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ONTOLOGY REPORT - ANNOTATIONS

Term:inositol lipid-mediated signaling
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Accession:GO:0048017 term browser browse the term
Definition:The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids.
Synonyms:exact_synonym: inositol lipid-mediated signal transduction;   inositol lipid-mediated signalling
 narrow_synonym: inositol phospholipid-mediated signaling


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inositol lipid-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adap2 ArfGAP with dual PH domains 2 acts_upstream_of_or_within ISO (PMID:14690521) RGD PMID:14690521 NCBI chr10:65,138,006...65,166,147
Ensembl chr10:65,138,020...65,165,604 		JBrowse link
G Pld1 phospholipase D1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Tnfaip8l3 TNF alpha induced protein 8 like 3 involved_in ISO (MGI:5613301|PMID:25242044) RGD PMID:25242044 MGI:5613301 NCBI chr 8:54,413,503...54,455,648
Ensembl chr 8:54,414,457...54,500,079 		JBrowse link
negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO MGI:88327 (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr17:41,620,807...41,632,621
Ensembl chr17:41,620,839...41,632,618 		JBrowse link
G Cryba1 crystallin, beta A1 IMP RGD PMID:21993393 RGD:10059647 NCBI chr10:62,608,373...62,614,726
Ensembl chr10:62,608,383...62,614,726 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:19903888)		 UniProt
RGD		 PMID:19903888 GO_REF:0000024 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E IDA RGD PMID:21436142 RGD:12911213 NCBI chr 3:9,216,776...9,229,539
Ensembl chr 3:9,216,776...9,229,450 		JBrowse link
G Klf4 Kruppel like factor 4 involved_in IMP PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Mir206 microRNA 206 involved_in ISO (PMID:26175229) RGD PMID:26175229 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir20a microRNA 20a acts_upstream_of ISO (PMID:28972028) RGD PMID:28972028 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir449a microRNA 449a involved_in ISO (PMID:25487955) RGD PMID:25487955 NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 acts_upstream_of_or_within ISO (MGI:3723397|PMID:17606624) RGD PMID:17606624 MGI:3723397 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (MGI:5883388|PMID:27951586) RGD PMID:27951586 MGI:5883388 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:16971513) RGD PMID:16971513 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902 		JBrowse link
G Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF involved_in ISO (MGI:6101642|PMID:28826662) RGD PMID:28826662 MGI:6101642 NCBI chr10:43,774,113...43,919,718
Ensembl chr10:43,789,293...43,919,723 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 involved_in ISO
IBA		 (PMID:17475214)
PMID:21873635
(MGI:3806716|PMID:18632611)		 RGD PMID:17475214 PMID:18632611 PMID:21873635 MGI:3806716, RGD:13792537 NCBI chr14:78,203,539...78,216,616
Ensembl chr14:78,204,053...78,216,608 		JBrowse link
G Serpine2 serpin family E member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:88380 (MGI:3810206|PMID:18398001)		 Ensembl
RGD		 PMID:18398001 GO_REF:0000107 MGI:3810206 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:97528 (MGI:3617099|PMID:16456542)		 UniProt
RGD		 PMID:16456542 GO_REF:0000024 MGI:3617099 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598 		JBrowse link
G Slc9a3r2 SLC9A3 regulator 2 acts_upstream_of_or_within ISO MGI:97528 (MGI:3617099|PMID:16456542) RGD PMID:16456542 MGI:3617099 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049 		JBrowse link
G Stambp Stam binding protein involved_in ISO (PMID:23542699) RGD PMID:23542699 NCBI chr 4:116,055,563...116,083,563
Ensembl chr 4:116,056,057...116,080,543 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6695683|PMID:29663649) RGD PMID:29663649 MGI:6695683 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO MGI:1857938 (MGI:3586939|PMID:16027169) RGD PMID:16027169 MGI:3586939 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17003487) RGD PMID:17003487 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor acts_upstream_of ISO (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of ISO MGI:88327 (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr17:41,620,807...41,632,621
