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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of receptor-mediated endocytosis
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Accession:GO:0048261 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: down regulation of receptor mediated endocytosis;   downregulation of receptor mediated endocytosis
 narrow_synonym: inhibition of receptor mediated endocytosis

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negative regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOC2 apolipoprotein C2 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chr 6:51,404,219...51,406,302 JBrowse link
G APOC3 apolipoprotein C3 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chr 9:44,211,171...44,213,538 JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:19,835,934...19,947,239
Ensembl chr 9:19,835,938...20,104,632 		JBrowse link
G RABGEF1 RAB guanine nucleotide exchange factor 1 involved_in IEA
ISO		 (MGI:3620385|PMID:16533754) Ensembl
MGI		 PMID:16533754 GO_REF:0000107 MGI:3620385 NCBI chr 3:16,308,112...16,376,604
Ensembl chr 3:16,308,112...16,376,587 		JBrowse link
negative regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEU3 neuraminidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:9,315,263...9,333,878
Ensembl chr 9:9,315,301...9,334,918 		JBrowse link
G SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3 ISO RGD PMID:15066995 RGD:13504745 NCBI chr 7:51,381,091...51,514,253
Ensembl chr 7:51,377,618...51,540,296 		JBrowse link
G SYT11 synaptotagmin 11 involved_in ISO PMID:26589353 ParkinsonsUK-UCL PMID:26589353 RGD:11079192 NCBI chr 4:94,139,345...94,163,091
Ensembl chr 4:94,139,347...94,163,050 		JBrowse link
G UBQLN2 ubiquilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:48,948,062...48,951,392
Ensembl chr  X:48,948,389...48,950,263 		JBrowse link
G UNC119 unc-119 lipid binding chaperone involved_in IBA
ISO		 (PMID:21873635)
(MGI:5559669|PMID:19781630)		 GO_Central
UniProt		 PMID:19781630 PMID:21873635 MGI:5559669 NCBI chr12:44,801,265...44,807,334
Ensembl chr12:44,801,268...44,807,299 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chr 6:4,598,752...4,641,450 JBrowse link
G UBQLN2 ubiquilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:48,948,062...48,951,392
Ensembl chr  X:48,948,389...48,950,263 		JBrowse link
negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO PMID:21810484
(PMID:21810484)
(MGI:5306885|PMID:21810484)		 ARUK-UCL PMID:21810484 MGI:5306885 RGD:14697730
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in
acts_upstream_of		 IEA
ISO		 (PMID:11222466) Ensembl
BHF-UCL		 PMID:11222466 GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648 		JBrowse link
G APP amyloid beta precursor protein NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,434,869...189,716,057 		JBrowse link
G ITGAV integrin subunit alpha V involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15215180) Ensembl
BHF-UCL		 PMID:15215180 GO_REF:0000107 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,840 		JBrowse link
G ITGB3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,505...16,752,292 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:157,388,370...157,409,620
Ensembl chr 6:157,388,372...157,409,604 		JBrowse link
G PSEN1 presenilin 1 NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr 7:96,478,179...96,567,884
Ensembl chr 7:96,478,181...96,569,132 		JBrowse link
negative regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD13A ankyrin repeat domain 13A involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:40,954,345...40,995,882
Ensembl chr14:40,954,345...40,990,422 		JBrowse link
G ANKRD13B ankyrin repeat domain 13B involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:45,787,661...45,806,003
Ensembl chr12:45,787,179...45,806,000 		JBrowse link
G ANKRD13D ankyrin repeat domain 13D involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:5,194,010...5,207,057
Ensembl chr 2:5,185,490...5,206,993 		JBrowse link
G ATXN2 ataxin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:32,656,537...32,772,082
Ensembl chr14:32,656,558...32,771,813 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 involved_in ISO PMID:11526121 UniProt PMID:11526121 RGD:8554437 NCBI chr12:52,550,138...52,574,021
Ensembl chr12:52,550,141...52,575,156 		JBrowse link
G FMR1 FMRP translational regulator 1 ISO RGD PMID:17881561 RGD:12050150 NCBI chr  X:120,361,232...120,400,282
Ensembl chr  X:120,361,229...120,399,835 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:2,129,492...2,145,632
Ensembl chr 8:2,125,405...2,145,647 		JBrowse link
G LRRTM1 leucine rich repeat transmembrane neuronal 1 ISO (MGI:5515239|PMID:23931994) MGI PMID:23931994 MGI:5515239 NCBI chr 3:63,585,784...63,590,368
Ensembl chr 3:63,587,499...63,590,407 		JBrowse link
G LRRTM2 leucine rich repeat transmembrane neuronal 2 involved_in IEA
ISO		 (MGI:5515239|PMID:23931994) Ensembl
MGI		 PMID:23931994 GO_REF:0000107 MGI:5515239 NCBI chr 2:140,803,624...140,810,013
Ensembl chr 2:140,803,120...140,809,495 		JBrowse link
G MTMR2 myotubularin related protein 2 involved_in ISO PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 9:27,864,335...27,974,448
Ensembl chr 9:27,854,491...27,974,423 		JBrowse link
G RIN3 Ras and Rab interactor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23185384) Ensembl
ARUK-UCL		 PMID:23185384 GO_REF:0000107 NCBI chr 7:114,035,137...114,166,548
Ensembl chr 7:114,035,353...114,166,543 		JBrowse link
G SDCBP syndecan binding protein involved_in ISO (PMID:25893292) UniProt PMID:25893292 NCBI chr 4:74,295,941...74,357,720
Ensembl chr 4:74,295,922...74,341,085 		JBrowse link
G WDR54 WD repeat domain 54 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:68,614,019...68,618,433
Ensembl chr 3:68,614,019...68,622,598 		JBrowse link
negative regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) ARUK-UCL PMID:21810484
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:157,388,370...157,409,620
Ensembl chr 6:157,388,372...157,409,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16537
    negative regulation of biological process 5346
      negative regulation of transport 509
        negative regulation of endocytosis 48
          negative regulation of receptor-mediated endocytosis 30
            negative regulation of clathrin-dependent endocytosis 5
            negative regulation of low-density lipoprotein receptor activity 7
            negative regulation of receptor internalization + 15
            negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
Path 2
Term Annotations click to browse term
  biological_process 16537
    localization 5935
      establishment of localization 4425
        transport 4263
          vesicle-mediated transport 1452
            endocytosis 538
              receptor-mediated endocytosis 256
                regulation of receptor-mediated endocytosis 127
                  negative regulation of receptor-mediated endocytosis 30
                    negative regulation of clathrin-dependent endocytosis 5
                    negative regulation of low-density lipoprotein receptor activity 7
                    negative regulation of receptor internalization + 15
                    negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
paths to the root