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ONTOLOGY REPORT - ANNOTATIONS

Term:ephrin receptor signaling pathway
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Accession:GO:0048013 term browser browse the term
Definition:The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: Eph receptor signaling pathway;   Eph receptor signalling pathway
 xref: Reactome:R-HSA-2682334 "EPH-Ephrin signaling"


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ephrin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07032856.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr18:82,141,202...82,142,778 JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in ISO
IEA		 UniProtKB:Q03137 (PMID:24658113)
GO_REF:0000107		 RGD
Ensembl		 PMID:24658113 GO_REF:0000107 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Anks1a ankyrin repeat and sterile alpha motif domain containing 1A involved_in IBA
ISO		 GO_REF:0000033
(PMID:17875921)		 GO_Central
RGD		 PMID:17875921 GO_REF:0000033 NCBI chr20:5,965,421...6,118,875
Ensembl chr20:5,963,678...6,117,148 		JBrowse link
G Anks1b ankyrin repeat and sterile alpha motif domain containing 1B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:26,200,649...27,366,552
Ensembl chr 7:24,312,843...25,477,693 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17143272)		 UniProt
RGD		 PMID:17143272 GO_REF:0000024 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Chn1 chimerin 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17785183)		 UniProt
RGD		 PMID:17785183 GO_REF:0000024 NCBI chr 3:78,917,329...79,084,040
Ensembl chr 3:58,510,536...58,676,490 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:11870224)		 UniProt
Ensembl
RGD		 PMID:11870224 GO_REF:0000024 GO_REF:0000107 NCBI chr10:61,028,736...61,054,971
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Diaph1 diaphanous-related formin 1 acts_upstream_of_or_within ISO MGI:1858500 (PMID:23890216) RGD PMID:23890216 NCBI chr18:29,920,889...30,020,280
Ensembl chr18:29,669,659...29,769,172 		JBrowse link
G Diaph2 diaphanous-related formin 2 acts_upstream_of_or_within ISO MGI:1194490 (PMID:23890216) RGD PMID:23890216 NCBI chr  X:96,700,535...97,528,080
Ensembl chr  X:92,395,251...93,229,869 		JBrowse link
G Efna1 ephrin A1 involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA
ISS		 UniProtKB:P07948|UniProtKB:P54764 (PMID:10655584), (PMID:24217950)
(PMID:17143272)
(PMID:14988728), (PMID:15145949)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
GO_REF:0000024		 RGD
GO_Central
Ensembl
InterPro
UniProt		 PMID:10655584 PMID:14988728 PMID:15145949 PMID:17143272 PMID:24217950 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Efna2 ephrin A2 involved_in TAS
IEA
ISO
IBA		 GO_REF:0000002
GO_REF:0000107
(PMID:9053851)
GO_REF:0000033		 InterPro
Ensembl
RGD
GO_Central		 PMID:9053851 PMID:10792438 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:1300471 NCBI chr 7:10,167,091...10,177,719
Ensembl chr 7:9,516,429...9,527,061 		JBrowse link
G Efna3 ephrin A3 involved_in TAS
IEA
ISO		 GO_REF:0000002
(PMID:9053851)
UniProtKB:P54764 (PMID:24217950)		 InterPro
RGD		 PMID:9053851 PMID:24217950 PMID:10954848 GO_REF:0000002, RGD:634739 NCBI chr 2:177,026,928...177,035,838
Ensembl chr 2:174,729,764...174,738,736 		JBrowse link
G Efna4 ephrin A4 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 2:177,046,463...177,050,713
Ensembl chr 2:174,748,724...174,752,979 		JBrowse link
G Efna5 ephrin A5 involved_in ISO
IBA
IEA
ISS		 (PMID:11870224)
(PMID:17448994), (PMID:9053851)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000024		 RGD
GO_Central
InterPro
UniProt		 PMID:9053851 PMID:11870224 PMID:17448994 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr 9:109,763,786...110,042,396
Ensembl chr 9:102,320,295...102,597,413 		JBrowse link
G Efnb1 ephrin B1 involved_in TAS
IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro
RGD		 PMID:12139920 GO_REF:0000002 GO_REF:0000033, RGD:727396 NCBI chr  X:68,297,529...68,310,335