Ensembl chr17:41,620,839...41,632,618 		JBrowse link
G C1qbp complement C1q binding protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:16177118)		 UniProt
RGD		 PMID:16177118 GO_REF:0000024 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:17307798) RGD PMID:17307798 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834 		JBrowse link
G Cd28 Cd28 molecule acts_upstream_of ISO (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Csf2 colony stimulating factor 2 involved_in ISO (PMID:24520418) RGD PMID:24520418 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:17078114) RGD PMID:17078114 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in ISO (PMID:7556068) RGD PMID:7556068 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 involved_in ISO (PMID:7556068) RGD PMID:7556068 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Fcgr3a Fc gamma receptor 3A involved_in ISO (PMID:23024279) RGD PMID:23024279 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921 		JBrowse link
G Gata3 GATA binding protein 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5285154|PMID:20696860)		 UniProt
RGD		 PMID:20696860 GO_REF:0000024 MGI:5285154 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A involved_in ISO (PMID:16517693) RGD PMID:16517693 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:16517693)		 UniProt
Ensembl
RGD		 PMID:16517693 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in
acts_upstream_of		 ISO
IEA		 (PMID:24508636)
(MGI:5005047|PMID:21413931)
GO_REF:0000107		 RGD
Ensembl		 PMID:21413931 PMID:24508636 GO_REF:0000107 MGI:5005047 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Irs1 insulin receptor substrate 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:7782332)		 Ensembl
RGD		 PMID:7782332 GO_REF:0000107 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Kbtbd2 kelch repeat and BTB domain containing 2 acts_upstream_of_or_within_positive_effect ISO MGI:5806485 (MGI:5806303|PMID:27708159) RGD PMID:27708159 MGI:5806303 NCBI chr 4:86,027,947...86,050,266
Ensembl chr 4:86,027,947...86,050,211 		JBrowse link
G Ltk leukocyte receptor tyrosine kinase involved_in ISO (PMID:9223670) RGD PMID:9223670 NCBI chr 3:106,734,675...106,741,552
Ensembl chr 3:106,734,676...106,743,369 		JBrowse link
G Myo16 myosin XVI involved_in IBA
ISO		 PMID:21873635
(MGI:5304984|PMID:21946561)		 RGD PMID:21946561 PMID:21873635 MGI:5304984, RGD:13792537 NCBI chr16:78,884,405...79,364,445
Ensembl chr16:78,884,406...79,248,388 		JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 GO_REF:0000024
MGI:1857444 (MGI:3032882|PMID:14724565)
GO_REF:0000107		 HGNC-UCL
RGD
Ensembl		 PMID:14724565 GO_REF:0000024 GO_REF:0000107 MGI:3032882 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Nyap1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 involved_in ISO
IBA		 (MGI:5304984|PMID:21946561)
PMID:21873635		 RGD PMID:21946561 PMID:21873635 MGI:5304984, RGD:13792537 NCBI chr12:18,956,192...18,967,624
Ensembl chr12:18,956,268...18,967,543 		JBrowse link
G Nyap2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 involved_in ISO
IBA		 (MGI:5304984|PMID:21946561)
PMID:21873635		 RGD PMID:21946561 PMID:21873635 MGI:5304984, RGD:13792537 NCBI chr 9:82,406,797...82,658,250
Ensembl chr 9:82,406,827...82,653,498 		JBrowse link
G Pdgfb platelet derived growth factor subunit B acts_upstream_of ISO MGI:1349482|MGI:1890662 (MGI:3617099|PMID:16456542) RGD PMID:16456542 MGI:3617099 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pear1 platelet endothelial aggregation receptor 1 involved_in ISO MGI:4363617 (MGI:5817200|PMID:27614188) RGD PMID:27614188 MGI:5817200 NCBI chr 2:173,206,298...173,234,106
Ensembl chr 2:173,207,664...173,227,440 		JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472 		JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612 		JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha involved_in IBA
ISO		 PMID:21873635
(MGI:6450443|PMID:30568254)
UniProtKB:P15692 (PMID:30496354)		 RGD PMID:30496354 PMID:30568254 PMID:21873635 MGI:6450443, RGD:13792537 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in ISO
IBA
IEA		 UniProtKB:P15692 (PMID:18558630), (PMID:25339672), (PMID:30496354)
UniProtKB:O35904 (MGI:4461861|PMID:18558630), (MGI:6444553|PMID:30496354)
PMID:21873635
