Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:platelet-derived growth factor receptor signaling pathway
go back to main search page
Accession:GO:0048008 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
Synonyms:exact_synonym: PDGF receptor signaling pathway;   PDGF receptor signalling pathway;   PDGFR signaling pathway


GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
 
platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (MGI:4462113|PMID:20417104)
(MGI:3814963|PMID:18827006)
MGI PMID:18827006 PMID:20417104 MGI:3814963 MGI:4462113 NCBI chrNW_004936487:17,690,206...17,819,619 JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (MGI:3814963|PMID:18827006) MGI PMID:18827006 MGI:3814963 NCBI chrNW_004936481:9,823,790...9,847,291 JBrowse link
G Arid5b AT-rich interaction domain 5B acts_upstream_of_or_within ISO (MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:3696608 NCBI chrNW_004936614:1,072,263...1,252,573 JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO (MGI:3687409|PMID:9083073) UniProt PMID:9083073 MGI:3687409 NCBI chrNW_004936475:23,994,130...24,032,829 JBrowse link
G Bcr BCR activator of RhoGEF and GTPase ISO RGD PMID:11560856 RGD:1600511 NCBI chrNW_004936619:288,377...432,297 JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 acts_upstream_of_or_within ISO (MGI:5699914|PMID:26437238) MGI PMID:26437238 MGI:5699914 NCBI chrNW_004936471:34,438,676...34,475,005 JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 acts_upstream_of_or_within ISO (MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:3696608 NCBI chrNW_004936473:28,398,528...28,409,962 JBrowse link
G Fer FER tyrosine kinase involved_in ISO (MGI:5319623|PMID:7623846) UniProt PMID:7623846 MGI:5319623 NCBI chrNW_004936531:3,512,976...3,898,885 JBrowse link
G Gab1 GRB2 associated binding protein 1 acts_upstream_of_or_within ISO (MGI:1355592|PMID:10779359) MGI PMID:10779359 MGI:1355592 NCBI chrNW_004936535:4,934,743...5,048,698 JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 involved_in ISO (MGI:5430891|PMID:17563371) BHF-UCL PMID:17563371 MGI:5430891 NCBI chrNW_004936483:16,489,127...16,594,712 JBrowse link
G Itgb3 integrin subunit beta 3 acts_upstream_of_or_within ISO (MGI:5462513|PMID:22984613) MGI PMID:22984613 MGI:5462513 NCBI chrNW_004936541:2,822,789...2,871,069 JBrowse link
G Jak2 Janus kinase 2 ISO PDGF-induced pancreatic stellate cell proliferation RGD PMID:15948243 RGD:1600095 NCBI chrNW_004936503:111,722...243,627 JBrowse link
G LOC101958103 TCDD inducible poly(ADP-ribose) polymerase acts_upstream_of_or_within ISO (MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:3696608 NCBI chrNW_004936519:3,683,972...3,712,081 JBrowse link
G LOC101976134 thioredoxin interacting protein acts_upstream_of_or_within ISO (MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:3696608 NCBI chrNW_004936867:722,544...726,595 JBrowse link
G Myo1e myosin IE acts_upstream_of_or_within ISO (MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:3696608 NCBI chrNW_004936471:20,244,424...20,435,604 JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 involved_in ISO (PMID:23554459) BHF-UCL PMID:23554459 NCBI chrNW_004936524:8,252,321...8,290,747 JBrowse link
G Nrp1 neuropilin 1 involved_in ISO (PMID:21245381) BHF-UCL PMID:21245381 NCBI chrNW_004936574:1,694,433...1,834,720 JBrowse link
G Pdgfa platelet derived growth factor subunit A involved_in ISO (PMID:2439522), (PMID:2536956), (PMID:2836953) BHF-UCL PMID:2439522 PMID:2536956 PMID:2836953 NCBI chrNW_004936754:808,894...828,554 JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO (PMID:19088079), (PMID:21245381), (PMID:23554459), (PMID:2439522), (PMID:2536956), (PMID:2836953) RGD
BHF-UCL
PMID:2439522 PMID:2536956 PMID:2836953 PMID:17449016 PMID:19088079 More... RGD:2292197 NCBI chrNW_004936492:2,353,840...2,368,573 JBrowse link
G Pdgfc platelet derived growth factor C involved_in
acts_upstream_of_or_within
ISO (PMID:10806482)
(MGI:3056973|PMID:15372073)
BHF-UCL
MGI
PMID:10806482 PMID:15372073 MGI:3056973 NCBI chrNW_004936576:3,357,399...3,555,828 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha involved_in
acts_upstream_of_or_within
ISO (PMID:10806482), (PMID:2536956)
(MGI:3696608|PMID:17143286)
BHF-UCL
MGI
PMID:2536956 PMID:10806482 PMID:17143286 MGI:3696608 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in
acts_upstream_of_or_within
ISO (PMID:1314164), (PMID:2536956)
(MGI:5699914|PMID:26437238)
(MGI:3696608|PMID:17143286)
UniProt
MGI
PMID:1314164 PMID:2536956 PMID:17143286 PMID:26437238 MGI:3696608 MGI:5699914 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Plat plasminogen activator, tissue type acts_upstream_of_or_within ISO (MGI:3056973|PMID:15372073) MGI PMID:15372073 MGI:3056973 NCBI chrNW_004936785:476,200...503,371 JBrowse link
