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ONTOLOGY REPORT - ANNOTATIONS

Term:sperm capacitation
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Accession:GO:0048240 term browser browse the term
Definition:A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
Comment:Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract.
Synonyms:related_synonym: sperm activation


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sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase involved_in IBA
ISO		 PMID:21873635
(PMID:26989199)		 RGD PMID:26989199 PMID:21873635 RGD:13792537 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061 		JBrowse link
G Bsph1 binder of sperm protein homolog 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:5465085|PMID:22539676)		 RGD PMID:22539676 PMID:21873635 MGI:5465085, RGD:13792537 NCBI chr 1:74,413,976...74,450,117
Ensembl chr 1:74,411,200...74,450,120 		JBrowse link
G Bsph2 binder of sperm protein homolog 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:74,502,664...74,511,659 JBrowse link
G C2cd6 C2 calcium dependent domain containing 6 involved_in ISO (MGI:6874530|PMID:34998468) RGD PMID:34998468 MGI:6874530 NCBI chr 9:60,434,926...60,530,843
Ensembl chr 9:60,434,925...60,530,806 		JBrowse link
G Cabyr calcium binding tyrosine phosphorylation regulated involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:3,892,062...3,904,391
Ensembl chr18:3,892,132...3,903,840 		JBrowse link
G Catsper2 cation channel, sperm associated 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:2683843 (MGI:2682517|PMID:14657366)		 RGD PMID:14657366 PMID:21873635 MGI:2682517, RGD:13792537 NCBI chr 3:108,368,654...108,389,380
Ensembl chr 3:108,368,668...108,388,050 		JBrowse link
G Catsper3 cation channel, sperm associated 3 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:3694352 (MGI:3694233|PMID:17227845)		 RGD PMID:17227845 PMID:21873635 MGI:3694233, RGD:13792537 NCBI chr17:8,810,122...8,840,881
Ensembl chr17:8,815,561...8,840,864 		JBrowse link
G Catsper4 cation channel, sperm associated 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:3694354 (MGI:3694233|PMID:17227845)		 RGD PMID:17227845 PMID:21873635 MGI:3694233, RGD:13792537 NCBI chr 5:146,427,682...146,447,346
Ensembl chr 5:146,427,683...146,446,942 		JBrowse link
G Catsperd cation channel sperm associated auxiliary subunit delta involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(MGI:5315675|PMID:21224844)		 UniProt
RGD		 PMID:21224844 PMID:21873635 GO_REF:0000024 MGI:5315675, RGD:13792537 NCBI chr 9:1,459,967...1,498,342
Ensembl chr 9:1,460,001...1,498,344 		JBrowse link
G Catspere catsper channel auxiliary subunit epsilon involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:89,799,669...89,954,723
Ensembl chr13:89,819,244...89,950,979 		JBrowse link
G Catsperz catsper channel auxiliary subunit zeta involved_in ISO (MGI:5825443|PMID:28226241), (MGI:6316499|PMID:31056283) RGD PMID:28226241 PMID:31056283 MGI:5825443 MGI:6316499 NCBI chr 1:204,114,816...204,118,582 JBrowse link
G Cftr CF transmembrane conductance regulator involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(MGI:5429843|PMID:21976599)		 Ensembl
UniProt
RGD		 PMID:21976599 GO_REF:0000024 GO_REF:0000107 MGI:5429843 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Dld dihydrolipoamide dehydrogenase acts_upstream_of_or_within ISO (MGI:3589712|PMID:15888450) RGD PMID:15888450 MGI:3589712 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Efcab9 EF-hand calcium binding domain 9 involved_in IBA
ISO		 PMID:21873635
(MGI:6316499|PMID:31056283)		 RGD PMID:31056283 PMID:21873635 MGI:6316499, RGD:13792537 NCBI chr10:17,107,123...17,112,245
Ensembl chr10:17,107,123...17,112,289 		JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 GO_REF:0000024
(MGI:5784979|PMID:21302280), (MGI:5784984|PMID:19342015)
MGI:2665512 (MGI:3619873|PMID:16371590)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16371590 PMID:19342015 PMID:21302280 GO_REF:0000024 GO_REF:0000107 MGI:3619873 MGI:5784979 MGI:5784984 NCBI chr 7:9,381,366...9,389,589
Ensembl chr 7:9,381,361...9,389,585 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 acts_upstream_of_or_within ISO (MGI:3603744|PMID:16183867) RGD PMID:16183867 MGI:3603744 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in ISO (MGI:4357734|PMID:19560455) RGD PMID:19560455 MGI:4357734 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ropn1 rhophilin associated tail protein 1 involved_in
acts_upstream_of_or_within		 IBA
ISO
ISS		 PMID:21873635
MGI:4144733 (MGI:5551621|PMID:23303679)
GO_REF:0000024		 RGD
UniProt		 PMID:23303679 PMID:21873635 GO_REF:0000024 MGI:5551621, RGD:13792537 NCBI chr11:66,097,854...66,127,148
Ensembl chr11:66,097,856...66,127,148 		JBrowse link