GO_REF:0000107		 RGD
Ensembl		 PMID:18558630 PMID:25339672 PMID:30496354 PMID:21873635 GO_REF:0000107 MGI:4461861 MGI:6444553, RGD:13792537 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta involved_in ISO
IBA		 UniProtKB:P01133|UniProtKB:P09038|UniProtKB:P15692 (PMID:25339672), (PMID:31915155)
PMID:21873635		 RGD PMID:25339672 PMID:31915155 PMID:21873635 RGD:13792537 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma involved_in IBA
ISO		 PMID:21873635
(MGI:4461861|PMID:18558630)
(PMID:12507995), (PMID:18558630)		 RGD PMID:12507995 PMID:18558630 PMID:21873635 MGI:4461861, RGD:13792537 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO
IEA		 (PMID:21321938), (PMID:7782332)
GO_REF:0000107		 RGD
Ensembl		 PMID:7782332 PMID:21321938 GO_REF:0000107 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:23604317)		 UniProt
Ensembl
RGD		 PMID:23604317 GO_REF:0000024 GO_REF:0000107 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 involved_in ISO (PMID:12507995) RGD PMID:12507995 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Plekha1 pleckstrin homology domain containing A1 involved_in ISO (PMID:12101241) RGD PMID:12101241 NCBI chr 1:185,427,982...185,479,157
Ensembl chr 1:185,428,048...185,479,156 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta acts_upstream_of ISO (MGI:3621068|PMID:16581799) RGD PMID:16581799 MGI:3621068 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 acts_upstream_of_or_within ISO MGI:3856561 (MGI:5550173|PMID:24367090) RGD PMID:24367090 MGI:5550173 NCBI chr 5:7,937,692...8,253,112
Ensembl chr 5:7,942,573...8,253,068 		JBrowse link
G Prr5 proline rich 5 acts_upstream_of ISO MGI:1919696 (MGI:5005047|PMID:21413931) RGD PMID:21413931 MGI:5005047 NCBI chr 7:115,795,351...115,837,880
Ensembl chr 7:115,813,954...115,834,834 		JBrowse link
G Prr5l proline rich 5 like acts_upstream_of
involved_in		 ISO
IEA		 MGI:1924714 (MGI:5005047|PMID:21413931)
GO_REF:0000107		 RGD
Ensembl		 PMID:21413931 GO_REF:0000107 MGI:5005047 NCBI chr 3:88,001,951...88,173,532
Ensembl chr 3:88,003,617...88,082,763 		JBrowse link
G Pten phosphatase and tensin homolog involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Reg1a regenerating family member 1 alpha involved_in ISO MGI:2446480 (MGI:3615755|PMID:16405968) RGD PMID:16405968 MGI:3615755 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570 		JBrowse link
G Serpina12 serpin family A member 12 acts_upstream_of
involved_in		 ISO
IEA		 MGI:5568548 (MGI:5563627|PMID:22837305)
GO_REF:0000107		 RGD
Ensembl		 PMID:22837305 GO_REF:0000107 MGI:5563627 NCBI chr 6:122,952,552...122,967,271
Ensembl chr 6:122,952,552...122,967,271 		JBrowse link
G Sirt2 sirtuin 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23908241)		 UniProt
RGD		 PMID:23908241 GO_REF:0000024 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Slc9a3r2 SLC9A3 regulator 2 acts_upstream_of ISO MGI:97528 (MGI:3617099|PMID:16456542) RGD PMID:16456542 MGI:3617099 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049 		JBrowse link
G Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:69,658,874...69,756,571
Ensembl chr16:69,658,875...69,752,949 		JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO (MGI:3050929|PMID:15249583)
MGI:1857938 (MGI:3586939|PMID:16027169)		 RGD PMID:15249583 PMID:16027169 MGI:3050929 MGI:3586939 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:23529610) RGD PMID:23529610 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15538381)		 UniProt
RGD		 PMID:15538381 GO_REF:0000024 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748 		JBrowse link
phosphatidylinositol-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car8 carbonic anhydrase 8 acts_upstream_of_or_within ISO (MGI:2664003|PMID:12611586) RGD PMID:12611586 MGI:2664003 NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374 		JBrowse link
G Csf1r colony stimulating factor 1 receptor involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(MGI:5294513|PMID:21610095)		 Ensembl
UniProt
RGD		 PMID:21610095 GO_REF:0000024 GO_REF:0000107 MGI:5294513 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Exoc1 exocyst complex component 1 involved_in ISO (PMID:25591774) RGD PMID:25591774 NCBI chr14:31,611,536...31,659,920
Ensembl chr14:31,611,547...31,659,914 		JBrowse link
