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ONTOLOGY REPORT - ANNOTATIONS


Term:response to pain
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Accession:GO:0048265 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
Synonyms:exact_synonym: physiological response to pain
 alt_id: GO:0048267



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response to pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 IMP RGD PMID:31746418 RGD:152995474 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Atat1 alpha tubulin acetyltransferase 1 involved_in IEA
ISO
GO_REF:0000107
MGI:5549959 (PMID:27976998)
Ensembl
RGD
PMID:27976998 GO_REF:0000107 NCBI chr20:2,844,595...2,857,809
Ensembl chr20:2,844,616...2,861,964
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856210 (PMID:11718712) RGD PMID:11718712 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B acts_upstream_of_or_within ISO (PMID:12074836) RGD PMID:12074836 NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E acts_upstream_of_or_within ISO (PMID:12074836) RGD PMID:12074836 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within ISO MGI:2148771 (PMID:10208559) RGD PMID:10208559 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO MGI:2677631 (PMID:29429934) RGD PMID:29429934 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027
JBrowse link
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO MGI:2153356 (PMID:24277578) RGD PMID:24277578 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Comt catechol-O-methyltransferase IMP RGD PMID:17084978 RGD:2289747 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Crh corticotropin releasing hormone IEP RGD PMID:21463663 RGD:5490545 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Dbh dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857556 (PMID:11805341)
Ensembl
RGD
PMID:11805341 GO_REF:0000107 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Ednrb endothelin receptor type B IMP RGD PMID:12847519 RGD:1581889 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in IDA PMID:17057711 UniProt PMID:17057711 RGD:8554553 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gja4 gap junction protein, alpha 4 IEP RGD PMID:11978404 RGD:728686 NCBI chr 5:139,633,324...139,635,857
Ensembl chr 5:139,633,287...139,635,925
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 acts_upstream_of_or_within ISO MGI:2179103 (PMID:11792319) RGD PMID:11792319 NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556
JBrowse link
G Mir154 microRNA 154 IEP RGD PMID:31746418 RGD:152995474 NCBI chr 6:128,752,947...128,753,030
Ensembl chr 6:128,752,947...128,753,030
JBrowse link
G Nmur2 neuromedin U receptor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3701426 (PMID:17030627)
Ensembl
RGD
PMID:17030627 GO_REF:0000107 NCBI chr10:40,166,223...40,182,078
Ensembl chr10:40,166,226...40,182,078
JBrowse link
G Prkcg protein kinase C, gamma involved_in ISO
ISS
(MGI:1097759|PMID:9323205)
GO_REF:0000024
RGD
UniProt
PMID:9323205 GO_REF:0000024 MGI:1097759 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Reln reelin involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
MGI:1856398 (PMID:16580148)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:16580148 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Ret ret proto-oncogene involved_in ISO (MGI:4441221|PMID:20237269) RGD PMID:20237269 MGI:4441221 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in ISO MGI:3604572|MGI:6392908|MGI:6415024|MGI:6415027 (PMID:17167076), (PMID:17363266), (PMID:27224030), (PMID:30557356) RGD PMID:17167076 PMID:17363266 PMID:27224030 PMID:30557356 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044
JBrowse link
G Slc6a2 solute carrier family 6 member 2 acts_upstream_of_or_within ISO (PMID:11805341) RGD PMID:11805341 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Tac1 tachykinin, precursor 1 acts_upstream_of_or_within ISO (PMID:11805341) RGD PMID:11805341 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 acts_upstream_of_or_within ISO (PMID:11805341) RGD PMID:11805341 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 acts_upstream_of_or_within ISO MGI:3624810 (PMID:16630838), (PMID:18272293), (PMID:18297068) RGD PMID:16630838 PMID:18272293 PMID:18297068 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 acts_upstream_of_or_within ISO MGI:1934023 (PMID:18272293), (PMID:18297068) RGD PMID:18272293 PMID:18297068 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Tspo translocator protein IEP RGD PMID:19555675 RGD:2317138 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Ucn urocortin IEP RGD PMID:21463663 RGD:5490545 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950
JBrowse link
behavioral response to acetic acid induced pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam11 ADAM metallopeptidase domain 11 involved_in ISO (MGI:3640265|PMID:16729981) RGD PMID:16729981 MGI:3640265 NCBI chr10:87,724,115...87,742,773
Ensembl chr10:87,724,234...87,741,562
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in IEA
ISO
GO_REF:0000107
MGI:3528983 (PMID:19931571)
Ensembl
RGD
PMID:19931571 GO_REF:0000107 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044
JBrowse link
behavioral response to formalin induced pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam11 ADAM metallopeptidase domain 11 involved_in ISO (MGI:3640265|PMID:16729981) RGD PMID:16729981 MGI:3640265 NCBI chr10:87,724,115...87,742,773
Ensembl chr10:87,724,234...87,741,562
