
JBrowse link
G MMP12 matrix metallopeptidase 12 acts_upstream_of_or_within ISO (MGI:3040752|PMID:12634787) MGI PMID:12634787 MGI:3040752 NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762
JBrowse link
G MYOCD myocardin acts_upstream_of_or_within ISO (MGI:4941650|PMID:21357509) MGI PMID:21357509 MGI:4941650 NCBI chr17:38,880,120...38,983,246
Ensembl chr17:43,584,259...43,681,659
JBrowse link
G PDGFA platelet derived growth factor subunit A acts_upstream_of_or_within
involved_in
ISO (MGI:3622881|PMID:11803579)
(MGI:5543868|PMID:23938297)
(MGI:1098909|PMID:9374392)
MGI
UniProt
PMID:9374392 PMID:11803579 PMID:23938297 MGI:1098909 MGI:3622881 MGI:5543868 NCBI chr 7:648,722...672,023 JBrowse link
G PDPN podoplanin acts_upstream_of_or_within ISO (MGI:3703126|PMID:16869965) MGI PMID:16869965 MGI:3703126 NCBI chr 1:12,728,569...12,759,781
Ensembl chr 1:13,728,233...13,759,584
JBrowse link
G PGR progesterone receptor acts_upstream_of_or_within ISO (MGI:5576858|PMID:24190884) MGI PMID:24190884 MGI:5576858 NCBI chr11:95,997,677...96,098,866 JBrowse link
G PHF14 PHD finger protein 14 acts_upstream_of_or_within ISO (MGI:5426441|PMID:22730381) MGI PMID:22730381 MGI:5426441 NCBI chr 7:11,608,934...11,822,039
Ensembl chr 7:10,972,503...11,169,377
JBrowse link
G PKDCC protein kinase domain containing, cytoplasmic involved_in ISO (MGI:4438146|PMID:19465597) UniProt PMID:19465597 MGI:4438146 NCBI chr2A:42,146,153...42,156,652 JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (MGI:1346745|PMID:10518543) MGI PMID:10518543 MGI:1346745 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295
JBrowse link
G PTHLH parathyroid hormone like hormone acts_upstream_of_or_within ISO (MGI:3042805|PMID:15162506) MGI PMID:15162506 MGI:3042805 NCBI chr12:58,341,361...58,355,804
Ensembl chr12:60,960,071...60,973,750
JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO (MGI:5486592|PMID:23583643) MGI PMID:23583643 MGI:5486592 NCBI chr 9:93,975,164...94,031,516
Ensembl chr 9:122,313,791...122,365,102
JBrowse link
G SELENON selenoprotein N acts_upstream_of_or_within ISO (MGI:5494499|PMID:23325319) MGI PMID:23325319 MGI:5494499 NCBI chr 1:25,058,907...25,076,817
Ensembl chr 1:26,127,125...26,141,745
JBrowse link
G SFTPD surfactant protein D involved_in ISO (PMID:9751757) UniProt PMID:9751757 NCBI chr10:76,275,147...76,318,952
Ensembl chr10:78,965,252...78,974,181
JBrowse link
G SLC7A11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO (MGI:5469541|PMID:23085521) MGI PMID:23085521 MGI:5469541 NCBI chr 4:130,529,677...130,601,396
Ensembl chr 4:141,849,343...141,959,849
JBrowse link
G SLFN12 schlafen family member 12 ISO RGD PMID:17911382 RGD:2304247 NCBI chr17:21,359,252...21,384,308
Ensembl chr17:21,652,566...21,676,326
JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO (MGI:5469952|PMID:22945695) MGI PMID:22945695 MGI:5469952 NCBI chr16:48,734,664...48,825,241
Ensembl chr16:68,131,905...68,142,871
JBrowse link
G SOX2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (MGI:3795352|PMID:18374910) MGI PMID:18374910 MGI:3795352 NCBI chr 3:178,744,881...178,747,392
Ensembl chr 3:186,922,705...186,923,662
JBrowse link
G STK40 serine/threonine kinase 40 acts_upstream_of_or_within ISO (MGI:5486391|PMID:23293024) MGI PMID:23293024 MGI:5486391 NCBI chr 1:35,607,231...35,653,443
Ensembl chr 1:36,775,581...36,821,654
JBrowse link
G STRA6 signaling receptor and transporter of retinol STRA6 involved_in ISO (PMID:17273977) DFLAT PMID:17273977 NCBI chr15:53,117,891...53,150,790
Ensembl chr15:72,741,482...72,770,876
JBrowse link
G TCF21 transcription factor 21 acts_upstream_of_or_within ISO (MGI:1347485|PMID:10572052) MGI PMID:10572052 MGI:1347485 NCBI chr 6:131,656,582...131,662,983
Ensembl chr 6:135,754,896...135,761,294
JBrowse link
G TGFB1 transforming growth factor beta 1 acts_upstream_of_or_within ISO (MGI:3040752|PMID:12634787) MGI PMID:12634787 MGI:3040752 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
JBrowse link
G TGFB3 transforming growth factor beta 3 involved_in ISO (MGI:77427|PMID:7493022) BHF-UCL PMID:7493022 MGI:77427 NCBI chr14:56,516,697...56,542,097
Ensembl chr14:75,359,505...75,382,412
JBrowse link
G TMEM38B transmembrane protein 38B acts_upstream_of_or_within ISO (MGI:3850579|PMID:19515693) MGI PMID:19515693 MGI:3850579 NCBI chr 9:76,854,177...76,938,334