G Ezr ezrin involved_in ISO (PMID:25591774) RGD PMID:25591774 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Gab2 GRB2-associated binding protein 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:2137187|PMID:11449275)		 UniProt
RGD		 PMID:11449275 GO_REF:0000024 MGI:2137187 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Gpr143 G protein-coupled receptor 143 involved_in ISO (PMID:16524428) RGD PMID:16524428 NCBI chr  X:22,002,914...22,027,720
Ensembl chr  X:22,002,914...22,027,715 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in TAS PMID:15758184 UniProt PMID:15758184 RGD:8554618 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Gsn gelsolin IMP RGD PMID:11861757 RGD:1303950 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO (PMID:7692086) RGD PMID:7692086 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor involved_in ISO
IEA		 (PMID:7692086)
GO_REF:0000107		 RGD
Ensembl		 PMID:7692086 GO_REF:0000107 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 TAS RGD PMID:11942857 RGD:729102 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F acts_upstream_of_or_within ISO MGI:4128518 (MGI:4943859|PMID:19875726) RGD PMID:19875726 MGI:4943859 NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276 		JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 involved_in ISO
ISS		 (PMID:27005320)
GO_REF:0000024		 RGD
UniProt		 PMID:27005320 GO_REF:0000024 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740 		JBrowse link
G Minpp1 multiple inositol-polyphosphate phosphatase 1 NAS RGD PMID:9359836 RGD:69893 NCBI chr 1:230,354,483...230,379,730
Ensembl chr 1:230,354,438...230,379,730 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming involved_in ISO (PMID:25591774) RGD PMID:25591774 NCBI chr 1:196,864,375...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Ncs1 neuronal calcium sensor 1 IDA RGD PMID:12034721 RGD:728470 NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829 		JBrowse link
G Npr3 natriuretic peptide receptor 3 IMP RGD PMID:12829435 RGD:1581460 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase involved_in ISO
ISS
IEA		 (PMID:18288188)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:18288188 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha involved_in ISO
ISS
IEA		 (PMID:2554309)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:2554309 GO_REF:0000024 GO_REF:0000107 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in ISS
ISO		 GO_REF:0000024
(PMID:2554309)		 UniProt
RGD		 PMID:2554309 GO_REF:0000024 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha involved_in IEA
IBA		 GO_REF:0000002
PMID:21873635		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr11:83,609,136...83,726,876
Ensembl chr11:83,609,069...83,724,080 		JBrowse link
G Pi4kb phosphatidylinositol 4-kinase beta involved_in IBA
IEA		 PMID:21873635
GO_REF:0000002		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 2:182,540,377...182,572,684
Ensembl chr 2:182,540,567...182,588,488 		JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472 		JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612 		JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma involved_in IBA
IEA		 PMID:21873635
GO_REF:0000104		 UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 involved_in IDA
IEA
IBA		 GO_REF:0000002
PMID:21873635		 InterPro
RGD		 PMID:12244116 PMID:21873635 GO_REF:0000002, RGD:633560, RGD:13792537 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in IBA
IEA		 PMID:21873635
GO_REF:0000002		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pirt phosphoinositide-interacting regulator of transient receptor potential channels involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:3834285|PMID:18455988)		 RGD PMID:18455988 PMID:21873635 MGI:3834285, RGD:13792537 NCBI chr10:51,613,202...51,628,108
Ensembl chr10:51,613,126...51,632,264 		JBrowse link
G Pitpnm2 phosphatidylinositol transfer protein, membrane-associated 2 involved_in ISO (PMID:10022914) RGD PMID:10022914 NCBI chr12:32,347,455...32,479,103
Ensembl chr12:32,380,805...32,479,102 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb2 phospholipase C, beta 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Plcb3 phospholipase C beta 3 involved_in IBA
IDA		 PMID:21873635
PMID:8454637		 GO_Central
