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ONTOLOGY REPORT - ANNOTATIONS

Term:ephrin receptor signaling pathway
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Accession:GO:0048013 term browser browse the term
Definition:The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: Eph receptor signaling pathway;   Eph receptor signalling pathway
 xref: Reactome:R-HSA-2682334 "EPH-Ephrin signaling"


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ephrin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675 		JBrowse link
G ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A involved_in ISS
IBA 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:34,889,255...35,097,990
Ensembl chr 6:34,889,255...35,091,406 		JBrowse link
G ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:98,734,786...99,984,936
Ensembl chr12:98,726,457...99,984,936 		JBrowse link
G ARHGEF28 Rho guanine nucleotide exchange factor 28 involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr 5:73,626,196...73,941,990
Ensembl chr 5:73,626,158...73,941,993 		JBrowse link
G ARHGEF7 Rho guanine nucleotide exchange factor 7 involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr13:111,114,619...111,305,734
Ensembl chr13:111,114,559...111,305,737 		JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253 		JBrowse link
G CHN1 chimerin 1 involved_in ISS
IBA 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr 2:174,798,809...175,005,381
Ensembl chr 2:174,798,809...175,005,381 		JBrowse link
G CRK CRK proto-oncogene, adaptor protein involved_in IDA (PMID:11870224) UniProt PMID:11870224 NCBI chr17:1,420,693...1,456,232
Ensembl chr17:1,420,689...1,463,162 		JBrowse link
G DIAPH1 diaphanous related formin 1 acts_upstream_of_or_within ISO (PMID:23890216) MGI PMID:23890216 NCBI chr 5:141,515,021...141,619,000
Ensembl chr 5:141,515,016...141,619,055 		JBrowse link
G DIAPH2 diaphanous related formin 2 acts_upstream_of_or_within ISO (PMID:23890216) MGI PMID:23890216 NCBI chr  X:96,684,842...97,604,997
Ensembl chr  X:96,684,712...97,604,997 		JBrowse link
G EFNA1 ephrin A1 involved_in
acts_upstream_of_or_within 		IEA
IGI
IBA
IDA 		(PMID:24217950)
(PMID:10655584) 		InterPro
Ensembl
ARUK-UCL
GO_Central
UniProt		 PMID:10655584 PMID:24217950 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:155,127,876...155,134,899
Ensembl chr 1:155,127,876...155,134,899 		JBrowse link
G EFNA2 ephrin A2 involved_in IEA
IBA
ISS 		Ensembl
GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr19:1,284,227...1,301,431
Ensembl chr19:1,285,873...1,301,431 		JBrowse link
G EFNA3 ephrin A3 involved_in IGI
IBA
IEA
ISS 		(PMID:24217950) ARUK-UCL
GO_Central
Ensembl
InterPro
UniProt		 PMID:24217950 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:155,078,837...155,087,538
Ensembl chr 1:155,078,837...155,087,538 		JBrowse link
G EFNA4 ephrin A4 involved_in IEA
IBA 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:155,063,740...155,069,553
Ensembl chr 1:155,063,737...155,069,553 		JBrowse link
G EFNA4-EFNA3 EFNA4-EFNA3 readthrough involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:155,063,740...155,087,538
Ensembl chr 1:155,063,748...155,086,807 		JBrowse link
G EFNA5 ephrin A5 involved_in IEA
IBA
IDA 		(PMID:11870224) InterPro
GO_Central
UniProt
Ensembl		 PMID:11870224 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:107,376,894...107,670,937
Ensembl chr 5:107,376,894...107,670,937 		JBrowse link
G EFNB1 ephrin B1 involved_in IEA
IBA 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr  X:68,829,021...68,842,160
Ensembl chr  X:68,829,021...68,842,160 		JBrowse link
G EFNB2 ephrin B2 involved_in IDA
IBA
IEA 		(PMID:12734395) UniProt
GO_Central
InterPro		 PMID:12734395 GO_REF:0000002 GO_REF:0000033 NCBI chr13:106,489,745...106,535,662
Ensembl chr13:106,489,745...106,535,662 		JBrowse link
G EFNB3 ephrin B3 acts_upstream_of_or_within
involved_in 		IDA
IBA 		(PMID:8808709) MGI
GO_Central		 PMID:8808709 GO_REF:0000033 NCBI chr17:7,705,202...7,711,372
Ensembl chr17:7,705,202...7,711,372 		JBrowse link
