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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of receptor-mediated endocytosis
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Accession:GO:0048261 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: down regulation of receptor mediated endocytosis;   downregulation of receptor mediated endocytosis
 narrow_synonym: inhibition of receptor mediated endocytosis

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negative regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoc1 apolipoprotein C1 involved_in ISO (PMID:1917954) RGD PMID:1917954 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921 		JBrowse link
G Apoc2 apolipoprotein C2 involved_in ISO (PMID:1917954) RGD PMID:1917954 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136 		JBrowse link
G Apoc3 apolipoprotein C3 involved_in ISO (PMID:1917954) RGD PMID:1917954 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
IEA		 (PMID:10436022)
GO_REF:0000107		 RGD
Ensembl		 PMID:10436022 GO_REF:0000107 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425 		JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (MGI:3620385|PMID:16533754) RGD PMID:16533754 MGI:3620385 NCBI chr12:29,960,132...30,004,727
Ensembl chr12:29,961,120...29,988,959 		JBrowse link
negative regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neu3 neuraminidase 3 involved_in ISO
IEA		 (PMID:26251452)
GO_REF:0000107		 RGD
Ensembl		 PMID:26251452 GO_REF:0000107 NCBI chr 1:164,803,574...164,814,777
Ensembl chr 1:164,803,574...164,814,651 		JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 IMP RGD PMID:15066995 RGD:13504745 NCBI chr 1:144,069,641...144,200,402
Ensembl chr 1:144,069,638...144,200,397 		JBrowse link
G Syt11 synaptotagmin 11 involved_in IMP PMID:26589353 ParkinsonsUK-UCL PMID:26589353, PMID:26589353 RGD:11079192, RGD:11079192 NCBI chr 2:188,112,301...188,138,180
Ensembl chr 2:188,112,286...188,138,177 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:18,723,313...18,726,732
Ensembl chr  X:18,723,341...18,726,732 		JBrowse link
G Unc119 unc-119 lipid binding chaperone involved_in ISS
ISO
IBA		 GO_REF:0000024
(MGI:5559669|PMID:19781630)
PMID:21873635		 UniProt
RGD		 PMID:19781630, PMID:21873635, PMID:21873635 GO_REF:0000024 MGI:5559669, RGD:13792537, RGD:13792537 NCBI chr10:65,606,919...65,612,324
Ensembl chr10:65,606,898...65,612,324 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) RGD PMID:17689978 NCBI chr19:52,086,325...52,112,633
Ensembl chr19:52,086,325...52,112,629 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:18,723,313...18,726,732
Ensembl chr  X:18,723,341...18,726,732 		JBrowse link
negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO
IDA		 (PMID:21810484)
(MGI:5306885|PMID:21810484)		 RGD PMID:21810484, PMID:21810484, PMID:21810484 MGI:5306885, RGD:14697730, RGD:14697730 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing acts_upstream_of ISO
IEA		 (PMID:11222466)
GO_REF:0000107		 RGD
Ensembl		 PMID:11222466 GO_REF:0000107 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G App amyloid beta precursor protein NOT
NOT|involved_in		 ISO UniProtKB:P35951|UniProtKB:P49768 (PMID:20005821) RGD PMID:20005821 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Itgav integrin subunit alpha V acts_upstream_of_or_within ISO
IEA		 (PMID:15215180)
GO_REF:0000107		 RGD
Ensembl		 PMID:15215180 GO_REF:0000107 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411 		JBrowse link
G Itgb3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) RGD PMID:15215180 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) RGD PMID:22848640 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726 		JBrowse link
G Psen1 presenilin 1 NOT
NOT|involved_in		 ISO UniProtKB:P05067|UniProtKB:P35951 (PMID:20005821) RGD PMID:20005821 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798 		JBrowse link
negative regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd13a ankyrin repeat domain 13a involved_in ISO (PMID:22298428) RGD PMID:22298428 NCBI chr12:47,558,587...47,588,486
