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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of receptor-mediated endocytosis
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Accession:GO:0048261 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: down regulation of receptor mediated endocytosis;   downregulation of receptor mediated endocytosis
 narrow_synonym: inhibition of receptor mediated endocytosis


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negative regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOC1 apolipoprotein C1 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chr19:41,862,168...41,878,231 JBrowse link
G APOC2 apolipoprotein C2 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chr19:41,892,954...41,896,461 JBrowse link
G APOC3 apolipoprotein C3 involved_in ISO (PMID:1917954) BHF-UCL PMID:1917954 NCBI chr11:111,667,816...111,670,861
Ensembl chr11:115,600,416...115,603,460
JBrowse link
G LOC100993573 rab5 GDP/GTP exchange factor ISO (MGI:3620385|PMID:16533754) MGI PMID:16533754 MGI:3620385 NCBI chr 7:59,268,053...59,344,555
Ensembl chr 7:73,775,002...73,850,446
JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:10436022) BHF-UCL PMID:10436022 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684
JBrowse link
negative regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEU3 neuraminidase 3 involved_in ISO (PMID:26251452) UniProt PMID:26251452 NCBI chr11:70,047,878...70,070,303
Ensembl chr11:73,353,332...73,373,270
JBrowse link
G SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3 ISO RGD PMID:15066995 RGD:13504745 NCBI chr15:61,988,584...62,153,543
Ensembl chr15:81,337,529...81,501,770
JBrowse link
G SYT11 synaptotagmin 11 involved_in ISO PMID:26589353 ParkinsonsUK-UCL PMID:26589353 RGD:11079192 NCBI chr 1:131,193,999...131,218,752
Ensembl chr 1:135,026,032...135,046,943
JBrowse link
G UBQLN2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:48,829,844...48,835,040
Ensembl chr  X:56,981,985...56,983,859
JBrowse link
G UNC119 unc-119 lipid binding chaperone ISO (MGI:5559669|PMID:19781630) UniProt PMID:19781630 MGI:5559669 NCBI chr17:28,223,428...28,229,361 JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chr16:64,636,198...64,670,019
Ensembl chr16:83,983,626...84,013,436
JBrowse link
G UBQLN2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:48,829,844...48,835,040
Ensembl chr  X:56,981,985...56,983,859
JBrowse link
negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO PMID:21810484
(MGI:5306885|PMID:21810484)
(PMID:21810484)
ARUK-UCL PMID:21810484 MGI:5306885 RGD:14697730 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing acts_upstream_of ISO (PMID:11222466) BHF-UCL PMID:11222466 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G APP amyloid beta precursor protein NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
JBrowse link
G ITGAV integrin subunit alpha V acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028
JBrowse link
G ITGB3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) BHF-UCL PMID:15215180 NCBI chr17:10,134,450...10,194,596 JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr 1:54,323,036...54,355,397
Ensembl chr 1:55,911,016...55,936,456
JBrowse link
G PSEN1 presenilin 1 NOT|involved_in ISO (PMID:20005821) ARUK-UCL PMID:20005821 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876
JBrowse link
negative regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD13A ankyrin repeat domain 13A involved_in ISO (PMID:22298428) UniProt PMID:22298428 NCBI chr12:107,575,427...107,615,706
Ensembl chr12:110,979,786...111,007,899
JBrowse link
G ANKRD13B ankyrin repeat domain 13B involved_in ISO (PMID:22298428) UniProt PMID:22298428 NCBI chr17:27,159,796...27,181,528
Ensembl chr17:27,676,809...27,684,253
JBrowse link
G ANKRD13D ankyrin repeat domain 13D involved_in ISO (PMID:22298428) UniProt PMID:22298428 NCBI chr11:62,647,609...62,660,766
Ensembl chr11:65,959,474...65,974,345
JBrowse link
G ATXN2 ataxin 2 involved_in ISO (PMID:18602463) UniProt PMID:18602463 NCBI chr12:109,024,620...109,174,135
Ensembl chr12:112,419,337...112,566,360
JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 involved_in ISO PMID:11526121 UniProt PMID:11526121 RGD:8554437 NCBI chr17:7,219,911...7,247,509
Ensembl chr17:7,207,483...7,235,985
JBrowse link
G FMR1 FMRP translational regulator 1 ISO RGD PMID:17881561 RGD:12050150 NCBI chr  X:136,937,889...136,976,828
Ensembl chr  X:147,365,748...147,405,321
JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 involved_in ISO (PMID:23386614) ARUK-UCL PMID:23386614 NCBI chr 4:3,663,649...3,683,450
Ensembl chr 4:3,646,179...3,666,098
JBrowse link
G LRRTM1 leucine rich repeat transmembrane neuronal 1 ISO (MGI:5515239|PMID:23931994) MGI PMID:23931994 MGI:5515239 NCBI chr2A:80,376,582...80,392,899
Ensembl chr2A:81,953,891...81,955,459
JBrowse link
G LRRTM2 leucine rich repeat transmembrane neuronal 2 ISO (MGI:5515239|PMID:23931994) MGI PMID:23931994 MGI:5515239 NCBI chr 5:134,247,933...134,254,188 JBrowse link
G MTMR2 myotubularin related protein 2 involved_in ISO PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr11:90,839,577...90,929,731
Ensembl chr11:94,367,038...94,457,138
JBrowse link
G RIN3 Ras and Rab interactor 3 acts_upstream_of_or_within ISO (PMID:23185384) ARUK-UCL PMID:23185384 NCBI chr14:73,148,000...73,322,798
Ensembl chr14:92,488,770...92,662,415
JBrowse link
G SDCBP syndecan binding protein involved_in ISO (PMID:25893292) UniProt PMID:25893292 NCBI chr 8:54,992,627...55,022,560
Ensembl chr 8:56,643,962...56,673,833
JBrowse link
G WDR54 WD repeat domain 54 involved_in ISO (PMID:30458214) UniProt PMID:30458214 NCBI chr2A:74,488,345...74,492,392
Ensembl chr2A:75,994,394...75,998,385
JBrowse link
negative regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776
JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr 1:54,323,036...54,355,397
Ensembl chr 1:55,911,016...55,936,456
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12618
    negative regulation of biological process 4862
      negative regulation of transport 500
        negative regulation of endocytosis 49
          negative regulation of receptor-mediated endocytosis 31
            negative regulation of clathrin-dependent endocytosis 5
            negative regulation of low-density lipoprotein receptor activity 7
            negative regulation of receptor internalization + 15
            negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
Path 2
Term Annotations click to browse term
  biological_process 12618
    localization 4966
      establishment of localization 3545
        transport 3381
          vesicle-mediated transport 1156
            endocytosis 426
              receptor-mediated endocytosis 237
                regulation of receptor-mediated endocytosis 125
                  negative regulation of receptor-mediated endocytosis 31
                    negative regulation of clathrin-dependent endocytosis 5
                    negative regulation of low-density lipoprotein receptor activity 7
                    negative regulation of receptor internalization + 15
                    negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
paths to the root