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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of receptor-mediated endocytosis
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Accession:GO:0048261 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: down regulation of receptor mediated endocytosis;   downregulation of receptor mediated endocytosis
 narrow_synonym: inhibition of receptor mediated endocytosis


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negative regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOC1 apolipoprotein C1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:110,520,177...110,522,563
Ensembl chr 1:110,520,198...110,631,412 		JBrowse link
G APOC2 apolipoprotein C2 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chr 1:110,504,806...110,506,986
Ensembl chr 1:110,504,815...110,506,961 		JBrowse link
G APOC3 apolipoprotein C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:16,744,423...16,746,992
Ensembl chr 5:16,744,423...16,746,992 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616 		JBrowse link
G RABGEF1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO (PMID:16533754) MGI PMID:16533754 NCBI chr 6:1,064,694...1,159,906
Ensembl chr 6:1,064,655...1,179,547 		JBrowse link
negative regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEU3 neuraminidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:23,456,424...23,484,872 JBrowse link
G SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3 ISO RGD PMID:15066995 RGD:13504745 NCBI chr 3:55,287,460...55,340,736
Ensembl chr 3:55,287,460...55,340,571 		JBrowse link
G SYT11 synaptotagmin 11 involved_in ISO PMID:26589353 ParkinsonsUK-UCL PMID:26589353 RGD:11079192 NCBI chr 7:41,910,102...41,929,020
Ensembl chr 7:41,912,920...41,929,617 		JBrowse link
G UBQLN2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:47,860,923...47,864,282 JBrowse link
G UNC119 unc-119 lipid binding chaperone involved_in ISS
IEA
IBA		 UniProt
TreeGrafter
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:42,754,575...42,760,337
Ensembl chr 9:42,754,887...42,760,482 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:68,313,699...68,342,253
Ensembl chr 5:68,314,000...68,378,311 		JBrowse link
G UBQLN2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:47,860,923...47,864,282 JBrowse link
negative regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD13A ankyrin repeat domain 13A involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:17,135,500...17,168,003
Ensembl chr26:17,137,297...17,167,932 		JBrowse link
G ANKRD13B ankyrin repeat domain 13B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:43,696,334...43,713,888
Ensembl chr 9:43,696,398...43,714,912 		JBrowse link
G ANKRD13D ankyrin repeat domain 13D involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:50,135,779...50,145,721
Ensembl chr18:50,135,792...50,145,846 		JBrowse link
G ANXA2 annexin A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:25,176,845...25,210,244
Ensembl chr30:25,115,842...25,218,281 		JBrowse link
G ATXN2 ataxin 2 involved_in ISO (PMID:18602463) UniProt PMID:18602463 NCBI chr26:9,073,667...9,188,429
Ensembl chr26:9,073,809...9,188,414 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 involved_in ISO PMID:11526121 UniProt PMID:11526121 RGD:8554437 NCBI chr 5:32,165,399...32,175,600
Ensembl chr 5:32,163,594...32,188,126 		JBrowse link
G FMR1 Fragile X messenger ribonucleoprotein 1 ISO RGD PMID:17881561 RGD:12050150 NCBI chr  X:116,249,079...116,287,008
Ensembl chr  X:116,249,142...116,321,439 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:60,840,804...60,852,821
Ensembl chr 3:60,840,882...60,901,258 		JBrowse link
G LRRTM1 leucine rich repeat transmembrane neuronal 1 acts_upstream_of_or_within ISO (PMID:23931994) MGI PMID:23931994 NCBI chr17:43,833,906...43,842,911
Ensembl chr17:43,834,562...43,836,130 		JBrowse link
G LRRTM2 leucine rich repeat transmembrane neuronal 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23931994) Ensembl
MGI		 PMID:23931994 GO_REF:0000107 NCBI chr11:26,392,642...26,397,018
Ensembl chr11:26,392,734...26,396,223 		JBrowse link
G MIR199-1 microRNA mir-199-1 involved_in ISO (PMID:26163491) BHF-UCL PMID:26163491 NCBI chr20:50,410,924...50,410,984
Ensembl chr20:50,410,913...50,410,994 		JBrowse link
G MIR199-2 microRNA mir-199-2 involved_in ISO (PMID:26163491) BHF-UCL PMID:26163491 NCBI chr 7:26,812,766...26,812,824
Ensembl chr 7:26,812,735...26,812,838 		JBrowse link
G MTMR2 myotubularin related protein 2 involved_in ISO PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr21:5,194,772...5,316,441
Ensembl chr21:5,194,604...5,315,375 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:18799458) ComplexPortal PMID:18799458 NCBI chr 5:54,197,211...54,210,724 JBrowse link
G RIN3 Ras and Rab interactor 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23185384) ARUK-UCL
Ensembl		 PMID:23185384 GO_REF:0000107 NCBI chr 8:1,733,051...1,804,138
Ensembl chr 8:1,700,161...1,803,950 		JBrowse link
G SDCBP syndecan binding protein involved_in ISO (PMID:25893292) UniProt PMID:25893292 NCBI chr29:9,331,876...9,370,489 JBrowse link
G WDR54 WD repeat domain 54 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:48,700,432...48,734,250
Ensembl chr17:48,700,431...48,704,344 		JBrowse link
negative regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857 		JBrowse link
G MIR17 microRNA mir-17 involved_in ISO (PMID:23285084) ARUK-UCL PMID:23285084 NCBI chr22:42,478,013...42,478,071
Ensembl chr22:42,478,000...42,478,083 		JBrowse link
G MIR185 microRNA mir-185 acts_upstream_of ISO (PMID:24296663) BHF-UCL PMID:24296663 NCBI chr26:29,296,014...29,296,069
Ensembl chr26:29,296,004...29,296,079 		JBrowse link
G MIR27B microRNA mir-27b involved_in ISO (PMID:26520906) ARUK-UCL PMID:26520906 NCBI chr 1:71,678,117...71,678,179
Ensembl chr 1:71,678,105...71,678,191 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr 5:54,197,211...54,210,724 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17878
    negative regulation of biological process 5711
      negative regulation of transport 531
        negative regulation of endocytosis 78
          negative regulation of receptor-mediated endocytosis 32
            negative regulation of clathrin-dependent endocytosis 5
            negative regulation of low-density lipoprotein receptor activity 0
            negative regulation of receptor internalization + 19
            negative regulation of receptor-mediated endocytosis involved in cholesterol transport 5
Path 2
Term Annotations click to browse term
  biological_process 17878
    localization 5577
      establishment of localization 4868
        transport 4542
          vesicle-mediated transport 1646
            regulation of vesicle-mediated transport 647
              regulation of endocytosis 358
                regulation of receptor-mediated endocytosis 143
                  negative regulation of receptor-mediated endocytosis 32
                    negative regulation of clathrin-dependent endocytosis 5
                    negative regulation of low-density lipoprotein receptor activity 0
                    negative regulation of receptor internalization + 19
                    negative regulation of receptor-mediated endocytosis involved in cholesterol transport 5
paths to the root