Ensembl chr12:47,558,590...47,588,335 		JBrowse link
G Ankrd13b ankyrin repeat domain 13B involved_in ISO (PMID:22298428) RGD PMID:22298428 NCBI chr10:62,674,416...62,691,949
Ensembl chr10:62,674,561...62,690,845 		JBrowse link
G Ankrd13d ankyrin repeat domain 13D involved_in ISO (PMID:22298428) RGD PMID:22298428 NCBI chr 1:219,520,316...219,532,718
Ensembl chr 1:219,520,075...219,532,609 		JBrowse link
G Atxn2 ataxin 2 involved_in ISO (PMID:18602463) RGD PMID:18602463 NCBI chr12:40,264,601...40,335,637
Ensembl chr12:40,266,662...40,332,612 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 involved_in IDA PMID:11526121 UniProt PMID:11526121, PMID:11526121 RGD:8554437, RGD:8554437 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599 		JBrowse link
G Fmr1 FMRP translational regulator 1 IMP RGD PMID:17881561 RGD:12050150 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO
IBA		 ComplexPortal:CPX-1134|UniProtKB:P04925 (PMID:23386614)
PMID:21873635		 RGD PMID:23386614, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr14:80,911,281...80,923,290
Ensembl chr14:80,911,270...80,924,831 		JBrowse link
G LRRTM1 leucine rich repeat transmembrane neuronal 1 acts_upstream_of_or_within ISO MGI:2389174 (MGI:5515239|PMID:23931994) RGD PMID:23931994 MGI:5515239 NCBI chr 4:108,300,927...108,316,373
Ensembl chr 4:108,301,129...108,316,373 		JBrowse link
G Lrrtm2 leucine rich repeat transmembrane neuronal 2 acts_upstream_of_or_within ISO MGI:2389173 (MGI:5515239|PMID:23931994) RGD PMID:23931994 MGI:5515239 NCBI chr18:28,012,877...28,017,925
Ensembl chr18:28,012,877...28,017,925 		JBrowse link
G Mtmr2 myotubularin related protein 2 involved_in IMP PMID:20410104 BHF-UCL PMID:20410104, PMID:20410104 RGD:8553482, RGD:8553482 NCBI chr 8:12,283,471...12,334,014
Ensembl chr 8:12,284,528...12,333,316 		JBrowse link
G Rin3 Ras and Rab interactor 3 acts_upstream_of_or_within ISO
IEA		 (PMID:23185384)
GO_REF:0000107		 RGD
Ensembl		 PMID:23185384 GO_REF:0000107 NCBI chr 6:126,170,672...126,279,682
Ensembl chr 6:126,170,720...126,279,682 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO
ISS		 (PMID:25893292)
GO_REF:0000024		 RGD
UniProt		 PMID:25893292 GO_REF:0000024 NCBI chr 5:19,471,664...19,498,499
Ensembl chr 5:19,471,664...19,498,485 		JBrowse link
G Wdr54 WD repeat domain 54 involved_in ISO (PMID:30458214) RGD PMID:30458214 NCBI chr 4:114,847,722...114,871,989
Ensembl chr 4:114,850,815...114,853,868
Ensembl chr 4:114,850,815...114,853,868 		JBrowse link
negative regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) RGD PMID:21810484 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) RGD PMID:22848640 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20082
    negative regulation of biological process 5713
      negative regulation of transport 527
        negative regulation of endocytosis 50
          negative regulation of receptor-mediated endocytosis 31
            negative regulation of clathrin-dependent endocytosis 5
            negative regulation of low-density lipoprotein receptor activity 7
            negative regulation of receptor internalization + 15
            negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
Path 2
Term Annotations click to browse term
  biological_process 20082
    localization 6506
      establishment of localization 4918
        transport 4755
          vesicle-mediated transport 1686
            endocytosis 699
              receptor-mediated endocytosis 260
                regulation of receptor-mediated endocytosis 127
                  negative regulation of receptor-mediated endocytosis 31
                    negative regulation of clathrin-dependent endocytosis 5
                    negative regulation of low-density lipoprotein receptor activity 7
                    negative regulation of receptor internalization + 15
                    negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
paths to the root