G Ropn1l rhophilin associated tail protein 1-like involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:4143866 (MGI:5551621|PMID:23303679)		 RGD PMID:23303679 PMID:21873635 MGI:5551621, RGD:13792537 NCBI chr 2:82,442,645...82,453,332
Ensembl chr 2:82,441,891...82,453,485 		JBrowse link
G Semg1 semenogelin 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:3709410|PMID:17123940)		 RGD PMID:17123940 PMID:21873635 MGI:3709410, RGD:13792537 NCBI chr 3:152,910,033...152,912,882
Ensembl chr 3:152,910,034...152,912,882 		JBrowse link
G Septin4 septin 4 acts_upstream_of_or_within ISO MGI:3574368 (MGI:3531234|PMID:15737931) RGD PMID:15737931 MGI:3531234 NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768 		JBrowse link
G Slc22a14 solute carrier family 22, member 14 acts_upstream_of_or_within ISO MGI:2137691 (MGI:6225860|PMID:27811987) RGD PMID:27811987 MGI:6225860 NCBI chr 8:118,894,537...118,916,446
Ensembl chr 8:118,895,259...118,908,255 		JBrowse link
G Slc26a3 solute carrier family 26 member 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5429843|PMID:21976599)		 UniProt
RGD		 PMID:21976599 GO_REF:0000024 MGI:5429843 NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772 		JBrowse link
G Slc26a6 solute carrier family 26 member 6 involved_in ISO (MGI:5429843|PMID:21976599) RGD PMID:21976599 MGI:5429843 NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 acts_upstream_of_or_within ISO (MGI:5428115|PMID:22228629) RGD PMID:22228629 MGI:5428115 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Svs3b seminal vesicle secretory protein 3B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:152,929,645...152,936,705
Ensembl chr 3:152,929,645...152,931,919 		JBrowse link
negative regulation of sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Paep progestagen associated endometrial protein involved_in ISO (PMID:15883155) RGD PMID:15883155 NCBI chr 3:8,531,136...8,534,430
Ensembl chr 3:8,531,138...8,534,430 		JBrowse link
positive regulation of flagellated sperm motility involved in capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in ISO (PMID:23765988)
(MGI:5784973|PMID:23765988)		 RGD PMID:23765988 MGI:5784973 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Defb1 defensin beta 1 involved_in ISO
ISS		 (PMID:25122636)
GO_REF:0000024		 RGD
UniProt		 PMID:25122636 GO_REF:0000024 NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604 		JBrowse link
G Iqcf1 IQ motif containing F1 involved_in ISO (MGI:5708001|PMID:25380116) RGD PMID:25380116 MGI:5708001 NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249 		JBrowse link
G Rnase9 ribonuclease A family member 9 acts_upstream_of_or_within ISO MGI:5637811 (MGI:5582126|PMID:24719258) RGD PMID:24719258 MGI:5582126 NCBI chr15:24,259,525...24,263,079
Ensembl chr15:24,259,525...24,263,079 		JBrowse link
regulation of sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tcp11 t-complex 11 involved_in IBA
ISS
ISO		 PMID:21873635
GO_REF:0000024
(MGI:1097498|PMID:9322250), (MGI:5816449|PMID:9820206)		 UniProt
RGD		 PMID:9322250 PMID:9820206 PMID:21873635 GO_REF:0000024 MGI:1097498 MGI:5816449, RGD:13792537 NCBI chr20:6,126,267...6,138,408
Ensembl chr20:6,126,269...6,136,055 		JBrowse link
G Tcp11x2 t-complex 11 family, X-linked 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:98,591,191...98,640,800
Ensembl chr  X:98,591,189...98,640,763 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19898
    reproductive process 1790
      cellular process involved in reproduction in multicellular organism 534
        sperm capacitation 33
          negative regulation of sperm capacitation 1
          positive regulation of actin filament polymerization involved in sperm capacitation 0
          positive regulation of flagellated sperm motility involved in capacitation 4
          positive regulation of sperm capacitation 0
          regulation of sperm capacitation + 3
Path 2
Term Annotations click to browse term
  biological_process 19898
    reproduction 1798
      reproductive process 1790
        multicellular organismal reproductive process 1067
          gamete generation 877
            male gamete generation 683
              spermatogenesis 662
                spermatid differentiation 251
                  spermatid development 242
                    sperm capacitation 33
                      negative regulation of sperm capacitation 1
                      positive regulation of actin filament polymerization involved in sperm capacitation 0
                      positive regulation of flagellated sperm motility involved in capacitation 4
                      positive regulation of sperm capacitation 0
                      regulation of sperm capacitation + 3
paths to the root