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ONTOLOGY REPORT - ANNOTATIONS

Term:response to pain
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Accession:GO:0048265 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
Synonyms:exact_synonym: physiological response to pain
 alt_id: GO:0048267


show annotations for term's descendants           Sort by:
response to pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 IMP RGD PMID:31746418 RGD:152995474 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240 		JBrowse link
G Atat1 alpha tubulin acetyltransferase 1 involved_in IEA
ISO 		GO_REF:0000107
MGI:5549959 (PMID:27976998) 		Ensembl
RGD		 PMID:27976998 GO_REF:0000107 NCBI chr20:2,849,399...2,862,614
Ensembl chr20:2,849,421...2,862,389 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856210 (PMID:11718712) RGD PMID:11718712 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B acts_upstream_of_or_within ISO (PMID:12074836) RGD PMID:12074836 NCBI chr 3:27,779,133...27,944,292
Ensembl chr 3:27,779,166...27,944,285 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E acts_upstream_of_or_within ISO (PMID:12074836) RGD PMID:12074836 NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983 		JBrowse link
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within ISO MGI:2148771 (PMID:10208559) RGD PMID:10208559 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO MGI:2677631 (PMID:29429934) RGD PMID:29429934 NCBI chr 4:75,109,358...77,366,258
Ensembl chr 4:75,109,858...77,366,258 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO
IEA 		MGI:2153356 (PMID:24277578)
GO_REF:0000107 		RGD
Ensembl		 PMID:24277578 GO_REF:0000107 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107 		JBrowse link
G Comt catechol-O-methyltransferase IMP RGD PMID:17084978 RGD:2289747 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533 		JBrowse link
G Crh corticotropin releasing hormone IEP RGD PMID:21463663 RGD:5490545 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Dbh dopamine beta-hydroxylase acts_upstream_of_or_within ISO
IEA 		MGI:1857556 (PMID:11805341)
GO_REF:0000107 		RGD
Ensembl		 PMID:11805341 GO_REF:0000107 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316 		JBrowse link
G Ednrb endothelin receptor type B IMP RGD PMID:12847519 RGD:1581889 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in IDA PMID:17057711 UniProt PMID:17057711 RGD:8554553 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412 		JBrowse link
G Gja4 gap junction protein, alpha 4 IEP RGD PMID:11978404 RGD:728686 NCBI chr 5:144,917,791...144,920,324
Ensembl chr 5:144,914,147...144,921,216 		JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 acts_upstream_of_or_within ISO MGI:2179103 (PMID:11792319) RGD PMID:11792319 NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:135,132,119...135,196,216 		JBrowse link
G Mir154 microRNA 154 IEP RGD PMID:31746418 RGD:152995474 NCBI chr 6:134,574,352...134,574,435
Ensembl chr 6:134,574,352...134,574,435 		JBrowse link
G Nmur2 neuromedin U receptor 2 acts_upstream_of_or_within ISO MGI:3701426 (PMID:17030627) RGD PMID:17030627 NCBI chr10:40,666,824...40,682,679
Ensembl chr10:40,645,101...40,682,679 		JBrowse link
G Prkcg protein kinase C, gamma involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:9323205) 		UniProt
Ensembl
RGD		 PMID:9323205 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814 		JBrowse link
G Reln reelin involved_in
acts_upstream_of_or_within 		ISS
ISO 		GO_REF:0000024
MGI:1856398 (PMID:16580148) 		UniProt
RGD		 PMID:16580148 GO_REF:0000024 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162 		JBrowse link
G Ret ret proto-oncogene involved_in ISO
IEA 		(PMID:20237269)
GO_REF:0000107 		RGD
Ensembl		 PMID:20237269 GO_REF:0000107 NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in ISO
IEA 		MGI:3604572|MGI:6392908|MGI:6415024|MGI:6415027 (PMID:17167076), (PMID:17363266), (PMID:27224030), (PMID:30557356)
GO_REF:0000107 		RGD
Ensembl		 PMID:17167076 PMID:17363266 PMID:27224030 PMID:30557356 GO_REF:0000107 NCBI chr 8:128,374,441...128,444,718
Ensembl chr 8:128,374,449...128,444,718 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 acts_upstream_of_or_within ISO
IEA 		(PMID:11805341)
GO_REF:0000107 		RGD
Ensembl		 PMID:11805341 GO_REF:0000107 NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 acts_upstream_of_or_within ISO
IEA 		(PMID:29337310)
GO_REF:0000107 		RGD
Ensembl		 PMID:29337310 GO_REF:0000107 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Tac1 tachykinin, precursor 1 acts_upstream_of_or_within ISO
IEA 		(PMID:11805341)