G EPHA1 EPH receptor A1 involved_in IEA GOC GO_REF:0000108 NCBI chr 7:143,391,129...143,408,856
Ensembl chr 7:143,390,289...143,408,856 		JBrowse link
G EPHA10 EPH receptor A10 involved_in IEA
IBA 		GOC
GO_Central		 GO_REF:0000033 GO_REF:0000108 NCBI chr 1:37,713,880...37,765,120
Ensembl chr 1:37,713,880...37,765,133 		JBrowse link
G EPHA2 EPH receptor A2 involved_in
acts_upstream_of_or_within 		IDA
IEA 		(PMID:10655584), (PMID:20861311) UniProt
Ensembl		 PMID:10655584 PMID:20861311 GO_REF:0000107 NCBI chr 1:16,124,337...16,156,069
Ensembl chr 1:16,124,337...16,156,069 		JBrowse link
G EPHA3 EPH receptor A3 involved_in IDA
IEA
IBA 		(PMID:11870224) UniProt
GOC
GO_Central		 PMID:11870224 GO_REF:0000033 GO_REF:0000108 NCBI chr 3:89,107,621...89,482,134
Ensembl chr 3:89,107,621...89,482,134 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IGI
IEA
IBA
ISS 		(PMID:24217950) ARUK-UCL
Ensembl
GOC
GO_Central		 PMID:24217950 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000108 NCBI chr 2:221,418,027...221,574,202
Ensembl chr 2:221,418,027...221,574,202 		JBrowse link
G EPHA5 EPH receptor A5 involved_in ISS
IEA
IBA 		UniProt
GOC
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000108 NCBI chr 4:65,319,567...65,670,489
Ensembl chr 4:65,319,563...65,670,495 		JBrowse link
G EPHA6 EPH receptor A6 involved_in IBA
IEA 		GO_Central
GOC		 GO_REF:0000033 GO_REF:0000108 NCBI chr 3:96,814,594...97,761,532
Ensembl chr 3:96,814,581...97,761,532 		JBrowse link
G EPHA7 EPH receptor A7 involved_in IEA
IBA
IDA 		(PMID:17726105) GOC
GO_Central
Ensembl
UniProt		 PMID:17726105 GO_REF:0000033 GO_REF:0000107 GO_REF:0000108 NCBI chr 6:93,240,020...93,419,559
Ensembl chr 6:93,240,020...93,419,687 		JBrowse link
G EPHA8 EPH receptor A8 involved_in ISS
IBA
IEA 		UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:22,563,489...22,603,595
Ensembl chr 1:22,563,489...22,603,595 		JBrowse link
G EPHB1 EPH receptor B1 involved_in
acts_upstream_of_or_within 		IDA
IEA
IBA 		(PMID:12925710), (PMID:18034775) UniProt
Ensembl
GOC
GO_Central		 PMID:12925710 PMID:18034775 GO_REF:0000033 GO_REF:0000107 GO_REF:0000108 NCBI chr 3:134,795,260...135,260,467
Ensembl chr 3:134,795,260...135,260,467 		JBrowse link
G EPHB2 EPH receptor B2 involved_in
acts_upstream_of_or_within 		ISS
IEA
IBA 		UniProt
Ensembl
GOC
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000108 NCBI chr 1:22,710,838...22,921,500
Ensembl chr 1:22,710,839...22,921,500 		JBrowse link
G EPHB3 EPH receptor B3 involved_in IDA
IBA 		(PMID:15536074), (PMID:8397371) UniProt
GO_Central		 PMID:8397371 PMID:15536074 GO_REF:0000033 NCBI chr 3:184,561,785...184,582,408
Ensembl chr 3:184,561,785...184,582,408 		JBrowse link
G EPHB4 EPH receptor B4 involved_in IDA
IEA
IBA 		(PMID:12734395) UniProt
GOC
GO_Central		 PMID:12734395 GO_REF:0000033 GO_REF:0000108 NCBI chr 7:100,802,565...100,827,523
Ensembl chr 7:100,802,565...100,827,523 		JBrowse link
G EPHB6 EPH receptor B6 involved_in IEA
IBA 		GOC
GO_Central		 GO_REF:0000033 GO_REF:0000108 NCBI chr 7:142,855,076...142,871,093
Ensembl chr 7:142,855,061...142,871,094 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452 		JBrowse link
G GIT1 GIT ArfGAP 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:29,573,475...29,589,648
Ensembl chr17:29,573,475...29,594,054 		JBrowse link
G KALRN kalirin RhoGEF kinase involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr 3:124,033,369...124,726,325
Ensembl chr 3:124,033,369...124,726,325 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in TAS
IGI 		(PMID:24217950) Reactome
ARUK-UCL		 PMID:24217950 Reactome:R-HSA-2682334 NCBI chr 8:55,879,835...56,014,169
Ensembl chr 8:55,879,835...56,014,169 		JBrowse link
G MMP2 matrix metallopeptidase 2 involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:136,862,208...136,951,606
Ensembl chr 3:136,862,208...136,951,606 		JBrowse link
G NCK2 NCK adaptor protein 2 involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:105,744,453...105,894,272
Ensembl chr 2:105,744,912...105,894,274 		JBrowse link
