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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin-like growth factor receptor signaling pathway
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Accession:GO:0048009 term browser browse the term
Definition:The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
Synonyms:exact_synonym: IGF receptor signaling pathway;   IGF receptor signalling pathway



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insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:8978681)
UniProt
RGD
PMID:8978681 GO_REF:0000024 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO MGI:2183829 (MGI:2670283|PMID:12865332) RGD PMID:12865332 MGI:2670283 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ghr growth hormone receptor involved_in ISO (PMID:7565946) RGD PMID:7565946 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
JBrowse link
G Gigyf1 GRB10 interacting GYF protein 1 acts_upstream_of_or_within
involved_in
ISO
IBA
PR:Q60751 (MGI:2671700|PMID:12771153)
PMID:21873635
RGD PMID:12771153 PMID:21873635 MGI:2671700, RGD:13792537 NCBI chr12:19,166,070...19,181,570
Ensembl chr12:19,166,088...19,175,023
JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:20670374)
MGI:4126459 (MGI:4366664|PMID:19744960)
PMID:21873635
RGD PMID:19744960 PMID:20670374 PMID:21873635 MGI:4366664, RGD:13792537 NCBI chr 9:88,001,212...88,127,040
Ensembl chr 9:88,001,301...88,125,715
JBrowse link
G Grb10 growth factor receptor bound protein 10 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
PR:Q60751 (MGI:2671700|PMID:12771153)
Ensembl
RGD
PMID:12771153 GO_REF:0000107 MGI:2671700 NCBI chr14:86,495,054...86,602,815
Ensembl chr14:86,495,054...86,602,806
JBrowse link
G Igf1 insulin-like growth factor 1 involved_in
acts_upstream_of_or_within
IDA
IEA
ISO
GO_REF:0000107
(MGI:2664440|PMID:12805218)
PMID:17023532
(PMID:19578119), (PMID:22351760)
Ensembl
RGD
PMID:12805218 PMID:19578119 PMID:22351760 PMID:16083987 PMID:17023532 GO_REF:0000107 MGI:2664440, RGD:1580473, RGD:1600072 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor involved_in IBA
IEA
ISS
ISO
PMID:21873635
GO_REF:0000107
GO_REF:0000024
(PMID:7679099)
Ensembl
UniProt
RGD
PMID:7679099 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igf2r insulin-like growth factor 2 receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
JBrowse link
G Irs1 insulin receptor substrate 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
UniProtKB:P08069 (PMID:7541045)
UniProt
Ensembl
RGD
PMID:7541045 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irs4 insulin receptor substrate 4 NAS RGD PMID:17720279 RGD:2301084 NCBI chr  X:105,344,016...105,359,985 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IMP
ISS
ISO
IEA
GO_REF:0000024
UniProtKB:P08069 (PMID:7541045), (PMID:7782332)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:7541045 PMID:7782332 PMID:9440811 GO_REF:0000024 GO_REF:0000107, RGD:1625263 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:4942268|PMID:9187110)
GO_REF:0000024
Ensembl
RGD
BHF-UCL
PMID:9187110 GO_REF:0000024 GO_REF:0000107 MGI:4942268 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO MGI:1270849|MGI:1927343 (MGI:3050929|PMID:15249583) RGD PMID:15249583 MGI:3050929 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Wdr6 WD repeat domain 6 NAS RGD PMID:17720279 RGD:2301084 NCBI chr 8:109,268,079...109,274,504
Ensembl chr 8:109,268,079...109,274,499
JBrowse link
negative regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn1 ataxin 1 acts_upstream_of_or_within ISO MGI:2429435 (MGI:3774689|PMID:18216249) RGD PMID:18216249 MGI:3774689 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
JBrowse link
G Atxn7 ataxin 7 acts_upstream_of_or_within ISO MGI:2651378 (MGI:3774689|PMID:18216249) RGD PMID:18216249 MGI:3774689 NCBI chr15:11,117,360...11,262,818
Ensembl chr15:11,118,886...11,263,106
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:19584291)
Ensembl
RGD
PMID:19584291 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925
JBrowse link
G Cilp cartilage intermediate layer protein involved_in ISO (PMID:12746903) RGD PMID:12746903 NCBI chr 8:65,777,281...65,792,251
Ensembl chr 8:65,777,281...65,792,251
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 involved_in
acts_upstream_of_or_within
ISO (PMID:10766744)
(MGI:3589307|PMID:16024235)
RGD PMID:10766744 PMID:16024235 MGI:3589307 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:12933696 RGD:1626126 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
JBrowse link
G Nkx3-1 NK3 homeobox 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:3839214|PMID:19258508)
UniProt
RGD
