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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of receptor-mediated endocytosis
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Accession:GO:0048260 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
Synonyms:exact_synonym: up regulation of receptor mediated endocytosis;   upregulation of receptor mediated endocytosis
 narrow_synonym: activation of receptor mediated endocytosis;   stimulation of receptor mediated endocytosis



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positive regulation of receptor-mediated endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 IMP RGD PMID:11717353 RGD:13452389 NCBI chr 1:95,384,303...95,414,249
Ensembl chr 1:95,384,309...95,414,147
JBrowse link
G B2m beta-2 microglobulin involved_in ISO UniProtKB:P02787|UniProtKB:Q07891|UniProtKB:Q30201|UniProtKB:Q9UP52 (PMID:18353247) RGD PMID:18353247 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bicd1 BICD cargo adaptor 1 involved_in IBA
ISO
PMID:21873635
(PMID:20164183)
RGD PMID:20164183 PMID:21873635 RGD:13792537 NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434
JBrowse link
G C3 complement C3 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05555 (MGI:5319446|PMID:22438044), (MGI:5905548|PMID:20199584)
Ensembl
RGD
PMID:20199584 PMID:22438044 GO_REF:0000107 MGI:5319446 MGI:5905548 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cbl Cbl proto-oncogene involved_in ISO (PMID:25178484) RGD PMID:25178484 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:2667257|PMID:12609829) RGD PMID:12609829 MGI:2667257 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (MGI:2667257|PMID:12609829) RGD PMID:12609829 MGI:2667257 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:11697889)
UniProtKB:C0HL13 (PMID:9228033)
UniProt
Ensembl
RGD
PMID:9228033 PMID:11697889 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G H1f1 H1.1 linker histone, cluster member involved_in ISO (MGI:5882919|PMID:9664069) RGD PMID:9664069 MGI:5882919 NCBI chr17:41,366,268...41,367,011
Ensembl chr17:41,366,268...41,367,011
JBrowse link
G Hfe homeostatic iron regulator involved_in ISO UniProtKB:P02787|UniProtKB:P61769|UniProtKB:Q07891|UniProtKB:Q9UP52 (PMID:18353247) RGD PMID:18353247 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
JBrowse link
G Hip1 huntingtin interacting protein 1 involved_in ISO (PMID:11532990), (PMID:11577110)
(MGI:2154594|PMID:11577110)
RGD PMID:11532990 PMID:11577110 MGI:2154594 NCBI chr12:21,133,319...21,267,796
Ensembl chr12:21,133,406...21,267,725
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K acts_upstream_of ISO (PMID:20371611) RGD PMID:20371611 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Il4 interleukin 4 involved_in IBA
ISO
IDA
PMID:21873635
(MGI:6272248|PMID:18941241)
RGD PMID:18941241 PMID:21873635 PMID:18941241 MGI:6272248, RGD:13792537, RGD:13825436 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Kif3a kinesin family member 3a IDA RGD PMID:15181154 RGD:1581596 NCBI chr10:37,725,930...37,761,183
Ensembl chr10:37,725,970...37,759,191
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:15166224) RGD PMID:15166224 NCBI chr 5:146,955,607...146,978,601
Ensembl chr 5:146,955,607...146,978,601
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase IMP RGD PMID:21807099 RGD:152999022 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:15470141 RGD:2299909 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO
ISS
(PMID:16542649)
PMID:8895569
RGD PMID:16542649 PMID:8895569 RGD:8553248 NCBI chr 5:135,121,176...135,141,076
Ensembl chr 5:135,121,163...135,142,048
JBrowse link
G Rab21 RAB21, member RAS oncogene family involved_in ISO (PMID:15561770) RGD PMID:15561770 NCBI chr 7:50,904,050...50,928,890
Ensembl chr 7:50,904,057...50,928,839
JBrowse link
G Serpine1 serpin family E member 1 involved_in ISO
IEA
IMP
(PMID:8626514)
GO_REF:0000107
RGD
Ensembl
PMID:8626514 PMID:8626514 GO_REF:0000107, RGD:8554276 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sgip1 SH3GL interacting endocytic adaptor 1 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
PMID:17626015
(MGI:4887327|PMID:17626015)
GO_REF:0000107
RGD
Ensembl
PMID:17626015 PMID:17626015 GO_REF:0000107 MGI:4887327, RGD:8554282 NCBI chr 5:117,536,752...117,734,593
Ensembl chr 5:117,537,746...117,734,575
