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ONTOLOGY REPORT - ANNOTATIONS


Term:autophagic cell death
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Accession:GO:0048102 term browser browse the term
Definition:A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
Comment:The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.
Synonyms:exact_synonym: programmed cell death by autophagy;   programmed cell death by macroautophagy
 broad_synonym: autophagic death
 related_synonym: autosis;   type II programmed cell death
 only_in_taxon: NCBITaxon:2759 ! Eukaryota


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autophagic cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acp2 acid phosphatase 2, lysosomal JBrowse link 2 91,202,812 91,214,098 RGD:2290270
G Bnip3 BCL2/adenovirus E1B interacting protein 3 JBrowse link 7 138,890,836 138,909,506 RGD:2290270
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 6 134,920,401 134,925,525 RGD:2290270
G Cdkn2d cyclin dependent kinase inhibitor 2D JBrowse link 9 21,288,459 21,291,421 RGD:2290270
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 8 13,159,161 13,175,338 RGD:2290270
G Sh3glb1 SH3-domain GRB2-like B1 (endophilin) JBrowse link 3 144,683,678 144,720,556 RGD:2290270
G Trp53inp1 transformation related protein 53 inducible nuclear protein 1 JBrowse link 4 11,156,441 11,174,379 RGD:2290270
induction by virus of host autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 2 118,388,583 118,475,234 RGD:2290270
negative regulation of autophagic cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmf BCL2 modifying factor JBrowse link 2 118,528,757 118,549,686 RGD:2290270
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 17 48,346,401 48,352,276 RGD:2290270
suppression by virus of host autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg7 autophagy related 7 JBrowse link 6 114,643,097 114,860,614 RGD:2290270

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  biological_process 23015
    cellular process 15767
      cell death 2090
        programmed cell death 1929
          autophagic cell death 11
            negative regulation of autophagic cell death 2
            positive regulation of autophagic cell death 0
            regulation of autophagic cell death + 4
            salivary gland cell autophagic cell death + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.