G Plekha1 pleckstrin homology domain containing A1 acts_upstream_of_or_within ISO (MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:3696608 NCBI chrNW_004936486:11,203,873...11,241,028 JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:14718524 RGD:1358422 NCBI chrNW_004936735:1,252,414...1,338,318 JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 acts_upstream_of_or_within ISO (MGI:3814963|PMID:18827006) MGI PMID:18827006 MGI:3814963 NCBI chrNW_004936668:2,602,261...2,687,903 JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J involved_in ISO (PMID:21091576) UniProt PMID:21091576 NCBI chrNW_004936562:1,161,764...1,234,800 JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO (MGI:2445332|PMID:12466202) MGI PMID:12466202 MGI:2445332 NCBI chrNW_004936487:18,305,537...18,411,170 JBrowse link
G Rgs14 regulator of G protein signaling 14 involved_in ISO PMID:19878719 UniProt PMID:19878719 RGD:8553779 NCBI chrNW_004936597:1,650,480...1,658,823 JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 acts_upstream_of_or_within ISO (MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:3696608 NCBI chrNW_004936521:7,850,370...7,899,998 JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO (MGI:5518963|PMID:23651497) MGI PMID:23651497 MGI:5518963 NCBI chrNW_004936475:18,667,563...18,755,132 JBrowse link
G Ston1 stonin 1 acts_upstream_of_or_within ISO (MGI:5699914|PMID:26437238) MGI PMID:26437238 MGI:5699914 NCBI chrNW_004936508:4,068,102...4,116,166 JBrowse link
G Zfand5 zinc finger AN1-type containing 5 acts_upstream_of_or_within ISO (MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:3696608 NCBI chrNW_004936503:8,377,544...8,382,530 JBrowse link
negative regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO (PMID:12070119)
(MGI:4943654|PMID:19460854)
UniProt PMID:12070119 PMID:19460854 MGI:4943654 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G Apod apolipoprotein D involved_in ISO (PMID:14551159) UniProt PMID:14551159 NCBI chrNW_004936833:260,798...277,060 JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate involved_in ISO (PMID:18977327) BHF-UCL PMID:18977327 NCBI chrNW_004936594:5,285,678...5,301,267 JBrowse link
G Inppl1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chrNW_004936498:1,524,128...1,539,680 JBrowse link
G Ndrg4 NDRG family member 4 involved_in ISO (PMID:12755708) BHF-UCL PMID:12755708 NCBI chrNW_004936475:10,254,511...10,296,593 JBrowse link
G Ptgir prostaglandin I2 receptor involved_in ISO (MGI:5437428|PMID:20622039) BHF-UCL PMID:20622039 MGI:5437428 NCBI chrNW_004936664:487,069...489,328 JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J involved_in ISO (PMID:14709717)
(MGI:4942250|PMID:12833140)
UniProt PMID:12833140 PMID:14709717 MGI:4942250 NCBI chrNW_004936562:1,161,764...1,234,800 JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 involved_in ISO (MGI:4943390|PMID:18190691) UniProt PMID:18190691 MGI:4943390 NCBI chrNW_004936594:119,808...136,620 JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:12239163) UniProt PMID:12239163 NCBI chrNW_004936685:2,077,017...2,175,298 JBrowse link
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO (MGI:4943654|PMID:19460854) UniProt PMID:19460854 MGI:4943654 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within ISO (MGI:5426441|PMID:22730381) MGI PMID:22730381 MGI:5426441 NCBI chrNW_004936761:585,261...768,794 JBrowse link
negative regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glrx glutaredoxin ISO RGD PMID:16893901 RGD:9686048 NCBI chrNW_004936523:7,535,650...7,544,339 JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (MGI:4365879|PMID:19742316) BHF-UCL PMID:19742316 MGI:4365879 NCBI chrNW_004936646:1,326,900...1,407,236 JBrowse link
G Myocd myocardin involved_in ISO (MGI:5644147|PMID:23825366) BHF-UCL PMID:23825366 MGI:5644147 NCBI chrNW_004936595:5,256,615...5,356,563 JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:3029644|PMID:14966296) UniProt PMID:14966296 MGI:3029644 NCBI chrNW_004936626:2,390,004...2,472,039 JBrowse link
platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfra platelet derived growth factor receptor alpha involved_in ISO (PMID:2554309)
(MGI:5294530|PMID:20110689)
UniProt PMID:2554309 PMID:20110689 MGI:5294530 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in ISO (PMID:24520051) UniProt PMID:24520051 NCBI chrNW_004936487:17,690,206...17,819,619 JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 involved_in ISO (PMID:24520051) UniProt PMID:24520051 NCBI chrNW_004936473:23,756,291...23,940,966 JBrowse link
G Lox lysyl oxidase acts_upstream_of_or_within ISO (MGI:3813418|PMID:18586678) MGI PMID:18586678 MGI:3813418 RGD:14390060 NCBI chrNW_004936575:2,526,067...2,533,996 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in ISO (PMID:2554309), (PMID:26599395) UniProt PMID:2554309 PMID:26599395 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 involved_in ISO (PMID:14966296)