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 IMP RGD PMID:15541315 RGD:2314546 NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322
JBrowse link
G Synj1 synaptojanin 1 IMP RGD PMID:15821731 RGD:2312450 NCBI chr11:30,192,629...30,269,277
Ensembl chr11:30,192,629...30,269,220
JBrowse link
G Tf transferrin involved_in ISO UniProtKB:Q07891|UniProtKB:Q9UP52 (PMID:12704209), (PMID:18353247) RGD PMID:12704209 PMID:18353247 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Vtn vitronectin involved_in ISO (PMID:8626514) RGD PMID:8626514 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
JBrowse link
positive regulation of clathrin-dependent endocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab2 DAB adaptor protein 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5442508|PMID:16984970)
(PMID:16984970)
Ensembl
RGD
PMID:16984970 GO_REF:0000107 MGI:5442508 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
JBrowse link
G Dgkd diacylglycerol kinase, delta involved_in ISO (PMID:17880279) RGD PMID:17880279 NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:11925437 RGD:728683 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157
JBrowse link
G Scyl2 SCY1 like pseudokinase 2 involved_in ISO (PMID:19643732) RGD PMID:19643732 NCBI chr 7:24,064,404...24,117,338
Ensembl chr 7:24,064,404...24,117,305
JBrowse link
G Wasl WASP like actin nucleation promoting factor involved_in IDA PMID:20730103 BHF-UCL PMID:20730103 RGD:8554834 NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) RGD PMID:25639753 NCBI chr16:24,694,231...24,703,466
Ensembl chr16:24,694,324...24,703,465
JBrowse link
G Apln apelin involved_in ISO
IDA
(PMID:11359874)
(MGI:5902690|PMID:11359874)
RGD PMID:11359874 PMID:11359874 MGI:5902690, RGD:12907555 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) RGD PMID:18723082 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
positive regulation of receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4840150|PMID:20956301)
UniProt
RGD
PMID:20956301 GO_REF:0000024 MGI:4840150 NCBI chr 1:15,768,047...15,886,744
Ensembl chr 1:15,762,462...15,891,041
JBrowse link
G Angpt1 angiopoietin 1 involved_in ISO
IEA
(PMID:19424712)
GO_REF:0000107
RGD
Ensembl
PMID:19424712 GO_REF:0000107 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 IMP RGD PMID:12105201 RGD:13461854 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
JBrowse link
G Arrb1 arrestin, beta 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:22457824)
UniProt
RGD
PMID:22457824 GO_REF:0000024 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrb2 arrestin, beta 2 involved_in IMP
ISO
Oprm1
(PMID:22457824)
RGD PMID:22457824 PMID:16120787 RGD:5510008 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atad1 ATPase family, AAA domain containing 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5050342|PMID:21496646)
UniProt
RGD
PMID:21496646 GO_REF:0000024 MGI:5050342 NCBI chr 1:230,544,227...230,610,524
Ensembl chr 1:230,544,047...230,596,548
JBrowse link
G Cd63 Cd63 molecule involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:23632027)
UniProt
Ensembl
RGD
PMID:23632027 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
JBrowse link
G Dab2 DAB adaptor protein 2 involved_in ISO (MGI:5476876|PMID:23354168) RGD PMID:23354168 MGI:5476876 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
JBrowse link
G Drd2 dopamine receptor D2 IMP RGD PMID:18809670 RGD:2311559 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 IMP RGD PMID:17989303 RGD:8553895 NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661
JBrowse link
G Egf epidermal growth factor involved_in ISO
IEA
(PMID:22732145)
GO_REF:0000107
RGD
Ensembl
PMID:22732145 GO_REF:0000107 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:25561520)
UniProt
RGD
PMID:25561520 GO_REF:0000024 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Gh1 growth hormone 1 NOT|involved_in ISO (PMID:9360546) RGD PMID:9360546 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (MGI:4845816|PMID:20660291) RGD PMID:20660291 MGI:4845816 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
JBrowse link
G Hamp hepcidin antimicrobial peptide involved_in ISO (PMID:15514116) RGD PMID:15514116 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Insr insulin receptor involved_in ISO (PMID:25401701) RGD PMID:25401701 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in ISO
ISS
(PMID:11526121)
