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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of mRNA splicing, via spliceosome
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Accession:GO:0048025 term browser browse the term
Definition:Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
Synonyms:exact_synonym: down regulation of nuclear mRNA splicing, via spliceosome;   downregulation of nuclear mRNA splicing, via spliceosome;   negative regulation of nuclear mRNA splicing, via spliceosome
 narrow_synonym: down regulation of nuclear mRNA splicing via U2-type spliceosome;   downregulation of nuclear mRNA splicing via U2-type spliceosome;   inhibition of nuclear mRNA splicing via U2-type spliceosome;   inhibition of nuclear mRNA splicing, via spliceosome;   negative regulation of nuclear mRNA splicing via U2-type spliceosome
 broad_synonym: negative regulation of pre-mRNA splicing
 alt_id: GO:0035056


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negative regulation of mRNA splicing, via spliceosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acin1 apoptotic chromatin condensation inducer 1 involved_in ISO (PMID:12665594) RGD PMID:12665594 NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 acts_upstream_of_or_within ISO (PMID:23636947) RGD PMID:23636947 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G C1qbp complement C1q binding protein involved_in ISO
ISS
IEA
IBA		 (PMID:10022843)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:10022843 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Celf4 CUGBP, Elav-like family member 4 acts_upstream_of_or_within ISO (PMID:23636947) RGD PMID:23636947 NCBI chr18:16,786,578...17,065,045
Ensembl chr18:16,786,867...17,064,786 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:21470964)		 Ensembl
RGD		 PMID:21470964 GO_REF:0000107 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G ENSRNOG00000066561 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 9:2,780,475...2,782,261 JBrowse link
G ENSRNOG00000070131 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 9:3,021,140...3,022,924 JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:18480465)		 Ensembl
RGD		 PMID:18480465 GO_REF:0000107 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:23636947)		 Ensembl
RGD		 PMID:23636947 GO_REF:0000107 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L IMP RGD PMID:22570490 RGD:9999428 NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553 		JBrowse link
G LOC100359916 heterogeneous nuclear ribonucleoprotein K-like involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:58,668,326...58,670,222
Ensembl chr 5:58,668,327...58,670,220 		JBrowse link
G Npm1 nucleophosmin 1 acts_upstream_of_or_within ISO (PMID:16376875) RGD PMID:16376875 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Pcbp4 poly(rC) binding protein 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:23636947)		 GO_Central
RGD		 PMID:23636947 GO_REF:0000033 NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276 		JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:15009664)
GO_REF:0000024
(MGI:6271441|PMID:17679093)
(PMID:23636947)		 RGD
UniProt		 PMID:15009664 PMID:17679093 PMID:23636947 GO_REF:0000024 MGI:6271441 NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397 		JBrowse link
G Ptbp3 polypyrimidine tract binding protein 3 acts_upstream_of_or_within ISO (PMID:23636947) RGD PMID:23636947 NCBI chr 5:74,313,367...74,399,439
Ensembl chr 5:74,315,101...74,399,791 		JBrowse link
G Rbm10 RNA binding motif protein 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:23636947)		 Ensembl
RGD		 PMID:23636947 GO_REF:0000107 NCBI chr  X:1,540,399...1,572,571
Ensembl chr  X:1,540,398...1,572,575 		JBrowse link
G Rbm20 RNA binding motif protein 20 involved_in IMP
IDA
ISO		 PMID:35394688
PMID:24960161
PMID:23307558
PMID:25573899
(MGI:5817050|PMID:27630136), (MGI:6162809|PMID:29895960), (MGI:6472247|PMID:33110103)
(PMID:24960161), (PMID:34732726)		 RGD PMID:24960161 PMID:27630136 PMID:29895960 PMID:33110103 PMID:34732726 More... MGI:5817050 MGI:6162809 MGI:6472247, RGD:152025505, RGD:152025509, RGD:152025504, RGD:152025519 NCBI chr 1:252,683,760...252,907,465
Ensembl chr 1:252,683,771...252,886,060 		JBrowse link
G Rbm42 RNA binding motif protein 42 acts_upstream_of_or_within ISO (PMID:23636947) RGD PMID:23636947 NCBI chr 1:85,898,618...85,908,569
Ensembl chr 1:85,898,625...85,908,573 		JBrowse link
G Rbmxl1 Rbmx like 1 involved_in IDA PMID:15009664 UniProt PMID:15009664 RGD:8554197 NCBI chr19:29,407,902...29,411,519
Ensembl chr19:29,407,912...29,412,859 		JBrowse link
G Rnps1 RNA binding protein with serine rich domain 1 involved_in ISO
ISS		 (PMID:12665594)
GO_REF:0000024		 RGD
UniProt		 PMID:12665594 GO_REF:0000024 NCBI chr10:13,445,516...13,455,858
Ensembl chr10:13,445,653...13,455,858 		JBrowse link
G Sap18 Sin3A associated protein 18 involved_in ISO (PMID:12665594) RGD PMID:12665594 NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038
Ensembl chr10:31,943,230...31,950,038 		JBrowse link
G Sfswap splicing factor SWAP involved_in IDA PMID:15009664 UniProt PMID:15009664 RGD:8554197 NCBI chr12:27,109,607...27,179,941
Ensembl chr12:27,109,611...27,179,884 		JBrowse link
G Srsf10 serine and arginine rich splicing factor 10 involved_in ISO (PMID:11684676)
(MGI:3688015|PMID:11684676)		 RGD PMID:11684676 MGI:3688015 NCBI chr 5:148,088,759...148,102,964
Ensembl chr 5:148,088,823...148,101,768 		JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 involved_in ISO (PMID:15009664) RGD PMID:15009664 NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229 		JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 involved_in ISO (PMID:15009664) RGD PMID:15009664 NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860 		JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 involved_in ISO (PMID:15009664) RGD PMID:15009664 NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965 		JBrowse link
G Srsf9 serine and arginine rich splicing factor 9 involved_in ISO
ISS		 (PMID:15009664)
GO_REF:0000024		 RGD
UniProt		 PMID:15009664 GO_REF:0000024 NCBI chr12:41,278,225...41,284,502
Ensembl chr12:41,275,687...41,284,499 		JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 involved_in ISO (PMID:15009664) RGD PMID:15009664 NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      negative regulation of metabolic process 3098
        negative regulation of macromolecule metabolic process 2865
          negative regulation of RNA metabolic process 1462
            negative regulation of RNA splicing 33
              negative regulation of mRNA splicing, via spliceosome 28
                negative regulation of mRNA cis splicing, via spliceosome 0
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      organic substance metabolic process 11328
        organic cyclic compound metabolic process 6260
          nucleobase-containing compound metabolic process 5743
            nucleic acid metabolic process 5144
              RNA metabolic process 4542
                RNA processing 1031
                  RNA splicing 467
                    RNA splicing, via transesterification reactions 352
                      RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 352
                        mRNA splicing, via spliceosome 352
                          regulation of mRNA splicing, via spliceosome 124
                            negative regulation of mRNA splicing, via spliceosome 28
                              negative regulation of mRNA cis splicing, via spliceosome 0
paths to the root