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ONTOLOGY REPORT - ANNOTATIONS


Term:platelet-derived growth factor receptor signaling pathway
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Accession:GO:0048008 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
Synonyms:exact_synonym: PDGF receptor signaling pathway;   PDGF receptor signalling pathway;   PDGFR signaling pathway



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platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (MGI:3814963|PMID:18827006)
(MGI:4462113|PMID:20417104)
MGI PMID:18827006 PMID:20417104 MGI:3814963 MGI:4462113 NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,711
JBrowse link
G ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (MGI:3814963|PMID:18827006) MGI PMID:18827006 MGI:3814963 NCBI chr 9:120,888,891...120,984,724
Ensembl chr 9:120,892,926...120,985,119
JBrowse link
G ARID5B AT-rich interaction domain 5B involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696608|PMID:17143286) Ensembl
MGI
PMID:17143286 GO_REF:0000107 MGI:3696608 NCBI chr14:65,408,603...65,598,485
Ensembl chr14:65,408,597...65,598,486
JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:12,369,332...12,404,822
Ensembl chr 6:12,367,758...12,404,822
JBrowse link
G BCR BCR activator of RhoGEF and GTPase ISO RGD PMID:11560856 RGD:1600511 NCBI chr14:49,208,662...49,322,109
Ensembl chr14:49,208,762...49,322,109
JBrowse link
G CSPG4 chondroitin sulfate proteoglycan 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5699914|PMID:26437238) Ensembl
MGI
PMID:26437238 GO_REF:0000107 MGI:5699914 NCBI chr 7:57,949,182...57,988,602
Ensembl chr 7:57,949,455...57,988,337
JBrowse link
G CSRNP1 cysteine and serine rich nuclear protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696608|PMID:17143286) Ensembl
MGI
PMID:17143286 GO_REF:0000107 MGI:3696608 NCBI chr13:23,833,130...23,845,198
Ensembl chr13:23,833,133...23,845,215
JBrowse link
G FER FER tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:113,774,120...114,207,307
Ensembl chr 2:113,774,412...114,206,930
JBrowse link
G GAB1 GRB2 associated binding protein 1 acts_upstream_of_or_within ISO (MGI:1355592|PMID:10779359) MGI PMID:10779359 MGI:1355592 NCBI chr 8:84,257,958...84,391,511
Ensembl chr 8:84,257,958...84,391,621
JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:53,020,479...53,129,964
Ensembl chr 7:52,958,106...53,129,960
JBrowse link
G ITGB3 integrin subunit beta 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5462513|PMID:22984613) Ensembl
MGI
PMID:22984613 GO_REF:0000107 MGI:5462513 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,505...16,752,292
JBrowse link
G JAK2 Janus kinase 2 ISO PDGF-induced pancreatic stellate cell proliferation RGD PMID:15948243 RGD:1600095 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148
JBrowse link
G MYO1E myosin IE involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696608|PMID:17143286) Ensembl
MGI
PMID:17143286 GO_REF:0000107 MGI:3696608 NCBI chr 1:112,677,545...112,902,005
Ensembl chr 1:112,677,810...112,901,999
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:241,569,867...241,611,735
Ensembl chr 1:241,569,905...241,611,734
JBrowse link
G NRP1 neuropilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:56,280,673...56,430,832
Ensembl chr10:56,280,363...56,430,777
JBrowse link
G PDGFA platelet derived growth factor subunit A involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:296,399...322,967
Ensembl chr 3:303,311...323,036
JBrowse link
G PDGFB platelet derived growth factor subunit B involved_in ISO (PMID:19088079), (PMID:21245381), (PMID:23554459), (PMID:2439522), (PMID:2536956), (PMID:2836953) RGD
BHF-UCL
PMID:2439522 PMID:2536956 PMID:2836953 PMID:17449016 PMID:19088079 More... RGD:2292197 Ensembl chr 5:8,986,461...9,007,446 JBrowse link
G PDGFC platelet derived growth factor C involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(MGI:3056973|PMID:15372073)
(PMID:21873635)
InterPro
MGI
GO_Central
PMID:15372073 PMID:21873635 GO_REF:0000002 MGI:3056973 NCBI chr 8:45,579,065...45,808,789
Ensembl chr 8:45,578,001...45,808,748
JBrowse link
G PDGFD platelet derived growth factor D involved_in IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 9:34,388,636...34,621,227
Ensembl chr 9:34,388,636...34,621,244
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha involved_in
acts_upstream_of_or_within
ISO (PMID:10806482), (PMID:2536956)
(MGI:3696608|PMID:17143286)
BHF-UCL
MGI
PMID:2536956 PMID:10806482 PMID:17143286 MGI:3696608 NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,442
JBrowse link
G PDGFRB platelet derived growth factor receptor beta involved_in
acts_upstream_of_or_within
ISO (PMID:1314164), (PMID:2536956)
(MGI:5699914|PMID:26437238)
(MGI:3696608|PMID:17143286)
UniProt
MGI
PMID:1314164 PMID:2536956 PMID:17143286 PMID:26437238 MGI:3696608 MGI:5699914 NCBI chr 2:151,155,753...151,192,818
Ensembl chr 2:151,155,754...151,192,647
JBrowse link
G PLAT plasminogen activator, tissue type involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3056973|PMID:15372073)
GO_Central
MGI
PMID:15372073 PMID:21873635 MGI:3056973 NCBI chr17:11,195,599...11,223,821
Ensembl chr17:11,195,602...11,224,032
JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696608|PMID:17143286) Ensembl
MGI
PMID:17143286 GO_REF:0000107 MGI:3696608 NCBI chr14:131,960,932...132,016,664