GO_REF:0000107 		RGD
Ensembl		 PMID:11805341 GO_REF:0000107 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Tacr1 tachykinin receptor 1 acts_upstream_of_or_within ISO
IEA 		(PMID:11805341)
GO_REF:0000107 		RGD
Ensembl		 PMID:11805341 GO_REF:0000107 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492 		JBrowse link
G Tmem45b transmembrane protein 45b involved_in ISS
ISO 		GO_REF:0000024
(PMID:36322717) 		UniProt
RGD		 PMID:36322717 GO_REF:0000024 NCBI chr 8:38,123,423...38,168,599
Ensembl chr 8:38,123,423...38,168,599 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 acts_upstream_of_or_within ISO
IEA 		MGI:3624810 (PMID:16630838), (PMID:18272293), (PMID:18297068)
GO_REF:0000107 		RGD
Ensembl		 PMID:16630838 PMID:18272293 PMID:18297068 GO_REF:0000107 NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 acts_upstream_of_or_within ISO MGI:1934023 (PMID:18272293), (PMID:18297068) RGD PMID:18272293 PMID:18297068 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
G Tspo translocator protein IEP RGD PMID:19555675 RGD:2317138 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460 		JBrowse link
G Ucn urocortin IEP RGD PMID:21463663 RGD:5490545 NCBI chr 6:30,958,086...30,958,916
Ensembl chr 6:30,957,383...30,959,422 		JBrowse link
behavioral response to acetic acid induced pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam11 ADAM metallopeptidase domain 11 involved_in ISO (PMID:16729981) RGD PMID:16729981 NCBI chr10:88,224,185...88,242,865
Ensembl chr10:88,224,347...88,242,864 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in IEA
ISO 		GO_REF:0000107
MGI:3528983 (PMID:19931571) 		Ensembl
RGD		 PMID:19931571 GO_REF:0000107 NCBI chr 8:128,374,441...128,444,718
Ensembl chr 8:128,374,449...128,444,718 		JBrowse link
behavioral response to formalin induced pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam11 ADAM metallopeptidase domain 11 involved_in ISO (PMID:16729981) RGD PMID:16729981 NCBI chr10:88,224,185...88,242,865
Ensembl chr10:88,224,347...88,242,864 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 acts_upstream_of_or_within ISO
IEA 		(PMID:24760869)
GO_REF:0000107 		RGD
Ensembl		 PMID:24760869 GO_REF:0000107 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787 		JBrowse link
G P2rx3 purinergic receptor P2X 3 IMP RGD PMID:24120766 RGD:10043614 NCBI chr 3:90,487,506...90,531,315
Ensembl chr 3:90,487,506...90,531,794 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in IEA
ISO 		GO_REF:0000107
MGI:3528983 (PMID:19931571) 		Ensembl
RGD		 PMID:19931571 GO_REF:0000107 NCBI chr 8:128,374,441...128,444,718
Ensembl chr 8:128,374,449...128,444,718 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 IMP RGD PMID:31550995 RGD:150429745 NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:71,553,189...71,701,377 		JBrowse link
behavioral response to pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in IEA
ISO 		GO_REF:0000107
MGI:1914047|MGI:1928394 (PMID:31874168) 		Ensembl
RGD		 PMID:31874168 GO_REF:0000107 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:2180190 (PMID:16890369) RGD PMID:16890369 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E acts_upstream_of_or_within ISO MGI:2179732 (PMID:10801976) RGD PMID:10801976 NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983 		JBrowse link
G Capn2 calpain 2 IDA RGD PMID:25150005 RGD:13792585 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625 		JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO MGI:1928394|MGI:87986 (PMID:31874168) RGD PMID:31874168 NCBI chr 4:75,109,358...77,366,258
Ensembl chr 4:75,109,858...77,366,258 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:17550594 RGD:1626231 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466 		JBrowse link
G Git2 GIT ArfGAP 2 acts_upstream_of_or_within ISO MGI:3762635 (PMID:23870131) RGD PMID:23870131 NCBI chr12:47,490,350...47,531,232
Ensembl chr12:47,490,369...47,533,250 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 IEP RGD PMID:25716866 RGD:401976466 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO MGI:2176347 (PMID:15673679) RGD PMID:15673679 NCBI chr11:40,655,974...41,056,966
Ensembl chr11:40,655,975...41,056,517 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B acts_upstream_of_or_within ISO MGI:1928295 (PMID:11711849) RGD PMID:11711849 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP RGD PMID:16098671 RGD:6480679 NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:243,049,081...243,173,230 		JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 acts_upstream_of_or_within ISO MGI:2679303 (PMID:14534243) RGD PMID:14534243 NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:135,132,119...135,196,216 		JBrowse link