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 acts_upstream_of_or_within ISO (PMID:24760869) RGD PMID:24760869 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G P2rx3 purinergic receptor P2X 3 IMP RGD PMID:24120766 RGD:10043614 NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in IEA
ISO
GO_REF:0000107
MGI:3528983 (PMID:19931571)
Ensembl
RGD
PMID:19931571 GO_REF:0000107 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 IMP RGD PMID:31550995 RGD:150429745 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
JBrowse link
behavioral response to pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in IEA
ISO
GO_REF:0000107
MGI:1914047|MGI:1928394 (PMID:31874168)
Ensembl
RGD
PMID:31874168 GO_REF:0000107 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:2180190 (PMID:16890369) RGD PMID:16890369 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E acts_upstream_of_or_within ISO MGI:2179732 (PMID:10801976) RGD PMID:10801976 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Capn2 calpain 2 IDA RGD PMID:25150005 RGD:13792585 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO MGI:1928394|MGI:87986 (PMID:31874168) RGD PMID:31874168 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:17550594 RGD:1626231 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Git2 GIT ArfGAP 2 acts_upstream_of_or_within ISO MGI:3762635 (PMID:23870131) RGD PMID:23870131 NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 IEP RGD PMID:25716866 RGD:401976466 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO MGI:2176347 (PMID:15673679) RGD PMID:15673679 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B acts_upstream_of_or_within ISO MGI:1928295 (PMID:11711849) RGD PMID:11711849 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP RGD PMID:16098671 RGD:6480679 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 acts_upstream_of_or_within ISO MGI:2679303 (PMID:14534243) RGD PMID:14534243 NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556
JBrowse link
G Lpar5 lysophosphatidic acid receptor 5 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:5431493 (PMID:22461625)
GO_Central
RGD
PMID:22461625 GO_REF:0000033 NCBI chr 4:157,870,493...157,883,979
Ensembl chr 4:157,881,796...157,882,950
JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
ISO
GO_REF:0000107
MGI:1914047|MGI:87986 (PMID:31874168)
Ensembl
RGD
PMID:31874168 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Osm oncostatin M acts_upstream_of_or_within ISO MGI:3574987 (PMID:14985435) RGD PMID:14985435 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G P2rx2 purinergic receptor P2X 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1097160|MGI:2687349 (PMID:15961431)
Ensembl
RGD
PMID:15961431 GO_REF:0000107 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891
JBrowse link
G P2rx3 purinergic receptor P2X 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1934019|MGI:2385840|MGI:2665170 (PMID:11069181), (PMID:11069182), (PMID:15961431)
Ensembl
RGD
PMID:11069181 PMID:11069182 PMID:15961431 GO_REF:0000107 NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178
JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in IMP PMID:12917686 ARUK-UCL PMID:12917686 RGD:13673840 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma treatment IDA RGD PMID:25919859 RGD:152025537 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pirt phosphoinositide-interacting regulator of transient receptor potential channels acts_upstream_of_or_within ISO MGI:3834636 (PMID:18455988) RGD PMID:18455988 NCBI chr10:51,613,202...51,628,108
Ensembl chr10:51,613,126...51,632,264
JBrowse link
G Runx1 RUNX family transcription factor 1 acts_upstream_of_or_within ISO (PMID:16446141) RGD PMID:16446141 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in ISO MGI:2180183 (PMID:24440715) RGD PMID:24440715 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in ISO MGI:3528983 (PMID:19931571) RGD PMID:19931571 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 involved_in IEA
ISO
GO_REF:0000107
MGI:5505523 (PMID:24440715)
Ensembl
RGD
PMID:24440715 GO_REF:0000107 NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3053097 (PMID:24440715)
MGI:3053098 (PMID:15314237)
Ensembl
RGD
PMID:15314237 PMID:24440715 GO_REF:0000107 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:18407414 RGD:2304276 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (MGI:5516179|PMID:22745497) RGD PMID:22745497 MGI:5516179 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thbs4 thrombospondin 4 involved_in IMP
ISO
IEA
PMID:22745497
(MGI:5516179|PMID:22745497)
GO_REF:0000107
RGD
Ensembl
PMID:22745497 PMID:22745497 GO_REF:0000107 MGI:5516179, RGD:8553360 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 acts_upstream_of_or_within ISO MGI:1934023 (PMID:17767493), (PMID:18272658), (PMID:18455988) RGD PMID:17767493 PMID:18272658 PMID:18455988 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Tspo translocator protein IMP RGD PMID:19555675 RGD:2317138 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Vwa1 von Willebrand factor A domain containing 1 acts_upstream_of_or_within ISO MGI:3809230 (PMID:19279005) RGD PMID:19279005 NCBI chr 5:166,377,451...166,382,784
Ensembl chr 5:166,377,455...166,382,637
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19872
    multicellular organismal process 8843
      multicellular organismal response to stress 135
        response to pain 53
          behavioral response to pain + 33
Path 2
Term Annotations click to browse term
  biological_process 19872
    response to stimulus 10557
      response to stress 4199
        multicellular organismal response to stress 135
          response to pain 53
            behavioral response to pain + 33
paths to the root