UniProt		 PMID:21873635 PMID:8454637 RGD:13792537, RGD:61699 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Plcb4 phospholipase C, beta 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Plcd1 phospholipase C, delta 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186 		JBrowse link
G Plcd3 phospholipase C, delta 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:88,026,707...88,048,080
Ensembl chr10:88,026,740...88,048,296 		JBrowse link
G Plcd4 phospholipase C, delta 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453 		JBrowse link
G Plce1 phospholipase C, epsilon 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438 		JBrowse link
G Plch1 phospholipase C, eta 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(PMID:15702972)		 RGD PMID:15702972 PMID:21873635 RGD:13792537 NCBI chr 2:148,148,908...148,363,616
Ensembl chr 2:148,148,921...148,364,097 		JBrowse link
G Plch2 phospholipase C, eta 2 involved_in ISO
IBA		 (PMID:18361507)
PMID:21873635		 RGD PMID:18361507 PMID:21873635 RGD:13792537 NCBI chr 5:165,544,209...165,613,769
Ensembl chr 5:165,544,200...165,602,356 		JBrowse link
G Plcl1 phospholipase C-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782 		JBrowse link
G Plcl2 phospholipase C-like 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:3,292,564...3,477,009
Ensembl chr 9:3,292,695...3,477,009 		JBrowse link
G Plcz1 phospholipase C, zeta 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:172,873,110...172,929,191
Ensembl chr 4:172,873,112...172,928,358 		JBrowse link
G Ptafr platelet-activating factor receptor involved_in ISO (PMID:1657923) RGD PMID:1657923 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
positive regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor acts_upstream_of_or_within ISO (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 involved_in IMP PMID:18469807
PMID:14528310		 UniProt PMID:18469807 PMID:14528310 RGD:8553892, RGD:1299350 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295 		JBrowse link
G Agt angiotensinogen involved_in ISO (PMID:15652490) RGD PMID:15652490 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Angpt1 angiopoietin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3848848|PMID:19409199)		 Ensembl
RGD		 PMID:19409199 GO_REF:0000107 MGI:3848848 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Cat catalase acts_upstream_of_or_within ISO (MGI:3037350|PMID:15020231) RGD PMID:15020231 MGI:3037350 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbl Cbl proto-oncogene involved_in ISO (PMID:17003487) RGD PMID:17003487 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 involved_in ISO
IDA		 (PMID:7544376)
PMID:10477596		 RGD PMID:7544376 PMID:10477596 RGD:8553666 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cntf ciliary neurotrophic factor IDA RGD PMID:15574731 RGD:1626128 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877 		JBrowse link
G Csf3 colony stimulating factor 3 involved_in ISO (PMID:23001182) RGD PMID:23001182 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO (PMID:23798385) RGD PMID:23798385 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Egf epidermal growth factor involved_in ISO
IEA		 UniProtKB:O00329 (PMID:31915155)
GO_REF:0000107		 RGD
Ensembl		 PMID:31915155 GO_REF:0000107 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IMP RGD PMID:16168116 RGD:1582137 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 acts_upstream_of_or_within ISO MGI:96083 (MGI:3796800|PMID:18458158) RGD PMID:18458158 MGI:3796800 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G F2 coagulation factor II involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:101780|MGI:101802 (MGI:3810206|PMID:18398001)		 Ensembl
RGD		 PMID:18398001 GO_REF:0000107 MGI:3810206 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5285163|PMID:20215560)
MGI:88380 (MGI:3810206|PMID:18398001)		 UniProt
Ensembl
RGD		 PMID:18398001 PMID:20215560 GO_REF:0000024 GO_REF:0000107 MGI:3810206 MGI:5285163 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5285163|PMID:20215560)		 UniProt
RGD		 PMID:20215560 GO_REF:0000024 MGI:5285163 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Fgf2 fibroblast growth factor 2 involved_in ISO UniProtKB:O00329 (PMID:31915155) RGD PMID:31915155 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:10739672) RGD PMID:10739672 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 involved_in ISO