Ensembl chr  X:64,257,351...64,270,157 		JBrowse link
G Efnb2 ephrin B2 involved_in ISO
IEA		 (PMID:12734395)
GO_REF:0000002
GO_REF:0000107		 RGD
InterPro
Ensembl		 PMID:12734395 GO_REF:0000002 GO_REF:0000107 NCBI chr16:87,485,215...87,529,224
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Efnb3 ephrin B3 involved_in
acts_upstream_of_or_within		 TAS
IBA
ISO		 GO_REF:0000033
(PMID:8808709)		 GO_Central
RGD		 PMID:8808709 PMID:12963092 GO_REF:0000033, RGD:1300456 NCBI chr10:54,773,282...54,780,727
Ensembl chr10:54,274,506...54,280,471 		JBrowse link
G Epha1 Eph receptor A1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846 		JBrowse link
G Epha10 EPH receptor A10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:137,139,588...137,175,637
Ensembl chr 5:137,140,735...137,174,157 		JBrowse link
G Epha2 Eph receptor A2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:10655584), (PMID:20861311)
GO_REF:0000107
(PMID:18948590)
(PMID:14988728)		 RGD
Ensembl		 PMID:10655584 PMID:14988728 PMID:18948590 PMID:20861311 GO_REF:0000107 NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Epha3 Eph receptor A3 involved_in IEA
IBA
ISO
ISS		 GO_REF:0000108
GO_REF:0000033
(PMID:21135139)
GO_REF:0000024
(PMID:11870224)		 GOC
GO_Central
RGD
UniProt		 PMID:11870224 PMID:21135139 GO_REF:0000024 GO_REF:0000033 GO_REF:0000108 NCBI chr11:14,585,041...14,920,721
Ensembl chr11:1,140,985...1,473,900 		JBrowse link
G Epha4 Eph receptor A4 involved_in ISO
IEA
IBA
IGI		 UniProtKB:P20827|UniProtKB:P52797 (PMID:24217950)
GO_REF:0000107
UniProtKB:P00520 (PMID:24658113)
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:24217950 PMID:24658113 PMID:24658113 GO_REF:0000033 GO_REF:0000107, RGD:12911004 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Epha5 EPH receptor A5 involved_in IDA
IBA
ISO
IEA		 PMID:20824214
GO_REF:0000033
(PMID:17448994)
GO_REF:0000108		 GO_Central
RGD
GOC		 PMID:17448994 PMID:20824214 GO_REF:0000033 GO_REF:0000108, RGD:8554330 NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317 		JBrowse link
G Epha6 Eph receptor A6 involved_in IEA
IBA		 GO_REF:0000108
GO_REF:0000033		 GOC
GO_Central		 GO_REF:0000033 GO_REF:0000108 NCBI chr11:39,757,501...40,708,901
Ensembl chr11:39,757,181...40,698,311 		JBrowse link
G Epha7 Eph receptor A7 involved_in ISS
IBA
ISO
IEA		 GO_REF:0000024
GO_REF:0000033
(PMID:11089974)
GO_REF:0000107
GO_REF:0000108
(PMID:17726105)		 UniProt
GO_Central
RGD
Ensembl
GOC		 PMID:11089974 PMID:17726105 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000108 NCBI chr 5:47,771,776...47,925,189
Ensembl chr 5:42,975,405...43,127,112 		JBrowse link
G Epha8 Eph receptor A8 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:11416136), (PMID:17875921), (PMID:9053851)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:9053851 PMID:11416136 PMID:17875921 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399 		JBrowse link
G Ephb1 Eph receptor B1 involved_in
acts_upstream_of_or_within		 ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:17310244)
GO_REF:0000108
(PMID:12925710), (PMID:18034775)		 UniProt
Ensembl
GO_Central
RGD
GOC		 PMID:12925710 PMID:17310244 PMID:18034775 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000108 NCBI chr 8:111,386,432...111,823,759
Ensembl chr 8:102,507,549...102,944,839 		JBrowse link
G Ephb2 Eph receptor B2 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:17310244), (PMID:17686994)
GO_REF:0000107
(PMID:11585923), (PMID:21029865)
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:11585923 PMID:17310244 PMID:17686994 PMID:21029865 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Ephb3 Eph receptor B3 involved_in ISO
IEA
IBA		 (PMID:15536074), (PMID:8397371)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:8397371 PMID:15536074 GO_REF:0000033 GO_REF:0000107 NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370 		JBrowse link
G Ephb4 EPH receptor B4 involved_in ISO
IEA
IBA		 (PMID:12734395)
GO_REF:0000107
GO_REF:0000033
(PMID:10518221)		 RGD
Ensembl
