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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of receptor-mediated endocytosis
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Accession:GO:0048261 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: down regulation of receptor mediated endocytosis;   downregulation of receptor mediated endocytosis
 narrow_synonym: inhibition of receptor mediated endocytosis

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negative regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOC1 apolipoprotein C1 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chr 1:110,520,177...110,522,563
Ensembl chr 1:110,520,198...110,631,412 		JBrowse link
G APOC2 apolipoprotein C2 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chr 1:110,504,806...110,506,986
Ensembl chr 1:110,504,815...110,506,961 		JBrowse link
G APOC3 apolipoprotein C3 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chr 5:16,744,423...16,746,992
Ensembl chr 5:16,744,423...16,746,992 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616 		JBrowse link
G RABGEF1 RAB guanine nucleotide exchange factor 1 ISO (MGI:3620385|PMID:16533754) MGI PMID:16533754 MGI:3620385 NCBI chr 6:1,064,694...1,159,906
Ensembl chr 6:1,064,655...1,179,547 		JBrowse link
negative regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEU3 neuraminidase 3 involved_in ISO (PMID:26251452) UniProt PMID:26251452 NCBI chr21:23,456,424...23,484,872 JBrowse link
G SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3 ISO RGD PMID:15066995 RGD:13504745 NCBI chr 3:55,287,460...55,340,736
Ensembl chr 3:55,287,460...55,340,571 		JBrowse link
G SYT11 synaptotagmin 11 ISO PMID:26589353 ParkinsonsUK-UCL PMID:26589353 RGD:11079192 NCBI chr 7:41,910,102...41,929,020
Ensembl chr 7:41,912,920...41,929,617 		JBrowse link
G UBQLN2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:47,860,923...47,864,282 JBrowse link
G UNC119 unc-119 lipid binding chaperone involved_in ISS
ISO
IBA		 (MGI:5559669|PMID:19781630)
(PMID:21873635)		 UniProt
UniProt
GO_Central		 PMID:19781630 PMID:21873635 GO_REF:0000024 MGI:5559669 NCBI chr 9:42,754,575...42,760,337
Ensembl chr 9:42,754,887...42,760,482 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chr 5:68,313,699...68,342,253
Ensembl chr 5:68,314,000...68,378,311 		JBrowse link
G UBQLN2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:47,860,923...47,864,282 JBrowse link
negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO PMID:21810484
(PMID:21810484)
(MGI:5306885|PMID:21810484)		 ARUK-UCL PMID:21810484 MGI:5306885 RGD:14697730 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing acts_upstream_of ISO (PMID:11222466) BHF-UCL PMID:11222466 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844 		JBrowse link
G APP amyloid beta precursor protein NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337 		JBrowse link
G ITGAV integrin subunit alpha V involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15215180) Ensembl
BHF-UCL		 PMID:15215180 GO_REF:0000107 NCBI chr36:28,815,215...28,890,569
Ensembl chr36:28,804,013...28,887,430 		JBrowse link
G ITGB3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr 5:54,197,211...54,210,724 JBrowse link
G PSEN1 presenilin 1 NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532 		JBrowse link
negative regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD13A ankyrin repeat domain 13A involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:17,135,500...17,168,003
Ensembl chr26:17,137,297...17,167,932 		JBrowse link
G ANKRD13B ankyrin repeat domain 13B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:43,696,334...43,713,888
Ensembl chr 9:43,696,398...43,714,912 		JBrowse link
G ANKRD13D ankyrin repeat domain 13D involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:50,135,779...50,145,721
Ensembl chr18:50,135,792...50,145,846 		JBrowse link
G ATXN2 ataxin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:9,073,667...9,188,429
Ensembl chr26:9,073,809...9,188,414 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 involved_in ISO PMID:11526121 UniProt PMID:11526121 RGD:8554437 NCBI chr 5:32,165,399...32,175,600
Ensembl chr 5:32,163,594...32,188,126 		JBrowse link
G FMR1 FMRP translational regulator 1 ISO RGD PMID:17881561 RGD:12050150 NCBI chr  X:116,249,079...116,287,008
Ensembl chr  X:116,249,142...116,321,439 		JBrowse link
G LOC482977 syndecan binding protein involved_in ISO (PMID:25893292) UniProt PMID:25893292 NCBI chr29:9,331,876...9,370,489 JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:60,840,804...60,852,821
Ensembl chr 3:60,840,882...60,901,258 		JBrowse link
G LRRTM1 leucine rich repeat transmembrane neuronal 1 involved_in IEA
ISO		 (MGI:5515239|PMID:23931994) Ensembl
MGI		 PMID:23931994 GO_REF:0000107 MGI:5515239 NCBI chr17:43,833,906...43,842,911
Ensembl chr17:43,834,562...43,836,130 		JBrowse link
G LRRTM2 leucine rich repeat transmembrane neuronal 2 involved_in IEA
ISO		 (MGI:5515239|PMID:23931994) Ensembl
MGI		 PMID:23931994 GO_REF:0000107 MGI:5515239 NCBI chr11:26,392,642...26,397,018
Ensembl chr11:26,392,734...26,396,223 		JBrowse link
G MTMR2 myotubularin related protein 2 ISO PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr21:5,194,772...5,316,441
Ensembl chr21:5,194,604...5,315,375 		JBrowse link
G RIN3 Ras and Rab interactor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23185384) Ensembl
ARUK-UCL		 PMID:23185384 GO_REF:0000107 NCBI chr 8:1,733,051...1,804,138
Ensembl chr 8:1,700,161...1,803,950 		JBrowse link
G WDR54 WD repeat domain 54 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:48,700,432...48,734,250
Ensembl chr17:48,700,431...48,704,344 		JBrowse link
negative regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr 5:54,197,211...54,210,724 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16149
    negative regulation of biological process 5419
      negative regulation of transport 511
        negative regulation of endocytosis 49
          negative regulation of receptor-mediated endocytosis 31
            negative regulation of clathrin-dependent endocytosis 5
            negative regulation of low-density lipoprotein receptor activity 7
            negative regulation of receptor internalization + 15
            negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
Path 2
Term Annotations click to browse term
  biological_process 16149
    localization 6015
      establishment of localization 4479
        transport 4317
          vesicle-mediated transport 1470
            endocytosis 543
              receptor-mediated endocytosis 259
                regulation of receptor-mediated endocytosis 127
                  negative regulation of receptor-mediated endocytosis 31
                    negative regulation of clathrin-dependent endocytosis 5
                    negative regulation of low-density lipoprotein receptor activity 7
                    negative regulation of receptor internalization + 15
                    negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
paths to the root