Ensembl chr14:131,946,792...132,016,660
JBrowse link
G PTEN phosphatase and tensin homolog ISO RGD PMID:14718524 RGD:1358422 NCBI chr14:99,929,590...100,021,619 JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3814963|PMID:18827006) Ensembl
MGI
PMID:18827006 GO_REF:0000107 MGI:3814963 NCBI chr14:39,202,165...39,292,041
Ensembl chr14:39,202,168...39,292,018
JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:14,548,489...14,724,823
Ensembl chr 2:14,548,425...14,726,715
JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2445332|PMID:12466202) Ensembl
MGI
PMID:12466202 GO_REF:0000107 MGI:2445332 NCBI chr 1:271,494,243...271,624,609
Ensembl chr 1:271,494,248...271,600,879
JBrowse link
G RGS14 regulator of G protein signaling 14 involved_in ISO PMID:19878719 UniProt PMID:19878719 RGD:8553779 NCBI chr 2:80,574,411...80,589,998
Ensembl chr 2:80,574,411...80,590,003
JBrowse link
G SGPL1 sphingosine-1-phosphate lyase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696608|PMID:17143286) Ensembl
MGI
PMID:17143286 GO_REF:0000107 MGI:3696608 NCBI chr14:73,696,902...73,781,830
Ensembl chr14:73,723,800...73,781,830
JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO (MGI:5518963|PMID:23651497) MGI PMID:23651497 MGI:5518963 NCBI chr 6:28,938,287...29,025,397
Ensembl chr 6:28,938,290...29,025,357
JBrowse link
G TIPARP TCDD inducible poly(ADP-ribose) polymerase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696608|PMID:17143286) Ensembl
MGI
PMID:17143286 GO_REF:0000107 MGI:3696608 NCBI chr13:96,496,386...96,524,879
Ensembl chr13:96,496,439...96,525,848
JBrowse link
G TXNIP thioredoxin interacting protein involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696608|PMID:17143286) Ensembl
MGI
PMID:17143286 GO_REF:0000107 MGI:3696608 NCBI chr 4:99,348,589...99,351,760
Ensembl chr 4:99,348,575...99,352,241
JBrowse link
G ZFAND5 zinc finger AN1-type containing 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696608|PMID:17143286) Ensembl
MGI
PMID:17143286 GO_REF:0000107 MGI:3696608 NCBI chr 1:225,703,027...225,714,522
Ensembl chr 1:225,703,199...225,714,365
JBrowse link
negative regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in ISS UniProt GO_REF:0000024 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G APOD apolipoprotein D involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr13:132,514,546...132,562,594
Ensembl chr13:132,514,949...132,562,599
JBrowse link
G HGS hepatocyte growth factor-regulated tyrosine kinase substrate involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,207,036...1,219,750
Ensembl chr12:1,205,161...1,228,153
JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chr 9:6,793,971...6,807,286
Ensembl chr 9:6,792,884...6,808,028
JBrowse link
G NDRG4 NDRG family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:20,222,876...20,265,581
Ensembl chr 6:20,223,871...20,265,577
JBrowse link
G PTGIR prostaglandin I2 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:52,522,639...52,527,338
Ensembl chr 6:52,522,630...52,527,613
JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:14,548,489...14,724,823
Ensembl chr 2:14,548,425...14,726,715
JBrowse link
G SLC9A3R1 SLC9A3 regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:6,466,138...6,483,539
Ensembl chr12:6,466,120...6,493,428
JBrowse link
G SNCA synuclein alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:129,247,724...129,388,307
Ensembl chr 8:129,248,819...129,388,307
JBrowse link
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G PHF14 PHD finger protein 14 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5426441|PMID:22730381) Ensembl
MGI
PMID:22730381 GO_REF:0000107 MGI:5426441 NCBI chr 9:80,677,185...80,866,160
Ensembl chr 9:80,677,967...80,866,146
JBrowse link
negative regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLRX glutaredoxin ISO RGD PMID:16893901 RGD:9686048 NCBI chr 2:102,425,580...102,437,851 JBrowse link
G LRP1 LDL receptor related protein 1 involved_in ISO (MGI:4365879|PMID:19742316) BHF-UCL PMID:19742316 MGI:4365879 NCBI chr 5:22,435,636...22,519,276 JBrowse link
G MYOCD myocardin involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:56,931,628...57,029,258
Ensembl chr12:56,931,317...57,029,538
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,251...96,847,133
JBrowse link
platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFRA platelet derived growth factor receptor alpha involved_in IEA Ensembl
GOC
GO_REF:0000107 GO_REF:0000108 NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,442
JBrowse link
platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,711
JBrowse link
G CLASP2 cytoplasmic linker associated protein 2 involved_in ISO (PMID:24520051) UniProt PMID:24520051 NCBI chr13:19,305,430...19,510,589
Ensembl chr13:19,305,180...19,510,585
JBrowse link
G LOX lysyl oxidase involved_in
acts_upstream_of_or_within
IEA
ISO
PMID:18586678
(MGI:3813418|PMID:18586678)
Ensembl
MGI
PMID:18586678 GO_REF:0000107 MGI:3813418 RGD:14390060 NCBI chr 2:125,595,115...125,607,026
Ensembl chr 2:125,593,116...125,607,594
JBrowse link
G PDGFRB platelet derived growth factor receptor beta involved_in IEA GOC
Ensembl
GO_REF:0000107 GO_REF:0000108 NCBI chr 2:151,155,753...151,192,818
Ensembl chr 2:151,155,754...151,192,647
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,104...52,086,736