Ensembl chr 9:104,980,935...105,128,988
JBrowse link
G TMTC3 transmembrane O-mannosyltransferase targeting cadherins 3 acts_upstream_of_or_within ISO (MGI:5300435|PMID:21956870) MGI PMID:21956870 MGI:5300435 NCBI chr12:85,683,455...85,741,118
Ensembl chr12:88,989,033...89,046,630
JBrowse link
G TNS3 tensin 3 acts_upstream_of_or_within ISO (MGI:3531231|PMID:15733665) MGI PMID:15733665 MGI:3531231 NCBI chr 7:47,915,668...48,223,267
Ensembl chr 7:48,025,720...48,221,437
JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:16230500 RGD:1580552 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
G WNT5A Wnt family member 5A ISO RGD PMID:17911382 RGD:2304247 NCBI chr 3:55,396,279...55,418,579
Ensembl chr 3:56,621,380...56,638,051
JBrowse link
G ZNF157 zinc finger protein 157 acts_upstream_of_or_within ISO (MGI:5424261|PMID:22588720) MGI PMID:22588720 MGI:5424261 NCBI chr  X:39,802,953...39,852,227
Ensembl chr  X:47,699,782...47,746,867
JBrowse link
alveolar primary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STRA6 signaling receptor and transporter of retinol STRA6 involved_in ISO (PMID:17273977) DFLAT PMID:17273977 NCBI chr15:53,117,891...53,150,790
Ensembl chr15:72,741,482...72,770,876
JBrowse link
alveolar secondary septum development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGFR3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chr 4:1,933,172...1,948,742
Ensembl chr 4:1,843,774...1,861,692
JBrowse link
G FGFR4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO (MGI:1309575|PMID:9716527) MGI PMID:9716527 MGI:1309575 NCBI chr 5:172,386,443...172,400,271
Ensembl chr 5:179,454,995...179,467,605
JBrowse link
G FOXA1 forkhead box A1 acts_upstream_of_or_within ISO (MGI:3613241|PMID:16214823) MGI PMID:16214823 MGI:3613241 NCBI chr14:18,347,284...18,352,705 JBrowse link
lung saccule development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASXL1 ASXL transcriptional regulator 1 acts_upstream_of_or_within ISO (MGI:5585348|PMID:24860998) MGI PMID:24860998 MGI:5585348 NCBI chr20:28,647,004...28,727,865
Ensembl chr20:29,774,582...29,850,453
JBrowse link
G CREB1 cAMP responsive element binding protein 1 acts_upstream_of_or_within ISO (MGI:4950818|PMID:21408140) MGI PMID:21408140 MGI:4950818 NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130
JBrowse link
G FGF10 fibroblast growth factor 10 involved_in ISO (PMID:17071719) UniProt PMID:17071719 NCBI chr 5:65,979,443...66,069,314
Ensembl chr 5:71,028,187...71,111,706
JBrowse link
G GATA6 GATA binding protein 6 acts_upstream_of_or_within ISO (MGI:3695537|PMID:17164424) MGI PMID:17164424 MGI:3695537 NCBI chr18:15,411,764...15,444,402 JBrowse link
G LTBP3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO (MGI:3584290|PMID:16049328) MGI PMID:16049328 MGI:3584290 NCBI chr11:60,897,897...60,917,690
Ensembl chr11:64,233,504...64,252,802
JBrowse link
G PTGES3 prostaglandin E synthase 3 acts_upstream_of_or_within ISO (MGI:3714109|PMID:17438133) MGI PMID:17438133 MGI:3714109 NCBI chr12:32,221,908...32,247,228
Ensembl chr12:32,476,835...32,503,181
JBrowse link
positive regulation of lung alveolus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:23962064 RGD:10395379 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12614
    developmental process 5888
      anatomical structure development 5491
        lung alveolus development 67
          lung saccule development + 10
          negative regulation of lung alveolus development 0
          positive regulation of lung alveolus development 1
          regulation of lung alveolus development + 1
Path 2
Term Annotations click to browse term
  biological_process 12614
    developmental process 5888
      anatomical structure development 5491
        multicellular organism development 5023
          system development 4723
            animal organ development 3649
              respiratory tube development 257
                lung development 254
                  lung alveolus development 67
                    lung saccule development + 10
                    negative regulation of lung alveolus development 0
                    positive regulation of lung alveolus development 1
                    regulation of lung alveolus development + 1
paths to the root