(MGI:3029644|PMID:14966296)
UniProt PMID:14966296 MGI:3029644 NCBI chrNW_004936514:4,065,455...4,083,847 JBrowse link
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfra platelet derived growth factor receptor alpha involved_in ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfa platelet derived growth factor subunit A involved_in ISO (PMID:19019919) UniProt PMID:19019919 NCBI chrNW_004936754:808,894...828,554 JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO (PMID:19019919) UniProt PMID:19019919 NCBI chrNW_004936492:2,353,840...2,368,573 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in ISO (MGI:5284758|PMID:19019919) UniProt PMID:19019919 MGI:5284758 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
positive regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor involved_in ISO (PMID:17991872) BHF-UCL PMID:17991872 NCBI chrNW_004936537:4,637,028...4,647,915 JBrowse link
G F7 coagulation factor VII involved_in ISO (PMID:17991872) BHF-UCL PMID:17991872 NCBI chrNW_004936472:505,751...515,375 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO PMID:16530387 UniProt PMID:16530387 RGD:8553998 NCBI chrNW_004936561:3,826,802...3,844,406 JBrowse link
positive regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hip1 huntingtin interacting protein 1 involved_in ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chrNW_004936543:2,496,301...2,569,019 JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chrNW_004936558:1,778,862...1,804,071 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (MGI:5518963|PMID:23651497) MGI PMID:23651497 MGI:5518963 NCBI chrNW_004936561:3,826,802...3,844,406 JBrowse link
regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fshr follicle stimulating hormone receptor acts_upstream_of_or_within ISO (MGI:3768889|PMID:16344272) MGI PMID:16344272 MGI:3768889 NCBI chrNW_004936508:3,601,205...3,754,234 JBrowse link
G Lrig2 leucine rich repeats and immunoglobulin like domains 2 acts_upstream_of_or_within ISO (MGI:5547441|PMID:24023893) MGI PMID:24023893 MGI:5547441 NCBI chrNW_004936690:1,591,741...1,642,183 JBrowse link
regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:6108066 NCBI chrNW_004936542:4,136,389...4,235,746 JBrowse link
G Cblb Cbl proto-oncogene B involved_in ISO (MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:6108066 NCBI chrNW_004936701:1,157,790...1,353,375 JBrowse link
G Ift20 intraflagellar transport 20 involved_in ISO (MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:6108066 NCBI chrNW_004936538:4,484,484...4,491,688 JBrowse link
regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lox lysyl oxidase acts_upstream_of_or_within ISO (MGI:5293278|PMID:21665949) MGI PMID:21665949 MGI:5293278 NCBI chrNW_004936575:2,526,067...2,533,996 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12174
    signaling 4325
      signal transduction 3837
        cell surface receptor signaling pathway 2068
          enzyme linked receptor protein signaling pathway 818
            transmembrane receptor protein tyrosine kinase signaling pathway 505
              platelet-derived growth factor receptor signaling pathway 60
                VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                negative regulation of platelet-derived growth factor receptor signaling pathway + 14
                platelet-derived growth factor receptor-alpha signaling pathway + 6
                platelet-derived growth factor receptor-beta signaling pathway + 14
                positive regulation of platelet-derived growth factor receptor signaling pathway + 5
                regulation of platelet-derived growth factor receptor signaling pathway + 25
Path 2
Term Annotations click to browse term
  biological_process 12174
    biological regulation 8886
      regulation of biological process 8417
        regulation of cellular process 7983
          signal transduction 3837
            cell surface receptor signaling pathway 2068
              enzyme linked receptor protein signaling pathway 818
                transmembrane receptor protein tyrosine kinase signaling pathway 505
                  platelet-derived growth factor receptor signaling pathway 60
                    VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                    negative regulation of platelet-derived growth factor receptor signaling pathway + 14
                    platelet-derived growth factor receptor-alpha signaling pathway + 6
                    platelet-derived growth factor receptor-beta signaling pathway + 14
                    positive regulation of platelet-derived growth factor receptor signaling pathway + 5
                    regulation of platelet-derived growth factor receptor signaling pathway + 25
paths to the root