IEA		 (PMID:14633857)
GO_REF:0000107		 RGD
Ensembl		 PMID:14633857 GO_REF:0000107 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fn1 fibronectin 1 involved_in ISO
IEA		 (PMID:19126672)
GO_REF:0000107		 RGD
Ensembl		 PMID:19126672 GO_REF:0000107 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fshr follicle stimulating hormone receptor involved_in ISS
ISO		 GO_REF:0000024
(PMID:24058690)		 UniProt
RGD		 PMID:24058690 GO_REF:0000024 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gh1 growth hormone 1 involved_in ISO (PMID:7782332) RGD PMID:7782332 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in IDA
IEA
ISO		 GO_REF:0000107
(PMID:15705806)		 Ensembl
RGD		 PMID:15705806 PMID:19717735 GO_REF:0000107, RGD:4892081 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hax1 HCLS1 associated protein X-1 involved_in ISO (PMID:23001182) RGD PMID:23001182 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714 		JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 involved_in ISO (PMID:23001182) RGD PMID:23001182 NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014 		JBrowse link
G Hcst hematopoietic cell signal transducer involved_in IBA
IEA
ISO		 PMID:21873635
GO_REF:0000002
(PMID:10426994)		 InterPro
RGD		 PMID:10426994 PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 1:85,676,976...85,679,083
Ensembl chr 1:85,676,979...85,679,012 		JBrowse link
G Hgf hepatocyte growth factor involved_in ISO (PMID:20655899) RGD PMID:20655899 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in
acts_upstream_of_or_within		 IDA
IBA
IEA
ISO		 PMID:17023532
PMID:21873635
GO_REF:0000107
(MGI:5005047|PMID:21413931)
(PMID:7688386)		 Ensembl
RGD		 PMID:7688386 PMID:21413931 PMID:17023532 PMID:21873635 GO_REF:0000107 MGI:5005047, RGD:1600072, RGD:13792537 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor involved_in IMP
IBA		 PMID:21873635 RGD
GO_Central		 PMID:25186839 PMID:21873635 RGD:10046020, RGD:13792537 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il18 interleukin 18 involved_in ISO
IEA		 (PMID:21321938)
GO_REF:0000107		 RGD
Ensembl		 PMID:21321938 GO_REF:0000107 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Ins2 insulin 2 involved_in ISO (PMID:7688386) RGD PMID:7688386 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISO (MGI:3828423|PMID:7782332) RGD PMID:7782332 MGI:3828423 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kdr kinase insert domain receptor involved_in IMP
IEA
ISO		 GO_REF:0000107
(PMID:9804796)		 Ensembl
RGD		 PMID:9804796 PMID:18221855 GO_REF:0000107, RGD:2292019 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lep leptin involved_in IDA
ISO
IBA		 PMID:11677594
(MGI:4821191|PMID:20620997)
PMID:21873635
(PMID:24340098)		 RGD PMID:20620997 PMID:24340098 PMID:11677594 PMID:21873635 MGI:4821191, RGD:10448951, RGD:13792537 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Maz MYC associated zinc finger protein involved_in ISO (PMID:25487955) RGD PMID:25487955 NCBI chr 1:181,629,742...181,635,193
Ensembl chr 1:181,629,729...181,650,408 		JBrowse link
G Mir126b microRNA 126b involved_in ISO (PMID:28578351) RGD PMID:28578351 NCBI chr 3:9,415,087...9,415,159 JBrowse link
G Mir21 microRNA 21 involved_in IMP
ISO		 (PMID:16762633) RGD PMID:16762633 PMID:31759996 RGD:41410819 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mydgf myeloid-derived growth factor involved_in ISO (MGI:5609664|PMID:25581518) RGD PMID:25581518 MGI:5609664 NCBI chr 9:999,659...1,008,895
Ensembl chr 9:1,000,722...1,008,822 		JBrowse link
G Myoc myocilin involved_in ISO
ISS
IEA		 (PMID:21656515)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:21656515 GO_REF:0000024 GO_REF:0000107 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase involved_in ISO (PMID:17218260) RGD PMID:17218260 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951 		JBrowse link
G Nkx3-1 NK3 homeobox 1 involved_in ISO
ISS		 (PMID:20395202)
GO_REF:0000024		 RGD
UniProt		 PMID:20395202 GO_REF:0000024 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nrg1 neuregulin 1 acts_upstream_of_or_within ISO MGI:104771 (MGI:3796800|PMID:18458158) RGD PMID:18458158 MGI:3796800 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in IMP
