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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:hepatocyte growth factor receptor signaling pathway
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Accession:GO:0048012 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a hepatocyte growth factor receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: HGF receptor signaling pathway;   HGF receptor signalling pathway
 narrow_synonym: Met signaling pathway
 xref: Reactome:R-HSA-8852405 "Signaling by MST1"


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hepatocyte growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO
IEA		 (PMID:21245381)
GO_REF:0000107		 RGD
Ensembl		 PMID:21245381 GO_REF:0000107 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Hgf hepatocyte growth factor involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:21245381)
GO_REF:0000107
GO_REF:0000033
(PMID:15314156), (PMID:21072211)		 RGD
Ensembl
GO_Central		 PMID:15314156 PMID:21072211 PMID:21245381 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:15314156) RGD PMID:15314156 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Muc20 mucin 20, cell surface associated involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000002
(PMID:15314156)		 GO_Central
InterPro
RGD		 PMID:15314156 GO_REF:0000002 GO_REF:0000033 NCBI chr11:67,987,816...68,001,496
Ensembl chr11:67,987,800...68,001,495 		JBrowse link
G Nrp1 neuropilin 1 involved_in ISO (PMID:21245381) RGD PMID:21245381 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 involved_in ISO
IEA		 (PMID:25198505)
GO_REF:0000107		 RGD
Ensembl		 PMID:25198505 GO_REF:0000107 NCBI chr 1:161,522,399...161,637,623
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (PMID:25198505) RGD PMID:25198505 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Stmn1 stathmin 1 involved_in ISO
IEA		 (PMID:25198505)
GO_REF:0000107		 RGD
Ensembl		 PMID:25198505 GO_REF:0000107 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
negative regulation of hepatocyte growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 involved_in ISO
IEA		 (PMID:17895370)
GO_REF:0000107		 RGD
Ensembl		 PMID:17895370 GO_REF:0000107 NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629 		JBrowse link
positive regulation of hepatocyte growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esm1 endothelial cell-specific molecule 1 involved_in ISO
IBA
IEA		 (PMID:11590178)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:11590178 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804 		JBrowse link
regulation of hepatocyte growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IEA		 (PMID:18819921)
GO_REF:0000107		 RGD
Ensembl		 PMID:18819921 GO_REF:0000107 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
ISS		 (PMID:18819921)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:18819921 GO_REF:0000024 GO_REF:0000107 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      signal transduction 7301
        cell surface receptor signaling pathway 2907
          enzyme-linked receptor protein signaling pathway 1067
            cell surface receptor protein tyrosine kinase signaling pathway 675
              hepatocyte growth factor receptor signaling pathway 12
                negative regulation of hepatocyte growth factor receptor signaling pathway 1
                positive regulation of hepatocyte growth factor receptor signaling pathway 1
                regulation of hepatocyte growth factor receptor signaling pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        signaling 7862
          signal transduction 7301
            cell surface receptor signaling pathway 2907
              enzyme-linked receptor protein signaling pathway 1067
                cell surface receptor protein tyrosine kinase signaling pathway 675
                  hepatocyte growth factor receptor signaling pathway 12
                    negative regulation of hepatocyte growth factor receptor signaling pathway 1
                    positive regulation of hepatocyte growth factor receptor signaling pathway 1
                    regulation of hepatocyte growth factor receptor signaling pathway + 4
paths to the root