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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of receptor-mediated endocytosis
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Accession:GO:0048261 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: down regulation of receptor mediated endocytosis;   downregulation of receptor mediated endocytosis
 narrow_synonym: inhibition of receptor mediated endocytosis


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negative regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoc1 apolipoprotein C1 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chrNW_004936706:1,519,248...1,520,102 JBrowse link
G Apoc2 apolipoprotein C2 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chrNW_004936706:1,531,219...1,531,921 JBrowse link
G Apoc3 apolipoprotein C3 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chrNW_004936542:2,106,927...2,108,412 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:10436022) BHF-UCL PMID:10436022 NCBI chrNW_004936498:13,785,638...13,885,931 JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 ISO (MGI:3620385|PMID:16533754) MGI PMID:16533754 MGI:3620385 NCBI chrNW_004936543:7,405,070...7,447,940 JBrowse link
negative regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neu3 neuraminidase 3 involved_in ISO (PMID:26251452) UniProt PMID:26251452 NCBI chrNW_004936498:3,897,511...3,915,013 JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 ISO RGD PMID:15066995 RGD:13504745 NCBI chrNW_004936483:18,051,023...18,176,514 JBrowse link
G Syt11 synaptotagmin 11 ISO PMID:26589353 ParkinsonsUK-UCL PMID:26589353 RGD:11079192 NCBI chrNW_004936580:5,123,196...5,142,976 JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chrNW_004936819:530,833...534,185 JBrowse link
G Unc119 unc-119 lipid binding chaperone ISO (MGI:5559669|PMID:19781630) UniProt PMID:19781630 MGI:5559669 NCBI chrNW_004936538:4,772,236...4,778,149 JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chrNW_004936641:3,779,024...3,802,883 JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chrNW_004936819:530,833...534,185 JBrowse link
negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO PMID:21810484
(PMID:21810484)
(MGI:5306885|PMID:21810484)
ARUK-UCL PMID:21810484 MGI:5306885 RGD:14697730 NCBI chrNW_004936669:922,978...941,996 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing acts_upstream_of ISO (PMID:11222466) BHF-UCL PMID:11222466 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G App amyloid beta precursor protein NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Itgav integrin subunit alpha V acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chrNW_004936506:10,750,116...10,839,018 JBrowse link
G Itgb3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chrNW_004936541:2,822,789...2,871,069 JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chrNW_004936522:6,271,339...6,300,202 JBrowse link
G Psen1 presenilin 1 NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chrNW_004936488:2,464,623...2,528,807 JBrowse link
negative regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd13a ankyrin repeat domain 13A involved_in ISO (PMID:22298428) UniProt PMID:22298428 NCBI chrNW_004936769:1,581,517...1,617,696 JBrowse link
G Ankrd13b ankyrin repeat domain 13B involved_in ISO (PMID:22298428) UniProt PMID:22298428 NCBI chrNW_004936538:5,700,063...5,724,335 JBrowse link
G Ankrd13d ankyrin repeat domain 13D involved_in ISO (PMID:22298428) UniProt PMID:22298428 NCBI chrNW_004936599:2,423,095...2,434,534 JBrowse link
G Atxn2 ataxin 2 involved_in ISO (PMID:18602463) UniProt PMID:18602463 NCBI chrNW_004936558:4,127,477...4,188,307 JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 involved_in ISO PMID:11526121 UniProt PMID:11526121 RGD:8554437 NCBI chrNW_004936595:487,918...513,843 JBrowse link
G Fmr1 FMRP translational regulator 1 ISO RGD PMID:17881561 RGD:12050150 NCBI chrNW_004936513:1,290,038...1,327,850 JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO (PMID:23386614) ARUK-UCL PMID:23386614 NCBI chrNW_004936477:20,234,582...20,250,756 JBrowse link
G Lrrtm1 leucine rich repeat transmembrane neuronal 1 ISO (MGI:5515239|PMID:23931994) MGI PMID:23931994 MGI:5515239 NCBI chrNW_004936556:5,915,265...5,934,004 JBrowse link
G Lrrtm2 leucine rich repeat transmembrane neuronal 2 ISO (MGI:5515239|PMID:23931994) MGI PMID:23931994 MGI:5515239 NCBI chrNW_004936531:7,968,111...7,973,823 JBrowse link
G Mtmr2 myotubularin related protein 2 ISO PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chrNW_004936700:1,790,592...1,873,019 JBrowse link
G Rin3 Ras and Rab interactor 3 acts_upstream_of_or_within ISO (PMID:23185384) ARUK-UCL PMID:23185384 NCBI chrNW_004936733:683,309...765,897 JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:25893292) UniProt PMID:25893292 NCBI chrNW_004936496:14,331,971...14,347,123 JBrowse link
G Wdr54 WD repeat domain 54 involved_in ISO (PMID:30458214) UniProt PMID:30458214 NCBI chrNW_004936556:646,312...649,961 JBrowse link
negative regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chrNW_004936669:922,978...941,996 JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chrNW_004936522:6,271,339...6,300,202 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12053
    negative regulation of biological process 4673
      negative regulation of transport 480
        negative regulation of endocytosis 47
          negative regulation of receptor-mediated endocytosis 31
            negative regulation of clathrin-dependent endocytosis 5
            negative regulation of low-density lipoprotein receptor activity 7
            negative regulation of receptor internalization + 15
            negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
Path 2
Term Annotations click to browse term
  biological_process 12053
    localization 4806
      establishment of localization 3442
        transport 3278
          vesicle-mediated transport 1127
            endocytosis 409
              receptor-mediated endocytosis 229
                regulation of receptor-mediated endocytosis 124
                  negative regulation of receptor-mediated endocytosis 31
                    negative regulation of clathrin-dependent endocytosis 5
                    negative regulation of low-density lipoprotein receptor activity 7
                    negative regulation of receptor internalization + 15
                    negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
paths to the root