GO_REF:0000024
RGD
UniProt
PMID:11526121 GO_REF:0000024 NCBI chr 4:14,388,322...15,870,036
Ensembl chr 4:14,386,399...15,870,240
JBrowse link
G Ntf3 neurotrophin 3 involved_in IEA
ISO
GO_REF:0000107
(PMID:23027130)
Ensembl
RGD
PMID:23027130 GO_REF:0000107 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Pard3 par-3 family cell polarity regulator involved_in ISO (MGI:5476876|PMID:23354168) RGD PMID:23354168 MGI:5476876 NCBI chr19:55,080,282...55,630,111
Ensembl chr19:55,080,282...55,629,778
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:17328821) RGD PMID:17328821 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IBA
IDA
PMID:21873635
PMID:18297063
GO_Central
UniProt
PMID:21873635 PMID:18297063 RGD:13792537, RGD:8554748 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848
JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5300392|PMID:22078883)
Ensembl
RGD
PMID:22078883 GO_REF:0000107 MGI:5300392 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Plk2 polo-like kinase 2 IMP RGD PMID:20802490 RGD:152995511 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 IMP RGD PMID:19625523 RGD:9835004 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882
JBrowse link
G Scyl2 SCY1 like pseudokinase 2 involved_in ISO (PMID:19643732) RGD PMID:19643732 NCBI chr 7:24,064,404...24,117,338
Ensembl chr 7:24,064,404...24,117,305
JBrowse link
G Sele selectin E involved_in ISO (PMID:9312078) RGD PMID:9312078 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Sfrp4 secreted frizzled-related protein 4 involved_in ISO
IEA
(PMID:16151791)
GO_REF:0000107
RGD
Ensembl
PMID:16151791 GO_REF:0000107 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736
JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA
ISO
GO_REF:0000107
(MGI:5300392|PMID:22078883), (MGI:5619729|PMID:23962979)
Ensembl
RGD
PMID:22078883 PMID:23962979 GO_REF:0000107 MGI:5300392 MGI:5619729 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Synj2bp synaptojanin 2 binding protein involved_in ISO (MGI:3623710|PMID:16648306) RGD PMID:16648306 MGI:3623710 NCBI chr 6:101,189,714...101,227,400
Ensembl chr 6:101,189,714...101,227,406
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 involved_in ISO (PMID:22354992) RGD PMID:22354992 NCBI chr 9:3,503,328...4,017,131
Ensembl chr 9:3,513,623...4,016,913
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (PMID:20660291) RGD PMID:20660291 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wnt3a Wnt family member 3A involved_in ISO (PMID:16890161) RGD PMID:16890161 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
positive regulation of receptor-mediated endocytosis involved in cholesterol transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO (PMID:22848640)
(MGI:5446858|PMID:22848640)
RGD PMID:22848640 MGI:5446858 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:12417523), (PMID:12464675), (PMID:15166224) RGD PMID:12417523 PMID:12464675 PMID:15166224 NCBI chr 5:146,955,607...146,978,601
Ensembl chr 5:146,955,607...146,978,601
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20050
    positive regulation of biological process 6787
      positive regulation of transport 1142
        positive regulation of endocytosis 133
          positive regulation of receptor-mediated endocytosis 64
            positive regulation by symbiont of host receptor-mediated endocytosis 0
            positive regulation of clathrin-dependent endocytosis 5
            positive regulation of receptor internalization + 35
            positive regulation of receptor-mediated endocytosis involved in cholesterol transport 2
Path 2
Term Annotations click to browse term
  biological_process 20050
    localization 5651
      establishment of localization 4979
        transport 4816
          vesicle-mediated transport 1660
            endocytosis 646
              receptor-mediated endocytosis 278
                regulation of receptor-mediated endocytosis 135
                  positive regulation of receptor-mediated endocytosis 64
                    positive regulation by symbiont of host receptor-mediated endocytosis 0
                    positive regulation of clathrin-dependent endocytosis 5
                    positive regulation of receptor internalization + 35
                    positive regulation of receptor-mediated endocytosis involved in cholesterol transport 2
paths to the root