GO_Central		 PMID:10518221 PMID:12734395 GO_REF:0000033 GO_REF:0000107 NCBI chr12:24,963,174...24,988,473
Ensembl chr12:19,326,427...19,351,314 		JBrowse link
G Ephb6 Eph receptor B6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230 		JBrowse link
G Git1 GIT ArfGAP 1 acts_upstream_of_or_within ISO
IEA		 (PMID:17310244)
GO_REF:0000107		 RGD
Ensembl		 PMID:17310244 GO_REF:0000107 NCBI chr10:62,840,165...62,854,508
Ensembl chr10:62,342,299...62,356,373 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO
IEA		 UniProtKB:P20827 (PMID:24217950)
GO_REF:0000107		 RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Nck1 NCK adaptor protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:19505147)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:19505147 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:109,897,723...109,958,247
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:17310244)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:17310244 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ngef neuronal guanine nucleotide exchange factor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17143272)		 UniProt
Ensembl
RGD		 PMID:17143272 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:95,594,823...95,692,381
Ensembl chr 9:88,146,956...88,244,914 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Ptk2 protein tyrosine kinase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10655584)		 UniProt
RGD		 PMID:10655584 GO_REF:0000024 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISO
IEA
ISS		 (PMID:10655584)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:10655584 GO_REF:0000024 GO_REF:0000107 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:17785183), (PMID:18094260)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17785183 PMID:18094260 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:107,570,569...107,849,613
Ensembl chr 6:101,839,404...102,116,950 		JBrowse link
G Ss18 SS18 subunit of BAF chromatin remodeling complex acts_upstream_of_or_within ISO
IEA		 (PMID:17686994)
GO_REF:0000107		 RGD
Ensembl		 PMID:17686994 GO_REF:0000107 NCBI chr18:6,047,619...6,169,151
Ensembl chr18:5,773,042...5,835,333 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 acts_upstream_of_or_within ISO (PMID:14988728) RGD PMID:14988728 NCBI chr11:42,517,527...42,866,280
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
positive regulation of ephrin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:17336907) RGD PMID:17336907 NCBI chr14:61,551,366...61,736,220
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
regulation of ephrin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anks1a ankyrin repeat and sterile alpha motif domain containing 1A acts_upstream_of_or_within ISO MGI:3867137 (PMID:20100865) RGD PMID:20100865 NCBI chr20:5,965,421...6,118,875
Ensembl chr20:5,963,678...6,117,148 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      signal transduction 7301
        cell surface receptor signaling pathway 2907
          enzyme-linked receptor protein signaling pathway 1067
            cell surface receptor protein tyrosine kinase signaling pathway 675
              ephrin receptor signaling pathway 44
                negative regulation of ephrin receptor signaling pathway 0
                positive regulation of ephrin receptor signaling pathway 1
                regulation of ephrin receptor signaling pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        signaling 7862
          signal transduction 7301
            cell surface receptor signaling pathway 2907
              enzyme-linked receptor protein signaling pathway 1067
                cell surface receptor protein tyrosine kinase signaling pathway 675
                  ephrin receptor signaling pathway 44
                    negative regulation of ephrin receptor signaling pathway 0
                    positive regulation of ephrin receptor signaling pathway 1
                    regulation of ephrin receptor signaling pathway + 2
paths to the root