PMID:19258508 GO_REF:0000024 MGI:3839214 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Trim72 tripartite motif containing 72 acts_upstream_of_or_within ISO MGI:96432 (MGI:5602876|PMID:23965929) RGD PMID:23965929 MGI:5602876 NCBI chr 1:182,613,753...182,621,613
Ensembl chr 1:182,613,712...182,621,606
JBrowse link
positive regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2687199 (MGI:2683859|PMID:14676301)
Ensembl
RGD
PMID:14676301 GO_REF:0000107 MGI:2683859 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cdh3 cadherin 3 involved_in ISO (PMID:22696062) RGD PMID:22696062 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Gh1 growth hormone 1 involved_in ISO (PMID:7565946) RGD PMID:7565946 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Ghsr growth hormone secretagogue receptor acts_upstream_of_or_within ISO MGI:3040440 (MGI:3039217|PMID:15070777) RGD PMID:15070777 MGI:3039217 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
JBrowse link
G Ift88 intraflagellar transport 88 acts_upstream_of_or_within ISO (MGI:4361959|PMID:19596798) RGD PMID:19596798 MGI:4361959 NCBI chr15:31,573,325...31,666,068
Ensembl chr15:31,573,376...31,672,147
JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA
(PMID:10766744), (PMID:7688386)
GO_REF:0000107
RGD
Ensembl
PMID:7688386 PMID:10766744 GO_REF:0000107 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:96439|MGI:96440 (MGI:3655403|PMID:16675541)
Ensembl
RGD
PMID:16675541 GO_REF:0000107 MGI:3655403 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 acts_upstream_of_or_within ISO MGI:96438|MGI:96440 (MGI:3655403|PMID:16675541) RGD PMID:16675541 MGI:3655403 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 acts_upstream_of_or_within ISO MGI:96438|MGI:96439 (MGI:3655403|PMID:16675541) RGD PMID:16675541 MGI:3655403 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Myorg myogenesis regulating glycosidase acts_upstream_of_or_within ISO (MGI:4422154|PMID:19706595) RGD PMID:19706595 MGI:4422154 NCBI chr 5:56,654,257...56,664,467
Ensembl chr 5:56,648,643...56,664,440
JBrowse link
G Phip pleckstrin homology domain interacting protein involved_in ISO (MGI:3723572|PMID:17636024) RGD PMID:17636024 MGI:3723572 NCBI chr 8:83,776,802...83,891,192
Ensembl chr 8:83,781,465...83,894,283
JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:12154096) RGD PMID:12154096 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ghrhr growth hormone releasing hormone receptor acts_upstream_of_or_within ISO MGI:1856425 (MGI:52244|PMID:7679139), (MGI:54816|PMID:7390396) RGD PMID:7390396 PMID:7679139 MGI:52244 MGI:54816 NCBI chr 4:84,498,159...84,532,847
Ensembl chr 4:84,500,212...84,532,776
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 involved_in IC
IBA
ISS
PMID:2974285
PMID:21873635
GO_REF:0000024
UniProt PMID:2974285 PMID:21873635 GO_REF:0000024, RGD:8553840, RGD:13792537 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966
JBrowse link
G Pou1f1 POU class 1 homeobox 1 acts_upstream_of_or_within ISO MGI:1856024 (MGI:54816|PMID:7390396) RGD PMID:7390396 MGI:54816 NCBI chr11:3,316,818...3,334,804
Ensembl chr11:3,317,058...3,334,801
JBrowse link
G Zfand2b zinc finger AN1-type containing 2B involved_in ISO (MGI:5780912|PMID:26692333) RGD PMID:26692333 MGI:5780912 NCBI chr 9:76,665,466...76,668,447
Ensembl chr 9:76,665,546...76,668,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    signaling 7439
      signal transduction 6859
        cell surface receptor signaling pathway 2772
          enzyme linked receptor protein signaling pathway 978
            transmembrane receptor protein tyrosine kinase signaling pathway 613
              insulin-like growth factor receptor signaling pathway 40
                negative regulation of insulin-like growth factor receptor signaling pathway 9
                positive regulation of insulin-like growth factor receptor signaling pathway 12
                regulation of insulin-like growth factor receptor signaling pathway + 26
Path 2
Term Annotations click to browse term
  biological_process 19390
    biological regulation 13476
      regulation of biological process 12735
        regulation of cellular process 12196
          signal transduction 6859
            cell surface receptor signaling pathway 2772
              enzyme linked receptor protein signaling pathway 978
                transmembrane receptor protein tyrosine kinase signaling pathway 613
                  insulin-like growth factor receptor signaling pathway 40
                    negative regulation of insulin-like growth factor receptor signaling pathway 9
                    positive regulation of insulin-like growth factor receptor signaling pathway 12
                    regulation of insulin-like growth factor receptor signaling pathway + 26
paths to the root