G NGEF neuronal guanine nucleotide exchange factor involved_in TAS
IEA
ISS 		Reactome
Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 Reactome:R-HSA-2682334 NCBI chr 2:232,878,701...233,013,256
Ensembl chr 2:232,878,701...233,013,256 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,636...156,881,850 		JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GOC GO_REF:0000108 NCBI chr15:87,859,751...88,256,739
Ensembl chr15:87,859,751...88,256,791 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr11:77,322,017...77,530,009
Ensembl chr11:77,322,017...77,474,635 		JBrowse link
G PAK3 p21 (RAC1) activated kinase 3 involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr  X:110,944,397...111,227,361
Ensembl chr  X:110,944,285...111,227,361 		JBrowse link
G PTK2 protein tyrosine kinase 2 involved_in IDA (PMID:10655584) UniProt PMID:10655584 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in IDA (PMID:10655584) UniProt PMID:10655584 NCBI chr12:112,418,947...112,509,918
Ensembl chr12:112,418,351...112,509,918 		JBrowse link
G RASA1 RAS p21 protein activator 1 involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr 5:87,267,883...87,391,916
Ensembl chr 5:87,267,883...87,391,931 		JBrowse link
G SIPA1L1 signal induced proliferation associated 1 like 1 involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:71,320,476...71,741,209
Ensembl chr14:71,320,449...71,741,229 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G SS18 SS18 subunit of BAF chromatin remodeling complex acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr18:26,016,253...26,091,219
Ensembl chr18:26,016,253...26,091,217 		JBrowse link
G TIAM1 TIAM Rac1 associated GEF 1 involved_in
acts_upstream_of_or_within 		TAS
ISO 		(PMID:14988728) Reactome
MGI		 PMID:14988728 Reactome:R-HSA-2682334 NCBI chr21:31,118,418...31,559,087
Ensembl chr21:31,118,416...31,559,977 		JBrowse link
G YES1 YES proto-oncogene 1, Src family tyrosine kinase involved_in TAS Reactome Reactome:R-HSA-2682334 NCBI chr18:721,588...812,753
Ensembl chr18:721,588...812,546 		JBrowse link
negative regulation of ephrin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR519D microRNA 519d involved_in IDA (PMID:29093007) ARUK-UCL PMID:29093007 NCBI chr19:53,713,347...53,713,434
Ensembl chr19:53,713,347...53,713,434 		JBrowse link
positive regulation of ephrin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in ISS
IEA 		BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:26,105,449...26,435,131
Ensembl chr 4:26,163,455...26,435,131 		JBrowse link
regulation of ephrin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A acts_upstream_of_or_within ISO (PMID:20100865) MGI PMID:20100865 NCBI chr 6:34,889,255...35,097,990
Ensembl chr 6:34,889,255...35,091,406 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27207
    cellular process 19782
      signal transduction 6672
        cell surface receptor signaling pathway 3226
          enzyme-linked receptor protein signaling pathway 1191
            cell surface receptor protein tyrosine kinase signaling pathway 746
              ephrin receptor signaling pathway 56
                negative regulation of ephrin receptor signaling pathway 1
                positive regulation of ephrin receptor signaling pathway 1
                regulation of ephrin receptor signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 27207
    biological regulation 13701
      regulation of biological process 13242
        signaling 7270
          signal transduction 6672
            cell surface receptor signaling pathway 3226
              enzyme-linked receptor protein signaling pathway 1191
                cell surface receptor protein tyrosine kinase signaling pathway 746
                  ephrin receptor signaling pathway 56
                    negative regulation of ephrin receptor signaling pathway 1
                    positive regulation of ephrin receptor signaling pathway 1
                    regulation of ephrin receptor signaling pathway + 3
paths to the root