IBA		 PMID:10985347
PMID:21873635		 UniProt
GO_Central		 PMID:10985347 PMID:21873635 RGD:8553408, RGD:13792537 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Osm oncostatin M involved_in ISO RNAcentral:URS0000574A2C_9606 (PMID:28972028) RGD PMID:28972028 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Pdgfa platelet derived growth factor subunit A involved_in IBA
ISS
ISO		 PMID:21873635
GO_REF:0000024
(PMID:11788434)		 UniProt
RGD		 PMID:11788434 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA
IEA		 GO_REF:0000024
MGI:1349482|MGI:1890662 (MGI:3617099|PMID:16456542)
PMID:21873635
(PMID:10734101), (PMID:11788434), (PMID:17942966), (PMID:19126672)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:10734101 PMID:11788434 PMID:16456542 PMID:17942966 PMID:19126672 More... GO_REF:0000024 GO_REF:0000107 MGI:3617099, RGD:13792537 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfc platelet derived growth factor C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:166,316,870...166,493,449
Ensembl chr 2:166,316,803...166,493,433 		JBrowse link
G Pdgfd platelet derived growth factor D involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in ISS
ISO		 GO_REF:0000024
(MGI:5009390|PMID:17942966)		 UniProt
RGD		 PMID:17942966 GO_REF:0000024 MGI:5009390 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5305503|PMID:22187460), (MGI:5305504|PMID:22187458) RGD PMID:22187458 PMID:22187460 MGI:5305503 MGI:5305504 NCBI chr 1:240,090,859...240,245,007
Ensembl chr 1:240,093,065...240,204,828 		JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:15705590 RGD:2299907 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Plxnb1 plexin B1 involved_in ISO (MGI:4413657|PMID:19788569) RGD PMID:19788569 MGI:4413657 NCBI chr 8:109,743,470...109,769,153
Ensembl chr 8:109,744,697...109,769,027 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta acts_upstream_of_or_within ISO (MGI:3621068|PMID:16581799) RGD PMID:16581799 MGI:3621068 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Prr5 proline rich 5 acts_upstream_of_or_within ISO MGI:1919696 (MGI:5005047|PMID:21413931) RGD PMID:21413931 MGI:5005047 NCBI chr 7:115,795,351...115,837,880
Ensembl chr 7:115,813,954...115,834,834 		JBrowse link
G Prr5l proline rich 5 like involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1924714 (MGI:5005047|PMID:21413931)		 Ensembl
RGD		 PMID:21413931 GO_REF:0000107 MGI:5005047 NCBI chr 3:88,001,951...88,173,532
Ensembl chr 3:88,003,617...88,082,763 		JBrowse link
G Ptk2 protein tyrosine kinase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15166238)		 UniProt
RGD		 PMID:15166238 GO_REF:0000024 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in ISO
IEA		 (PMID:19838216)
GO_REF:0000107		 RGD
Ensembl		 PMID:19838216 GO_REF:0000107 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Rara retinoic acid receptor, alpha involved_in IMP PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Reln reelin involved_in IEA
ISO		 GO_REF:0000107
(MGI:5286805|PMID:21664258)		 Ensembl
RGD		 PMID:21664258 GO_REF:0000107 MGI:5286805 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Rgl2 ral guanine nucleotide dissociation stimulator-like 2 acts_upstream_of_or_within ISO (MGI:5547674|PMID:24069211) RGD PMID:24069211 MGI:5547674 NCBI chr20:4,948,495...4,956,774
Ensembl chr20:4,948,497...4,969,911 		JBrowse link
G Ror1 receptor tyrosine kinase-like orphan receptor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:114,744,311...115,088,155
Ensembl chr 5:114,744,304...115,088,155 		JBrowse link
G Ror2 receptor tyrosine kinase-like orphan receptor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:11,972,830...12,148,152
Ensembl chr17:11,972,830...12,148,152 		JBrowse link
G Selp selectin P involved_in ISO
IEA		 (PMID:17632516)
GO_REF:0000107		 RGD
Ensembl		 PMID:17632516 GO_REF:0000107 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Sema3e semaphorin 3E involved_in ISO (PMID:25985275) RGD PMID:25985275 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229 		JBrowse link
G Sema4d semaphorin 4D involved_in ISO (PMID:16055703) RGD PMID:16055703 NCBI chr17:13,430,324...13,537,146
Ensembl chr17:13,430,379...13,537,138 		JBrowse link
G Serpina12 serpin family A member 12 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5568548 (MGI:5563627|PMID:22837305)		 Ensembl
