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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of receptor-mediated endocytosis
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Accession:GO:0048261 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: down regulation of receptor mediated endocytosis;   downregulation of receptor mediated endocytosis
 narrow_synonym: inhibition of receptor mediated endocytosis



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negative regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoc1 apolipoprotein C1 involved_in ISO (PMID:1917954) RGD PMID:1917954 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
JBrowse link
G Apoc2 apolipoprotein C2 involved_in ISO (PMID:1917954) RGD PMID:1917954 NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476
JBrowse link
G Apoc3 apolipoprotein C3 involved_in ISO
IEA
(PMID:1917954)
GO_REF:0000107
RGD
Ensembl
PMID:1917954 GO_REF:0000107 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
IEA
(PMID:10436022)
GO_REF:0000107
RGD
Ensembl
PMID:10436022 GO_REF:0000107 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (MGI:3620385|PMID:16533754) RGD PMID:16533754 MGI:3620385 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744
JBrowse link
negative regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neu3 neuraminidase 3 involved_in ISO (PMID:26251452) RGD PMID:26251452 NCBI chr 1:154,137,732...154,148,879
Ensembl chr 1:154,050,855...154,148,813
JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 IMP RGD PMID:15066995 RGD:13504745 NCBI chr 1:136,124,502...136,255,669
Ensembl chr 1:136,124,499...136,255,584
JBrowse link
G Syt11 synaptotagmin 11 involved_in IMP PMID:26589353 ParkinsonsUK-UCL PMID:26589353 RGD:11079192 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:17,853,086...17,856,505
Ensembl chr  X:17,853,114...17,856,505
JBrowse link
G Unc119 unc-119 lipid binding chaperone involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:5559669|PMID:19781630)
PMID:21873635
UniProt
RGD
PMID:19781630 PMID:21873635 GO_REF:0000024 MGI:5559669, RGD:13792537 NCBI chr10:63,237,862...63,243,339
Ensembl chr10:63,237,903...63,243,339
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) RGD PMID:17689978 NCBI chr19:47,501,351...47,527,722
Ensembl chr19:47,501,302...47,527,684
JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:17,853,086...17,856,505
Ensembl chr  X:17,853,114...17,856,505
JBrowse link
negative regulation of low-density lipoprotein receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in
IDA
IEA
ISO
PMID:21810484
GO_REF:0000107
(MGI:5306885|PMID:21810484)
(PMID:21810484)
Ensembl
RGD
PMID:21810484 PMID:21810484 GO_REF:0000107 MGI:5306885, RGD:14697730 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing acts_upstream_of ISO (PMID:11222466) RGD PMID:11222466 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G App amyloid beta precursor protein NOT|involved_in ISO UniProtKB:P35951|UniProtKB:P49768 (PMID:20005821) RGD PMID:20005821 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Itgav integrin subunit alpha V acts_upstream_of_or_within ISO (PMID:15215180) RGD PMID:15215180 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb3 integrin subunit beta 3 acts_upstream_of_or_within ISO (PMID:15215180) RGD PMID:15215180 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) RGD PMID:22848640 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Psen1 presenilin 1 NOT|involved_in ISO UniProtKB:P05067|UniProtKB:P35951 (PMID:20005821) RGD PMID:20005821 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
negative regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd13a ankyrin repeat domain 13a involved_in ISO (PMID:22298428) RGD PMID:22298428 NCBI chr12:41,798,196...41,828,327
Ensembl chr12:41,798,199...41,829,327
JBrowse link
G Ankrd13b ankyrin repeat domain 13B involved_in ISO (PMID:22298428) RGD PMID:22298428 NCBI chr10:62,319,660...62,338,342
Ensembl chr10:62,319,647...62,340,253
JBrowse link
G Ankrd13d ankyrin repeat domain 13D involved_in ISO (PMID:22298428) RGD PMID:22298428 NCBI chr 1:201,565,712...201,577,987
Ensembl chr 1:201,565,712...201,577,933
JBrowse link
G Anxa2 annexin A2 involved_in ISO (PMID:18799458) RGD PMID:18799458 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Atxn2 ataxin 2 involved_in ISO (PMID:18602463) RGD PMID:18602463 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 involved_in IDA PMID:11526121 UniProt PMID:11526121 RGD:8554437 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Fmr1 FMRP translational regulator 1 IMP RGD PMID:17881561 RGD:12050150 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO
IBA
ComplexPortal:CPX-1134|UniProtKB:P04925 (PMID:23386614)
PMID:21873635
RGD PMID:23386614 PMID:21873635 RGD:13792537 NCBI chr14:75,651,371...75,663,380
Ensembl chr14:75,651,376...75,665,414
JBrowse link
G LRRTM1 leucine rich repeat transmembrane neuronal 1 acts_upstream_of_or_within ISO MGI:2389174 (MGI:5515239|PMID:23931994) RGD PMID:23931994 MGI:5515239 NCBI chr 4:109,701,815...109,718,924
Ensembl chr 4:109,701,815...109,717,184
JBrowse link
G Lrrtm2 leucine rich repeat transmembrane neuronal 2 acts_upstream_of_or_within ISO MGI:2389173 (MGI:5515239|PMID:23931994) RGD PMID:23931994 MGI:5515239 NCBI chr18:26,817,816...26,822,864
Ensembl chr18:26,817,816...26,822,864
JBrowse link
G Mtmr2 myotubularin related protein 2 involved_in IMP PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO
IEA
(PMID:18799458)
GO_REF:0000107
RGD
Ensembl
PMID:18799458 GO_REF:0000107 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Rin3 Ras and Rab interactor 3 acts_upstream_of_or_within ISO (PMID:23185384) RGD PMID:23185384 NCBI chr 6:121,431,803...121,540,957
Ensembl chr 6:121,431,339...121,540,957
JBrowse link
G Sdcbp syndecan binding protein involved_in ISS
ISO
GO_REF:0000024
(PMID:25893292)
UniProt
RGD
PMID:25893292 GO_REF:0000024 NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572
JBrowse link
G Wdr54 WD repeat domain 54 involved_in ISO (PMID:30458214) RGD PMID:30458214 NCBI chr 4:115,654,968...115,677,979
Ensembl chr 4:115,654,968...115,661,562
JBrowse link
negative regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in
ISO
IEA
(PMID:21810484)
GO_REF:0000107
RGD
Ensembl
PMID:21810484 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:22848640) RGD PMID:22848640 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    negative regulation of biological process 5677
      negative regulation of transport 531
        negative regulation of endocytosis 51
          negative regulation of receptor-mediated endocytosis 32
            negative regulation of clathrin-dependent endocytosis 5
            negative regulation of low-density lipoprotein receptor activity 7
            negative regulation of receptor internalization + 17
            negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
Path 2
Term Annotations click to browse term
  biological_process 19497
    localization 6488
      establishment of localization 4887
        transport 4725
          vesicle-mediated transport 1677
            endocytosis 691
              receptor-mediated endocytosis 260
                regulation of receptor-mediated endocytosis 127
                  negative regulation of receptor-mediated endocytosis 32
                    negative regulation of clathrin-dependent endocytosis 5
                    negative regulation of low-density lipoprotein receptor activity 7
                    negative regulation of receptor internalization + 17
                    negative regulation of receptor-mediated endocytosis involved in cholesterol transport 2
paths to the root