JBrowse link
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFRA platelet derived growth factor receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,442
JBrowse link
G PDGFRB platelet derived growth factor receptor beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:151,155,753...151,192,818
Ensembl chr 2:151,155,754...151,192,647
JBrowse link
G VEGFA vascular endothelial growth factor A involved_in ISS UniProt GO_REF:0000024 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFA platelet derived growth factor subunit A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:296,399...322,967
Ensembl chr 3:303,311...323,036
JBrowse link
G PDGFB platelet derived growth factor subunit B involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:8,986,461...9,007,446 JBrowse link
G PDGFRB platelet derived growth factor receptor beta involved_in ISO (MGI:5284758|PMID:19019919) UniProt PMID:19019919 MGI:5284758 NCBI chr 2:151,155,753...151,192,818
Ensembl chr 2:151,155,754...151,192,647
JBrowse link
positive regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,992...122,837,672
JBrowse link
G F7 coagulation factor VII involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:78,512,389...78,518,668
Ensembl chr11:78,512,158...78,518,671
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO PMID:16530387 UniProt PMID:16530387 RGD:8553998 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860
JBrowse link
positive regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIP1 huntingtin interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:10,416,418...10,578,374
Ensembl chr 3:10,524,080...10,573,447
JBrowse link
G HIP1R huntingtin interacting protein 1 related involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:29,996,388...30,024,343
Ensembl chr14:29,993,655...30,024,216
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5518963|PMID:23651497) Ensembl
MGI
PMID:23651497 GO_REF:0000107 MGI:5518963 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860
JBrowse link
regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FSHR follicle stimulating hormone receptor acts_upstream_of_or_within ISO (MGI:3768889|PMID:16344272) MGI PMID:16344272 MGI:3768889 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G LRIG2 leucine rich repeats and immunoglobulin like domains 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5547441|PMID:24023893) Ensembl
MGI
PMID:24023893 GO_REF:0000107 MGI:5547441 NCBI chr 4:107,348,662...107,511,308
Ensembl chr 4:107,348,662...107,493,948
JBrowse link
regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBL Cbl proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:46,416,937...46,512,855
Ensembl chr 9:46,404,999...46,512,834
JBrowse link
G CBLB Cbl proto-oncogene B involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:153,480,525...153,700,115
Ensembl chr13:153,395,978...153,700,064
JBrowse link
G IFT20 intraflagellar transport 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:44,609,586...44,616,685
Ensembl chr12:44,609,586...44,616,669
JBrowse link
regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOX lysyl oxidase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5293278|PMID:21665949) Ensembl
MGI
PMID:21665949 GO_REF:0000107 MGI:5293278 NCBI chr 2:125,595,115...125,607,026
Ensembl chr 2:125,593,116...125,607,594
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16581
    signaling 6571
      signal transduction 6029
        cell surface receptor signaling pathway 2521
          enzyme linked receptor protein signaling pathway 943
            transmembrane receptor protein tyrosine kinase signaling pathway 590
              platelet-derived growth factor receptor signaling pathway 60
                VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                negative regulation of platelet-derived growth factor receptor signaling pathway + 14
                platelet-derived growth factor receptor-alpha signaling pathway + 6
                platelet-derived growth factor receptor-beta signaling pathway + 14
                positive regulation of platelet-derived growth factor receptor signaling pathway + 5
                regulation of platelet-derived growth factor receptor signaling pathway + 25
Path 2
Term Annotations click to browse term
  biological_process 16581
    biological regulation 12071
      regulation of biological process 11445
        regulation of cellular process 10978
          signal transduction 6029
            cell surface receptor signaling pathway 2521
              enzyme linked receptor protein signaling pathway 943
                transmembrane receptor protein tyrosine kinase signaling pathway 590
                  platelet-derived growth factor receptor signaling pathway 60
                    VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                    negative regulation of platelet-derived growth factor receptor signaling pathway + 14
                    platelet-derived growth factor receptor-alpha signaling pathway + 6
                    platelet-derived growth factor receptor-beta signaling pathway + 14
                    positive regulation of platelet-derived growth factor receptor signaling pathway + 5
                    regulation of platelet-derived growth factor receptor signaling pathway + 25
paths to the root