G Lpar5 lysophosphatidic acid receptor 5 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:5431493 (PMID:22461625) 		GO_Central
RGD		 PMID:22461625 GO_REF:0000033 NCBI chr 4:159,556,735...159,570,216
Ensembl chr 4:159,554,805...159,571,894 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
ISO 		GO_REF:0000107
MGI:1914047|MGI:87986 (PMID:31874168) 		Ensembl
RGD		 PMID:31874168 GO_REF:0000107 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Osm oncostatin M acts_upstream_of_or_within ISO MGI:3574987 (PMID:14985435) RGD PMID:14985435 NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827 		JBrowse link
G P2rx2 purinergic receptor P2X 2 acts_upstream_of_or_within ISO
IEA 		MGI:1097160|MGI:2687349 (PMID:15961431)
GO_REF:0000107 		RGD
Ensembl		 PMID:15961431 GO_REF:0000107 NCBI chr12:51,999,107...52,002,627
Ensembl chr12:51,999,372...52,002,627 		JBrowse link
G P2rx3 purinergic receptor P2X 3 acts_upstream_of_or_within ISO MGI:1934019|MGI:2385840|MGI:2665170 (PMID:11069181), (PMID:11069182), (PMID:15961431) RGD PMID:11069181 PMID:11069182 PMID:15961431 NCBI chr 3:90,487,506...90,531,315
Ensembl chr 3:90,487,506...90,531,794 		JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in IMP PMID:12917686 ARUK-UCL PMID:12917686 RGD:13673840 NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma treatment IDA RGD PMID:25919859 RGD:152025537 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509 		JBrowse link
G Pirt phosphoinositide-interacting regulator of transient receptor potential channels acts_upstream_of_or_within ISO
IEA 		MGI:3834636 (PMID:18455988)
GO_REF:0000107 		RGD
Ensembl		 PMID:18455988 GO_REF:0000107 NCBI chr10:51,613,202...51,628,108
Ensembl chr10:52,111,959...52,131,422 		JBrowse link
G Runx1 RUNX family transcription factor 1 acts_upstream_of_or_within ISO (PMID:16446141) RGD PMID:16446141 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in ISO MGI:2180183 (PMID:24440715) RGD PMID:24440715 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:128,228,424...128,340,298 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in ISO
IEA 		MGI:3528983 (PMID:19931571)
GO_REF:0000107 		RGD
Ensembl		 PMID:19931571 GO_REF:0000107 NCBI chr 8:128,374,441...128,444,718
Ensembl chr 8:128,374,449...128,444,718 		JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 involved_in IEA
ISO 		GO_REF:0000107
MGI:5505523 (PMID:24440715) 		Ensembl
RGD		 PMID:24440715 GO_REF:0000107 NCBI chr 3:70,554,496...70,666,198
Ensembl chr 3:70,556,224...70,666,198 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:3053098 (PMID:15314237)
GO_REF:0000107
MGI:3053097 (PMID:24440715) 		RGD
Ensembl		 PMID:15314237 PMID:24440715 GO_REF:0000107 NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:71,553,189...71,701,377 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:18407414 RGD:2304276 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492 		JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:22745497) RGD PMID:22745497 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402 		JBrowse link
G Thbs4 thrombospondin 4 involved_in IMP
IEA
ISO 		PMID:22745497
GO_REF:0000117
(PMID:22745497)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:22745497 PMID:22745497 GO_REF:0000107 GO_REF:0000117, RGD:8553360 NCBI chr 2:25,718,219...25,760,345
Ensembl chr 2:25,718,219...25,761,369 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 acts_upstream_of_or_within ISO MGI:1934023 (PMID:17767493), (PMID:18272658), (PMID:18455988) RGD PMID:17767493 PMID:18272658 PMID:18455988 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
G Tspo translocator protein IMP RGD PMID:19555675 RGD:2317138 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460 		JBrowse link
G Vwa1 von Willebrand factor A domain containing 1 acts_upstream_of_or_within ISO
IEA 		MGI:3809230 (PMID:19279005)
GO_REF:0000107 		RGD
Ensembl		 PMID:19279005 GO_REF:0000107 NCBI chr 5:171,659,694...171,664,880
Ensembl chr 5:171,659,698...171,664,880 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    multicellular organismal process 9161
      multicellular organismal response to stress 143
        response to pain 55
          behavioral response to pain + 33
Path 2
Term Annotations click to browse term
  biological_process 20668
    response to stimulus 11201
      response to stress 4461
        multicellular organismal response to stress 143
          response to pain 55
            behavioral response to pain + 33
paths to the root