RGD		 PMID:22837305 GO_REF:0000107 MGI:5563627 NCBI chr 6:122,952,552...122,967,271
Ensembl chr 6:122,952,552...122,967,271 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:4821191|PMID:20620997) RGD PMID:20620997 MGI:4821191 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4950303|PMID:21367821)		 UniProt
RGD		 PMID:21367821 GO_REF:0000024 MGI:4950303 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Tek TEK receptor tyrosine kinase involved_in ISO
IBA		 (PMID:12816861), (PMID:18425120), (PMID:19223473)
PMID:21873635		 RGD PMID:12816861 PMID:18425120 PMID:19223473 PMID:21873635 RGD:13792537 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO
ISS		 (PMID:18223299)
GO_REF:0000024		 RGD
AgBase		 PMID:18223299 GO_REF:0000024 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tnf tumor necrosis factor involved_in IMP PMID:12729461 ARUK-UCL PMID:12729461 RGD:13673777 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6458378|PMID:30684126) RGD PMID:30684126 MGI:6458378 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Ube3a ubiquitin protein ligase E3A acts_upstream_of_or_within ISO MGI:2181811 (MGI:3616918|PMID:16254014) RGD PMID:16254014 MGI:3616918 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250 		JBrowse link
G Unc5b unc-5 netrin receptor B involved_in IEA
ISO		 GO_REF:0000107
(PMID:18469807)		 Ensembl
RGD		 PMID:18469807 GO_REF:0000107 NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO UniProtKB:O00329|UniProtKB:P42336 (PMID:30496354), (PMID:31915155)
UniProtKB:O00329 (PMID:31915155)		 RGD PMID:30496354 PMID:31915155 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wnt16 Wnt family member 16 involved_in ISO (PMID:19951988) RGD PMID:19951988 NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380 		JBrowse link
regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in IDA PMID:11694516 UniProt PMID:11694516 RGD:11041061 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cep55 centrosomal protein 55 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394 		JBrowse link
G Crnn cornulin involved_in ISO
IBA		 (PMID:30009832)
PMID:21873635		 RGD PMID:30009832 PMID:21873635 RGD:13792537 NCBI chr 2:178,733,329...178,736,404
Ensembl chr 2:178,731,796...178,736,216 		JBrowse link
G Dipk2a divergent protein kinase domain 2A involved_in IBA
ISO		 PMID:21873635
(PMID:23784961)		 RGD PMID:23784961 PMID:21873635 RGD:13792537 NCBI chr 8:95,070,695...95,089,815
Ensembl chr 8:95,030,279...95,089,815 		JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 involved_in ISO (MGI:4881347|PMID:21074248) RGD PMID:21074248 MGI:4881347 NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530 		JBrowse link
G Fbxl2 F-box and leucine-rich repeat protein 2 involved_in ISO (PMID:23604317) RGD PMID:23604317 NCBI chr 8:113,916,660...113,965,137
Ensembl chr 8:113,913,373...113,965,066 		JBrowse link
G Lime1 Lck interacting transmembrane adaptor 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:3769059|PMID:16249387)		 RGD PMID:16249387 PMID:21873635 MGI:3769059, RGD:13792537 NCBI chr 3:168,490,535...168,496,627
Ensembl chr 3:168,490,074...168,493,127 		JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B involved_in ISO (PMID:25007873) RGD PMID:25007873 NCBI chr 3:147,323,652...147,419,658
Ensembl chr 3:147,324,126...147,418,937 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 involved_in ISO (PMID:23604317) RGD PMID:23604317 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 acts_upstream_of_or_within ISO MGI:2386261 (MGI:3758152|PMID:17190838) RGD PMID:17190838 MGI:3758152 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20094
    signaling 7674
      signal transduction 7105
        intracellular signal transduction 2740
          inositol lipid-mediated signaling 187
            phosphatidylinositol-mediated signaling + 184
Path 2
Term Annotations click to browse term
  biological_process 20094
    biological regulation 13926
      regulation of biological process 13157
        regulation of cellular process 12435
          signal transduction 7105
            intracellular signal transduction 2740
              inositol lipid-mediated signaling 187
                phosphatidylinositol-mediated signaling + 184
paths to the root