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ONTOLOGY REPORT - ANNOTATIONS

Term:flap endonuclease activity
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Accession:GO:0048256 term browser browse the term
Definition:Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis.


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flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exo1 exonuclease 1 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055 		JBrowse link
G Fen1 flap structure specific endonuclease 1 enables ISO
IDA		 (PMID:12162748) MGI PMID:12162748 GO_REF:0000119 MGI:4834177 NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533 		JBrowse link
3'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mus81 MUS81 structure-specific endonuclease subunit enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr19:5,532,589...5,538,461
Ensembl chr19:5,532,373...5,538,430 		JBrowse link
5'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 enables IDA
IBA
ISO		 (MGI:5499273|PMID:23604072) BHF-UCL
GO_Central
MGI		 PMID:23604072 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5499273 NCBI chr10:62,782,762...62,809,967
Ensembl chr10:62,782,805...62,809,964 		JBrowse link
G Exo1 exonuclease 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055 		JBrowse link
G Fan1 FANCD2/FANCI-associated nuclease 1 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:63,994,627...64,023,874
Ensembl chr 7:63,996,506...64,023,843 		JBrowse link
G Fen1 flap structure specific endonuclease 1 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533 		JBrowse link
G Gen1 GEN1, Holliday junction 5' flap endonuclease enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr12:11,288,929...11,316,030
Ensembl chr12:11,288,921...11,315,802 		JBrowse link
G Slx1b SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:126,288,099...126,294,955
Ensembl chr 7:126,288,640...126,294,956 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    catalytic activity 5714
      catalytic activity, acting on a nucleic acid 614
        catalytic activity, acting on DNA 244
          DNA nuclease activity 64
            DNA endonuclease activity 42
              flap endonuclease activity 7
                3'-flap endonuclease activity 1
                5'-flap endonuclease activity 6
Path 2
Term Annotations click to browse term
  molecular_function 28831
    catalytic activity 5714
      hydrolase activity 2454
        hydrolase activity, acting on ester bonds 785
          nuclease activity 224
            endonuclease activity 126
              DNA endonuclease activity 42
                flap endonuclease activity 7
                  3'-flap endonuclease activity 1
                  5'-flap endonuclease activity 6
paths to the root